{"id":"https://openalex.org/W2789892005","doi":"https://doi.org/10.1038/s41419-018-0347-x","title":"Lysine methyltransferase SMYD2 promotes triple negative breast cancer progression","display_name":"Lysine methyltransferase SMYD2 promotes triple negative breast cancer progression","publication_year":2018,"publication_date":"2018-02-27","ids":{"openalex":"https://openalex.org/W2789892005","doi":"https://doi.org/10.1038/s41419-018-0347-x","mag":"2789892005","pmid":"https://pubmed.ncbi.nlm.nih.gov/29487338","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5832424"},"language":"en","primary_location":{"id":"doi:10.1038/s41419-018-0347-x","doi":"https://doi.org/10.1038/s41419-018-0347-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-018-0347-x","pdf_url":"https://www.nature.com/articles/s41419-018-0347-x.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41419-018-0347-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010020250","display_name":"Xiaoyan Li","orcid":"https://orcid.org/0000-0002-7460-0776","observed_orcids":["https://orcid.org/0000-0002-7460-0776"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda Xiaoyan Li","raw_affiliation_strings":["Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, 66160, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, 66160, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079856225","display_name":"Julie Xia Zhou","orcid":"https://orcid.org/0000-0002-4876-4080","observed_orcids":["https://orcid.org/0000-0002-4876-4080"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie Xia Zhou","raw_affiliation_strings":["Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, 66160, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, 66160, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050373233","display_name":"James P. Calvet","orcid":"https://orcid.org/0000-0001-5928-9820","observed_orcids":["https://orcid.org/0000-0001-5928-9820"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James P. Calvet","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS, 66160, USA","Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS, 66160, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS, 66160, USA","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS, 66160, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033625395","display_name":"Andrew K. Godwin","orcid":"https://orcid.org/0000-0002-3987-9580","observed_orcids":["https://orcid.org/0000-0002-3987-9580"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew K. Godwin","raw_affiliation_strings":["Department of Pathology & Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, 66160, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology & Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, 66160, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024030506","display_name":"Roy A. Jensen","orcid":"https://orcid.org/0000-0003-4430-2281","observed_orcids":["https://orcid.org/0000-0003-4430-2281"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roy A. Jensen","raw_affiliation_strings":["Department of Pathology & Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, 66160, USA"],"raw_orcid":"https://orcid.org/0000-0003-4430-2281","affiliations":[{"raw_affiliation_string":"Department of Pathology & Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, 66160, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100355306","display_name":"Xiaogang Li","orcid":"https://orcid.org/0000-0001-8135-342X","observed_orcids":["https://orcid.org/0000-0001-8135-342X"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiaogang Li","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS, 66160, USA. xli3@kumc.edu","Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS, 66160, USA. xli3@kumc.edu","Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, 66160, USA. xli3@kumc.edu","Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS, 66160, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS, 66160, USA. xli3@kumc.edu","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS, 66160, USA. xli3@kumc.edu","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, 66160, USA. xli3@kumc.edu","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS, 66160, USA","institution_ids":["https://openalex.org/I4210128618"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100355306"],"corresponding_institution_ids":["https://openalex.org/I4210128618"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":4.7114,"has_fulltext":true,"cited_by_count":111,"citation_normalized_percentile":{"value":0.96473589,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"9","issue":"3","first_page":"326","last_page":"326"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.093299999833107,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/smyd2","display_name":"SMYD2","score":1.0},{"id":"https://openalex.org/keywords/protein-lysine-methyltransferase","display_name":"lysine methyltransferase","score":0.9480000138282776},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.8759999871253967},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.8809999823570251},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9179999828338623},{"id":"https://openalex.org/keywords/nf-kappab-p65","display_name":"NF-\u03baB