{"id":"https://openalex.org/W2784528367","doi":null,"title":"Development of Modified Vaccinia Virus Ankara-based Influenza Vaccines","display_name":"Development of Modified Vaccinia Virus Ankara-based Influenza Vaccines","publication_year":2018,"publication_date":"2018-01-31","ids":{"openalex":"https://openalex.org/W2784528367","mag":"2784528367"},"language":"en","primary_location":{"id":"pmh:oai:repub.eur.nl:104030","doi":null,"is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/104030","pdf_url":"http://repub.eur.nl/pub/104030","source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://repub.eur.nl/pub/104030","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034557186","display_name":"Arwen F. Altenburg","orcid":"https://orcid.org/0000-0002-5361-4909","observed_orcids":["https://orcid.org/0000-0002-5361-4909"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Arwen F. Altenburg","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5361-4909","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5034557186"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11767","display_name":"Poxvirus research and outbreaks","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/modified-vaccinia-ankara","display_name":"modified vaccinia Ankara","score":0.8809999823570251},{"id":"https://openalex.org/keywords/influenza-vaccination","display_name":"influenza vaccination","score":0.9340000152587891},{"id":"https://openalex.org/keywords/recombinant-viral-vectors","display_name":"recombinant viral vectors","score":0.6460000276565552},{"id":"https://openalex.org/keywords/hemagglutinin","display_name":"hemagglutinin","score":0.906000018119812},{"id":"https://openalex.org/keywords/antigenic-variation","display_name":"antigenic variation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/broad-spectrum-immunity","display_name":"broad-spectrum immunity","score":0.6890000104904175},{"id":"https://openalex.org/keywords/vaccine-production","display_name":"vaccine production","score":0.4830000102519989},{"id":"https://openalex.org/keywords/in-vivo-cell-culture","display_name":"in vivo cell culture","score":0.4729999899864197},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.5120000243186951}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.8323732614517212},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.692651093006134},{"id":"https://openalex.org/C7842527","wikidata":"https://www.wikidata.org/wiki/Q575258","display_name":"Antigenic drift","level":4,"score":0.644468367099762},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6120112538337708},{"id":"https://openalex.org/C2781356689","wikidata":"https://www.wikidata.org/wiki/Q1986297","display_name":"Vaccinia","level":4,"score":0.5913540720939636},{"id":"https://openalex.org/C2780689484","wikidata":"https://www.wikidata.org/wiki/Q383260","display_name":"Influenza vaccine","level":3,"score":0.5345567464828491},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5129330158233643},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.4971065819263458},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4860840141773224},{"id":"https://openalex.org/C2778692840","wikidata":"https://www.wikidata.org/wiki/Q9136673","display_name":"Hemagglutinin (influenza)","level":3,"score":0.4643709063529968},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4515801668167114},{"id":"https://openalex.org/C180915046","wikidata":"https://www.wikidata.org/wiki/Q575264","display_name":"Original antigenic sin","level":5,"score":0.44587212800979614},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4270945191383362},{"id":"https://openalex.org/C106192422","wikidata":"https://www.wikidata.org/wiki/Q736798","display_name":"Herd immunity","level":3,"score":0.4268789291381836},{"id":"https://openalex.org/C86282344","wikidata":"https://www.wikidata.org/wiki/Q575314","display_name":"Antigenic