{"id":"https://openalex.org/W2785163754","doi":"https://doi.org/10.1074/jbc.ra117.000342","title":"LSD1 demethylase and the methyl-binding protein PHF20L1 prevent SET7 methyltransferase\u2013dependent proteolysis of the stem-cell protein SOX2","display_name":"LSD1 demethylase and the methyl-binding protein PHF20L1 prevent SET7 methyltransferase\u2013dependent proteolysis of the stem-cell protein SOX2","publication_year":2018,"publication_date":"2018-01-22","ids":{"openalex":"https://openalex.org/W2785163754","doi":"https://doi.org/10.1074/jbc.ra117.000342","mag":"2785163754","pmid":"https://pubmed.ncbi.nlm.nih.gov/29358331","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5846134"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.ra117.000342","doi":"https://doi.org/10.1074/jbc.ra117.000342","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.ra117.000342","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.ra117.000342","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100644953","display_name":"Chunxiao Zhang","orcid":"https://orcid.org/0000-0001-5543-4509","observed_orcids":["https://orcid.org/0000-0001-5543-4509"]},"institutions":[{"id":"https://openalex.org/I133999245","display_name":"University of Nevada, Las Vegas","ror":"https://ror.org/0406gha72","country_code":"US","type":"education","lineage":["https://openalex.org/I133999245"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Chunxiao Zhang","raw_affiliation_strings":["From the Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","the Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China","Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","institution_ids":["https://openalex.org/I133999245"]},{"raw_affiliation_string":"the Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","institution_ids":["https://openalex.org/I133999245"]},{"raw_affiliation_string":"Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102997654","display_name":"Nam Hoang","orcid":"https://orcid.org/0000-0002-6719-4642","observed_orcids":["https://orcid.org/0000-0002-6719-4642"]},"institutions":[{"id":"https://openalex.org/I133999245","display_name":"University of Nevada, Las Vegas","ror":"https://ror.org/0406gha72","country_code":"US","type":"education","lineage":["https://openalex.org/I133999245"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nam Hoang","raw_affiliation_strings":["From the Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","institution_ids":["https://openalex.org/I133999245"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","institution_ids":["https://openalex.org/I133999245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100657643","display_name":"Feng Leng","orcid":"https://orcid.org/0000-0001-7504-8621","observed_orcids":["https://orcid.org/0000-0001-7504-8621"]},"institutions":[{"id":"https://openalex.org/I133999245","display_name":"University of Nevada, Las Vegas","ror":"https://ror.org/0406gha72","country_code":"US","type":"education","lineage":["https://openalex.org/I133999245"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Feng Leng","raw_affiliation_strings":["From the Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","the Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China","Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","institution_ids":["https://openalex.org/I133999245"]},{"raw_affiliation_string":"the Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","institution_ids":["https://openalex.org/I133999245"]},{"raw_affiliation_string":"Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090708858","display_name":"Lovely Saxena","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133999245","display_name":"University of Nevada, Las Vegas","ror":"https://ror.org/0406gha72","country_code":"US","type":"education","lineage":["https://openalex.org/I133999245"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lovely Saxena","raw_affiliation_strings":["From the Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","institution_ids":["https://openalex.org/I133999245"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","institution_ids":["https://openalex.org/I133999245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069390370","display_name":"Logan Lee","orcid":"https://orcid.org/0000-0001-5496-281X","observed_orcids":["https://orcid.org/0000-0001-5496-281X"]},"institutions":[{"id":"https://openalex.org/I133999245","display_name":"University of Nevada, Las Vegas","ror":"https://ror.org/0406gha72","country_code":"US","type":"education","lineage":["https://openalex.org/I133999245"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Logan Lee","raw_affiliation_strings":["From the Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","institution_ids":["https://openalex.org/I133999245"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","institution_ids":["https://openalex.org/I133999245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047718399","display_name":"Salvador Alejo","orcid":"https://orcid.org/0000-0002-1390-9892","observed_orcids":["https://orcid.org/0000-0002-1390-9892"]},"institutions":[{"id":"https://openalex.org/I133999245","display_name":"University