{"id":"https://openalex.org/W2788959636","doi":null,"title":"The Role of RGS14 in Learning, Memory, and SynapticPlasticity","display_name":"The Role of RGS14 in Learning, Memory, and SynapticPlasticity","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2788959636","mag":"2788959636"},"language":"en","primary_location":{"id":"mag:2788959636","doi":null,"is_oa":false,"landing_page_url":"https://oatd.org/oatd/record?record=oai\\:emory\\:pid.emory.edu\\%2Fark\\:\\%2F25593\\%2Fbnsps","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033194384","display_name":"Sarah Emerson Lee","orcid":"https://orcid.org/0000-0001-6098-7423","observed_orcids":["https://orcid.org/0000-0001-6098-7423"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sarah E. Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6098-7423","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5033194384"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33026459,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.5541999936103821,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.5541999936103821,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.4417000114917755,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rgs14","display_name":"RGS14","score":1.0},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9169999957084656},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.9020000100135803},{"id":"https://openalex.org/keywords/long-term-potentiation","display_name":"long-term potentiation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.7260000109672546},{"id":"https://openalex.org/keywords/spatial-learning","display_name":"spatial learning","score":0.8009999990463257},{"id":"https://openalex.org/keywords/object-recognition-memory","display_name":"object recognition memory","score":0.9959999918937683},{"id":"https://openalex.org/keywords/g-protein-signaling","display_name":"G protein signaling","score":0.7710000276565552},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9919999837875366},{"id":"https://openalex.org/keywords/scaffold-proteins","display_name":"scaffold proteins","score":0.7459999918937683},{"id":"https://openalex.org/keywords/schaffer-collateral-synapses","display_name":"Schaffer collateral synapses","score":0.8420000076293945},{"id":"https://openalex.org/keywords/cognitive-enhancement","display_name":"cognitive enhancement","score":0.9459999799728394}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7746214866638184},{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.7418301701545715},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.7210723757743835},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5973833203315735},{"id":"https://openalex.org/C2778039732","wikidata":"https://www.wikidata.org/wiki/Q7430916","display_name":"Schaffer collateral","level":4,"score":0.5698676109313965},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5329768657684326},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.5234954953193665},{"id":"https://openalex.org/C194973443","wikidata":"https://www.wikidata.org/wiki/Q1420291","display_name":"Metaplasticity","level":4,"score":0.5098675489425659},{"id":"https://openalex.org/C48455012","wikidata":"https://www.wikidata.org/wiki/Q2892593","display_name":"Memory consolidation","level":3,"score":0.4113752841949463},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.383087158203125},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3487324118614197},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.1751800775527954},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.13157609105110168},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05614423751831055},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2788959636","doi":null,"is_oa":false,"landing_page_url":"https://oatd.org/oatd/record?record=oai\\:emory\\:pid.emory.edu\\%2Fark\\:\\%2F25593\\%2Fbnsps","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2039668561","https://openalex.org/W2034262866","https://openalex.org/W2951512361","https://openalex.org/W4312093758","https://openalex.org/W3177431162","https://openalex.org/W3173793063","https://openalex.org/W4404493117","https://openalex.org/W2787888718","https://openalex.org/W4400138828","https://openalex.org/W4400682430"],"abstract_inverted_index":{"The":[0,58],"hippocampus":[1],"is":[2,44,78,84,91,105,202],"crucial":[3],"for":[4],"converting":[5],"new\nexperiences":[6],"into":[7],"long-":[8],"term":[9],"memories":[10],"following":[11],"initial":[12],"learning.\nLearning":[13],"and":[14,65,83,100,102,113,178,219],"memory":[15,181,225],"are":[16],"closely":[17],"linked":[18],"to":[19,56,121,215,232],"synaptic":[20,73,95,161],"plasticity,\nwhich":[21],"involves":[22],"altering":[23],"the":[24,32,38,45,137,173],"strength":[25],"of":[26,37,133,136,153,175,179,206],"connections":[27],"between":[28],"of\nneurons":[29],"especially":[30],"within":[31],"dentate":[33],"gyrus":[34],"(DG)-CA3-CA1\ntrisynaptic":[35],"circuit":[36,43],"hippocampus.":[39],"Conspicuously":[40],"absent":[41],"from\nthis":[42],"intervening":[46],"CA2":[47,59,67,125,212],"whose":[48],"existence":[49],"as":[50,223],"a":[51,70,203,224],"distinct\nregion":[52],"has":[53],"been":[54],"subject":[55],"debate.":[57],"only":[60],"recently":[61],"been\nimplicated":[62],"in":[63,97,124,163,172,191,211],"learning":[64,177],"memory.":[66,103],"neurons":[68,214],"have":[69],"striking":[71],"lack\nof":[72],"long-term":[74],"potentiation":[75],"(LTP).":[76],"RGS14":[77,90,104,138,143,220],"differentially\nexpressed":[79],"during":[80],"postnatal":[81],"development":[82],"highly":[85],"enriched":[86],"in\nCA2":[87],"pyramidal":[88,213],"neurons.":[89,126],"critically":[92],"important":[93],"for\nsuppressing":[94],"plasticity":[96,123,162],"these":[98],"cells":[99],"hippocampal\nlearning":[101],"an":[106],"unusual":[107],"scaffolding":[108],"protein":[109,112],"that\nintegrates":[110],"G":[111],"MAP":[114],"kinase":[115],"signaling":[116,207],"pathways":[117,208],"making":[118],"it\nwell":[119],"positioned":[120],"suppress":[122],"Supporting\nthis":[127],"idea,":[128],"we":[129],"find":[130],"that":[131,141,145,227],"deletion":[132],"exons":[134],"2-7":[135],"gene\nyields":[139],"mice":[140,169],"lack":[142],"(RGS14-KO)":[144],"also":[146],"express":[147],"robust":[148],"LTP\nfollowing":[149],"high":[150],"frequency":[151],"stimulation":[152],"Schaffer":[154],"collateral\nsynapses,":[155],"but":[156],"with":[157,183,238],"no":[158,189],"impact":[159],"on":[160,194],"CA1":[164],"neurons.\nWhen":[165],"tested":[166],"behaviorally,":[167],"RGS14-KO":[168],"exhibited":[170],"marked\nenhancement":[171],"acquisition":[174],"spatial":[176],"object\nrecognition":[180],"compared":[182],"their":[184,192],"wild":[185],"type":[186],"littermates,":[187],"but\nshowed":[188],"differences":[190],"performance":[193],"tests":[195],"of\nnon-hippocampal-dependent":[196],"behaviors.":[197],"These":[198],"results":[199],"demonstrate":[200],"that\nRGS14":[201],"key":[204],"regulator":[205],"linking":[209],"synaptic\nplasticity":[210],"hippocampal-based":[216],"learning\nand":[217],"memory,":[218],"may":[221],"serve":[222],"filter":[226],"could":[228],"be":[229],"a\npharmacological":[230],"target":[231],"provide":[233],"general":[234],"cognitive":[235],"enhancement":[236],"in\npatients":[237],"neurodegenerative":[239],"disorders.":[240]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2018-03-06T00:00:00"}