shift","level":5,"score":0.42638036608695984},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3834514617919922},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3130355477333069},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30377495288848877},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.12444162368774414},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.09150782227516174},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.06146326661109924},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.05314329266548157},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:repub.eur.nl:104030","doi":null,"is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/104030","pdf_url":"http://repub.eur.nl/pub/104030","source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:eur:oai:pure.eur.nl:publications/19d75097-ecb4-45e0-b998-b4aa661bc3d8","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/19d75097-ecb4-45e0-b998-b4aa661bc3d8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:eur:oai:repub.eur.nl:104030","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/104030","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:2784528367","doi":null,"is_oa":false,"landing_page_url":"https://repub.eur.nl/pub/104030/Thesis-Arwen-Altenburg.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repub.eur.nl:104030","doi":null,"is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/104030","pdf_url":"http://repub.eur.nl/pub/104030","source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2024668281","display_name":"InFLUenza virus UNIVersal VACcine development program","funder_award_id":"602604","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G730875482","display_name":"Novel strategies to combat future influenza pandemics","funder_award_id":"250136","funder_id":"https://openalex.org/F4320338352","funder_display_name":"FP7 Ideas: European Research Council"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320338352","display_name":"FP7 Ideas: European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2784528367.pdf","grobid_xml":"https://content.openalex.org/works/W2784528367.grobid-xml"},"referenced_works_count":311,"referenced_works":["https://openalex.org/W39794858","https://openalex.org/W124119194","https://openalex.org/W919967210","https://openalex.org/W1483301458","https://openalex.org/W1492664191","https://openalex.org/W1515053395","https://openalex.org/W1517818958","https://openalex.org/W1524785464","https://openalex.org/W1546151618","https://openalex.org/W1554889623","https://openalex.org/W1570034014","https://openalex.org/W1603918837","https://openalex.org/W1620097935","https://openalex.org/W1693145019","https://openalex.org/W1774386111","https://openalex.org/W1805709456","https://openalex.org/W1816587284","https://openalex.org/W1862362836","https://openalex.org/W1902557223","https://openalex.org/W1955834521","https://openalex.org/W1963710267","https://openalex.org/W1963790908","https://openalex.org/W1963861196","https://openalex.org/W1967978769","https://openalex.org/W1973139453","https://openalex.org/W1976629220","https://openalex.org/W1976852215","https://openalex.org/W1977189837","https://openalex.org/W1977906296","https://openalex.org/W1978036248","https://openalex.org/W1978452294","https://openalex.org/W1979158913","https://openalex.org/W1980489153","https://openalex.org/W1982310373","https://openalex.org/W1982962140","https://openalex.org/W1984567215","https://openalex.org/W1984848656","https://openalex.org/W1985641201","https://openalex.org/W1985704471","https://openalex.org/W1985767121","https://openalex.org/W1986059049","https://openalex.org/W1986865880","https://openalex.org/W1987341774","https://openalex.org/W1987580014","https://openalex.org/W1987938089","https://openalex.org/W1988511365","https://openalex.org/W1989490778","https://openalex.org/W1989622501","https://openalex.org/W1989865128","https://openalex.org/W1990245784","https://openalex.org/W1990525844","https://openalex.org/W1991083095","https://openalex.org/W1991656907","https://openalex.org/W1992439635","https://openalex.org/W1993251450","https://openalex.org/W1993547722","https://openalex.org/W1993577147","https://openalex.org/W1994186503","https://openalex.org/W1994629883","https://openalex.org/W1996109976","https://openalex.org/W1996257646","https://openalex.org/W1996360948