{"id":"https://openalex.org/W2785998129","doi":"https://doi.org/10.1534/g3.118.200182","title":"A Host-Pathogen Interaction Screen Identifies ada2 as a Mediator of Candida glabrata Defenses Against Reactive Oxygen Species","display_name":"A Host-Pathogen Interaction Screen Identifies ada2 as a Mediator of Candida glabrata Defenses Against Reactive Oxygen Species","publication_year":2018,"publication_date":"2018-03-15","ids":{"openalex":"https://openalex.org/W2785998129","doi":"https://doi.org/10.1534/g3.118.200182","mag":"2785998129","pmid":"https://pubmed.ncbi.nlm.nih.gov/29535147","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5940155"},"language":"en","primary_location":{"id":"doi:10.1534/g3.118.200182","doi":"https://doi.org/10.1534/g3.118.200182","is_oa":true,"landing_page_url":"https://doi.org/10.1534/g3.118.200182","pdf_url":"https://academic.oup.com/g3journal/article-pdf/8/5/1637/37126339/g3journal1637.pdf","source":{"id":"https://openalex.org/S109822313","display_name":"G3 Genes Genomes Genetics","issn_l":"2160-1836","issn":["2160-1836"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319844","host_organization_name":"Genetics Society of America","host_organization_lineage":["https://openalex.org/P4310319844"],"host_organization_lineage_names":["Genetics Society of America"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 Genes|Genomes|Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/g3journal/article-pdf/8/5/1637/37126339/g3journal1637.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025825446","display_name":"Ilias Kounatidis","orcid":"https://orcid.org/0000-0001-9877-0457","observed_orcids":["https://orcid.org/0000-0001-9877-0457"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ilias Kounatidis","raw_affiliation_strings":["Cell Biology, Development and Genetics Laboratory, Department of Biochemistry, University of Oxford, South Parks Rd, Oxford OX1 3QU UK","Cell Biology, Development and Genetics Laboratory, Department of Biochemistry, University of Oxford, OX1 3QU UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology, Development and Genetics Laboratory, Department of Biochemistry, University of Oxford, South Parks Rd, Oxford OX1 3QU UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Cell Biology, Development and Genetics Laboratory, Department of Biochemistry, University of Oxford, OX1 3QU UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059926490","display_name":"Lauren Ames","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lauren Ames","raw_affiliation_strings":["Exeter Biosciences, College of Life and Environmental Sciences Geoffrey Pope Building University of Exeter Stocker Rd Exeter EX4 4QD, UK","Exeter Biosciences, College of Life and Environmental Sciences, University of Exeter, EX4 4QD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exeter Biosciences, College of Life and Environmental Sciences Geoffrey Pope Building University of Exeter Stocker Rd Exeter EX4 4QD, UK","institution_ids":["https://openalex.org/I23923803"]},{"raw_affiliation_string":"Exeter Biosciences, College of Life and Environmental Sciences, University of Exeter, EX4 4QD, UK","institution_ids":["https://openalex.org/I23923803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041545128","display_name":"Rupal Mistry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rupal Mistry","raw_affiliation_strings":["Cell Biology, Development and Genetics Laboratory, Department of Biochemistry, University of Oxford, South Parks Rd, Oxford OX1 3QU UK","Cell Biology, Development and Genetics Laboratory, Department of Biochemistry, University of Oxford, OX1 3QU UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology, Development and Genetics Laboratory, Department of Biochemistry, University of Oxford, South Parks Rd, Oxford OX1 3QU UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Cell Biology, Development and Genetics Laboratory, Department of Biochemistry, University of Oxford, OX1 3QU UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039267268","display_name":"Hsueh-lui Ho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hsueh-lui Ho","raw_affiliation_strings":["Exeter Biosciences, College of Life and Environmental Sciences Geoffrey Pope Building University of Exeter Stocker Rd Exeter EX4 4QD, UK","Exeter Biosciences, College of Life and Environmental Sciences, University of Exeter, EX4 4QD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exeter Biosciences, College of Life and Environmental Sciences Geoffrey Pope Building University of Exeter Stocker Rd Exeter EX4 4QD, UK","institution_ids":["https://openalex.org/I23923803"]},{"raw_affiliation_string":"Exeter Biosciences, College