{"id":"https://openalex.org/W2785707994","doi":"https://doi.org/10.1158/1535-7163.targ-17-a112","title":"Abstract A112: RanBP9 protects cells from genotoxic stress and increased expression is predictive of worse response to platinum in NSCLC patients","display_name":"Abstract A112: RanBP9 protects cells from genotoxic stress and increased expression is predictive of worse response to platinum in NSCLC patients","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2785707994","doi":"https://doi.org/10.1158/1535-7163.targ-17-a112","mag":"2785707994"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.targ-17-a112","doi":"https://doi.org/10.1158/1535-7163.targ-17-a112","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.targ-17-a112","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019771690","display_name":"Anna Tessari","orcid":"https://orcid.org/0000-0002-6036-1954","observed_orcids":["https://orcid.org/0000-0002-6036-1954"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Tessari","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020407484","display_name":"Kareesma Parbhoo","orcid":"https://orcid.org/0000-0002-4806-9571","observed_orcids":["https://orcid.org/0000-0002-4806-9571"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kareesma Parbhoo","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002813181","display_name":"Meghan Pawlikowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meghan Pawlikowski","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046301295","display_name":"Matteo Fassan","orcid":"https://orcid.org/0000-0001-6515-5482","observed_orcids":["https://orcid.org/0000-0001-6515-5482"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Fassan","raw_affiliation_strings":["2University of Padova, Padova, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Padova, Padova, Italy;","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053162229","display_name":"Eliana Rulli","orcid":"https://orcid.org/0000-0003-1058-4137","observed_orcids":["https://orcid.org/0000-0003-1058-4137"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Eliana Rulli","raw_affiliation_strings":["3IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy;","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007427257","display_name":"Claudia Foray","orcid":"https://orcid.org/0000-0003-0384-5765","observed_orcids":["https://orcid.org/0000-0003-0384-5765"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claudia Foray","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027149352","display_name":"Alessandra Fabbri","orcid":"https://orcid.org/0000-0002-1589-1569","observed_orcids":["https://orcid.org/0000-0002-1589-1569"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Fabbri","raw_affiliation_strings":["4Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy;","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018517679","display_name":"Valerio Embrione","orcid":"https://orcid.org/0000-0003-0184-3862","observed_orcids":["https://orcid.org/0000-0003-0184-3862"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valerio Embrione","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047481473","display_name":"Monica Ganzinelli","orcid":"https://orcid.org/0000-0002-0526-0835","observed_orcids":["https://orcid.org/0000-0002-0526-0835"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Monica Ganzinelli","raw_affiliation_strings":["4Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy;","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043350645","display_name":"Marina Capece","orcid":"https://orcid.org/0000-0002-7624-8059","observed_orcids":["https://orcid.org/0000-0002-7624-8059"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marina Capece","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060760341","display_name":"Moray J. Campbell","orcid":"https://orcid.org/0000-0002-3355-0928","observed_orcids":["https://orcid.org/0000-0002-3355-0928"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moray J. Campbell","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091714925","display_name":"Massimo Broggini","orcid":"https://orcid.org/0000-0002-8138-9358","observed_orcids":["https://orcid.org/0000-0002-8138-9358"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Broggini","raw_affiliation_strings":["3IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy;","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089499956","display_name":"Krista La Perle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krista La Perle","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049996919","display_name":"Gabriella Farina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150268","display_name":"Azienda Ospedaliera Fatebenefratelli e Oftalmico","ror":"https://ror.org/05v558c44","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150268","https://openalex.org/I4210156709"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gabriella Farina","raw_affiliation_strings":["5Ospedale Fatebenefratelli and Oftalmico, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Ospedale Fatebenefratelli and Oftalmico, Milan, Italy","institution_ids":["https://openalex.org/I4210150268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030262791","display_name":"Sara