","https://openalex.org/W1997241045","https://openalex.org/W1999768026","https://openalex.org/W2001089308","https://openalex.org/W2002041201","https://openalex.org/W2003051762","https://openalex.org/W2003753251","https://openalex.org/W2004143596","https://openalex.org/W2004206622","https://openalex.org/W2005238188","https://openalex.org/W2012680073","https://openalex.org/W2014937439","https://openalex.org/W2015053383","https://openalex.org/W2015307349","https://openalex.org/W2017698380","https://openalex.org/W2019206924","https://openalex.org/W2020818331","https://openalex.org/W2021537447","https://openalex.org/W2023251537","https://openalex.org/W2023268216","https://openalex.org/W2023545435","https://openalex.org/W2024020757","https://openalex.org/W2024152920","https://openalex.org/W2024524568","https://openalex.org/W2025154999","https://openalex.org/W2025268482","https://openalex.org/W2026479383","https://openalex.org/W2027646537","https://openalex.org/W2027682055","https://openalex.org/W2028189879","https://openalex.org/W2030501166","https://openalex.org/W2031425216","https://openalex.org/W2031843685","https://openalex.org/W2032976848","https://openalex.org/W2033299041","https://openalex.org/W2035217221","https://openalex.org/W2036182565","https://openalex.org/W2037324016","https://openalex.org/W2039200386","https://openalex.org/W2040440325","https://openalex.org/W2040984333","https://openalex.org/W2041319603","https://openalex.org/W2045165780","https://openalex.org/W2045523521","https://openalex.org/W2045640660","https://openalex.org/W2046560352","https://openalex.org/W2047717992","https://openalex.org/W2048705260","https://openalex.org/W2048967324","https://openalex.org/W2050084139","https://openalex.org/W2050161155","https://openalex.org/W2050306167","https://openalex.org/W2051525580","https://openalex.org/W2053449086","https://openalex.org/W2055499730","https://openalex.org/W2056718686","https://openalex.org/W2058935282","https://openalex.org/W2059229970","https://openalex.org/W2059385530","https://openalex.org/W2060539718","https://openalex.org/W2060566204","https://openalex.org/W2061221862","https://openalex.org/W2062690397","https://openalex.org/W2064971673","https://openalex.org/W2065306943","https://openalex.org/W2065417495","https://openalex.org/W2065764138","https://openalex.org/W2066218699","https://openalex.org/W2066273396","https://openalex.org/W2066717808","https://openalex.org/W2067170256","https://openalex.org/W2067493370","https://openalex.org/W2069831575","https://openalex.org/W2070424376","https://openalex.org/W2070601214","https://openalex.org/W2071688420","https://openalex.org/W2071950719","https://openalex.org/W2072237100","https://openalex.org/W2072546058","https://openalex.org/W2074660641","https://openalex.org/W2076096828","https://openalex.org/W2076251336","https://openalex.org/W2076787697","https://openalex.org/W2077219861","https://openalex.org/W2077361603","https://openalex.org/W2078626132","https://openalex.org/W2080798548","https://openalex.org/W2081282655","https://openalex.org/W2082104694","https://openalex.org/W2082445383","https://openalex.org/W2084648294","https://openalex.org/W2085544883","https://openalex.org/W2085687119","https://openalex.org/W2086853340","https://openalex.org/W2087142631","https://openalex.org/W2087398251","https://openalex.org/W2087557652","https://openalex.org/W2089147775","https://openalex.org/W2089532164","https://openalex.org/W2090434219","https://openalex.org/W2090449499","https://openalex.org/W2091660088","https://openalex.org/W2092351819","https://openalex.org/W2092778039","https://openalex.org/W2094999215","https://openalex.org/W2095184125","https://openalex.org/W2097373201","https://openalex.org/W2097398162","https://openalex.org/W2097911237","https://openalex.org/W2098227537","https://openalex.org/W2098337510","https://openalex.org/W2098500164","https://openalex.org/W2099480075","https://openalex.org/W2099679503","https://openalex.org/W2100796800","https://openalex.org/W2101179800","https://openalex.org/W2101436388","https://openalex.org/W2102237050","https://openalex.org/W2102497131","