{"id":"https://openalex.org/W2784328840","doi":"https://doi.org/10.20517/10.20517/2394-5079.2017.46","title":"Clinical and molecular sub-classification of hepatocellular carcinoma relative to alpha-fetoprotein level in an Asia-Pacific island cohort","display_name":"Clinical and molecular sub-classification of hepatocellular carcinoma relative to alpha-fetoprotein level in an Asia-Pacific island cohort","publication_year":2018,"publication_date":"2018-01-12","ids":{"openalex":"https://openalex.org/W2784328840","doi":"https://doi.org/10.20517/10.20517/2394-5079.2017.46","mag":"2784328840","pmid":"https://pubmed.ncbi.nlm.nih.gov/29376136","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5786161"},"language":"en","primary_location":{"id":"doi:10.20517/10.20517/2394-5079.2017.46","doi":"https://doi.org/10.20517/10.20517/2394-5079.2017.46","is_oa":true,"landing_page_url":"https://doi.org/10.20517/10.20517/2394-5079.2017.46","pdf_url":"https://hrjournal.net/article/download/3175","source":{"id":"https://openalex.org/S4210208932","display_name":"Hepatoma Research","issn_l":"2394-5079","issn":["2394-5079","2454-2520"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatoma Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://hrjournal.net/article/download/3175","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074447812","display_name":"Scott T. Nishioka","orcid":"https://orcid.org/0000-0002-2764-1153","observed_orcids":["https://orcid.org/0000-0002-2764-1153"]},"institutions":[{"id":"https://openalex.org/I4210104115","display_name":"Queen's Medical Center","ror":"https://ror.org/016gbn942","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104115"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott T. Nishioka","raw_affiliation_strings":["The Queen's Medical Center, Honolulu, HI 96813, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Queen's Medical Center, Honolulu, HI 96813, USA","institution_ids":["https://openalex.org/I4210104115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068946104","display_name":"Miles M. Sato","orcid":"https://orcid.org/0000-0002-1691-5198","observed_orcids":["https://orcid.org/0000-0002-1691-5198"]},"institutions":[{"id":"https://openalex.org/I4210104115","display_name":"Queen's Medical Center","ror":"https://ror.org/016gbn942","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104115"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miles M. Sato","raw_affiliation_strings":["The Queen's Medical Center, Honolulu, HI 96813, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Queen's Medical Center, Honolulu, HI 96813, USA","institution_ids":["https://openalex.org/I4210104115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069748932","display_name":"Linda L. Wong","orcid":"https://orcid.org/0000-0003-3143-5384","observed_orcids":["https://orcid.org/0000-0003-3143-5384"]},"institutions":[{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda L. Wong","raw_affiliation_strings":["Cancer Biology Program and Genomics Shared Resource, University of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96822, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology Program and Genomics Shared Resource, University of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96822, USA","institution_ids":["https://openalex.org/I1331384533","https://openalex.org/I4390039246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014295522","display_name":"Maarit Tiirikainen","orcid":"https://orcid.org/0000-0002-8124-3818","observed_orcids":["https://orcid.org/0000-0002-8124-3818"]},"institutions":[{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maarit Tiirikainen","raw_affiliation_strings":["Cancer Biology Program and Genomics Shared Resource, University of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96822, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology Program and Genomics Shared Resource, University of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96822, USA","institution_ids":["https://openalex.org/I1331384533","https://openalex.org/I4390039246"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028096127","display_name":"Sandi Alexander Kwee","orcid":"https://orcid.org/0000-0002-4624-8787","observed_orcids":["https://orcid.org/0000-0002-4624-8787"]},"institutions":[{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]},{"id":"https://openalex.org/I4210104115","display_name":"Queen's