{"id":"https://openalex.org/W2785523944","doi":"https://doi.org/10.1038/s41398-018-0099-5","title":"A GABAergic cell type in the lateral habenula links hypothalamic homeostatic and midbrain motivation circuits with sex steroid signaling","display_name":"A GABAergic cell type in the lateral habenula links hypothalamic homeostatic and midbrain motivation circuits with sex steroid signaling","publication_year":2018,"publication_date":"2018-02-23","ids":{"openalex":"https://openalex.org/W2785523944","doi":"https://doi.org/10.1038/s41398-018-0099-5","mag":"2785523944","pmid":"https://pubmed.ncbi.nlm.nih.gov/29479060","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5865187"},"language":"en","primary_location":{"id":"doi:10.1038/s41398-018-0099-5","doi":"https://doi.org/10.1038/s41398-018-0099-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41398-018-0099-5","pdf_url":"https://www.nature.com/articles/s41398-018-0099-5.pdf","source":{"id":"https://openalex.org/S163345920","display_name":"Translational Psychiatry","issn_l":"2158-3188","issn":["2158-3188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41398-018-0099-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005746555","display_name":"Limei Zhang","orcid":"https://orcid.org/0000-0002-7422-5136","observed_orcids":["https://orcid.org/0000-0002-7422-5136"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]},{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX","US"],"is_corresponding":true,"raw_author_name":"Limei Zhang","raw_affiliation_strings":["Departmento de Fisiolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico. limei@unam.mx","Section on Molecular Neuroscience, National Institute of Mental Health (NIH), Bethesda, USA. limei@unam.mx","Departmento de Fisiolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico"],"raw_orcid":"https://orcid.org/0000-0002-7422-5136","affiliations":[{"raw_affiliation_string":"Departmento de Fisiolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico. limei@unam.mx","institution_ids":["https://openalex.org/I8961855"]},{"raw_affiliation_string":"Section on Molecular Neuroscience, National Institute of Mental Health (NIH), Bethesda, USA. limei@unam.mx","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]},{"raw_affiliation_string":"Departmento de Fisiolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073212557","display_name":"Vito S. Hern\u00e1ndez","orcid":"https://orcid.org/0000-0002-1486-1659","observed_orcids":["https://orcid.org/0000-0002-1486-1659","https://orcid.org/0000-0003-0295-6068"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Vito S. Hern\u00e1ndez","raw_affiliation_strings":["Departmento de Fisiolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departmento de Fisiolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090150393","display_name":"Jerome D. Swinny","orcid":"https://orcid.org/0000-0002-8194-5481","observed_orcids":["https://orcid.org/0000-0002-8194-5481"]},"institutions":[{"id":"https://openalex.org/I63072094","display_name":"University of Portsmouth","ror":"https://ror.org/03ykbk197","country_code":"GB","type":"education","lineage":["https://openalex.org/I63072094"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jerome D. Swinny","raw_affiliation_strings":["Institute for Biomedical and Biomolecular Sciences, School of Pharmacy & Biomedical Sciences, University of Portsmouth, Portsmouth, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical and Biomolecular Sciences, School of Pharmacy & Biomedical Sciences, University of Portsmouth, Portsmouth, UK","institution_ids":["https://openalex.org/I63072094"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anil K. Verma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Anil K. Verma","raw_affiliation_strings":["Departmento de Fisiolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departmento de Fisiolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050597969","display_name":"Torsten Giesecke","orcid":"https://orcid.org/0000-0002-6658-5027","observed_orcids":["https://orcid.org/0000-0002-6658-5027"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Torsten Giesecke","raw_affiliation_strings":["Department of Anatomy, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043025293","display_name":"Andrew Clayton Emery","orcid":"https://orcid.org/0000-0002-6760-2570","observed_orcids":["https://orcid.org/0000-0002-6760-2570"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew C. Emery","raw_affiliation_strings":["Section on Molecular Neuroscience, National Institute of Mental Health (NIH), Bethesda, USA"],"raw_orcid":"https://orcid.org/0000-0002-6760-2570","affiliations":[{"raw_affiliation_string":"Section on Molecular Neuroscience, National Institute of Mental Health (NIH), Bethesda, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085820518","display_name":"Kerim Mutig","orcid":"https://orcid.org/0000-0001-9006-5112","observed_orcids":["https://orcid.org/0000-0001-9006-5112"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kerim Mutig","raw_affiliation_strings":["Department of Anatomy, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025650833","display_name":"Luis Miguel Garc\u00eda\u2010Segura","orcid":"https://orcid.org/0000-0002-2450-2916","observed_orcids":["https://orcid.org/0000-0002-2450-2916"]},"institutions":[{"id":"https://openalex.org/I2184545","display_name":"Instituto