{"id":"https://openalex.org/W2789596223","doi":"https://doi.org/10.3389/fendo.2018.00116","title":"Effects of Oleacein on High-Fat Diet-Dependent Steatosis, Weight Gain, and Insulin Resistance in Mice","display_name":"Effects of Oleacein on High-Fat Diet-Dependent Steatosis, Weight Gain, and Insulin Resistance in Mice","publication_year":2018,"publication_date":"2018-03-19","ids":{"openalex":"https://openalex.org/W2789596223","doi":"https://doi.org/10.3389/fendo.2018.00116","mag":"2789596223","pmid":"https://pubmed.ncbi.nlm.nih.gov/29615982","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5868215"},"language":"en","primary_location":{"id":"doi:10.3389/fendo.2018.00116","doi":"https://doi.org/10.3389/fendo.2018.00116","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2018.00116","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2018.00116/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fendo.2018.00116/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010048970","display_name":"Giovanni Enrico Lombardo","orcid":"https://orcid.org/0000-0003-1101-8874","observed_orcids":["https://orcid.org/0000-0003-1101-8874"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Enrico Lombardo","raw_affiliation_strings":["Department of Health Sciences, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068743854","display_name":"Saverio Massimo Lepore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Saverio Massimo Lepore","raw_affiliation_strings":["Department of Health Sciences, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021668559","display_name":"Valeria Maria Morittu","orcid":"https://orcid.org/0000-0001-6790-5734","observed_orcids":["https://orcid.org/0000-0001-6790-5734"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valeria Maria Morittu","raw_affiliation_strings":["Department of Health Sciences, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053892251","display_name":"Biagio Arcidiacono","orcid":"https://orcid.org/0000-0003-4343-678X","observed_orcids":["https://orcid.org/0000-0003-4343-678X"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Biagio Arcidiacono","raw_affiliation_strings":["Department of Health Sciences, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015129045","display_name":"Carmela Colica","orcid":"https://orcid.org/0000-0001-6424-1223","observed_orcids":["https://orcid.org/0000-0001-6424-1223"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carmela Colica","raw_affiliation_strings":["CNR, IBFM UOS of Germaneto, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNR, IBFM UOS of Germaneto, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044437910","display_name":"Antonio Procopio","orcid":"https://orcid.org/0000-0003-0225-033X","observed_orcids":["https://orcid.org/0000-0003-0225-033X","https://orcid.org/0000-0002-2205-1541"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Procopio","raw_affiliation_strings":["Department of Health Sciences, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014209031","display_name":"Valentina Maggisano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valentina Maggisano","raw_affiliation_strings":["Department of Health Sciences, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026972803","display_name":"Stefania Bulotta","orcid":"https://orcid.org/0000-0002-9033-5976","observed_orcids":["https://orcid.org/0000-0002-9033-5976"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefania Bulotta","raw_affiliation_strings":["Department of Health Sciences, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105282178","display_name":"Nicola Costa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nicola Costa","raw_affiliation_strings":["Department of Health Sciences, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012424541","display_name":"Chiara Mignogna","orcid":"https://orcid.org/0000-0001-5576-4946","observed_orcids":["https://orcid.org/0000-0001-5576-4946"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Mignogna","raw_affiliation_strings":["Department of Health Sciences, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy","Interdepartmental Service Center, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]},{"raw_affiliation_string":"Interdepartmental Service Center, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088201710","display_name":"Domenico Britti","orcid":"https://orcid.org/0000-0001-7355-8791","observed_orcids":["https://orcid.org/0000-0001-7355-8791"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Domenico Britti","raw_affiliation_strings":["Department of Health Sciences, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076502823","display_name":"Antonio Brunetti","orcid":"https://orcid.org/0000-0003-1533-8779","observed_orcids":["https://orcid.org/0000-0003-1533-8779"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Antonio Brunetti","raw_affiliation_strings":["Department of Health Sciences, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027192215","display_name":"Diego