{"id":"https://openalex.org/W2784124279","doi":"https://doi.org/10.1021/acs.biochem.7b01113","title":"Design of Small Molecules That Compete with Nucleotide Binding to an Engineered Oncogenic KRAS Allele","display_name":"Design of Small Molecules That Compete with Nucleotide Binding to an Engineered Oncogenic KRAS Allele","publication_year":2018,"publication_date":"2018-01-09","ids":{"openalex":"https://openalex.org/W2784124279","doi":"https://doi.org/10.1021/acs.biochem.7b01113","mag":"2784124279","pmid":"https://pubmed.ncbi.nlm.nih.gov/29313669","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5960803"},"language":"en","primary_location":{"id":"doi:10.1021/acs.biochem.7b01113","doi":"https://doi.org/10.1021/acs.biochem.7b01113","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biochem.7b01113","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC5960803","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042030290","display_name":"Yan Zhang","orcid":"https://orcid.org/0000-0001-7999-2601","observed_orcids":["https://orcid.org/0000-0001-7999-2601"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Zhang","raw_affiliation_strings":["Quantitative Proteomics and Metabolomics Center, Columbia University, New York, New York 10027, United States","\u2020 Department of Chemistry and \u2021 Department of Biological Sciences, Columbia University, Northwest Corner Building, 12th Floor, MC 4846, 550 West 120th Street, New York, New York 10027, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Proteomics and Metabolomics Center, Columbia University, New York, New York 10027, United States","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"\u2020 Department of Chemistry and \u2021 Department of Biological Sciences, Columbia University, Northwest Corner Building, 12th Floor, MC 4846, 550 West 120th Street, New York, New York 10027, United States","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026053288","display_name":"Marie\u2010H\u00e9l\u00e8ne Larraufie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marie-H\u00e9l\u00e8ne Larraufie","raw_affiliation_strings":["Quantitative Proteomics and Metabolomics Center, Columbia University, New York, New York 10027, United States","\u2020 Department of Chemistry and \u2021 Department of Biological Sciences, Columbia University, Northwest Corner Building, 12th Floor, MC 4846, 550 West 120th Street, New York, New York 10027, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Proteomics and Metabolomics Center, Columbia University, New York, New York 10027, United States","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"\u2020 Department of Chemistry and \u2021 Department of Biological Sciences, Columbia University, Northwest Corner Building, 12th Floor, MC 4846, 550 West 120th Street, New York, New York 10027, United States","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035914141","display_name":"Leila S. Musavi","orcid":"https://orcid.org/0000-0001-8234-9561","observed_orcids":["https://orcid.org/0000-0001-8234-9561"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leila Musavi","raw_affiliation_strings":["Quantitative Proteomics and Metabolomics Center, Columbia University, New York, New York 10027, United States","\u2020 Department of Chemistry and \u2021 Department of Biological Sciences, Columbia University, Northwest Corner Building, 12th Floor, MC 4846, 550 West 120th Street, New York, New York 10027, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Proteomics and Metabolomics Center, Columbia University, New York, New York 10027, United States","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"\u2020 Department of Chemistry and \u2021 Department of Biological Sciences, Columbia University, Northwest Corner Building, 12th Floor, MC 4846, 550 West 120th Street, New York, New York 10027, United States","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053497620","display_name":"Hemanth Akkiraju","orcid":"https://orcid.org/0000-0003-0729-4067","observed_orcids":["https://orcid.org/0000-0003-0729-4067"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hemanth Akkiraju","raw_affiliation_strings":["Quantitative\rProteomics and Metabolomics Center, Columbia University, New York, New York 10027, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative\rProteomics and Metabolomics Center, Columbia University, New York, New York 10027, United States","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017647222","display_name":"Lewis M. Brown","orcid":"https://orcid.org/0000-0002-5485-7419","observed_orcids":["https://orcid.org/0000-0002-5485-7419","https://orcid.org/0000-0002-1864-3077"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lewis M. Brown","raw_affiliation_strings":["Quantitative\rProteomics and Metabolomics Center, Columbia University, New York, New York 10027, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative\rProteomics and Metabolomics Center, Columbia University, New York, New York 10027, United States","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030207693","display_name":"Brent R. Stockwell","orcid":"https://orcid.org/0000-0002-3532-3868","observed_orcids":["https://orcid.org/0000-0002-3532-3868"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brent R. Stockwell","raw_affiliation_strings":["Quantitative Proteomics and Metabolomics Center, Columbia University, New York, New York 10027, United States","\u2020 Department of Chemistry and \u2021 Department of Biological Sciences, Columbia University, Northwest Corner Building, 12th Floor, MC 4846, 550 West 120th Street, New York, New York 10027, United States"],"raw_orcid":"https://orcid.org/0000-0002-3532-3868","affiliations":[{"raw_affiliation_string":"Quantitative Proteomics and Metabolomics Center, Columbia University, New York, New York 10027, United States","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"\u2020 Department of Chemistry and \u2021 Department of Biological Sciences, Columbia University, Northwest Corner Building, 12th Floor, MC 4846, 550 West 120th Street, New York, New York 10027, United States","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030207693"],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.4683,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.55605091,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"57","issue":"8","first_page":"1380","last_page":"1389"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.8970000147819519},{"id":"https://openalex.org/keywords/ras-mutations","display_name":"RAS