Cajal","ror":"https://ror.org/012gwbh42","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I2184545"]},{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210149569","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y Envejecimiento Saludable","ror":"https://ror.org/04j0sev46","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4210149569","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Luis M. Garcia-Segura","raw_affiliation_strings":["CIBERFES, Instituto de Salud Carlos III, Madrid, Spain","Instituto Cajal, C.S.I.C., Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIBERFES, Instituto de Salud Carlos III, Madrid, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210149569"]},{"raw_affiliation_string":"Instituto Cajal, C.S.I.C., Madrid, Spain","institution_ids":["https://openalex.org/I2184545"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073913033","display_name":"Lee E. Eiden","orcid":"https://orcid.org/0000-0001-7524-944X","observed_orcids":["https://orcid.org/0000-0001-7524-944X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lee E. Eiden","raw_affiliation_strings":["Section on Molecular Neuroscience, National Institute of Mental Health (NIH), Bethesda, USA. eidenl@nih.gov","Section on Molecular Neuroscience, National Institute of Mental Health (NIH), Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Molecular Neuroscience, National Institute of Mental Health (NIH), Bethesda, USA. eidenl@nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]},{"raw_affiliation_string":"Section on Molecular Neuroscience, National Institute of Mental Health (NIH), Bethesda, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5005746555","https://openalex.org/A5073913033"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500","https://openalex.org/I8961855"],"apc_list":{"value":5290,"currency":"USD","value_usd":5290},"apc_paid":{"value":5290,"currency":"USD","value_usd":5290},"fwci":5.7905,"has_fulltext":true,"cited_by_count":116,"citation_normalized_percentile":{"value":0.97826762,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"8","issue":"1","first_page":"50","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.7807999849319458,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.7807999849319458,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.14589999616146088,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.03660000115633011,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lateral-habenula","display_name":"lateral habenula","score":0.9909999966621399},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.9490000009536743},{"id":"https://openalex.org/keywords/aromatase","display_name":"aromatase","score":0.847000002861023},{"id":"https://openalex.org/keywords/vasopressin","display_name":"vasopressin","score":0.6740000247955322},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.8529999852180481},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.996999979019165},{"id":"https://openalex.org/keywords/orexin-2-receptor","display_name":"orexin receptor 2","score":0.9620000123977661},{"id":"https://openalex.org/keywords/axonal-projection-patterns","display_name":"axonal projection patterns","score":0.6069999933242798},{"id":"https://openalex.org/keywords/gonadal-status","display_name":"gonadal status","score":0.6940000057220459},{"id":"https://openalex.org/keywords/predator-stress","display_name":"predator stress","score":0.8799999952316284},{"id":"https://openalex.org/keywords/forced-swim-stress","display_name":"forced swim stress","score":0.9390000104904175},{"id":"https://openalex.org/keywords/depression-like-behavior","display_name":"depression-like behavior","score":0.3540000021457672}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7034673094749451},{"id":"https://openalex.org/C44796713","wikidata":"https://www.wikidata.org/wiki/Q2659374","display_name":"Neuroactive steroid","level":4,"score":0.6693401336669922},{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.6034091114997864},{"id":"https://openalex.org/C85714458","wikidata":"https://www.wikidata.org/wiki/Q17152690","display_name":"Medium spiny neuron","level":4,"score":0.5965383052825928},{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.5804570317268372},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.573340654373169},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5469298362731934},{"id":"https://openalex.org/C2776166826","wikidata":"https://www.wikidata.org/wiki/Q415287","display_name":"Aromatase","level":4,"score":0.4565465450286865},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.433594286441803},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.383103609085083},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.37431997060775757},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3638400137424469},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.3062518537044525},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.24196642637252808},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.14207640290260315},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09690365195274353},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008636","descriptor_name":"Mesencephalon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008636","descriptor_name":"Mesencephalon","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009042","descriptor_name":"Motivation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012739","descriptor_name":"Gonadal