{"id":"https://openalex.org/W2788736668","doi":"https://doi.org/10.7554/elife.35588","title":"SAC1 degrades its lipid substrate PtdIns4P in the endoplasmic reticulum to maintain a steep chemical gradient with donor membranes","display_name":"SAC1 degrades its lipid substrate PtdIns4P in the endoplasmic reticulum to maintain a steep chemical gradient with donor membranes","publication_year":2018,"publication_date":"2018-02-20","ids":{"openalex":"https://openalex.org/W2788736668","doi":"https://doi.org/10.7554/elife.35588","mag":"2788736668","pmid":"https://pubmed.ncbi.nlm.nih.gov/29461204","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5829913"},"language":"en","primary_location":{"id":"doi:10.7554/elife.35588","doi":"https://doi.org/10.7554/elife.35588","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.35588","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.35588","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053667433","display_name":"James P. Zewe","orcid":"https://orcid.org/0000-0001-5086-9052","observed_orcids":["https://orcid.org/0000-0001-5086-9052"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James P. Zewe","raw_affiliation_strings":["University of Pittsburgh School of Medicine, Department of Cell Biology (Pittsburgh, PA, United States)","Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States"],"raw_orcid":"https://orcid.org/0000-0001-5086-9052","affiliations":[{"raw_affiliation_string":"University of Pittsburgh School of Medicine, Department of Cell Biology (Pittsburgh, PA, United States)","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057930934","display_name":"Rachel C. Wills","orcid":"https://orcid.org/0000-0003-2161-9235","observed_orcids":["https://orcid.org/0000-0003-2161-9235"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel C. Wills","raw_affiliation_strings":["University of Pittsburgh School of Medicine, Department of Cell Biology (Pittsburgh, PA, United States)","Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States"],"raw_orcid":"https://orcid.org/0000-0003-2161-9235","affiliations":[{"raw_affiliation_string":"University of Pittsburgh School of Medicine, Department of Cell Biology (Pittsburgh, PA, United States)","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061945511","display_name":"Sahana Sangappa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sahana Sangappa","raw_affiliation_strings":["University of Pittsburgh School of Medicine, Department of Cell Biology (Pittsburgh, PA, United States)","Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh School of Medicine, Department of Cell Biology (Pittsburgh, PA, United States)","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085272656","display_name":"Brady D. Goulden","orcid":"https://orcid.org/0000-0002-1954-2091","observed_orcids":["https://orcid.org/0000-0002-1954-2091"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brady D. Goulden","raw_affiliation_strings":["University of Pittsburgh School of Medicine, Department of Cell Biology (Pittsburgh, PA, United States)","Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States"],"raw_orcid":"https://orcid.org/0000-0002-1954-2091","affiliations":[{"raw_affiliation_string":"University of Pittsburgh School of Medicine, Department of Cell Biology (Pittsburgh, PA, United States)","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029793456","display_name":"Gerald R. V. Hammond","orcid":"https://orcid.org/0000-0002-6660-3272","observed_orcids":["https://orcid.org/0000-0002-6660-3272","https://orcid.org/0000-0002-9814-5536"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald R. V. Hammond","raw_affiliation_strings":["University of Pittsburgh School of Medicine, Department of Cell Biology (Pittsburgh, PA, United States)","Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States"],"raw_orcid":"https://orcid.org/0000-0002-9814-5536","affiliations":[{"raw_affiliation_string":"University of Pittsburgh School of Medicine, Department of Cell Biology (Pittsburgh, PA, United States)","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":12.2035,"has_fulltext":false,"cited_by_count":161,"citation_normalized_percentile":{"value":0.99456387,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"7","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.08049999922513962,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.968999981880188},{"id":"https://openalex.org/keywords/membrane-contact-sites","display_name":"membrane contact sites","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.8587279319763184},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5622668862342834},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.5496717691421509},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5007023811340332},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45199090242385864},{"id":"https://openalex.org/C88020867","wikidata":"https://www.wikidata.org/wiki/Q6815123","display_name":"Membrane contact site","level":5,"score":0.44923311471939087},{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.43426939845085144},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3924218714237213},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35016047954559326},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.1499907672405243},{"id":"https://openalex.org/C161200384","wikidata":"https://www.wikidata.org/wiki/Q1757382","display_name":"Integral membrane protein","level":4,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018129","descriptor_name":"Phosphatidylinositol Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.7554/elife.35588","doi":"https://doi.org/10.7554/elife.35588","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.35588","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"doi:10.1101/258087","doi":"https://doi.org/10.1101/258087","is_oa":true,"landing_page_url":"https://doi.org/10.1101/258087","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2018/01/31/258087.