of Life and Environmental Sciences, University of Exeter, EX4 4QD, UK","institution_ids":["https://openalex.org/I23923803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005840185","display_name":"Ken Haynes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ken Haynes","raw_affiliation_strings":["Exeter Biosciences, College of Life and Environmental Sciences Geoffrey Pope Building University of Exeter Stocker Rd Exeter EX4 4QD, UK","Exeter Biosciences, College of Life and Environmental Sciences, University of Exeter, EX4 4QD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exeter Biosciences, College of Life and Environmental Sciences Geoffrey Pope Building University of Exeter Stocker Rd Exeter EX4 4QD, UK","institution_ids":["https://openalex.org/I23923803"]},{"raw_affiliation_string":"Exeter Biosciences, College of Life and Environmental Sciences, University of Exeter, EX4 4QD, UK","institution_ids":["https://openalex.org/I23923803"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078197004","display_name":"Petros Ligoxygakis","orcid":"https://orcid.org/0000-0002-9498-9993","observed_orcids":["https://orcid.org/0000-0002-9498-9993"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Petros Ligoxygakis","raw_affiliation_strings":["Cell Biology, Development and Genetics Laboratory, Department of Biochemistry, University of Oxford, South Parks Rd, Oxford OX1 3QU UK","Cell Biology, Development and Genetics Laboratory, Department of Biochemistry, University of Oxford, OX1 3QU UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology, Development and Genetics Laboratory, Department of Biochemistry, University of Oxford, South Parks Rd, Oxford OX1 3QU UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Cell Biology, Development and Genetics Laboratory, Department of Biochemistry, University of Oxford, OX1 3QU UK","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5078197004"],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":{"value":2709,"currency":"USD","value_usd":2709},"apc_paid":{"value":2119,"currency":"EUR","value_usd":2285},"fwci":0.5463,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.588101,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"8","issue":"5","first_page":"1637","last_page":"1647"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.5419999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.5419999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.43970000743865967,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida-glabrata","display_name":"Candida glabrata","score":1.0},{"id":"https://openalex.org/keywords/adenosine-deaminase-2","display_name":"ADA2","score":0.8569999933242798},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.9480000138282776},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9700000286102295},{"id":"https://openalex.org/keywords/oxidative-stress-tolerance","display_name":"oxidative stress resistance","score":0.9860000014305115},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.8289999961853027},{"id":"https://openalex.org/keywords/antifungal-drug-targets","display_name":"antifungal drug targets","score":0.6639999747276306},{"id":"https://openalex.org/keywords/bas1","display_name":"BAS1","score":0.609000027179718},{"id":"https://openalex.org/keywords/ino2","display_name":"INO2","score":0.996999979019165},{"id":"https://openalex.org/keywords/fungal-virulence","display_name":"fungal virulence","score":0.6449999809265137},{"id":"https://openalex.org/keywords/azole-resistance","display_name":"azole resistance","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C2780670043","wikidata":"https://www.wikidata.org/wiki/Q139137","display_name":"Candida glabrata","level":3,"score":0.9054920673370361},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8156285285949707},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6767215132713318},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5652940273284912},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5477069616317749},{"id":"https://openalex.org/C2776453879","wikidata":"https://www.wikidata.org/wiki/Q1835536","display_name":"Biomphalaria glabrata","level":5,"score":0.5459517240524292},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5450407266616821},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.48593226075172424},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.47188153862953186},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.41933420300483704},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3621021807193756},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34330734610557556},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3286428451538086},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.22194266319274902},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09132388234138489},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.0},{"id":"https://openalex.org/C2776225656","wikidata":"https://www.wikidata.org/wiki/Q221159","display_name":"Schistosomiasis","level":3,"score":0.0},{"id":"https://openalex.org/C2776863245","wikidata":"https://www.wikidata.org/wiki/Q2324689","display_name":"Schistosoma