{"id":"https://openalex.org/W2783809656","doi":"https://doi.org/10.1016/j.intimp.2017.12.016","title":"Inflammation induced ER stress affects absorptive intestinal epithelial cells function and integrity","display_name":"Inflammation induced ER stress affects absorptive intestinal epithelial cells function and integrity","publication_year":2018,"publication_date":"2018-01-08","ids":{"openalex":"https://openalex.org/W2783809656","doi":"https://doi.org/10.1016/j.intimp.2017.12.016","mag":"2783809656","pmid":"https://pubmed.ncbi.nlm.nih.gov/29324356"},"language":"en","primary_location":{"id":"doi:10.1016/j.intimp.2017.12.016","doi":"https://doi.org/10.1016/j.intimp.2017.12.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.intimp.2017.12.016","pdf_url":null,"source":{"id":"https://openalex.org/S158377717","display_name":"International Immunopharmacology","issn_l":"1567-5769","issn":["1567-5769","1878-1705"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunopharmacology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2783809656"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084189488","display_name":"Sucheera Chotikatum","orcid":"https://orcid.org/0009-0006-2593-3204","observed_orcids":["https://orcid.org/0009-0006-2593-3204"]},"institutions":[{"id":"https://openalex.org/I189991","display_name":"University of Veterinary Medicine Hannover, Foundation","ror":"https://ror.org/015qjqf64","country_code":"DE","type":"education","lineage":["https://openalex.org/I189991"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sucheera Chotikatum","raw_affiliation_strings":["Department of Physiological Chemistry, University of Veterinary Medicine Hannover, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Chemistry, University of Veterinary Medicine Hannover, Hannover, Germany","institution_ids":["https://openalex.org/I189991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044873395","display_name":"Hassan Y. Naim","orcid":"https://orcid.org/0000-0003-4884-8425","observed_orcids":["https://orcid.org/0000-0003-4884-8425"]},"institutions":[{"id":"https://openalex.org/I189991","display_name":"University of Veterinary Medicine Hannover, Foundation","ror":"https://ror.org/015qjqf64","country_code":"DE","type":"education","lineage":["https://openalex.org/I189991"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Hassan Y. Naim","raw_affiliation_strings":["Department of Physiological Chemistry, University of Veterinary Medicine Hannover, Hannover, Germany. Electronic address: hassan.naim@tiho-hannover.de","Department of Physiological Chemistry, University of Veterinary Medicine Hannover, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Chemistry, University of Veterinary Medicine Hannover, Hannover, Germany. Electronic address: hassan.naim@tiho-hannover.de","institution_ids":["https://openalex.org/I189991"]},{"raw_affiliation_string":"Department of Physiological Chemistry, University of Veterinary Medicine Hannover, Hannover, Germany","institution_ids":["https://openalex.org/I189991"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007358380","display_name":"Nahed El\u2010Najjar","orcid":"https://orcid.org/0000-0002-2278-8586","observed_orcids":["https://orcid.org/0000-0002-2278-8586"]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Nahed El-Najjar","raw_affiliation_strings":["Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, Germany; Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Germany. Electronic address: Nahed.El-Najjar@klinik.uni-regensburg.de","Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Germany","Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2278-8586","affiliations":[{"raw_affiliation_string":"Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, Germany; Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Germany. Electronic address: Nahed.El-Najjar@klinik.uni-regensburg.de","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007358380","https://openalex.org/A5044873395"],"corresponding_institution_ids":["https://openalex.org/I189991","https://openalex.org/I3129555431"],"apc_list":{"value":3220,"currency":"USD","value_usd":3220},"apc_paid":null,"fwci":3.9515,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.93573238,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"55","issue":null,"first_page":"336","last_page":"344"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.6460000276565552,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.6460000276565552,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.32199999690055847,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9850000143051147},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.902999997138977},{"id":"https://openalex.org/keywords/intestinal-barrier-integrity","display_name":"intestinal barrier integrity","score":0.6899999976158142},{"id":"https://openalex.org/keywords/apical-membrane-trafficking","display_name":"apical membrane trafficking","score":0.5419999957084656},{"id":"https://openalex.org/keywords/sucrase-isomaltase","display_name":"sucrase-isomaltase","score":0.9409999847412109},{"id":"https://openalex.org/keywords/dipeptidyl-peptidase-4","display_name":"dipeptidyl peptidase IV","score":0.9319999814033508},{"id":"https://openalex.org/keywords/ezrin","display_name":"ezrin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tight-junction-proteins","display_name":"tight junction proteins","score":0.8370000123977661},{"id":"https://openalex.org/keywords/connexin-43","display_name":"connexin 43","score":0.8679999709129333},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.9010000228881836},{"id":"https://openalex.org/keywords/zonula-occludens-1","display_name":"zonula occludens-1","score":0.8939999938011169},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7580000162124634},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.8579999804496765},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.7879999876022339},{"id":"https://openalex.org/keywords/caco-2-cells","display_name":"Caco-2 cells","score":0.9649999737739563}],"concepts":[{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.8409606218338013},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.721977174282074},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.6945167779922485},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5820551514625549},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.5585675835609436},{"id":"https://openalex.org/C2780246058","wikidata":"https://www.wikidata.org/wiki/Q18032329","display_name":"Ezrin","level":4,"score":0.5346960425376892},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.5310994386672974},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.5025568008422852},{"id":"https://openalex.org/C2781077229","wikidata":"https://www.wikidata.org/wiki/Q509615","display_name":"Intestinal