Russo","orcid":"https://orcid.org/0000-0001-7559-1595","observed_orcids":["https://orcid.org/0000-0001-7559-1595"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Diego Russo","raw_affiliation_strings":["Department of Health Sciences, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103799941","display_name":"Marilena Celano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marilena Celano","raw_affiliation_strings":["Department of Health Sciences, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences, University \"Magna Gr\u00e6cia\" of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5027192215","https://openalex.org/A5076502823"],"corresponding_institution_ids":["https://openalex.org/I36443711"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":2.4494,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.89549668,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":null,"first_page":"116","last_page":"116"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10909","display_name":"Edible Oils Quality and Analysis","score":0.5785999894142151,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10909","display_name":"Edible Oils Quality and Analysis","score":0.5785999894142151,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.1339000016450882,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.04919999837875366,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oleacein","display_name":"oleacein","score":1.0},{"id":"https://openalex.org/keywords/secoiridoids","display_name":"secoiridoids","score":0.925000011920929},{"id":"https://openalex.org/keywords/extra-virgin-olive-oil","display_name":"extra virgin olive oil","score":0.9459999799728394},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.953000009059906},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.968999981880188},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.949999988079071},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.8220000267028809},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7120000123977661},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.5320000052452087},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9380000233650208},{"id":"https://openalex.org/keywords/srebp-1","display_name":"SREBP1","score":0.8849999904632568},{"id":"https://openalex.org/keywords/fas","display_name":"Fas","score":0.8690000176429749},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/nutraceuticals","display_name":"nutraceuticals","score":0.859000027179718},{"id":"https://openalex.org/keywords/mediterranean-diet","display_name":"Mediterranean diet","score":0.5099999904632568},{"id":"https://openalex.org/keywords/serum-cholesterol","display_name":"serum cholesterol","score":0.5600000023841858},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9539999961853027}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8445570468902588},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8152297735214233},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7655435800552368},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.7217394113540649},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.701621413230896},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.6575210094451904},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.516491174697876},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4721051752567291},{"id":"https://openalex.org/C2779113265","wikidata":"https://www.wikidata.org/wiki/Q107525054","display_name":"Insulin tolerance test","level":5,"score":0.468472421169281},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.4218555688858032},{"id":"https://openalex.org/C2780833929","wikidata":"https://www.wikidata.org/wiki/Q1501412","display_name":"Glucose tolerance test","level":4,"score":0.41440629959106445},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32033485174179077},{"id":"https://openalex.org/C3017594256","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin sensitivity","level":4,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fendo.2018.00116","doi":"https://doi.org/10.3389/fendo.2018.00116","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2018.00116","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2018.00116/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5868215","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5868215","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Endocrinol (Lausanne)","raw_type":"Text"},{"id":"pmid:29615982","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29615982","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ffb860feee0046f3b7ff6af25801d946","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ffb860feee0046f3b7ff6af25801d946","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Endocrinology, Vol 9 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fendo.2018.00116","doi":"https://doi.org/10.3389/fendo.2018.00116","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2018.00116","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2018.00116/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2789596223.pdf","grobid_xml":"https://content.openalex.org/works/W2789596223.