Medical Center","ror":"https://ror.org/016gbn942","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104115"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sandi A. Kwee","raw_affiliation_strings":["Cancer Biology Program and Genomics Shared Resource, University of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96822, USA","Hamamatsu/Queen's PET Imaging Center, The Queen's Medical Center, Honolulu, HI 96813, USA","The Queen's Medical Center, Honolulu, HI 96813, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology Program and Genomics Shared Resource, University of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96822, USA","institution_ids":["https://openalex.org/I1331384533","https://openalex.org/I4390039246"]},{"raw_affiliation_string":"Hamamatsu/Queen's PET Imaging Center, The Queen's Medical Center, Honolulu, HI 96813, USA","institution_ids":["https://openalex.org/I4210104115"]},{"raw_affiliation_string":"The Queen's Medical Center, Honolulu, HI 96813, USA","institution_ids":["https://openalex.org/I4210104115"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5028096127"],"corresponding_institution_ids":["https://openalex.org/I1331384533","https://openalex.org/I4210104115","https://openalex.org/I4390039246"],"apc_list":null,"apc_paid":null,"fwci":1.7241,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.83465325,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":98},"biblio":{"volume":"4","issue":"1","first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":1.0},{"id":"https://openalex.org/keywords/alpha-fetoprotein","display_name":"alpha-fetoprotein","score":0.9850000143051147},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.5720000267028809},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.859000027179718},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7570000290870667},{"id":"https://openalex.org/keywords/hawaii","display_name":"Hawaii","score":0.41499999165534973},{"id":"https://openalex.org/keywords/pacific-island-populations","display_name":"Pacific Island populations","score":0.6830000281333923},{"id":"https://openalex.org/keywords/gene-set-enrichment-analysis","display_name":"gene set enrichment analysis","score":0.6269999742507935},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.38499999046325684}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8587474226951599},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.834809422492981},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6255928874015808},{"id":"https://openalex.org/C2780624289","wikidata":"https://www.wikidata.org/wiki/Q306076","display_name":"Alpha-fetoprotein","level":3,"score":0.5380766987800598},{"id":"https://openalex.org/C3018858268","wikidata":"https://www.wikidata.org/wiki/Q1070940","display_name":"Asia pacific","level":2,"score":0.4819362163543701},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.47490155696868896},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.46004465222358704},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4292263388633728},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4106155037879944},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34552788734436035},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3285502791404724},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.19001612067222595},{"id":"https://openalex.org/C2549261","wikidata":"https://www.wikidata.org/wiki/Q43455","display_name":"Ethnology","level":1,"score":0.1077207624912262},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.20517/10.20517/2394-5079.2017.46","doi":"https://doi.org/10.20517/10.20517/2394-5079.2017.46","is_oa":true,"landing_page_url":"https://doi.org/10.20517/10.20517/2394-5079.2017.46","pdf_url":"https://hrjournal.net/article/download/3175","source":{"id":"https://openalex.org/S4210208932","display_name":"Hepatoma Research","issn_l":"2394-5079","issn":["2394-5079","2454-2520"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatoma Research","raw_type":"journal-article"},{"id":"doi:10.20517/2394-5079.2017.46","doi":"https://doi.org/10.20517/2394-5079.2017.46","is_oa":true,"landing_page_url":"https://doi.org/10.20517/2394-5079.2017.46","pdf_url":"https://hrjournal.net/article/download/2350","source":{"id":"https://openalex.org/S4210208932","display_name":"Hepatoma