epithelium","level":3,"score":0.4975135624408722},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.4472794532775879},{"id":"https://openalex.org/C3018436504","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Apical membrane","level":3,"score":0.41178107261657715},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39637982845306396},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3738465905189514},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3375917971134186},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28606951236724854},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2646901309490204},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2055603563785553},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11806192994117737},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.07190579175949097},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099149","descriptor_name":"Ezrin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004152","descriptor_name":"Dipeptidyl-Peptidases and Tripeptidyl-Peptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007365","descriptor_name":"Intercellular Junctions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007365","descriptor_name":"Intercellular Junctions","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013394","descriptor_name":"Sucrase-Isomaltase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018031","descriptor_name":"Connexin 43","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059865","descriptor_name":"Endoplasmic Reticulum Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D062826","descriptor_name":"Zonula Occludens-1 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.intimp.2017.12.016","doi":"https://doi.org/10.1016/j.intimp.2017.12.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.intimp.2017.12.016","pdf_url":null,"source":{"id":"https://openalex.org/S158377717","display_name":"International Immunopharmacology","issn_l":"1567-5769","issn":["1567-5769","1878-1705"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunopharmacology","raw_type":"journal-article"},{"id":"pmid:29324356","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29324356","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International immunopharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:epub.uni-regensburg.de:47485","doi":null,"is_oa":false,"landing_page_url":"https://epub.uni-regensburg.de/47485/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":99,"referenced_works":["https://openalex.org/W68177541","https://openalex.org/W136234913","https://openalex.org/W184898749","https://openalex.org/W628797561","https://openalex.org/W1536544150","https://openalex.org/W1543006452","https://openalex.org/W1554042779","https://openalex.org/W1912311803","https://openalex.org/W1942660701","https://openalex.org/W1967949491","https://openalex.org/W1968890426","https://openalex.org/W1973895879","https://openalex.org/W1976140509","https://openalex.org/W1979729107","https://openalex.org/W1980134702","https://openalex.org/W1981060905","https://openalex.org/W1985866220","https://openalex.org/W1987868560","https://openalex.org/W1987971027","https://openalex.org/W1988482079","https://openalex.org/W1989506542","https://openalex.org/W1991708379","https://openalex.org/W1993649794","https://openalex.org/W1999203970","https://openalex.org/W2001992996","https://openalex.org/W2002033637","https://openalex.org/W2002254994","https://openalex.org/W2008711121","https://openalex.org/W2011054971","https://openalex.org/W2024346860","https://openalex.org/W2025511820","https://openalex.org/W2025819729","https://openalex.org/W2032632343","https://openalex.org/W2032930150","https://openalex.org/W2038712067","https://openalex.org/W2040376369","https://openalex.org/W2040392762","https://openalex.org/W2041454039","https://openalex.org/W2041600084","https://openalex.org/W2041758632","https://openalex.org/W2042176582","https://openalex.org/W2049465581","https://openalex.org/W2050014601","https://openalex.org/W2053223951","https://openalex.org/W2057447694","https://openalex.org/W2068511150","https://openalex.org/W2069924169","https://openalex.org/W2072138444","https://openalex.org/W2073038040","https://openalex.org/W2075592077","https://openalex.org/W2080317520","https://openalex.org/W2081165530","https://openalex.org/W2084961602","https://openalex.org/W2088723978","https://openalex.org/W2089021255","https://openalex.org/W2089198803","https://openalex.org/W2090337136","https://openalex.org/W2091557210","https://openalex.org/W2096947423","https://openalex.org/W2098870970","https://openalex.org/W2099662390","https://openalex.org/W2100321761","https://openalex.org/W2100428145","https://openalex.org/W2109044779","https://openalex.org/W2114315236","https://openalex.org/W2115147216","https://openalex.org/W2122039020","https://openalex.org/W2122359837","https://openalex.org/W2122505806","https://openalex.org/W2123321368","https://openalex.org/W2126376871","https://openalex.org/W2133425838","https://openalex.org/W2133800816","https://openalex.org/W2145441474","https://openalex.org/W2146906769","https://openalex.org/W2149795485","https://openalex.org/W2153074213","https://openalex.org/W2154555351","https://openalex.org/W2155579605","https://openalex.org/W2159584973","https://openalex.org/W2160881772","https://openalex.org/W2161673176","https://openalex.org/W2161789287","https://openalex.org/W2166710590","https://openalex.org/W2166734267","https://openalex.org/W2169433327","https://openalex.org/W2170062483","https://openalex.org/W2170527492","https://openalex.org/W2267174543","https://openalex.org/W2298923378","https://openalex.org/W2300697960","https://openalex.org/W2306462975","https://openalex.org/W2331746153","https://openalex.org/W2521588407","https://openalex.org/W2568502991","https://openalex.org/W2606367637","https://openalex.org/W3029052526","https://openalex.org/W4230633180","https://openalex.org/W6619814628"],"related_works":["https://openalex.org/W2268583062","https://openalex.org/W2049465581","https://openalex.org/W3016345324","https://openalex.org/W2083075230","https://openalex.org/W1966860807","https://openalex.org/W2767153955","https://openalex.org/W3016446538","https://openalex.org/W2300697960","https://openalex.org/W3176921937"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2018-01-26T00:00:00"}