https://openalex.org/W2104391453","https://openalex.org/W2104726858","https://openalex.org/W2104845020","https://openalex.org/W2105225614","https://openalex.org/W2105903827","https://openalex.org/W2106367537","https://openalex.org/W2107419471","https://openalex.org/W2107587363","https://openalex.org/W2108075163","https://openalex.org/W2108633532","https://openalex.org/W2109804337","https://openalex.org/W2110990893","https://openalex.org/W2111323042","https://openalex.org/W2111408218","https://openalex.org/W2112982331","https://openalex.org/W2114366888","https://openalex.org/W2115473644","https://openalex.org/W2116736752","https://openalex.org/W2116834921","https://openalex.org/W2117175288","https://openalex.org/W2117236001","https://openalex.org/W2117430529","https://openalex.org/W2119041597","https://openalex.org/W2119820756","https://openalex.org/W2120432686","https://openalex.org/W2122157993","https://openalex.org/W2123271650","https://openalex.org/W2123347544","https://openalex.org/W2125092960","https://openalex.org/W2126153224","https://openalex.org/W2126309815","https://openalex.org/W2127840828","https://openalex.org/W2127852419","https://openalex.org/W2128733072","https://openalex.org/W2129169740","https://openalex.org/W2129380034","https://openalex.org/W2130737480","https://openalex.org/W2131127386","https://openalex.org/W2131598001","https://openalex.org/W2132287875","https://openalex.org/W2133364035","https://openalex.org/W2135213915","https://openalex.org/W2135487927","https://openalex.org/W2135613694","https://openalex.org/W2135858175","https://openalex.org/W2136281747","https://openalex.org/W2136323284","https://openalex.org/W2139167536","https://openalex.org/W2139427540","https://openalex.org/W2139699918","https://openalex.org/W2139924928","https://openalex.org/W2141848036","https://openalex.org/W2143447266","https://openalex.org/W2143833474","https://openalex.org/W2145822650","https://openalex.org/W2146671000","https://openalex.org/W2147233754","https://openalex.org/W2147567659","https://openalex.org/W2148156220","https://openalex.org/W2148275137","https://openalex.org/W2148338221","https://openalex.org/W2149024166","https://openalex.org/W2150962558","https://openalex.org/W2151178959","https://openalex.org/W2151430773","https://openalex.org/W2151568075","https://openalex.org/W2151809231","https://openalex.org/W2151868151","https://openalex.org/W2152571428","https://openalex.org/W2152617913","https://openalex.org/W2154403354","https://openalex.org/W2154434805","https://openalex.org/W2155962399","https://openalex.org/W2156521114","https://openalex.org/W2156622172","https://openalex.org/W2156841329","https://openalex.org/W2157479530","https://openalex.org/W2157802109","https://openalex.org/W2158112812","https://openalex.org/W2158372391","https://openalex.org/W2158989551","https://openalex.org/W2159734253","https://openalex.org/W2159882198","https://openalex.org/W2160224960","https://openalex.org/W2160805048","https://openalex.org/W2162249641","https://openalex.org/W2162822510","https://openalex.org/W2163135112","https://openalex.org/W2163960578","https://openalex.org/W2164613298","https://openalex.org/W2164807254","https://openalex.org/W2165040021","https://openalex.org/W2165896641","https://openalex.org/W2168050323","https://openalex.org/W2168513578","https://openalex.org/W2169355435","https://openalex.org/W2169905609","https://openalex.org/W2171298782","https://openalex.org/W2172059715","https://openalex.org/W2190981469","https://openalex.org/W2192309339","https://openalex.org/W2196401199","https://openalex.org/W2213649682","https://openalex.org/W2265341716","https://openalex.org/W2286448385","https://openalex.org/W2297142125","https://openalex.org/W2318325499","https://openalex.org/W2322519697","https://openalex.org/W2325250956","https://openalex.org/W2343060625","https://openalex.org/W2343372581","https://openalex.org/W2344939011","https://openalex.org/W2423199363","https://openalex.org/W2470517214","https://openalex.org/W2498936972","https://openalex.org/W2513393629","https://openalex.org/W2515993714","https://openalex.org/W2523571328","https