of Nevada, Las Vegas","ror":"https://ror.org/0406gha72","country_code":"US","type":"education","lineage":["https://openalex.org/I133999245"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Salvador Alejo","raw_affiliation_strings":["From the Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","institution_ids":["https://openalex.org/I133999245"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","institution_ids":["https://openalex.org/I133999245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112041197","display_name":"Dandan Qi","orcid":"https://orcid.org/0009-0007-6079-6492","observed_orcids":["https://orcid.org/0009-0007-6079-6492"]},"institutions":[{"id":"https://openalex.org/I133999245","display_name":"University of Nevada, Las Vegas","ror":"https://ror.org/0406gha72","country_code":"US","type":"education","lineage":["https://openalex.org/I133999245"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Dandan Qi","raw_affiliation_strings":["From the Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","the Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China","Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","institution_ids":["https://openalex.org/I133999245"]},{"raw_affiliation_string":"the Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","institution_ids":["https://openalex.org/I133999245"]},{"raw_affiliation_string":"Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045877499","display_name":"Anthony Khal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133999245","display_name":"University of Nevada, Las Vegas","ror":"https://ror.org/0406gha72","country_code":"US","type":"education","lineage":["https://openalex.org/I133999245"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Khal","raw_affiliation_strings":["From the Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","institution_ids":["https://openalex.org/I133999245"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","institution_ids":["https://openalex.org/I133999245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100769312","display_name":"Hong Sun","orcid":"https://orcid.org/0000-0003-2100-1451","observed_orcids":["https://orcid.org/0000-0003-2100-1451"]},"institutions":[{"id":"https://openalex.org/I133999245","display_name":"University of Nevada, Las Vegas","ror":"https://ror.org/0406gha72","country_code":"US","type":"education","lineage":["https://openalex.org/I133999245"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Sun","raw_affiliation_strings":["From the Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","institution_ids":["https://openalex.org/I133999245"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","institution_ids":["https://openalex.org/I133999245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087766294","display_name":"Fei Lu","orcid":"https://orcid.org/0000-0001-5086-1157","observed_orcids":["https://orcid.org/0000-0001-5086-1157","https://orcid.org/0009-0007-8572-2465"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Lu","raw_affiliation_strings":["the Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China","Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100323333","display_name":"Hui Zhang","orcid":"https://orcid.org/0000-0001-6028-2554","observed_orcids":["https://orcid.org/0000-0001-6028-2554"]},"institutions":[{"id":"https://openalex.org/I133999245","display_name":"University of Nevada, Las Vegas","ror":"https://ror.org/0406gha72","country_code":"US","type":"education","lineage":["https://openalex.org/I133999245"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hui Zhang","raw_affiliation_strings":["From the Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and hui.zhang@unlv.edu","Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and hui.zhang@unlv.edu","institution_ids":["https://openalex.org/I133999245"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Nevada 89154 and","institution_ids":["https://openalex.org/I133999245"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100323333"],"corresponding_institution_ids":["https://openalex.org/I133999245"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.4844,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.81739739,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":98},"biblio":{"volume":"293","issue":"10","first_page":"3663","last_page":"3674"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.5307999849319458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.5307999849319458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.4138000011444092,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.01489999983459711,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sox2","display_name":"SOX2","score":0.9869999885559082},{"id":"https://openalex.org/keywords/lsd1","display_name":"LSD1","score":0.9390000104904175},{"id":"https://openalex.org/keywords/set7","display_name":"SET7","score":0.953000009059906},{"id":"https://openalex.org/keywords/lysine-demethylation","display_name":"lysine demethylation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/lysine-methylation","display_name":"lysine