{"id":"https://openalex.org/W2789409102","doi":"https://doi.org/10.1016/j.jchromb.2018.03.016","title":"Metabolism of the synthetic cannabinoids AMB-CHMICA and 5C-AKB48 in pooled human hepatocytes and rat hepatocytes analyzed by UHPLC-(IMS)-HR-MS E","display_name":"Metabolism of the synthetic cannabinoids AMB-CHMICA and 5C-AKB48 in pooled human hepatocytes and rat hepatocytes analyzed by UHPLC-(IMS)-HR-MS E","publication_year":2018,"publication_date":"2018-03-14","ids":{"openalex":"https://openalex.org/W2789409102","doi":"https://doi.org/10.1016/j.jchromb.2018.03.016","mag":"2789409102","pmid":"https://pubmed.ncbi.nlm.nih.gov/29549742"},"language":"en","primary_location":{"id":"doi:10.1016/j.jchromb.2018.03.016","doi":"https://doi.org/10.1016/j.jchromb.2018.03.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jchromb.2018.03.016","pdf_url":null,"source":{"id":"https://openalex.org/S103248676","display_name":"Journal of Chromatography B","issn_l":"1570-0232","issn":["1570-0232","1873-376X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography B","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://lirias.kuleuven.be/handle/123456789/619108","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077697009","display_name":"Marie Mardal","orcid":"https://orcid.org/0000-0002-3203-7305","observed_orcids":["https://orcid.org/0000-0002-3203-7305"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Marie Mardal","raw_affiliation_strings":["Section of Forensic Chemistry, University of Copenhagen, Department of Forensic Medicines, Frederik V's vej 11, 2100 K\u00f8benhavn \u00d8, Denmark. Electronic address: marie.mardal@sund.ku.dk"],"raw_orcid":"https://orcid.org/0000-0002-3203-7305","affiliations":[{"raw_affiliation_string":"Section of Forensic Chemistry, University of Copenhagen, Department of Forensic Medicines, Frederik V's vej 11, 2100 K\u00f8benhavn \u00d8, Denmark. Electronic address: marie.mardal@sund.ku.dk","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088992462","display_name":"Petur Weihe Dalsgaard","orcid":"https://orcid.org/0000-0002-8967-7477","observed_orcids":["https://orcid.org/0000-0002-8967-7477"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Petur Weihe Dalsgaard","raw_affiliation_strings":["Section of Forensic Chemistry, University of Copenhagen, Department of Forensic Medicines, Frederik V's vej 11, 2100 K\u00f8benhavn \u00d8, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Forensic Chemistry, University of Copenhagen, Department of Forensic Medicines, Frederik V's vej 11, 2100 K\u00f8benhavn \u00d8, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101603753","display_name":"Bing Qi","orcid":"https://orcid.org/0000-0001-8025-493X","observed_orcids":["https://orcid.org/0000-0001-8025-493X"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Bing Qi","raw_affiliation_strings":["Drug delivery and Disposition, KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, O&N2, Herestraat 49, 3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug delivery and Disposition, KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, O&N2, Herestraat 49, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077010930","display_name":"Christian Brinch Mollerup","orcid":"https://orcid.org/0000-0001-8187-6474","observed_orcids":["https://orcid.org/0000-0001-8187-6474"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Christian Brinch Mollerup","raw_affiliation_strings":["Section of Forensic Chemistry, University of Copenhagen, Department of Forensic Medicines, Frederik V's vej 11, 2100 K\u00f8benhavn \u00d8, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Forensic Chemistry, University of Copenhagen, Department of Forensic Medicines, Frederik V's vej 11, 2100 K\u00f8benhavn \u00d8, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041322811","display_name":"Pieter Annaert","orcid":"https://orcid.org/0000-0003-3525-7351","observed_orcids":["https://orcid.org/0000-0003-3525-7351"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Pieter Annaert","raw_affiliation_strings":["Drug delivery and Disposition, KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, O&N2, Herestraat 49, 3000 Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-3525-7351","affiliations":[{"raw_affiliation_string":"Drug delivery and Disposition, KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, O&N2, Herestraat 49, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078174062","display_name":"Krist\u00edan L\u00ednnet","orcid":"https://orcid.org/0000-0001-6974-5535","observed_orcids":["https://orcid.org/0000-0001-6974-5535"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kristian Linnet","raw_affiliation_strings":["Section of Forensic Chemistry, University of Copenhagen, Department of Forensic Medicines, Frederik V's vej 11, 2100 K\u00f8benhavn \u00d8, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-6974-5535","affiliations":[{"raw_affiliation_string":"Section of Forensic Chemistry, University of Copenhagen, Department of Forensic Medicines, Frederik V's vej 11, 2100 K\u00f8benhavn \u00d8, Denmark","institution_ids":["https://openalex.org/I124055696"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5077697009"],"corresponding_institution_ids":["https://openalex.org/I124055696"],"apc_list":{"value":3640,"currency":"USD","value_usd":3640},"apc_paid":null,"fwci":3.3312,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.91255577,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"1083","issue":null,"first_page":"189","last_page":"197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-cannabinoids","display_name":"synthetic cannabinoids","score":0.8230000138282776},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.6520000100135803},{"id":"https://openalex.org/keywords/hepatocyte-incubation","display_name":"hepatocyte