mutations","score":0.7490000128746033},{"id":"https://openalex.org/keywords/nucleotide-binding-site","display_name":"nucleotide binding site","score":0.8130000233650208},{"id":"https://openalex.org/keywords/covalent-inhibitors","display_name":"covalent inhibitors","score":0.7379999756813049},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.6389999985694885},{"id":"https://openalex.org/keywords/protein-modification","display_name":"protein modification","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.9296290874481201},{"id":"https://openalex.org/C1167327","wikidata":"https://www.wikidata.org/wiki/Q14884140","display_name":"HRAS","level":5,"score":0.8694334626197815},{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.8074748516082764},{"id":"https://openalex.org/C21790070","wikidata":"https://www.wikidata.org/wiki/Q18030215","display_name":"Neuroblastoma RAS viral oncogene homolog","level":5,"score":0.7388617396354675},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.5635402798652649},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.5270959138870239},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4836891293525696},{"id":"https://openalex.org/C85771745","wikidata":"https://www.wikidata.org/wiki/Q5514732","display_name":"GTP-binding protein regulators","level":4,"score":0.4678075313568115},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4641384482383728},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.4495559334754944},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4094557762145996},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.408941388130188},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3795899450778961},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.2797706723213196},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2752702832221985},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13719499111175537},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12061712145805359}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006153","descriptor_name":"Guanosine Diphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/acs.biochem.7b01113","doi":"https://doi.org/10.1021/acs.biochem.7b01113","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biochem.7b01113","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:29313669","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29313669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4878205","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5960803","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5960803","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5960803/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4878205","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5960803","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1329058410","display_name":"Defining the functions and translational potential of ferroptosis","funder_award_id":"R35CA209896","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2768115383","display_name":"Roles and Regulation of wild-type and mutant forms of p53","funder_award_id":"P01CA087497","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5232792412","display_name":"Discovery of allele-selective KRAS inhibitors","funder_award_id":"R21CA177591","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1953264505","https://openalex.org/W1969882218","https://openalex.org/W1971652848","https://openalex.org/W1992639113","https://openalex.org/W1995770177","https://openalex.org/W1996287860","https://openalex.org/W2008077692","https://openalex.org/W2010993054","https://openalex.org/W2014545373","https://openalex.org/W2014557438","https://openalex.org/W2032757019","https://openalex.org/W2046865369","https://openalex.org/W2051053786","https://openalex.org/W2056263277","https://openalex.org/W2058497224","https://openalex.org/W2058999781","https://openalex.org/W2060032114","https://openalex.org/W2060630299","https://openalex.org/W2071018921","https://openalex.org/W2072732120","https://openalex.org/W2081235623","https://openalex.org/W2081719547","https://openalex.org/W2081990599","https://openalex.org/W2087973518","https://openalex.org/W2099405888","https://openalex.org/W2104964384","https://openalex.org/W2112078762","https://openalex.org/W2113609800","https://openalex.org/W2128339707","https://openalex.org/W2141965353","https://openalex.org/W2154864629","https://openalex.org/W2156390684","https://openalex.org/W2156477912","https://openalex.org/W2501247313","https://openalex.org/W2589235955","https://openalex.org/W4256609065"],"related_works":["https://openalex.org/W4361005898","https://openalex.org/W2128339707","https://openalex.org/W3022977271","https://openalex.org/W3045038436","https://openalex.org/W4246927867","https://openalex.org/W2624769269","https://openalex.org/W2299393394","https://openalex.org/W2966060449","https://openalex.org/W3004562612","https://openalex.org/W2048038289"],"abstract_inverted_index":{"RAS":[0,19,81,136],"mutations":[1],"are":[2],"found":[3],"in":[4,33],"30%":[5],"of":[6,41,45,56,76,134],"all":[7],"human":[8],"cancers,":[9],"with":[10,30,86,113],"KRAS":[11,29,46,57,124],"the":[12,17,34,42,73,101,104,131],"most":[13],"frequently":[14],"mutated":[15],"among":[16],"three":[18],"isoforms":[20],"(KRAS,":[21],"NRAS,":[22],"and":[23,49,58,66,78,90,108,115,126],"HRAS).":[24],"However,":[25],"directly":[26],"targeting":[27,130],"oncogenic":[28,135],"small":[31],"molecules":[32],"nucleotide-binding":[35,106,132],"site":[36,107,133],"has":[37],"been":[38],"difficult":[39],"because":[40],"high":[43,74],"affinity":[44,75],"for":[47,64,80,122,129],"GDP":[48,79,114],"GTP.":[50,116],"We":[51],"designed":[52],"an":[53],"engineered":[54,93,105],"allele":[55],"a":[59,87,91,119],"covalent":[60,88,97],"inhibitor":[61,89,98],"that":[62,72],"competes":[63],"GTP":[65,77],"GDP.":[67],"This":[68,117],"ligand-receptor":[69],"combination":[70],"demonstrates":[71],"proteins":[82],"can":[83],"be":[84],"overcome":[85],"suitably":[92],"binding":[94],"site.":[95],"The":[96],"irreversibly":[99],"modifies":[100],"protein":[102],"at":[103],"is":[109],"able":[110],"to":[111],"compete":[112],"provides":[118],"new":[120],"tool":[121],"studying":[123],"function":[125],"suggests":[127],"strategies":[128],"proteins.":[137]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-01-26T00:00:00"}