{"id":"https://openalex.org/W2789430800","doi":"https://doi.org/10.2210/pdb2wyx/pdb","title":"Neutron structure of a class A Beta-lactamase Toho-1 E166A R274N R276N triple mutant","display_name":"Neutron structure of a class A Beta-lactamase Toho-1 E166A R274N R276N triple mutant","publication_year":2009,"publication_date":"2009-11-20","ids":{"openalex":"https://openalex.org/W2789430800","doi":"https://doi.org/10.2210/pdb2wyx/pdb","mag":"2789430800"},"language":"en","primary_location":{"id":"doi:10.2210/pdb2wyx/pdb","doi":"https://doi.org/10.2210/pdb2wyx/pdb","is_oa":false,"landing_page_url":"https://doi.org/10.2210/pdb2wyx/pdb","pdf_url":null,"source":{"id":"https://openalex.org/S7407063902","display_name":"Worldwide Protein Data Bank","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Worldwide Protein Data Bank","raw_type":"dataset"},"volume":null,"type":"dataset","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001294880","display_name":"Stephen J. Tomanicek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S.J. Tomanicek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011183452","display_name":"Matthew Paul Blakeley","orcid":"https://orcid.org/0000-0002-6412-4358","observed_orcids":["https://orcid.org/0000-0002-6412-4358"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M.P. Blakeley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037343064","display_name":"J.B. Cooper","orcid":"https://orcid.org/0000-0003-2256-1506","observed_orcids":["https://orcid.org/0000-0003-2256-1506"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Cooper","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081002958","display_name":"Y. Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027485418","display_name":"Pavel V. Afonine","orcid":"https://orcid.org/0000-0002-5052-991X","observed_orcids":["https://orcid.org/0000-0002-5052-991X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Afonine","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5015921759","display_name":"Leighton Coates","orcid":"https://orcid.org/0000-0003-2342-049X","observed_orcids":["https://orcid.org/0000-0003-2342-049X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Coates","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.8823000192642212,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.8823000192642212,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.08609999716281891,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-lactamase","display_name":"beta-lactamase","score":0.8529999852180481},{"id":"https://openalex.org/keywords/class-a-beta-lactamase","display_name":"class A beta-lactamase","score":0.8130000233650208},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.6669999957084656},{"id":"https://openalex.org/keywords/triple-mutant","display_name":"triple mutant","score":0.8169999718666077},{"id":"https://openalex.org/keywords/neutron-diffraction","display_name":"neutron diffraction","score":0.5509999990463257},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.5920000076293945},{"id":"https://openalex.org/keywords/enzyme-active-site","display_name":"enzyme active site","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5831546783447266},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.5313582420349121},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.4434441328048706},{"id":"https://openalex.org/C2777212361","wikidata":"https://www.wikidata.org/wiki/Q5127848","display_name":"Class (philosophy)","level":2,"score":0.41002756357192993},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31599029898643494},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28247541189193726},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.22724920511245728},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1312119960784912},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.10971152782440186},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.09341162443161011}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2210/pdb2wyx/pdb","doi":"https://doi.org/10.2210/pdb2wyx/pdb","is_oa":false,"landing_page_url":"https://doi.org/10.2210/pdb2wyx/pdb","pdf_url":null,"source":{"id":"https://openalex.org/S7407063902","display_name":"Worldwide Protein Data Bank","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Worldwide Protein Data Bank","raw_type":"dataset"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2976519049","https://openalex.org/W2790542383","https://openalex.org/W2976967473","https://openalex.org/W2063893529"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2018-03-29T00:00:00"}