{"id":"https://openalex.org/W2786209272","doi":"https://doi.org/10.1039/c7md00619e","title":"Structure-guided design of a potent peptide inhibitor targeting the interaction between CRK and ABL kinase","display_name":"Structure-guided design of a potent peptide inhibitor targeting the interaction between CRK and ABL kinase","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2786209272","doi":"https://doi.org/10.1039/c7md00619e","mag":"2786209272","pmid":"https://pubmed.ncbi.nlm.nih.gov/30108942","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6072116"},"language":"en","primary_location":{"id":"doi:10.1039/c7md00619e","doi":"https://doi.org/10.1039/c7md00619e","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c7md00619e","pdf_url":null,"source":{"id":"https://openalex.org/S191926780","display_name":"MedChemComm","issn_l":"2040-2503","issn":["2040-2503","2040-2511"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MedChemComm","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6072116","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084189505","display_name":"Qingliang Shen","orcid":"https://orcid.org/0000-0002-7046-0964","observed_orcids":["https://orcid.org/0000-0002-7046-0964"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qingliang Shen","raw_affiliation_strings":["College Station","Department of Biochemistry and Biophysics","Texas A&M University","USA","Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College Station","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics","institution_ids":[]},{"raw_affiliation_string":"Texas A&M University","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048324380","display_name":"Veer S. Bhatt","orcid":"https://orcid.org/0000-0001-9385-3843","observed_orcids":["https://orcid.org/0000-0001-9385-3843"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veer S. Bhatt","raw_affiliation_strings":["College Station","Department of Biochemistry and Biophysics","Texas A&M University","USA","Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College Station","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics","institution_ids":[]},{"raw_affiliation_string":"Texas A&M University","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035775735","display_name":"Inna V. Krieger","orcid":"https://orcid.org/0000-0001-7144-3069","observed_orcids":["https://orcid.org/0000-0001-7144-3069"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Inna Krieger","raw_affiliation_strings":["College Station","Department of Biochemistry and Biophysics","Texas A&M University","USA","Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College Station","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics","institution_ids":[]},{"raw_affiliation_string":"Texas A&M University","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103456216","display_name":"James C. Sacchettini","orcid":"https://orcid.org/0000-0001-5767-2367","observed_orcids":["https://orcid.org/0000-0001-5767-2367"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James C. Sacchettini","raw_affiliation_strings":["College Station","Department of Biochemistry and Biophysics","Texas A&M University","USA","Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College Station","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics","institution_ids":[]},{"raw_affiliation_string":"Texas A&M University","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102708327","display_name":"Jaehyun Cho","orcid":"https://orcid.org/0000-0002-6190-6151","observed_orcids":["https://orcid.org/0000-0002-6190-6151"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jae-Hyun Cho","raw_affiliation_strings":["College Station","Department of Biochemistry and Biophysics","Texas A&M University","USA","Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA"],"raw_orcid":"https://orcid.org/0000-0002-6190-6151","affiliations":[{"raw_affiliation_string":"College Station","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics","institution_ids":[]},{"raw_affiliation_string":"Texas A&M University","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102708327"],"corresponding_institution_ids":["https://openalex.org/I91045830"],"apc_list":null,"apc_paid":null,"fwci":0.1027,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.34690083,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"9","issue":"3","first_page":"519","last_page":"524"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.7128999829292297,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.7128999829292297,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.12470000237226486,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.04470000043511391,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crk","display_name":"Crk","score":0.6570000052452087},{"id":"https://openalex.org/keywords/c-abl","display_name":"c-Abl","score":0.996999979019165},{"id":"https://openalex.org/keywords/peptide-inhibitors","display_name":"peptide inhibitors","score":0.8659999966621399},{"id":"https://openalex.org/keywords/structure-guided-design","display_name":"structure-guided