Research","issn_l":"2394-5079","issn":["2394-5079","2454-2520"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatoma Research","raw_type":"journal-article"},{"id":"pmid:29376136","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29376136","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatoma research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5786161","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5786161","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Hepatoma Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.20517/10.20517/2394-5079.2017.46","doi":"https://doi.org/10.20517/10.20517/2394-5079.2017.46","is_oa":true,"landing_page_url":"https://doi.org/10.20517/10.20517/2394-5079.2017.46","pdf_url":"https://hrjournal.net/article/download/3175","source":{"id":"https://openalex.org/S4210208932","display_name":"Hepatoma Research","issn_l":"2394-5079","issn":["2394-5079","2454-2520"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatoma Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1035472155","display_name":"RCMI Multidisciplinary And Translational Research Infrastructure EXpansion (RAMAT","funder_award_id":"U54MD007584","funder_id":"https://openalex.org/F4320337534","funder_display_name":"National Institute on Minority Health and Health Disparities"},{"id":"https://openalex.org/G8846445174","display_name":"Functional Genomics and Molecular Imaging of Liver Disease and Cancer","funder_award_id":"R01CA161209","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000870016","display_name":"University of Hawaii Cancer Center CCSG","funder_award_id":"P30CA071789","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337534","display_name":"National Institute on Minority Health and Health Disparities","ror":"https://ror.org/0493hgw16"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2784328840.pdf","grobid_xml":"https://content.openalex.org/works/W2784328840.grobid-xml"},"referenced_works_count":100,"referenced_works":["https://openalex.org/W274428048","https://openalex.org/W1038682962","https://openalex.org/W1542425243","https://openalex.org/W1632089579","https://openalex.org/W1757407923","https://openalex.org/W1898858549","https://openalex.org/W1899681036","https://openalex.org/W1916703769","https://openalex.org/W1943649358","https://openalex.org/W1969061845","https://openalex.org/W1970131212","https://openalex.org/W1971837077","https://openalex.org/W1979667390","https://openalex.org/W1980154502","https://openalex.org/W1980901087","https://openalex.org/W1982755338","https://openalex.org/W1995180061","https://openalex.org/W2003619330","https://openalex.org/W2005092573","https://openalex.org/W2006854332","https://openalex.org/W2011925705","https://openalex.org/W2022226503","https://openalex.org/W2023815439","https://openalex.org/W2035669429","https://openalex.org/W2036922484","https://openalex.org/W2037198878","https://openalex.org/W2048177238","https://openalex.org/W2049402010","https://openalex.org/W2056052081","https://openalex.org/W2062115311","https://openalex.org/W2064914836","https://openalex.org/W2068975778","https://openalex.org/W2073830661","https://openalex.org/W2079462324","https://openalex.org/W2083934827","https://openalex.org/W2090296093","https://openalex.org/W2094434031","https://openalex.org/W2097388257","https://openalex.org/W2099789788","https://openalex.org/W2101084712","https://openalex.org/W2106721500","https://openalex.org/W2107713887","https://openalex.org/W2108035402","https://openalex.org/W2117766751","https://openalex.org/W2121833624","https://openalex.org/W2123339548","https://openalex.org/W2126956071","https://openalex.org/W2127151069","https://openalex.org/W2130410032","https://openalex.org/W2136415416","https://openalex.org/W2144463869","https://openalex.org/W2161019027","https://openalex.org/W2168076454","https://openalex.org/W2170845559","https://openalex.org/W2171017754","https://openalex.org/W2203982515","https://openalex.org/W2213448039","https://openalex.org/W2221837786","https://openalex.org/W2266736818","https://openalex.org/W2291726879","https://openalex.org/W2292250576","https://openalex.org/W2317554121","https://openalex.org/W2335913920","https://openalex.org/W2403104238","https://openalex.org/W2469109878","https://openalex.org/W2531453937","https://openalex.org/W2546772022","https://openalex.org/W2556418641","https://openalex.org/W2582878252","https://openalex.org/W2583985389","https://openalex.org/W2585161964","https://openalex.org/W2586792441","https://openalex.org/W2588664246","https://openalex.org/W2593387920","https://openalex.org/W2594177569","https://openalex.org/W2598604584","https://openalex.org/W2602905880","https://openalex.org/W2605753778","https://openalex.org/W2606367731","https://openalex.org/W2612649098","https://openalex.org/W2618584271","https://openalex.org/W2727497670","https://openalex.org/W2736582179","https://openalex.org/W2744914748","https://openalex.org/W2748400966","https://openalex.org/W2751505630","https://openalex.org/W2771146486","https://openalex.org/W2791735135","https://openalex.org/W2792247396","https://openalex.org/W2800042556","https://openalex.org/W2800879080","https://openalex.org/W2805592007","https://openalex.org/W2810008953","https://openalex.org/W2810652813","https://openalex.org/W2883204623","https://openalex.org/W2884220646","https://openalex.org/W2997727194","https://openalex.org/W4246859404","https://openalex.org/W7075744769","https://openalex.org/W7096869818"],"related_works":["https://openalex.org/W2944315933","https://openalex.org/W2170845559","https://openalex.org/W2776397633","https://openalex.org/W3019436205","https://openalex.org/W2947192178","https://openalex.org/W3211365788","https://openalex.org/W2113530405","https://openalex.org/W2030209959","https://openalex.org/W2898661148","https://openalex.org/W1964327336"],"abstract_inverted_index":{"Aim:":[0],"Increased":[1],"serum":[2],"alpha-fetoprotein":[3],"(AFP)":[4],"levels":[5],"are":[6,217,223],"associated":[7,132,188],"with":[8,74,124,133,189,199],"specific":[9],"molecular":[10,36,57,106,116,191],"sub-classes":[11,107,185],"of":[12,27,180,186],"hepatocellular":[13],"carcinoma":[14],"(HCC),":[15],"supporting":[16],"AFP":[17,59,119,134,166],"as":[18],"a":[19,72,75,203],"predictive":[20,212],"or":[21],"therapeutic":[22],"biomarker":[23],"for":[24,82,214,219,233],"precision":[25],"treatment":[26],"this":[28],"disease.":[29],"Considering":[30],"recent":[31],"efforts":[32,228],"to":[33,48,126,176,225,229],"validate":[34],"HCC":[35,56,91,187,215],"classification":[37,46,173,208],"systems":[38],"across":[39],"different":[40,190],"populations,":[41],"we":[42],"applied":[43],"existing":[44],"signature-based":[45],"templates":[47],"Hawaii":[49],"cohorts":[50],"and":[51,61,78,110,118,129,136,162,170,193,210],"examined":[52,142],"whether":[53],"associations":[54],"between":[55],"sub-class,":[58],"levels,":[60],"clinical":[62,127,138,160],"features":[63,128,192],"found":[64,69,175],"elsewhere":[65],"can":[66,196],"also":[67,141],"be":[68,177,197],"in":[70,202],"Hawaii,":[71],"region":[73],"unique":[76],"demographic":[77],"risk":[79],"factor":[80],"profile":[81],"HCC.":[83,234],"Methods:":[84],"Whole-genome":[85],"expression":[86],"profiling":[87],"was":[88],"performed":[89],"on":[90,115],"tumors":[92],"collected":[93],"from":[94],"40":[95],"patients":[96],"following":[97],"partial":[98],"hepatectomy.":[99],"Tumors":[100],"underwent":[101],"transcriptome-based":[102],"categorization":[103],"into":[104],"3":[105],"(S1,":[108],"S2,":[109],"S3).":[111],"Patient":[112],"groups":[113],"based":[114],"sub-class":[117],"level":[120,135,147],"were":[121,140,174],"then":[122],"compared":[123],"regards":[125],"survival.":[130,182],"Differences":[131],"other":[137,211],"parameters":[139],"at":[143],"the":[144,163],"gene":[145,149],"signature":[146],"by":[148],"set":[150],"enrichment":[151],"analysis.":[152],"Results:":[153],"target":[154],"activation,":[155],"high":[156],"cell":[157],"proliferation,":[158],"poor":[159],"prognosis,":[161],"S2":[164],"sub-class.":[165],">":[167],"400":[168],"ng/mL":[169],"non-S3":[171],"tumor":[172],"significant":[178],"predictors":[179],"overall":[181],"Conclusion:":[183],"Distinct":[184],"survival":[194],"outcomes":[195],"detected":[198],"statistical":[200],"confidence":[201],"Pacific":[204],"Island":[205],"cohort.":[206],"Molecular":[207],"signatures":[209],"markers":[213],"that":[216],"valid":[218],"all":[220],"patient":[221],"populations":[222],"needed":[224],"support":[226],"multi-center":[227],"develop":[230],"targeted":[231],"therapies":[232]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-01-26T00:00:00"}