p65","score":0.9909999966621399},{"id":"https://openalex.org/keywords/protein-methylation","display_name":"protein methylation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.7039999961853027},{"id":"https://openalex.org/keywords/il-6-signaling","display_name":"IL-6 signaling","score":0.8420000076293945},{"id":"https://openalex.org/keywords/tnf-signaling","display_name":"TNF signaling","score":0.9269999861717224},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7350000143051147},{"id":"https://openalex.org/keywords/ptpn13","display_name":"PTPN13","score":0.9629999995231628},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.6809999942779541},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.9769999980926514},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.9710000157356262},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.6646897792816162},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6474976539611816},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.5083128809928894},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.48508110642433167},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.4843827188014984},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.45091208815574646},{"id":"https://openalex.org/C150425827","wikidata":"https://www.wikidata.org/wiki/Q2560317","display_name":"Histone methyltransferase","level":4,"score":0.45029282569885254},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.43217992782592773},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.42706161737442017},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4219997823238373},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4211330711841583},{"id":"https://openalex.org/C50171091","wikidata":"https://www.wikidata.org/wiki/Q17917770","display_name":"EZH2","level":4,"score":0.4121595025062561},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40715867280960083},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3987728953361511},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3486884832382202},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3004714846611023},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2949864864349365},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2848048210144043},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16499954462051392},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011495","descriptor_name":"Histone-Lysine N-Methyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015091","descriptor_name":"beta-Alanine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D015091","descriptor_name":"beta-Alanine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048588","descriptor_name":"Benzoxazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051996","descriptor_name":"Transcription Factor RelA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41419-018-0347-x","doi":"https://doi.org/10.1038/s41419-018-0347-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-018-0347-x","pdf_url":"https://www.nature.com/articles/s41419-018-0347-x.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4746522","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5832424","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5832424","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5832424","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Dis","raw_type":"Text"},{"id":"pmid:29487338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29487338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell death & disease","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6168f714ef864f3fbc1474eb1951f9fd","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/6168f714ef864f3fbc1474eb1951f9fd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Death and Disease, Vol 9, Iss 3, Pp 1-17 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41419-018-0347-x","doi":"https://doi.org/10.1038/s41419-018-0347-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-018-0347-x","pdf_url":"https://www.nature.com/articles/s41419-018-0347-x.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8600000143051147,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1927146676","display_name":null,"funder_award_id":"K01 DK107729","funder_id":"https://openalex.org/F4320306478","funder_display_name":"PKD Foundation"},{"id":"https://openalex.org/G2094498244","display_name":"Kansas PKD Research and Translation Core Center","funder_award_id":"P30DK106912","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2776647444","display_name":null,"funder_award_id":"NIH K01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2853296776","display_name":null,"funder_award_id":"GM103418.","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2940345213","display_name":"ADPKD: understanding mechanisms and discovering treatments","funder_award_id":"R01DK084097","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3523366467","display_name":"Crosstalk of DNMT1 and Sirt1 in Autosomal Dominant Polycystic Kidney Disease","funder_award_id":"K01DK107729","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3844156422","display_name":"Novel Approaches for the Control of Microbial