design","score":0.8109999895095825},{"id":"https://openalex.org/keywords/imatinib-resistance","display_name":"imatinib resistance","score":0.9430000185966492},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitor-resistance","display_name":"tyrosine kinase inhibitor resistance","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C133570447","wikidata":"https://www.wikidata.org/wiki/Q17909794","display_name":"Adapter molecule crk","level":4,"score":0.8907623291015625},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5183128118515015},{"id":"https://openalex.org/C125418893","wikidata":"https://www.wikidata.org/wiki/Q587961","display_name":"ABL","level":4,"score":0.5060943961143494},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4925094544887543},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4831832945346832},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40766844153404236},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32507264614105225},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24789726734161377},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21949058771133423},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.19162678718566895},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.18756988644599915},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.1299108862876892},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.05904218554496765}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1039/c7md00619e","doi":"https://doi.org/10.1039/c7md00619e","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c7md00619e","pdf_url":null,"source":{"id":"https://openalex.org/S191926780","display_name":"MedChemComm","issn_l":"2040-2503","issn":["2040-2503","2040-2511"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MedChemComm","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5335887","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6072116","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6072116","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6072116","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medchemcomm","raw_type":"Text"},{"id":"pmid:30108942","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30108942","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MedChemComm","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5335887","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6072116","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310164","display_name":"Texas A and M University","ror":"https://ror.org/01f5ytq51"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W125596170","https://openalex.org/W141181845","https://openalex.org/W158709665","https://openalex.org/W1623683757","https://openalex.org/W1976440155","https://openalex.org/W1983934308","https://openalex.org/W1994131040","https://openalex.org/W2001937658","https://openalex.org/W2035805526","https://openalex.org/W2037420327","https://openalex.org/W2041755933","https://openalex.org/W2056189051","https://openalex.org/W2057603067","https://openalex.org/W2065744404","https://openalex.org/W2067362444","https://openalex.org/W2073306537","https://openalex.org/W2088452786","https://openalex.org/W2095906189","https://openalex.org/W2103824791","https://openalex.org/W2125079066","https://openalex.org/W2131321938","https://openalex.org/W2148996678","https://openalex.org/W2149532912","https://openalex.org/W2150148922","https://openalex.org/W2150937737","https://openalex.org/W2159220993","https://openalex.org/W2159233031","https://openalex.org/W2160300034","https://openalex.org/W2160315153","https://openalex.org/W2164220403","https://openalex.org/W2165854300","https://openalex.org/W2284549295","https://openalex.org/W2412506411","https://openalex.org/W2462418556","https://openalex.org/W2546981737","https://openalex.org/W2605080036"],"related_works":["https://openalex.org/W2292640366","https://openalex.org/W1999512536","https://openalex.org/W2154437955","https://openalex.org/W4224859704","https://openalex.org/W2092606584","https://openalex.org/W1971248653","https://openalex.org/W1973734600","https://openalex.org/W2322063723","https://openalex.org/W2093715918","https://openalex.org/W2979307601"],"abstract_inverted_index":{"biochemical":[0],"assay":[1],"demonstrated":[2],"that":[3],"PRM-3":[4,16],"inhibits":[5],"the":[6,19,45],"ABL-dependent":[7],"phosphorylation":[8,21],"of":[9,48],"CRK-II":[10],"more":[11],"effectively":[12],"than":[13],"imatinib.":[14],"Remarkably,":[15],"also":[17],"inhibited":[18],"CRK":[20],"by":[22],"T315I-ABL":[23],"kinase,":[24],"which":[25],"is":[26],"resistant":[27],"to":[28,43],"all":[29],"first-":[30],"and":[31],"second-generation":[32],"tyrosine":[33],"kinase":[34],"inhibitors.":[35],"Our":[36],"study":[37],"provides":[38],"a":[39],"promising":[40],"alternative":[41],"approach":[42],"overcome":[44],"drug":[46],"resistance":[47],"ABL":[49],"kinase.":[50]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2018-02-23T00:00:00"}