L. Cole","orcid":"https://orcid.org/0000-0002-4422-3172","observed_orcids":["https://orcid.org/0000-0002-4422-3172"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Cole","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016191595","display_name":"Mirko Marabese","orcid":"https://orcid.org/0000-0001-9379-0301","observed_orcids":["https://orcid.org/0000-0001-9379-0301"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mirko Marabese","raw_affiliation_strings":["3IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy;","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113793371","display_name":"Joseph M. Amann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph M. Amann","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059652753","display_name":"David Paul Carbone","orcid":"https://orcid.org/0000-0003-3002-1921","observed_orcids":["https://orcid.org/0000-0003-3002-1921"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David P. Carbone","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091509029","display_name":"Marina Chiara Garassino","orcid":"https://orcid.org/0000-0002-3821-5598","observed_orcids":["https://orcid.org/0000-0002-3821-5598"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marina C. Garassino","raw_affiliation_strings":["4Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy;","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079700663","display_name":"Carlo Maria Croce","orcid":"https://orcid.org/0000-0003-3788-1457","observed_orcids":["https://orcid.org/0000-0003-3788-1457"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlo M. Croce","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071802503","display_name":"Dario Palmieri","orcid":"https://orcid.org/0000-0002-0797-4268","observed_orcids":["https://orcid.org/0000-0002-0797-4268"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dario Palmieri","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046342653","display_name":"Vincenzo Coppola","orcid":"https://orcid.org/0000-0001-6163-1779","observed_orcids":["https://orcid.org/0000-0001-6163-1779"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincenzo Coppola","raw_affiliation_strings":["1The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"1_Supplement","first_page":"A112","last_page":"A112"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.24240000545978546,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.24240000545978546,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.19259999692440033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.1890999972820282,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ranbp9","display_name":"RanBP9","score":0.996999979019165},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9919999837875366},{"id":"https://openalex.org/keywords/platinum-based-chemotherapy","display_name":"platinum-based chemotherapy","score":0.5320000052452087},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.781000018119812},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9779999852180481},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9300000071525574},{"id":"https://openalex.org/keywords/poly-adp-ribose-polymerase","display_name":"poly(ADP-ribose) polymerase","score":0.7450000047683716},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.9340000152587891},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5849999785423279},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.5550000071525574},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.5270000100135803},{"id":"https://openalex.org/keywords/genotoxic-stress","display_name":"genotoxic stress","score":0.6600000262260437},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.7620000243186951},{"id":"https://openalex.org/keywords/knockout-models","display_name":"knockout models","score":0.49000000953674316},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7960000038146973},{"id":"https://openalex.org/keywords/platinum-resistance","display_name":"platinum resistance","score":0.5189999938011169},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.7174099683761597},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5881806015968323},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5519600510597229},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5441017150878906},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.525558590888977},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5198298096656799},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4760812819004059},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47113460302352905},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4026627540588379},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37766575813293457},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3401387929916382},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.32953834533691406},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.09857025742530823},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08089306950569153},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.targ-17-a112","doi":"https://doi.org/10.1158/1535-7163.targ-17-a112","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.targ-17-a112","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2885178982","https://openalex.org/W2886271867","https://openalex.org/W2767402120","https://openalex.org/W4386497948","https://openalex.org/W3038004641","https://openalex.org/W2892308499","https://openalex.org/W3107302670","https://openalex.org/W2810874778","https://openalex.org/W3030438655","https://openalex.org/W3045908868"],"abstract_inverted_index":{"Abstract":[0],"Platinum-based":[1],"therapies":[2],"currently":[3],"represent":[4,46],"the":[5,23,26,50,67,94,111,247,275,365],"most":[6],"common":[7],"first-line":[8,203],"treatment":[9,204],"for":[10],"non-small":[11],"cell":[12,36,155],"lung":[13,130],"cancer":[14,35],"(NSCLC).":[15],"The":[16],"efficacy":[17,239],"of":[18,25,44,52,66,74,132,150,164,181,189,225,231,249,267,353,364],"platinum":[19,200,357],"compounds":[20,201],"depends":[21],"on":[22],"activation":[24],"cellular":[27],"DNA":[28,104],"damage":[29,105],"response":[30,198,268,355],"(DDR),":[31],"which":[32,186],"leads":[33],"to":[34,71,103,118,136,199,269,277,356],"death.":[37],"However,":[38],"severe":[39],"toxic":[40],"effects":[41],"and":[42,60,63,96,125,161,170,196,235,287,348,371],"development":[43],"resistance":[45],"major":[47],"limitations":[48],"in":[49,93,128,152,158,168,171,185,240,252,272,358],"use":[51],"these":[53,257],"drugs.":[54],"Thus,":[55],"a":[56,87,178,253,263],"better":[57],"mechanistic":[58],"understanding":[59],"new":[61],"prognostic":[62,285],"predictive":[64,265,352],"biomarkers":[65],"DDR":[68,95,160],"are":[69],"required":[70],"improve":[72],"outcomes":[73],"NSCLC":[75,154,183,359],"treatment.":[76],"We":[77,144],"have":[78],"previously":[79],"reported":[80],"that":[81,97,120,147,223,246,260],"RanBP9":[82,121,151,190,226,250,261,342],"(Palmieri":[83],"et":[84],"al.,":[85],"2016),":[86],"poorly":[88],"characterized":[89],"scaffold":[90],"protein,":[91],"participates":[92],"its":[98,283],"downregulation":[99],"causes":[100],"enhanced":[101],"sensitivity":[102],"induced":[106],"by":[107,177],"ionizing":[108],"radiation.":[109],"In":[110],"present":[112],"study,":[113],"we":[114,221],"used":[115],"immunohistochemical":[116],"analysis":[117,180],"reveal":[119,259],"expression":[122,350],"is":[123,227,262,351],"significantly":[124],"commonly":[126],"elevated":[127],"178":[129],"tumors":[131],"different":[133],"histotypes":[134],"compared":[135],"their":[137],"normal":[138],"adjacent":[139],"tissue":[140],"(p<0.02":[141],"-":[142,215],"0.001).":[143],"also":[145],"show":[146,222],"knockout":[148],"(KO)":[149],"A549":[153],"lines":[156],"resulted":[157],"reduced":[159],"higher":[162,187],"levels":[163,188],"cisplatin-induced":[165],"apoptosis":[166],"both":[167],"vitro":[169],"vivo.":[172],"These":[173],"findings":[174],"were":[175],"validated":[176],"retrospective":[179],"134":[182],"patients":[184,360],"associated":[191,228],"with":[192,229,242],"tumor":[193],"stage":[194],"(p<0.0001),":[195],"poor":[197],"as":[202],"(PFS,":[205],"HR":[206],"(RanBP9":[207],"positive":[208],"vs":[209],"negative)":[210],"1.71,":[211],"95%":[212],"CI":[213],"1.142":[214],"2.563,":[216],"p":[217],"=":[218],"0.0093).":[219],"Finally,":[220],"ablation":[224],"overactivation":[230],"poly(ADP-ribose)":[232],"polymerase":[233],"(PARP)":[234],"increased":[236,349],"cisplatin":[237],"antineoplastic":[238],"combination":[241],"PARP":[243],"inhibitors,":[244],"indicating":[245],"absence":[248],"results":[251,258],"BRCAness-like":[254],"phenotype.":[255],"Overall,":[256],"novel":[264],"biomarker":[266],"genotoxic":[270,346],"treatments":[271],"NSCLC,":[273],"paving":[274],"way":[276],"prospective":[278],"studies":[279],"aimed":[280],"at":[281],"assessing":[282],"clinical":[284],"value":[286],"therapeutic":[288],"targeting.":[289],"Citation":[290],"Format:":[291],"Anna":[292],"Tessari,":[293],"Kareesma":[294],"Parbhoo,":[295],"Meghan":[296],"Pawlikowski,":[297],"Matteo":[298],"Fassan,":[299],"Eliana":[300],"Rulli,":[301],"Claudia":[302],"Foray,":[303],"Alessandra":[304],"Fabbri,":[305],"Valerio":[306],"Embrione,":[307],"Monica":[308],"Ganzinelli,":[309],"Marina":[310,332],"Capece,":[311],"Moray":[312],"J.":[313],"Campbell,":[314],"Massimo":[315],"Broggini,":[316],"Krista":[317],"La":[318],"Perle,":[319],"Gabriella":[320],"Farina,":[321],"Sara":[322],"Cole,":[323],"Mirko":[324],"Marabese,":[325],"Joseph":[326],"M.":[327,336],"Amann,":[328],"David":[329],"P.":[330],"Carbone,":[331],"C.":[333],"Garassino,":[334],"Carlo":[335],"Croce,":[337],"Dario":[338],"Palmieri,":[339],"Vincenzo":[340],"Coppola.":[341],"protects":[343],"cells":[344],"from":[345],"stress":[347],"worse":[354],"[abstract].":[361],"In:":[362],"Proceedings":[363],"AACR-NCI-EORTC":[366],"International":[367],"Conference:":[368],"Molecular":[369],"Targets":[370],"Cancer":[372,383],"Therapeutics;":[373],"2017":[374],"Oct":[375],"26-30;":[376],"Philadelphia,":[377],"PA.":[378],"Philadelphia":[379],"(PA):":[380],"AACR;":[381],"Mol":[382],"Ther":[384],"2018;17(1":[385],"Suppl):Abstract":[386],"nr":[387],"A112.":[388]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2018-02-23T00:00:00"}