mansoni","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015723","descriptor_name":"Gene Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D041221","descriptor_name":"Candida glabrata","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D041221","descriptor_name":"Candida glabrata","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1534/g3.118.200182","doi":"https://doi.org/10.1534/g3.118.200182","is_oa":true,"landing_page_url":"https://doi.org/10.1534/g3.118.200182","pdf_url":"https://academic.oup.com/g3journal/article-pdf/8/5/1637/37126339/g3journal1637.pdf","source":{"id":"https://openalex.org/S109822313","display_name":"G3 Genes Genomes Genetics","issn_l":"2160-1836","issn":["2160-1836"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319844","host_organization_name":"Genetics Society of America","host_organization_lineage":["https://openalex.org/P4310319844"],"host_organization_lineage_names":["Genetics Society of America"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 Genes|Genomes|Genetics","raw_type":"journal-article"},{"id":"doi:10.1101/248955","doi":"https://doi.org/10.1101/248955","is_oa":true,"landing_page_url":"https://doi.org/10.1101/248955","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2018/01/17/248955.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:4861870","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5940155","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5940155","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5940155","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 (Bethesda)","raw_type":"Text"},{"id":"pmid:29535147","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29535147","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 (Bethesda, Md.)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6435cfa5680c48698152e76074f571de","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6435cfa5680c48698152e76074f571de","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"G3: Genes, Genomes, Genetics, Vol 8, Iss 5, Pp 1637-1647 (2018)","raw_type":"article"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:7fca797c-f412-4652-9cda-cf546bf68f31","doi":null,"is_oa":true,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:7fca797c-f412-4652-9cda-cf546bf68f31","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symplectic Elements at Oxford","raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1534/g3.118.200182","doi":"https://doi.org/10.1534/g3.118.200182","is_oa":true,"landing_page_url":"https://doi.org/10.1534/g3.118.200182","pdf_url":"https://academic.oup.com/g3journal/article-pdf/8/5/1637/37126339/g3journal1637.pdf","source":{"id":"https://openalex.org/S109822313","display_name":"G3 Genes Genomes Genetics","issn_l":"2160-1836","issn":["2160-1836"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319844","host_organization_name":"Genetics Society of America","host_organization_lineage":["https://openalex.org/P4310319844"],"host_organization_lineage_names":["Genetics Society of America"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 Genes|Genomes|Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3200588343","display_name":null,"funder_award_id":"NC/K500392/1","funder_id":"https://openalex.org/F4320320333","funder_display_name":"National Centre for the Replacement, Refinement and Reduction of Animals in Research"},{"id":"https://openalex.org/G4230203742","display_name":"Combinatorial Responses of Fungal Pathogens To Their Human Hosts: an Integrative Systems Biology Approach","funder_award_id":"BB/F005210/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320333","display_name":"National Centre for the Replacement, Refinement and Reduction of Animals in Research","ror":"https://ror.org/02w0kg036"},{"id":"https://openalex.org/F4320321457","display_name":"Bodossaki Foundation","ror":"https://ror.org/04qajcj06"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2785998129.pdf","grobid_xml":"https://content.openalex.org/works/W2785998129.