incubation","score":0.796999990940094},{"id":"https://openalex.org/keywords/metabolite-identification","display_name":"metabolite identification","score":0.8069999814033508},{"id":"https://openalex.org/keywords/oxidative-dechlorination","display_name":"oxidative dechlorination","score":0.8119999766349792},{"id":"https://openalex.org/keywords/hydroxylation","display_name":"hydroxylation","score":0.9509999752044678},{"id":"https://openalex.org/keywords/o-demethylation","display_name":"O-demethylation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/in-silico-fragmentation","display_name":"in silico fragmentation","score":0.6970000267028809},{"id":"https://openalex.org/keywords/ion-mobility-spectrometry","display_name":"ion mobility spectrometry","score":0.7829999923706055},{"id":"https://openalex.org/keywords/unifi","display_name":"UNIFI","score":0.6970000267028809},{"id":"https://openalex.org/keywords/meteors","display_name":"meteors","score":0.453000009059906},{"id":"https://openalex.org/keywords/new-psychoactive-substances","display_name":"new psychoactive substances","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9209200739860535},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5947052836418152},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5889256000518799},{"id":"https://openalex.org/C2777846614","wikidata":"https://www.wikidata.org/wiki/Q19904200","display_name":"Synthetic cannabinoids","level":4,"score":0.5747544765472412},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.4944331645965576},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3549966812133789},{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.2627359926700592},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11688068509101868},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07772451639175415}],"mesh":[{"descriptor_ui":"D000218","descriptor_name":"Adamantane","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000218","descriptor_name":"Adamantane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000218","descriptor_name":"Adamantane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002186","descriptor_name":"Cannabinoids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002186","descriptor_name":"Cannabinoids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002186","descriptor_name":"Cannabinoids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013287","descriptor_name":"Illicit Drugs","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013287","descriptor_name":"Illicit Drugs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013287","descriptor_name":"Illicit Drugs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.jchromb.2018.03.016","doi":"https://doi.org/10.1016/j.jchromb.2018.03.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jchromb.2018.03.016","pdf_url":null,"source":{"id":"https://openalex.org/S103248676","display_name":"Journal of Chromatography B","issn_l":"1570-0232","issn":["1570-0232","1873-376X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography B","raw_type":"journal-article"},{"id":"pmid:29549742","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29549742","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chromatography. B, Analytical technologies in the biomedical and life sciences","raw_type":"Journal Article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/619108","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/619108","pdf_url":null,"source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences, vol. 1083, (189-197)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/1eb69dd7-4262-4b66-8916-3c763e516576","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/1eb69dd7-4262-4b66-8916-3c763e516576","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mardal, M, Dalsgaard, P W, Qi, B, Mollerup, C B, Annaert, P & Linnet, K 2018, 'Metabolism of the synthetic cannabinoids AMB-CHMICA and 5C-AKB48 in pooled human hepatocytes and rat hepatocytes analyzed by UHPLC-(IMS)-HR-MS E', Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 1083, pp. 189-197. https://doi.org/10.1016/j.jchromb.2018.03.016","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/619108","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/619108","pdf_url":null,"source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences, vol. 1083, (189-197)","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1521486310","https://openalex.org/W1718456507","https://openalex.org/W1761777809","https://openalex.org/W1882705587","https://openalex.org/W1986904152","https://openalex.org/W1999753265","https://openalex.org/W2014132931","https://openalex.org/W2021178430","https://openalex.org/W2046833126","https://openalex.org/W2057960223","https://openalex.org/W2093535383","https://openalex.org/W2101776453","https://openalex.org/W2131775827","https://openalex.org/W2186697446","https://openalex.org/W2265096866","https://openalex.org/W2315494361","https://openalex.org/W2463316012","https://openalex.org/W2470236573","https://openalex.org/W2480367158","https://openalex.org/W2492836649","https://openalex.org/W2497322062","https://openalex.org/W2535615485","https://openalex.org/W2538527849","https://openalex.org/W2547054258","https://openalex.org/W2590035520","https://openalex.org/W2603733408","https://openalex.org/W2617544335","https://openalex.org/W2738605516","https://openalex.org/W2767952334"],"related_works":["https://openalex.org/W7135787714","https://openalex.org/W4225324903","https://openalex.org/W3133741783","https://openalex.org/W2763238110","https://openalex.org/W2422346997","https://openalex.org/W1521486310","https://openalex.org/W2072652666","https://openalex.org/W2492836649","https://openalex.org/W2606881498","https://openalex.org/W2129536608"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2018-03-29T00:00:00"}