{"id":"https://openalex.org/W2789757496","doi":"https://doi.org/10.2147/ott.s155275","title":"Evodiamine activates cellular apoptosis through suppressing PI3K/AKT and activating MAPK in glioma","display_name":"Evodiamine activates cellular apoptosis through suppressing PI3K/AKT and activating MAPK in glioma","publication_year":2018,"publication_date":"2018-03-01","ids":{"openalex":"https://openalex.org/W2789757496","doi":"https://doi.org/10.2147/ott.s155275","mag":"2789757496","pmid":"https://pubmed.ncbi.nlm.nih.gov/29535541","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5841348"},"language":"en","primary_location":{"id":"doi:10.2147/ott.s155275","doi":"https://doi.org/10.2147/ott.s155275","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ott.s155275","pdf_url":"https://www.dovepress.com/getfile.php?fileID=40785","source":{"id":"https://openalex.org/S120324992","display_name":"OncoTargets and Therapy","issn_l":"1178-6930","issn":["1178-6930"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoTargets and Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=40785","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100324898","display_name":"Rong Wang","orcid":"https://orcid.org/0000-0002-9947-4307","observed_orcids":["https://orcid.org/0000-0002-9947-4307"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210105400","display_name":"The First People's Hospital of Changzhou","ror":"https://ror.org/01gaj0s81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong Wang","raw_affiliation_strings":["Department of Neurosurgery, The First People's Hospital of Changzhou, Changzhou, Jiangsu, China","Modern Medical Research Center, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The First People's Hospital of Changzhou, Changzhou, Jiangsu, China","institution_ids":["https://openalex.org/I4210105400"]},{"raw_affiliation_string":"Modern Medical Research Center, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055333454","display_name":"Danni Deng","orcid":"https://orcid.org/0000-0001-9409-1318","observed_orcids":["https://orcid.org/0000-0001-9409-1318"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Danni Deng","raw_affiliation_strings":["Modern Medical Research Center, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Modern Medical Research Center, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089827304","display_name":"Nan Shao","orcid":"https://orcid.org/0000-0001-5523-7142","observed_orcids":["https://orcid.org/0000-0001-5523-7142"]},"institutions":[{"id":"https://openalex.org/I4210105400","display_name":"The First People's Hospital of Changzhou","ror":"https://ror.org/01gaj0s81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Naiyuan Shao","raw_affiliation_strings":["Department of Neurosurgery, The First People's Hospital of Changzhou, Changzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The First People's Hospital of Changzhou, Changzhou, Jiangsu, China","institution_ids":["https://openalex.org/I4210105400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015876962","display_name":"Yuan Xu","orcid":"https://orcid.org/0000-0003-1093-9428","observed_orcids":["https://orcid.org/0000-0003-1093-9428"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Xu","raw_affiliation_strings":["Modern Medical Research Center, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Modern Medical Research Center, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100616928","display_name":"Lian Xue","orcid":"https://orcid.org/0000-0002-8287-8516","observed_orcids":["https://orcid.org/0000-0002-8287-8516"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lian Xue","raw_affiliation_strings":["Modern Medical Research Center, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Modern Medical Research Center, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073071897","display_name":"Ya Peng","orcid":"https://orcid.org/0000-0002-2761-4374","observed_orcids":["https://orcid.org/0000-0002-2761-4374"]},"institutions":[{"id":"https://openalex.org/I4210105400","display_name":"The First People's Hospital of Changzhou","ror":"https://ror.org/01gaj0s81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ya Peng","raw_affiliation_strings":["Department of Neurosurgery, The First People's Hospital of Changzhou, Changzhou, Jiangsu, China"],"raw_orcid":"https://orcid.org/0000-0002-2761-4374","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The First People's Hospital of Changzhou, Changzhou, Jiangsu, China","institution_ids":["https://openalex.org/I4210105400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064008985","display_name":"Yatian Liu","orcid":"https://orcid.org/0000-0001-7803-0494","observed_orcids":["https://orcid.org/0000-0001-7803-0494"]},"institutions":[{"id":"https://openalex.org/I4210128482","display_name":"Jiangsu Cancer Hospital","ror":"https://ror.org/03108sf43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128482"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yatian Liu","raw_affiliation_strings":["Department