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1559695241","https://openalex.org/W1575164178","https://openalex.org/W1941779326","https://openalex.org/W1964339096","https://openalex.org/W1966963462","https://openalex.org/W1968299410","https://openalex.org/W1977454530","https://openalex.org/W1983181251","https://openalex.org/W1986481314","https://openalex.org/W1988820663","https://openalex.org/W1991488616","https://openalex.org/W1995203663","https://openalex.org/W1996364851","https://openalex.org/W1998871484","https://openalex.org/W2000610406","https://openalex.org/W2011504031","https://openalex.org/W2019892034","https://openalex.org/W2022006512","https://openalex.org/W2025357023","https://openalex.org/W2027581246","https://openalex.org/W2030791386","https://openalex.org/W2040557294","https://openalex.org/W2043169858","https://openalex.org/W2048869977","https://openalex.org/W2066515050","https://openalex.org/W2072386048","https://openalex.org/W2075016274","https://openalex.org/W2079639127","https://openalex.org/W2085031713","https://openalex.org/W2088309256","https://openalex.org/W2096393734","https://openalex.org/W2100246797","https://openalex.org/W2105335336","https://openalex.org/W2105891919","https://openalex.org/W2106860332","https://openalex.org/W2109962249","https://openalex.org/W2110555587","https://openalex.org/W2114570899","https://openalex.org/W2117885696","https://openalex.org/W2124162233","https://openalex.org/W2124786856","https://openalex.org/W2124863746","https://openalex.org/W2129688861","https://openalex.org/W2134298953","https://openalex.org/W2135840745","https://openalex.org/W2135989597","https://openalex.org/W2137428110","https://openalex.org/W2137441463","https://openalex.org/W2137590150","https://openalex.org/W2141563676","https://openalex.org/W2142794903","https://openalex.org/W2143326683","https://openalex.org/W2148709825","https://openalex.org/W2159303975","https://openalex.org/W2160042020","https://openalex.org/W2161971164","https://openalex.org/W2163499990","https://openalex.org/W2169540909","https://openalex.org/W2169946405","https://openalex.org/W2782285131","https://openalex.org/W4242475063","https://openalex.org/W7075680744"],"related_works":["https://openalex.org/W2782285131","https://openalex.org/W2134035883","https://openalex.org/W3111871765","https://openalex.org/W2982132672","https://openalex.org/W2888397971","https://openalex.org/W2998431554","https://openalex.org/W6981604232","https://openalex.org/W2030187753","https://openalex.org/W3097628759","https://openalex.org/W3088375515"],"abstract_inverted_index":{"Abstract":[0],"Candida":[1],"glabrata":[2,23,42,82,96,113,135,155,172],"(C.":[3],"glabrata)":[4],"forms":[5],"part":[6],"of":[7,54,76,94,110,124,131,153],"the":[8,74,92,111,151,163,179],"normal":[9],"human":[10],"gut":[11],"microbiota":[12],"but":[13],"can":[14],"cause":[15],"life-threatening":[16],"invasive":[17],"infections":[18],"in":[19,69,80,106,119,137,143,178],"immune-compromised":[20],"individuals.":[21],"C.":[22,41,81,95,112,134,154,171],"displays":[24],"high":[25],"resistance":[26],"to":[27,62,165],"common":[28],"azole":[29],"antifungals,":[30],"which":[31],"necessitates":[32],"new":[33],"treatments.":[34],"In":[35],"this":[36,104],"investigation,":[37],"we":[38],"identified":[39],"five":[40],"deletion":[43],"mutants":[44,58,90],"(\u2206ada2,":[45],"\u2206bas1,":[46],"\u2206hir3,":[47],"\u2206ino2":[48],"and":[49,64],"\u2206met31)":[50],"from":[51],"a":[52],"library":[53],"196":[55],"transcription":[56,78],"factor":[57],"that":[59,148],"were":[60],"unable":[61],"grow":[63],"activate":[65],"an":[66],"immune":[67,158],"response":[68,152],"Drosophila":[70],"larvae.":[71],"This":[72],"highlighted":[73],"importance":[75],"these":[77,89],"factors":[79],"infectivity.":[83],"Further":[84],"ex":[85],"vivo":[86,107],"investigation":[87],"into":[88],"revealed":[91],"requirement":[93],"ADA2":[97,132,149],"for":[98,170,176],"oxidative":[99],"stress":[100],"tolerance.":[101],"We":[102,146],"confirmed":[103],"observation":[105],"whereby":[108],"growth":[109],"\u0394ada2":[114],"strain":[115],"was":[116],"permitted":[117],"only":[118],"flies":[120],"with":[121],"suppressed":[122],"production":[123],"reactive":[125],"oxygen":[126],"species":[127],"(ROS).":[128],"Conversely,":[129],"overexpression":[130],"promoted":[133],"replication":[136],"infected":[138],"wild":[139],"type":[140],"larvae":[141],"resulting":[142],"larval":[144],"killing.":[145],"propose":[147],"orchestrates":[150],"against":[156],"ROS-mediated":[157],"defenses":[159],"during":[160],"infection.":[161],"With":[162],"need":[164],"find":[166],"alternative":[167],"antifungal":[168],"treatment":[169],"infections,":[173],"genes":[174],"required":[175],"survival":[177],"host":[180],"environment,":[181],"such":[182],"as":[183],"ADA2,":[184],"provide":[185],"promising":[186],"potential":[187],"targets.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-02-23T00:00:00"}
