{"id":"https://openalex.org/W278963705","doi":null,"title":"[Hemodynamic effects of a transdermal formulation of isosorbide dinitrate and its pharmacokinetics in conscious dogs].","display_name":"[Hemodynamic effects of a transdermal formulation of isosorbide dinitrate and its pharmacokinetics in conscious dogs].","publication_year":1982,"publication_date":"1982-10-01","ids":{"openalex":"https://openalex.org/W278963705","mag":"278963705","pmid":"https://pubmed.ncbi.nlm.nih.gov/7152395"},"language":"ja","primary_location":{"id":"pmid:7152395","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7152395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon yakurigaku zasshi. Folia pharmacologica Japonica","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032111748","display_name":"Kentaro Kogi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Kogi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070214872","display_name":"Osamu Tanaka","orcid":"https://orcid.org/0009-0007-6678-3502","observed_orcids":["https://orcid.org/0009-0007-6678-3502"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Tanaka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027958946","display_name":"Tetsu Kimura","orcid":"https://orcid.org/0000-0001-7981-2244","observed_orcids":["https://orcid.org/0000-0001-7981-2244"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Kimura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"T Saito","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Saito","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5711,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.54254254,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"80","issue":"4","first_page":"279","last_page":"88"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isosorbide-dinitrate","display_name":"isosorbide dinitrate","score":1.0},{"id":"https://openalex.org/keywords/transdermal-drug-delivery","display_name":"transdermal drug delivery","score":0.9520000219345093},{"id":"https://openalex.org/keywords/transdermal-patch","display_name":"transdermal patch","score":0.7129999995231628},{"id":"https://openalex.org/keywords/sustained-release-tablets","display_name":"sustained-release tablets","score":0.8349999785423279},{"id":"https://openalex.org/keywords/pulse-pressure","display_name":"pulse pressure","score":0.8389999866485596},{"id":"https://openalex.org/keywords/hemodynamic-effects","display_name":"hemodynamic effects","score":0.7940000295639038},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.6000000238418579},{"id":"https://openalex.org/keywords/isosorbide-2-mononitrate","display_name":"isosorbide-2-mononitrate","score":0.9549999833106995},{"id":"https://openalex.org/keywords/isosorbide-mononitrate","display_name":"isosorbide mononitrate","score":1.0},{"id":"https://openalex.org/keywords/first-pass-metabolism","display_name":"first-pass metabolism","score":0.9800000190734863},{"id":"https://openalex.org/keywords/angina","display_name":"angina pectoris","score":0.8930000066757202},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C2778949068","wikidata":"https://www.wikidata.org/wiki/Q179748","display_name":"Isosorbide dinitrate","level":2,"score":0.9748162627220154},{"id":"https://openalex.org/C536894130","wikidata":"https://www.wikidata.org/wiki/Q170397","display_name":"Integrated Services Digital Network","level":2,"score":0.790421187877655},{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.5243511199951172},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5060033202171326},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4666706621646881},{"id":"https://openalex.org/C2780167933","wikidata":"https://www.wikidata.org/wiki/Q1550652","display_name":"Pulse (music)","level":3,"score":0.4464322626590729},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39150795340538025},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3425447344779968},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3072727620601654},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.09317353367805481},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.07158157229423523},{"id":"https://openalex.org/C94915269","wikidata":"https://www.wikidata.org/wiki/Q1834857","display_name":"Detector","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007548","descriptor_name":"Isosorbide Dinitrate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007548","descriptor_name":"Isosorbide Dinitrate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D007548","descriptor_name":"Isosorbide Dinitrate","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007548","descriptor_name":"Isosorbide Dinitrate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012869","descriptor_name":"Skin Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7152395","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7152395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon yakurigaku zasshi. Folia pharmacologica Japonica","raw_type":"Comparative Study"},{"id":"mag:278963705","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7152395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2065793986","https://openalex.org/W2139061482","https://openalex.org/W2107720392","https://openalex.org/W2026170953","https://openalex.org/W1989380217","https://openalex.org/W2468401560","https://openalex.org/W2333543647","https://openalex.org/W2039372029","https://openalex.org/W2520929285","https://openalex.org/W1975612457"],"abstract_inverted_index":{"Transdermal":[0],"application":[1,107,123,140,158],"of":[2,9,19,51,58,65,73,88,108,116,120,124,141,147,159,166,177,184,227,249],"isosorbide":[3,94,98],"dinitrate":[4],"(ISDN)":[5],"in":[6,16,26,62,174,181,201,216,244],"the":[7,44,70,117,125,136,142,144,157,160,167,175,178,182,185,192,198,207,213,217,223,237,245],"form":[8,226],"a":[10,17,23,55,63,152,231],"tape":[11],"(ISDN-Tape)":[12],"to":[13,191,203],"conscious":[14,74],"dogs,":[15],"dose":[18,64],"40":[20,66],"mg/dog,":[21,67],"caused":[22],"slow":[24],"decrease":[25],"pulse":[27,39,71,137],"pressure.":[28,84,138],"The":[29,38,85,112,162],"maximum":[30,163],"effect":[31,134,215,235],"was":[32,41,149,220],"obtained":[33],"12":[34],"hour":[35],"after":[36,48,106,122,156],"application.":[37,52],"pressure":[40,72,79],"still":[42],"under":[43],"initial":[45],"level":[46,154],"even":[47],"48":[49],"hours":[50],"In":[53],"contrast,":[54],"sustained-release":[56],"tablet":[57],"ISDN":[59,89,121,148,195],"(ISDN-SR-Tablet),":[60],"given":[61,196,205],"significantly":[68],"decreased":[69],"dogs":[75],"by":[76,103,206],"reducing":[77],"systolic":[78],"and":[80,90,97,247],"slightly":[81],"elevating":[82],"diastolic":[83],"plasma":[86,118,145,164],"concentrations":[87,165],"its":[91],"two":[92,168],"metabolites,":[93,169],"2-mononitrate":[95],"(2-ISMN)":[96],"5-mononitrate":[99],"(5-ISMN),":[100],"were":[101,171,189],"measured":[102],"gas":[104],"chromatography":[105],"ISDN-Tape":[109,179],"or":[110],"ISDN-SR-Tablets.":[111],"time":[113],"course":[114],"pattern":[115],"concentration":[119,146],"both":[126],"preparations":[127],"ran":[128],"quite":[129],"parallel":[130],"with":[131],"their":[132],"decreasing":[133],"on":[135],"After":[139],"ISDN-Tape,":[143],"maintained":[150],"at":[151],"higher":[153],"than":[155,180,236],"ISDN-SR-Tablet.":[161,186],"however,":[170],"considerably":[172],"lower":[173],"case":[176,183],"These":[187],"results":[188],"ascribed":[190],"fact":[193],"that":[194,204,222],"through":[197],"transdermal":[199,224],"route,":[200,209],"contrast":[202],"peroral":[208],"does":[210],"not":[211],"undergo":[212],"first-pass":[214],"liver.":[218],"It":[219],"concluded":[221],"dosage":[225,239],"ISDN,":[228],"which":[229],"possesses":[230],"more":[232],"prolonged":[233],"pharmacologic":[234],"oral":[238],"form,":[240],"may":[241],"be":[242],"useful":[243],"prevention":[246],"cure":[248],"angina":[250],"pectoris.":[251]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}