of Radiation Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I4210128482","https://openalex.org/I83519826"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043366101","display_name":"Feng Zhi","orcid":"https://orcid.org/0000-0002-3414-0162","observed_orcids":["https://orcid.org/0000-0002-3414-0162"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210105400","display_name":"The First People's Hospital of Changzhou","ror":"https://ror.org/01gaj0s81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105400"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Feng Zhi","raw_affiliation_strings":["Department of Neurosurgery, The First People's Hospital of Changzhou, Changzhou, Jiangsu, China","Modern Medical Research Center, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The First People's Hospital of Changzhou, Changzhou, Jiangsu, China","institution_ids":["https://openalex.org/I4210105400"]},{"raw_affiliation_string":"Modern Medical Research Center, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China","institution_ids":["https://openalex.org/I3923682"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5043366101","https://openalex.org/A5064008985"],"corresponding_institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210105400","https://openalex.org/I4210128482","https://openalex.org/I83519826"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":3.4267,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.95089598,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"Volume 11","issue":null,"first_page":"1183","last_page":"1192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/evodiamine","display_name":"evodiamine","score":1.0},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.878000020980835},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9810000061988831},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9580000042915344},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.7829999923706055},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.9990000128746033},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.972000002861023},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.996999979019165},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.8149999976158142},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.6209999918937683},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9750000238418579},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8980000019073486},{"id":"https://openalex.org/keywords/poly-adp-ribose-polymerase","display_name":"poly(ADP-ribose) polymerase","score":0.6869999766349792},{"id":"https://openalex.org/keywords/cytochrome-c","display_name":"cytochrome c","score":0.9169999957084656}],"concepts":[{"id":"https://openalex.org/C2779883843","wikidata":"https://www.wikidata.org/wiki/Q27894193","display_name":"Evodiamine","level":2,"score":0.818138062953949},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7853281497955322},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.7395306825637817},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7278534173965454},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6405258178710938},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5828729867935181},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.47766053676605225},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.4542939066886902},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44272613525390625},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4381397068500519},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.41009950637817383},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4053305983543396},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3526386022567749},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3233162760734558},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.22785383462905884},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10756272077560425}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.2147/ott.s155275","doi":"https://doi.org/10.2147/ott.s155275","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ott.s155275","pdf_url":"https://www.dovepress.com/getfile.php?fileID=40785","source":{"id":"https://openalex.org/S120324992","display_name":"OncoTargets and Therapy","issn_l":"1178-6930","issn":["1178-6930"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoTargets and Therapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4754774","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5841348","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:29535541","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29535541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoTargets and therapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5841348","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5841348/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Onco Targets