://openalex.org/W2525969270","https://openalex.org/W2527139575","https://openalex.org/W2529693366","https://openalex.org/W2537813141","https://openalex.org/W2541414417","https://openalex.org/W2559387150","https://openalex.org/W2565755592","https://openalex.org/W2566874692","https://openalex.org/W2605491919","https://openalex.org/W2612489719","https://openalex.org/W2743783127","https://openalex.org/W2766504208","https://openalex.org/W4236514778"],"related_works":["https://openalex.org/W2024020757","https://openalex.org/W2037679812","https://openalex.org/W2090434219","https://openalex.org/W1970073176","https://openalex.org/W7100601799","https://openalex.org/W2085966385","https://openalex.org/W2575333632","https://openalex.org/W2577859405","https://openalex.org/W2109804337","https://openalex.org/W4221094284"],"abstract_inverted_index":{"Influenza":[0],"viruses":[1,43,66],"continuously":[2],"circulate":[3,71],"in":[4,72,97,161,185,208,239,244],"the":[5,31,73,82,89,191,225,236,243,253,284],"human":[6,218],"population":[7],"and":[8,64,94,132,140,193,212,251,273,277],"are":[9,54,68,95,144,149],"estimated":[10],"to":[11,35,70,125,152,216,230,283],"cause":[12],"3-5":[13],"million":[14],"cases":[15],"of":[16,22,56,84,155,158,165,195,248,256,286],"severe":[17],"respiratory":[18],"illness":[19],"annually":[20],"worldwide":[21],"which":[23],"250.000-500.000":[24],"have":[25],"a":[26,162,220],"fatal":[27],"outcome.":[28],"Vaccination":[29],"is":[30,44],"most":[32],"efficient":[33,96],"measure":[34],"control":[36],"infectious":[37],"diseases,":[38],"however,":[39],"vaccination":[40,260],"against":[41,88,101,130],"influenza":[42,52,59,75,104,121,135,179,197,268,288],"complicated":[45],"by":[46,261,275],"their":[47],"antigenic":[48],"variability.":[49],"Current":[50],"seasonal":[51,78,118],"vaccines":[53,79,198,250],"comprised":[55],"components":[57],"from":[58,113],"A":[60],"(H1N1":[61],"&":[62],"H3N2)":[63],"B":[65],"that":[67,234],"expected":[69],"next":[74],"season.":[76],"These":[77,280],"aim":[80],"at":[81],"induction":[83],"virus":[85,172,180],"neutralizing":[86],"antibodies":[87],"surface":[90],"glycoprotein":[91],"hemagglutinin":[92],"(HA)":[93],"providing":[98],"protective":[99,128],"immunity":[100,129],"antigenically":[102,116,133],"similar":[103],"viruses.":[105,122],"However,":[106],"they":[107],"afford":[108],"little":[109],"or":[110,119,177],"no":[111],"protection":[112],"infection":[114],"with":[115,258],"distinct":[117,134],"pandemic":[120],"In":[123,188],"order":[124],"induce":[126],"broadly":[127],"multiple":[131,178],"viruses,":[136],"novel":[137,147,266],"vaccine":[138,159,168,227,269],"targets":[139],"antigen":[141],"delivery":[142],"systems":[143],"investigated.":[145],"Furthermore,":[146,265],"techniques":[148],"under":[150],"development":[151,192,285],"facilitate":[153],"production":[154],"large":[156],"quantities":[157],"doses":[160],"short":[163],"period":[164],"time.":[166],"The":[167],"vector":[169,228],"Modified":[170],"Vaccinia":[171],"Ankara":[173],"(MVA)":[174],"expressing":[175],"one":[176],"antigens":[181],"could":[182],"potentially":[183],"provide":[184],"these":[186],"needs.":[187],"this":[189,240],"thesis,":[190],"use":[194],"rMVA-based":[196,259,267],"was":[199],"addressed.":[200],"Even":[201],"though":[202],"MVA":[203,226],"has":[204,213],"been":[205,214],"tested":[206],"extensively":[207],"various":[209],"animal":[210],"models":[211],"administered":[215],">100.000":[217],"subjects,":[219],"few":[221],"key":[222],"questions":[223],"regarding":[224],"remained":[229],"be":[231],"answered.":[232],"To":[233],"end,":[235],"studies":[237,281],"described":[238],"thesis":[241],"elucidated":[242],"vivo":[245],"cell":[246],"tropism":[247],"MVA-based":[249],"assessed":[252],"potential":[254],"risk":[255],"interference":[257],"orthopoxvirus-specific":[262],"pre-existing":[263],"immunity.":[264],"candidates":[270],"were":[271],"developed":[272],"evaluated":[274],"pre-clinical":[276],"clinical":[278],"testing.":[279],"contribute":[282],"next-generation":[287],"vaccines.":[289]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2018-02-02T00:00:00"}