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:4745988","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5829913","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5829913","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5829913","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Text"},{"id":"pmid:29461204","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29461204","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:825edf39c5774b9e9123023015526644","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/825edf39c5774b9e9123023015526644","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, Vol 7 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.7554/elife.35588","doi":"https://doi.org/10.7554/elife.35588","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.35588","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000920531","display_name":"Directing Membrane Function with Inositol Lipids in Health and Disease","funder_award_id":"R35GM119412","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320308380","display_name":"Yale University","ror":"https://ror.org/03v76x132"},{"id":"https://openalex.org/F4320309170","display_name":"Florida State University","ror":"https://ror.org/05g3dte14"},{"id":"https://openalex.org/F4320310169","display_name":"University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690"},{"id":"https://openalex.org/F4320310174","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W926747247","https://openalex.org/W1563184306","https://openalex.org/W1723155917","https://openalex.org/W1934704664","https://openalex.org/W1963354829","https://openalex.org/W1964192543","https://openalex.org/W1964940964","https://openalex.org/W1978593035","https://openalex.org/W1980445622","https://openalex.org/W1984152194","https://openalex.org/W1997697808","https://openalex.org/W1999289004","https://openalex.org/W2001773683","https://openalex.org/W2002961222","https://openalex.org/W2009283961","https://openalex.org/W2022144068","https://openalex.org/W2026418724","https://openalex.org/W2029589437","https://openalex.org/W2033433686","https://openalex.org/W2038816032","https://openalex.org/W2041914510","https://openalex.org/W2044409787","https://openalex.org/W2044841339","https://openalex.org/W2046526649","https://openalex.org/W2054697729","https://openalex.org/W2058706417","https://openalex.org/W2059412195","https://openalex.org/W2060712219","https://openalex.org/W2064892346","https://openalex.org/W2064894346","https://openalex.org/W2066383101","https://openalex.org/W2069947705","https://openalex.org/W2071379461","https://openalex.org/W2087801016","https://openalex.org/W2088532612","https://openalex.org/W2088679015","https://openalex.org/W2089094879","https://openalex.org/W2093883442","https://openalex.org/W2107099939","https://openalex.org/W2110310164","https://openalex.org/W2111332270","https://openalex.org/W2112878896","https://openalex.org/W2115734610","https://openalex.org/W2115794369","https://openalex.org/W2120540699","https://openalex.org/W2123505183","https://openalex.org/W2124804382","https://openalex.org/W2126736952","https://openalex.org/W2130561025","https://openalex.org/W2132440898","https://openalex.org/W2140804868","https://openalex.org/W2150333062","https://openalex.org/W2150392611","https://openalex.org/W2158422128","https://openalex.org/W2158633487","https://openalex.org/W2158771952","https://openalex.org/W2160973386","https://openalex.org/W2162228329","https://openalex.org/W2162720885","https://openalex.org/W2164080428","https://openalex.org/W2165130769","https://openalex.org/W2165552188","https://openalex.org/W2166173441","https://openalex.org/W2168363131","https://openalex.org/W2174686320","https://openalex.org/W2182369134","https://openalex.org/W2233116271","https://openalex.org/W2318022761","https://openalex.org/W2325065547","https://openalex.org/W2329177125","https://openalex.org/W2337533535","https://openalex.org/W2397356564","https://openalex.org/W2410538657","https://openalex.org/W2469926161","https://openalex.org/W2528920961","https://openalex.org/W2550424949","https://openalex.org/W2589191356","https://openalex.org/W2618097669","https://openalex.org/W2619611668","https://openalex.org/W4233808990"],"related_works":["https://openalex.org/W3175274287","https://openalex.org/W4389021253","https://openalex.org/W2792553801","https://openalex.org/W1723155917","https://openalex.org/W2124393593","https://openalex.org/W2789706707","https://openalex.org/W2046526649","https://openalex.org/W4385271453","https://openalex.org/W2896913429","https://openalex.org/W2247997447"],"abstract_inverted_index":{"Abstract":[0],"Gradients":[1],"of":[2,18,83,87,128],"PtdIns4":[3,33,88],"P":[4,34,89],"between":[5,115],"organelle":[6],"membranes":[7],"and":[8,102,118,137,147],"the":[9,28,40,44,91],"endoplasmic":[10],"reticulum":[11],"(ER)":[12],"are":[13],"thought":[14],"to":[15,31,42,52,69],"drive":[16],"counter-transport":[17],"other":[19],"lipids":[20],"via":[21],"non-vesicular":[22,134],"traffic.":[23,64],"This":[24],"novel":[25],"pathway":[26],"requires":[27],"SAC1":[29,47,73,84,94,104],"phosphatase":[30],"degrade":[32],"in":[35,54,75,90,108,133,143],"a":[36,111],"\u201ccis\u201d":[37,126],"configuration":[38],"at":[39,56,98],"ER":[41],"maintain":[43],"gradient.":[45],"However,":[46],"has":[48,105],"also":[49],"been":[50],"proposed":[51],"act":[53],"\u201ctrans\u201d":[55],"membrane":[57,99],"contact":[58,100],"sites,":[59,101],"which":[60,71],"could":[61],"oppose":[62],"lipid":[63,135,139,145],"It":[65],"is":[66,113],"therefore":[67],"crucial":[68],"determine":[70],"mode":[72],"uses":[74],"living":[76],"cells.":[77],"We":[78],"report":[79],"that":[80,93,103],"acute":[81],"inhibition":[82],"causes":[85],"accumulation":[86],"ER,":[92],"does":[95],"not":[96],"enrich":[97],"little":[106],"activity":[107,127],"\u201ctrans\u201d,":[109],"unless":[110],"linker":[112],"added":[114],"its":[116,131],"ER-anchored":[117],"catalytic":[119],"domains.":[120],"The":[121],"data":[122],"reveal":[123],"an":[124],"obligate":[125],"SAC1,":[129],"supporting":[130],"role":[132],"traffic":[136,140],"implicating":[138],"more":[141],"broadly":[142],"inositol":[144],"homeostasis":[146],"function.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":22},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":34},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":14}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-03-06T00:00:00"}