Ther","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:6b77612c5af14025aaf7a904210b56b8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6b77612c5af14025aaf7a904210b56b8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"OncoTargets and Therapy, Vol Volume 11, Pp 1183-1192 (2018)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/37042","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/evodiamine-activates-cellular-apoptosis-through-suppressing-pi3kakt-an-peer-reviewed-article-OTT","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/ott.s155275","doi":"https://doi.org/10.2147/ott.s155275","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ott.s155275","pdf_url":"https://www.dovepress.com/getfile.php?fileID=40785","source":{"id":"https://openalex.org/S120324992","display_name":"OncoTargets and Therapy","issn_l":"1178-6930","issn":["1178-6930"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoTargets and Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2789757496.pdf","grobid_xml":"https://content.openalex.org/works/W2789757496.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W153349786","https://openalex.org/W1135784656","https://openalex.org/W1607777232","https://openalex.org/W1701760291","https://openalex.org/W1745634660","https://openalex.org/W1972779889","https://openalex.org/W1987442362","https://openalex.org/W1988398656","https://openalex.org/W1996405087","https://openalex.org/W2000398643","https://openalex.org/W2037753878","https://openalex.org/W2038553774","https://openalex.org/W2040792964","https://openalex.org/W2049217551","https://openalex.org/W2051972593","https://openalex.org/W2054720094","https://openalex.org/W2056686330","https://openalex.org/W2062289724","https://openalex.org/W2067275727","https://openalex.org/W2094632857","https://openalex.org/W2096946132","https://openalex.org/W2114111268","https://openalex.org/W2134295452","https://openalex.org/W2135086805","https://openalex.org/W2142518692","https://openalex.org/W2144323242","https://openalex.org/W2157846159","https://openalex.org/W2162004394","https://openalex.org/W2169673209","https://openalex.org/W2218539157","https://openalex.org/W2220606183","https://openalex.org/W2463107800","https://openalex.org/W2468774824","https://openalex.org/W2554189289","https://openalex.org/W2586952808","https://openalex.org/W2600434382","https://openalex.org/W2616821940","https://openalex.org/W6606251697","https://openalex.org/W6659908237"],"related_works":["https://openalex.org/W7055509248","https://openalex.org/W2616821940","https://openalex.org/W4225372893","https://openalex.org/W2394426764","https://openalex.org/W2040792964","https://openalex.org/W3096215379","https://openalex.org/W4362594801","https://openalex.org/W4403104744","https://openalex.org/W4220672747","https://openalex.org/W4362597055"],"abstract_inverted_index":{"BACKGROUND:":[0],"Glioblastoma":[1],"multiforme":[2],"(GBM)":[3],"is":[4,16,43],"the":[5,11,51,63,76],"most":[6],"malignant":[7],"primary":[8],"tumor":[9],"of":[10,54],"central":[12],"nervous":[13],"system":[14],"and":[15,60,82,87,109,126,131,145,161],"associated":[17],"with":[18],"a":[19,80,98,175],"very":[20],"poor":[21],"prognosis.":[22],"No":[23],"further":[24],"improvements":[25],"in":[26,79,97,119,164],"outcomes":[27],"have":[28],"been":[29],"reported":[30],"since":[31],"radiotherapy-temozolomide":[32],"therapy":[33],"was":[34],"introduced.":[35],"Therefore,":[36],"developing":[37],"new":[38,176],"agents":[39],"to":[40,49,61,69,136],"treat":[41],"GBM":[42,58,179],"important.":[44],"AIM:":[45],"This":[46],"study":[47],"aimed":[48],"evaluate":[50],"anti-tumor":[52],"effect":[53],"evodiamine":[55],"(Evo)":[56],"on":[57],"cells,":[59],"determine":[62],"underlying":[64],"mechanisms":[65],"involved.":[66],"RESULTS:":[67],"According":[68],"MTT":[70],"assay":[71],"results,":[72],"Evo":[73,93,102,116,150,170],"significantly":[74],"inhibited":[75],"cell":[77,95,152],"proliferation":[78,153],"time-":[81],"dose-dependent":[83],"manner.":[84,100],"Fluorescence":[85],"microscopy":[86],"flow":[88],"cytometry":[89],"analyses":[90],"revealed":[91],"that":[92,169],"induced":[94,103,117],"apoptosis":[96,118,157],"concentration-dependent":[99],"Moreover,":[101],"reactive":[104],"oxygen":[105],"species":[106],"(ROS)":[107],"production":[108],"mitochondrial":[110],"membrane":[111],"potential":[112],"(MMP)":[113],"disruption.":[114],"Finally,":[115],"cancer":[120],"cells":[121],"by":[122,154],"suppressing":[123,159],"PI3K/AKT":[124,160],"signaling":[125],"inducing":[127,155],"MAPK":[128,163],"phosphorylation":[129],"(p38":[130],"JNK,":[132],"but":[133],"not":[134],"ERK)":[135],"regulate":[137],"apoptotic":[138],"proteins":[139],"(Bax,":[140],"Bcl-2,":[141],"Cytochrome":[142],"c,":[143],"Caspase-3,":[144],"PARP).":[146],"CONCLUSION:":[147],"In":[148],"summary,":[149],"inhibits":[151],"cellular":[156],"via":[158],"activating":[162],"GBM;":[165],"these":[166],"results":[167],"indicate":[168],"may":[171],"be":[172],"regarded":[173],"as":[174],"approach":[177],"for":[178],"treatment.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2018-03-29T00:00:00"}