Steroid Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019262","descriptor_name":"Habenula","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019262","descriptor_name":"Habenula","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D050495","descriptor_name":"Vesicular Inhibitory Amino Acid Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050599","descriptor_name":"Vesicular Glutamate Transport Protein 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059330","descriptor_name":"GABAergic Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059330","descriptor_name":"GABAergic Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41398-018-0099-5","doi":"https://doi.org/10.1038/s41398-018-0099-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41398-018-0099-5","pdf_url":"https://www.nature.com/articles/s41398-018-0099-5.pdf","source":{"id":"https://openalex.org/S163345920","display_name":"Translational Psychiatry","issn_l":"2158-3188","issn":["2158-3188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Psychiatry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4774363","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5865187","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5865187","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5865187","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Psychiatry","raw_type":"Text"},{"id":"pmid:29479060","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29479060","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational psychiatry","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7d4a99ba9254457aaefbb727163704c4","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7d4a99ba9254457aaefbb727163704c4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Translational Psychiatry, Vol 8, Iss 1, Pp 1-14 (2018)","raw_type":"article"},{"id":"doi:10.60692/je0p3-a4463","doi":"https://doi.org/10.60692/je0p3-a4463","is_oa":true,"landing_page_url":"https://doi.org/10.60692/je0p3-a4463","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/sdjta-k9r70","doi":"https://doi.org/10.60692/sdjta-k9r70","is_oa":true,"landing_page_url":"https://doi.org/10.60692/sdjta-k9r70","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1038/s41398-018-0099-5","doi":"https://doi.org/10.1038/s41398-018-0099-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41398-018-0099-5","pdf_url":"https://www.nature.com/articles/s41398-018-0099-5.pdf","source":{"id":"https://openalex.org/S163345920","display_name":"Translational Psychiatry","issn_l":"2158-3188","issn":["2158-3188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2018386919","display_name":null,"funder_award_id":"CB-176919","funder_id":"https://openalex.org/F4320321739","funder_display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda"},{"id":"https://openalex.org/G2614617285","display_name":null,"funder_award_id":"CB-238744","funder_id":"https://openalex.org/F4320321739","funder_display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda"},{"id":"https://openalex.org/G5281915054","display_name":null,"funder_award_id":"NIMH-IRP-1ZIAMH002386","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G7079031600","display_name":null,"funder_award_id":"PAPIIT-IN216214","funder_id":"https://openalex.org/F4320335100","funder_display_name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico"},{"id":"https://openalex.org/G9000903643","display_name":"Chemical Coding of Neurotransmission","funder_award_id":"ZIAMH002386","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320321739","display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","ror":"https://ror.org/059ex5q34"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320335100","display_name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2785523944.pdf","grobid_xml":"https://content.openalex.org/works/W2785523944.grobid-xml"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W1542275754","https://openalex.org/W1550463592","https://openalex.org/W1627229807","https://openalex.org/W1961916079","https://openalex.org/W1964196268","https://openalex.org/W1972389227","https://openalex.org/W1975829212","https://openalex.org/W1977741133","https://openalex.org/W1978528899","https://openalex.org/W1978574015","https://openalex.org/W1980687533","https://openalex.org/W1987107045","https://openalex.org/W1987880564","https://openalex.org/W1988743639","https://openalex.org/W1989570097","https://openalex.org/W1990422815","https://openalex.org/W1991236735","https://openalex.org/W1993417422","https://openalex.org/W2001413748","https://openalex.org/W2002758208","https://openalex.org/W2013001152","https://openalex.org/W2014548509","https://openalex.org/W2016500289","https://openalex.org/W2018760402","https://openalex.org/W2020107272","https://openalex.org/W2020645326","https://openalex.org/W2024418933","https://openalex.org/W2026887008","https://openalex.org/W2027906603","https://openalex.org/W2029484549","https://openalex.org/W2033263745","https://openalex.org/W2036756085","https://openalex.org/W2037457092","https://openalex.org/W2040246407","https