methylation","score":0.8519999980926514},{"id":"https://openalex.org/keywords/ubiquitin-mediated-degradation","display_name":"ubiquitin-mediated proteolysis","score":0.8610000014305115},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.9259999990463257},{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":0.9670000076293945},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.9210000038146973},{"id":"https://openalex.org/keywords/teratocarcinoma-cells","display_name":"teratocarcinoma cells","score":0.9330000281333923},{"id":"https://openalex.org/keywords/histone-methyltransferase","display_name":"histone methyltransferase","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C2777933648","wikidata":"https://www.wikidata.org/wiki/Q21114866","display_name":"SOX2","level":4,"score":0.7814940214157104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6114282011985779},{"id":"https://openalex.org/C2781364455","wikidata":"https://www.wikidata.org/wiki/Q2531584","display_name":"Demethylase","level":4,"score":0.5713803172111511},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5628256797790527},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5527912974357605},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.5121290683746338},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.4819033443927765},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4465312361717224},{"id":"https://openalex.org/C207701140","wikidata":"https://www.wikidata.org/wiki/Q420522","display_name":"Homeobox protein NANOG","level":5,"score":0.42167437076568604},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.4182884395122528},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4135698974132538},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3918067514896393},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.31512951850891113},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2704565227031708},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.15116235613822937},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0564650297164917},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002868","descriptor_name":"Chromosomal Proteins, Non-Histone","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D002868","descriptor_name":"Chromosomal Proteins, Non-Histone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002868","descriptor_name":"Chromosomal Proteins, Non-Histone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002868","descriptor_name":"Chromosomal Proteins, Non-Histone","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011495","descriptor_name":"Histone-Lysine N-Methyltransferase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011495","descriptor_name":"Histone-Lysine N-Methyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011495","descriptor_name":"Histone-Lysine N-Methyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011495","descriptor_name":"Histone-Lysine N-Methyltransferase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018243","descriptor_name":"Teratocarcinoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018243","descriptor_name":"Teratocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018243","descriptor_name":"Teratocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055748","descriptor_name":"SOXB1 Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055748","descriptor_name":"SOXB1 Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055748","descriptor_name":"SOXB1 Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056466","descriptor_name":"Histone Demethylases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D056466","descriptor_name":"Histone Demethylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056466","descriptor_name":"Histone Demethylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056466","descriptor_name":"Histone Demethylases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1074/jbc.ra117.000342","doi":"https://doi.org/10.1074/jbc.ra117.000342","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.ra117.000342","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5392717","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5846134","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5846134","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5846134","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:29358331","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29358331","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Comparative Study"},{"id":"pmh:oai:oasis.library.unlv.edu:chem_fac_articles-1181","doi":null,"is_oa":true,"landing_page_url":"https://oasis.library.unlv.edu/chem_fac_articles/182","pdf_url":null,"source":{"id":"https://openalex.org/S4377196371","display_name":"Digital Scholarship - UNLV (University of Nevada Reno)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134113660","host_organization_name":"University of Nevada, Reno","host_organization_lineage":["https://openalex.org/I134113660"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chemistry and Biochemistry Faculty