Pathogens","funder_award_id":"P30GM103326","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000023610","display_name":null,"funder_award_id":"DK106912","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000150948","display_name":null,"funder_award_id":"GM103418","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000248580","display_name":null,"funder_award_id":"CA168524","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000869322","display_name":"Kansas IDeA Network of Biomedical Research Excellence 5","funder_award_id":"P20GM103418","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000911857","display_name":"The University of Kansas Cancer Center","funder_award_id":"P30CA168524","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306478","display_name":"PKD Foundation","ror":"https://ror.org/05g0xkn45"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2789892005.pdf","grobid_xml":"https://content.openalex.org/works/W2789892005.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W165235925","https://openalex.org/W1504155896","https://openalex.org/W1573937463","https://openalex.org/W1764369779","https://openalex.org/W1964715103","https://openalex.org/W1969346276","https://openalex.org/W1970308473","https://openalex.org/W1972752117","https://openalex.org/W1978154786","https://openalex.org/W1988924112","https://openalex.org/W1989949054","https://openalex.org/W1990116612","https://openalex.org/W1993188287","https://openalex.org/W2007840001","https://openalex.org/W2007868505","https://openalex.org/W2009858080","https://openalex.org/W2017673293","https://openalex.org/W2030062212","https://openalex.org/W2031930309","https://openalex.org/W2035411102","https://openalex.org/W2043617798","https://openalex.org/W2044227662","https://openalex.org/W2044702943","https://openalex.org/W2045985868","https://openalex.org/W2054464764","https://openalex.org/W2057267524","https://openalex.org/W2059287377","https://openalex.org/W2071407989","https://openalex.org/W2093045397","https://openalex.org/W2094183784","https://openalex.org/W2097255042","https://openalex.org/W2106836397","https://openalex.org/W2114843025","https://openalex.org/W2123192739","https://openalex.org/W2123934552","https://openalex.org/W2124343538","https://openalex.org/W2127989042","https://openalex.org/W2129363220","https://openalex.org/W2133415120","https://openalex.org/W2135503632","https://openalex.org/W2138474420","https://openalex.org/W2141108574","https://openalex.org/W2143336748","https://openalex.org/W2146634563","https://openalex.org/W2149441684","https://openalex.org/W2149931953","https://openalex.org/W2153086428","https://openalex.org/W2167154785","https://openalex.org/W2169840774","https://openalex.org/W2175564726","https://openalex.org/W2259802687","https://openalex.org/W2623336038"],"related_works":["https://openalex.org/W4391400748","https://openalex.org/W4400357456","https://openalex.org/W7149488509","https://openalex.org/W2552775537","https://openalex.org/W7214270043","https://openalex.org/W2410037697","https://openalex.org/W2005784985","https://openalex.org/W1982682419","https://openalex.org/W4408394409","https://openalex.org/W2904360942"],"abstract_inverted_index":{"We":[0],"identified":[1,181],"SMYD2,":[2,101,124,143],"a":[3,16,182],"SMYD":[4],"(SET":[5],"and":[6,33,71,80,92,97,103,147,151,165,203],"MYND":[7],"domain)":[8],"family":[9],"protein":[10],"with":[11,54],"lysine":[12],"methyltransferase":[13],"activity,":[14],"as":[15],"novel":[17,75,183],"breast":[18,29,35,45,195],"cancer":[19,30,46,196],"oncogene.":[20],"SMYD2":[21,40,53,65,159,184,191],"was":[22],"expressed":[23],"at":[24],"significantly":[25,59],"higher":[26],"levels":[27],"in":[28,34,43,63,105,108,153,174],"cell":[31,48,90],"lines":[32,49],"tumor":[36,61],"tissues.":[37],"Silencing":[38],"of":[39,52,73,84,116,123,129,137,142,149,158],"by":[41,121,140,163],"RNAi":[42],"triple-negative":[44],"(TNBC)":[47],"or":[50],"inhibition":[51],"its":[55,74],"specific":[56],"inhibitor,":[57],"AZ505,":[58],"reduced":[60],"growth":[62],"vivo.":[64],"executes":[66],"this":[67],"activity":[68],"via":[69,206],"methylation":[70,146],"activation":[72,148],"non-histone":[76],"substrates,":[77],"including":[78,200],"STAT3":[79,110,138,150],"the":[81,114,126,135],"p65":[82,118,127,152],"subunit":[83,119,128],"NF-\u03baB,":[85],"leading":[86,144],"to":[87,113,134,145,172,192],"increased":[88],"TNBC":[89,106,175],"proliferation":[91],"survival.":[93],"There":[94],"are":[95],"cross-talk":[96],"synergistic":[98],"effects":[99],"among":[100],"STAT3,":[102],"NF-\u03baB":[104,117,130],"cells,":[107],"that":[109],"can":[111,131,160],"contribute":[112,133],"modification":[115,136],"post-translationally":[120,139],"recruitment":[122,141],"whereas":[125],"also":[132],"these":[154],"cells.":[155],"The":[156],"expression":[157],"be":[161],"upregulated":[162],"IL-6-STAT3":[164],"TNF\u03b1-NF-\u03baB":[166],"signaling,":[167],"which":[168,189],"integrates":[169],"epigenetic":[170],"regulation":[171],"inflammation":[173],"development.":[176],"In":[177],"addition,":[178],"we":[179],"have":[180],"transcriptional":[185],"target":[186],"gene,":[187],"PTPN13,":[188],"links":[190],"other":[193],"known":[194],"associated":[197],"signaling":[198,205],"pathways,":[199],"ERK,":[201],"mTOR,":[202],"Akt":[204],"PTPN13":[207],"mediated":[208],"phosphorylation.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-03-29T00:00:00"}