://openalex.org/W2044045228","https://openalex.org/W2045821490","https://openalex.org/W2046270739","https://openalex.org/W2051472355","https://openalex.org/W2056566075","https://openalex.org/W2057245027","https://openalex.org/W2059542358","https://openalex.org/W2062666488","https://openalex.org/W2064633211","https://openalex.org/W2064750807","https://openalex.org/W2064910482","https://openalex.org/W2066081427","https://openalex.org/W2066619549","https://openalex.org/W2067565316","https://openalex.org/W2075619161","https://openalex.org/W2075990267","https://openalex.org/W2077036718","https://openalex.org/W2088734002","https://openalex.org/W2091064555","https://openalex.org/W2091245412","https://openalex.org/W2091680313","https://openalex.org/W2094172312","https://openalex.org/W2107239333","https://openalex.org/W2107325419","https://openalex.org/W2115902692","https://openalex.org/W2116040831","https://openalex.org/W2116663570","https://openalex.org/W2119077745","https://openalex.org/W2125331276","https://openalex.org/W2139558973","https://openalex.org/W2142910727","https://openalex.org/W2144334843","https://openalex.org/W2145865543","https://openalex.org/W2150561524","https://openalex.org/W2157513542","https://openalex.org/W2162109306","https://openalex.org/W2163815564","https://openalex.org/W2164509516","https://openalex.org/W2197078876","https://openalex.org/W2306879415","https://openalex.org/W2323146661","https://openalex.org/W2324837494","https://openalex.org/W2333514000","https://openalex.org/W2515552584","https://openalex.org/W2613341703","https://openalex.org/W2707968037","https://openalex.org/W2738248099","https://openalex.org/W2740023910","https://openalex.org/W2745928330","https://openalex.org/W2760672146","https://openalex.org/W2951442864","https://openalex.org/W3092855188","https://openalex.org/W4245541226"],"related_works":["https://openalex.org/W3176108482","https://openalex.org/W4389025244","https://openalex.org/W1965165964","https://openalex.org/W4281663033","https://openalex.org/W2071143997","https://openalex.org/W2049791338","https://openalex.org/W2006695602","https://openalex.org/W2057245027","https://openalex.org/W4383872946","https://openalex.org/W1557591071"],"abstract_inverted_index":{"The":[0,209],"lateral":[1],"habenula":[2],"(LHb)":[3],"has":[4],"a":[5,10,45,64,224,237],"key":[6],"role":[7],"in":[8,48,56,107,175,185,201],"integrating":[9],"variety":[11],"of":[12,52,125,168,232],"neural":[13],"circuits":[14,33],"associated":[15],"with":[16,198],"reward":[17,149],"and":[18,31,39,71,79,115,120,130,132,151,153,156,160,172,178,205,215],"aversive":[19],"behaviors.":[20],"There":[21],"is":[22,60,141],"limited":[23],"information":[24],"about":[25],"how":[26],"the":[27,35,49,53,85,95,166,213],"different":[28],"cell":[29,46,139,188],"types":[30],"neuronal":[32],"within":[34],"LHb":[36,54,114],"coordinate":[37],"physiological":[38],"motivational":[40,199],"states.":[41],"Here,":[42],"we":[43,93],"report":[44],"type":[47,140],"medial":[50],"division":[51],"(LHbM)":[55],"male":[57],"rats":[58],"that":[59,195,212],"distinguished":[61],"by:":[62],"(1)":[63],"molecular":[65],"signature":[66],"for":[67,87,127,134,239],"GABAergic":[68,96],"neurotransmission":[69],"(Slc32a1/VGAT)":[70],"estrogen":[72,169],"receptor":[73,136],"(Esr1/ER\u03b1)":[74],"expression,":[75],"at":[76],"both":[77,112,174],"mRNA":[78,86,133],"protein":[80],"levels,":[81],"as":[82,84,236],"well":[83],"vesicular":[88],"glutamate":[89],"transporter":[90],"Slc17a6/VGLUT2,":[91],"which":[92],"term":[94],"estrogen-receptive":[97],"neuron":[98],"(GERN);":[99],"(2)":[100],"its":[101,122],"axonal":[102,230],"projection":[103],"patterns,":[104],"identified":[105],"by":[106],"vivo":[108],"juxtacellular":[109],"labeling,":[110],"to":[111,116,144,203,221,234],"local":[113],"midbrain":[117,148],"modulatory":[118],"systems;":[119],"(3)":[121],"somatic":[123],"expression":[124,167,231],"receptors":[126],"vasopressin,":[128],"serotonin":[129],"dopamine,":[131],"orexin":[135],"2.":[137],"This":[138],"anatomically":[142],"located":[143],"receive":[145],"afferents":[146,164],"from":[147],"(dopamine":[150],"serotonin)":[152],"hypothalamic":[154],"water":[155],"energy":[157],"homeostasis":[158,214],"(vasopressin":[159],"orexin)":[161],"circuits.":[162],"These":[163],"shared":[165],"synthase":[170],"(aromatase)":[171],"VGLUT2,":[173],"their":[176],"somata":[177],"axon":[179],"terminals.":[180],"We":[181],"demonstrate":[182],"dynamic":[183],"changes":[184],"LHbM":[186],"VGAT+":[187],"density,":[189],"dependent":[190],"upon":[191],"gonadal":[192],"functional":[193],"status,":[194],"closely":[196],"correlate":[197],"behavior":[200],"response":[202],"predator":[204],"forced":[206],"swim":[207],"stressors.":[208],"findings":[210],"suggest":[211],"reward-related":[216],"glutamatergic":[217],"convergent":[218],"projecting":[219],"pathways":[220],"LHbMC":[222],"employ":[223],"localized":[225],"neurosteroid":[226],"signaling":[227],"mechanism":[228],"via":[229],"aromatase,":[233],"act":[235],"switch":[238],"GERN":[240],"excitation/inhibition":[241],"output":[242],"prevalence,":[243],"influencing":[244],"depressive":[245],"or":[246],"motivated":[247],"behavior.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":31},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-02-23T00:00:00"}