Research","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1074/jbc.ra117.000342","doi":"https://doi.org/10.1074/jbc.ra117.000342","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.ra117.000342","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2449601139","display_name":"Control of Epigenetic Inheritance By Proteolysis","funder_award_id":"R15GM116087","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4337467711","display_name":null,"funder_award_id":"2014A030313779","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G7284039369","display_name":"Novel Regulation of Receptor Tyrosine Kinases by ASM (Acidic Sphingomyelinase)","funder_award_id":"R15NS096694","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1964813856","https://openalex.org/W1965784662","https://openalex.org/W1974370722","https://openalex.org/W1974820106","https://openalex.org/W1978083226","https://openalex.org/W1978357765","https://openalex.org/W1983396394","https://openalex.org/W1989769057","https://openalex.org/W1994844375","https://openalex.org/W1998813566","https://openalex.org/W2004499293","https://openalex.org/W2006932105","https://openalex.org/W2013785611","https://openalex.org/W2014069479","https://openalex.org/W2023171799","https://openalex.org/W2028898542","https://openalex.org/W2029150071","https://openalex.org/W2029372290","https://openalex.org/W2032735361","https://openalex.org/W2034463782","https://openalex.org/W2040365591","https://openalex.org/W2041081187","https://openalex.org/W2043624735","https://openalex.org/W2049195493","https://openalex.org/W2050879491","https://openalex.org/W2057877925","https://openalex.org/W2073759231","https://openalex.org/W2073996456","https://openalex.org/W2075296132","https://openalex.org/W2079777624","https://openalex.org/W2110015307","https://openalex.org/W2111954828","https://openalex.org/W2111964212","https://openalex.org/W2139334516","https://openalex.org/W2141797256","https://openalex.org/W2142891979","https://openalex.org/W2148679920","https://openalex.org/W2150170782","https://openalex.org/W2150609732","https://openalex.org/W2157771031","https://openalex.org/W2157840751","https://openalex.org/W2162779169","https://openalex.org/W2163656014","https://openalex.org/W2168970170","https://openalex.org/W2210554177","https://openalex.org/W2406001921","https://openalex.org/W2534422312","https://openalex.org/W4212766227","https://openalex.org/W6646027120"],"related_works":["https://openalex.org/W2885287752","https://openalex.org/W2043624735","https://openalex.org/W4391815377","https://openalex.org/W3161982955","https://openalex.org/W4391741703","https://openalex.org/W7161769099","https://openalex.org/W2101575082","https://openalex.org/W1978083226","https://openalex.org/W1964813856","https://openalex.org/W2789326366"],"abstract_inverted_index":{"The":[0],"pluripotency-controlling":[1,216],"stem-cell":[2,217],"protein":[3,91,218],"SRY-box":[4],"2":[5],"(SOX2)":[6],"plays":[7],"a":[8,86,122],"pivotal":[9],"role":[10],"in":[11,36,68,111,120,146,168,231],"maintaining":[12],"the":[13,42,53,81,102,186,212,215,224],"self-renewal":[14],"and":[15,21,45,56,85,128,144,148,171,182,194,229],"pluripotency":[16],"of":[17,23,154,188,214,226],"embryonic":[18,26,38,173,191],"stem":[19,39,174,192,233],"cells":[20,40,193,196],"also":[22,116,126,130,178],"teratocarcinoma":[24,71],"or":[25,157],"carcinoma":[27],"cells.":[28,175,234],"SOX2":[29,50,60,75,132,147,151,160,200,219],"is":[30,77,220],"monomethylated":[31,106,118,142],"at":[32],"lysine":[33,83],"119":[34],"(Lys-119)":[35],"mouse":[37,112,172,190],"by":[41,80,165,197,210,223],"SET7":[43,125,166],"methyltransferase,":[44],"this":[46],"methylation":[47],"triggers":[48],"ubiquitin-dependent":[49],"proteolysis.":[51,133,152,201],"However,":[52],"molecular":[54],"regulators":[55],"mechanisms":[57],"controlling":[58],"SET7-induced":[59],"proteolysis":[61,76],"are":[62],"unknown.":[63],"Here,":[64],"we":[65],"report":[66],"that":[67,97,124,129,138,180],"human":[69],"ovarian":[70],"PA-1":[72,170,195],"cells,":[73],"methylation-dependent":[74,199],"dynamically":[78,221],"regulated":[79,127,222],"LSD1":[82,98,156,181],"demethylase":[84],"methyl-binding":[87],"protein,":[88],"PHD":[89],"finger":[90],"20-like":[92],"1":[93],"(PHF20L1).":[94],"We":[95],"found":[96],"not":[99],"only":[100],"removes":[101],"methyl":[103],"group":[104],"from":[105],"Lys-117":[107,145],"(equivalent":[108],"to":[109],"Lys-119":[110],"SOX2),":[113],"but":[114],"it":[115],"demethylates":[117],"Lys-42":[119,143],"SOX2,":[121],"reaction":[123],"triggered":[131],"Our":[134,176],"studies":[135,177],"further":[136],"revealed":[137],"PHF20L1":[139,158,183,230],"binds":[140],"both":[141,169],"thereby":[149],"prevents":[150],"Down-regulation":[153],"either":[155],"promoted":[159],"proteolysis,":[161],"which":[162,211],"was":[163],"prevented":[164],"inactivation":[167],"disclosed":[179],"normally":[184],"regulate":[185],"growth":[187],"pluripotent":[189,232],"preventing":[198],"In":[202],"conclusion,":[203],"our":[204],"findings":[205],"reveal":[206],"an":[207],"important":[208],"mechanism":[209],"stability":[213],"activities":[225],"SET7,":[227],"LSD1,":[228]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-02-02T00:00:00"}