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1499313373","https://openalex.org/W1549420169","https://openalex.org/W1805907968","https://openalex.org/W1963854785","https://openalex.org/W1966296314","https://openalex.org/W1966884669","https://openalex.org/W1967611546","https://openalex.org/W1983003002","https://openalex.org/W1998143374","https://openalex.org/W2005203528","https://openalex.org/W2007531727","https://openalex.org/W2007809519","https://openalex.org/W2009789674","https://openalex.org/W2011574523","https://openalex.org/W2018333108","https://openalex.org/W2028033722","https://openalex.org/W2032514894","https://openalex.org/W2038961236","https://openalex.org/W2039999119","https://openalex.org/W2053151522","https://openalex.org/W2061429720","https://openalex.org/W2064935325","https://openalex.org/W2070773715","https://openalex.org/W2074299448","https://openalex.org/W2075481792","https://openalex.org/W2089142647","https://openalex.org/W2093311244","https://openalex.org/W2094166298","https://openalex.org/W2119118503","https://openalex.org/W2134283276","https://openalex.org/W2167984796","https://openalex.org/W2169024285","https://openalex.org/W2188026469","https://openalex.org/W2198418015","https://openalex.org/W2235650520","https://openalex.org/W2266857411","https://openalex.org/W2396589892","https://openalex.org/W2467091785","https://openalex.org/W2562635737","https://openalex.org/W2610525859","https://openalex.org/W2755444985","https://openalex.org/W2761548023","https://openalex.org/W2766563081","https://openalex.org/W2769058668","https://openalex.org/W2959198180"],"related_works":["https://openalex.org/W2198418015","https://openalex.org/W3154345975","https://openalex.org/W2064935325","https://openalex.org/W2532824621","https://openalex.org/W2353196192","https://openalex.org/W2272345182","https://openalex.org/W4390397335","https://openalex.org/W2321389144","https://openalex.org/W1535746632","https://openalex.org/W3173264602"],"abstract_inverted_index":{"Many":[0],"reports":[1],"indicate":[2,230],"that":[3,125,231],"the":[4,10,22,35,42,49,123,186],"protective":[5,36,85,247],"action":[6,23,86],"of":[7,24,27,38,41,64,69,80,87,100,150,172,185,202,209,243,249],"nutraceuticals":[8],"in":[9,46,57,115,122,155,165,188,213,274],"Mediterranean":[11],"diet,":[12],"against":[13,89,252],"metabolic":[14,254],"and":[15,77,95,103,109,131,135,153,204,206,219],"cardiovascular":[16],"diseases,":[17],"can":[18,264],"be":[19,237,265],"attributed":[20],"to":[21,140,193,260,270],"polyphenolic":[25],"components":[26],"extra-virgin":[28],"olive":[29],"oil":[30],"(EVOO).":[31],"Here,":[32],"we":[33],"evaluated":[34],"effects":[37],"oleacein,":[39,70,127,161,244],"one":[40],"most":[43],"abundant":[44],"secoiridoids":[45],"EVOO,":[47],"on":[48],"damages/metabolic":[50],"alterations":[51],"caused":[52],"by":[53,160,226,240],"high-fat":[54],"diet":[55],"(HFD)":[56],"male":[58],"C57BL/6JolaHsd":[59],"mice.":[60],"After":[61],"5":[62],"weeks":[63],"treatment":[65,175],"with":[66,98,118,143,176,199],"20":[67],"mg/kg":[68],"body":[71,189],"weight,":[72,190],"glycemia,":[73],"insulinemia,":[74],"serum":[75,107,133,211,221],"lipids,":[76],"histologic":[78,111],"examination":[79,112],"liver":[81,96,136,156,166,195],"tissue":[82],"indicated":[83],"a":[84,170,179,246],"oleacein":[88,177,263],"abdominal":[90],"fat":[91],"accumulation,":[92],"weight":[93],"gain,":[94],"steatosis,":[97],"improvement":[99,164],"insulin-dependent":[101],"glucose":[102,218],"lipid":[104],"metabolism.":[105],"Both":[106],"parameters":[108],"hepatic":[110,233],"were":[113,138,157,223],"altered":[114,216],"mice":[116],"fed":[117,142],"HFD.":[119],"By":[120],"contrast,":[121],"animals":[124],"received":[126],"plasma":[128,217],"glucose,":[129],"cholesterol":[130],"triglyceride":[132,220],"levels,":[134],"histology":[137],"similar":[139],"controls":[141],"normocaloric":[144],"diet.":[145],"In":[146,169],"addition,":[147],"protein":[148],"levels":[149,201,208,222],"FAS,":[151],"SREBP-1,":[152],"phospho-ERK":[154,205],"positively":[158],"modulated":[159],"indicating":[162],"an":[163,268],"insulin":[167,234,272],"sensitivity.":[168],"group":[171],"obese":[173],"mice,":[174],"determined":[178],"light,":[180],"but":[181],"still":[182],"significant":[183],"reduction":[184],"increase":[187],"mainly":[191],"due":[192],"lesser":[194],"steatosis":[196],"enlargement,":[197],"associated":[198],"reduced":[200],"SREBP-1":[203],"lower":[207],"total":[210],"cholesterol;":[212],"these":[214],"animals,":[215],"not":[224],"reverted":[225],"oleacein.":[227],"These":[228],"results":[229],"HFD-related":[232],"resistance":[235],"may":[236],"partially":[238],"prevented":[239],"oral":[241],"administration":[242],"suggesting":[245],"role":[248],"this":[250],"nutraceutical":[251],"diet-dependent":[253],"alterations.":[255],"Additional":[256],"studies":[257],"are":[258],"necessary":[259],"check":[261],"whether":[262],"used":[266],"as":[267],"adjuvant":[269],"improve":[271],"sensitivity":[273],"humans.":[275]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-03-29T00:00:00"}