{"id":"https://openalex.org/W2783802128","doi":"https://doi.org/10.1111/hepr.13058","title":"Efficacy and safety of ombitasvir/paritaprevir/ritonavir combination therapy for genotype 1b chronic hepatitis C patients complicated with chronic kidney disease","display_name":"Efficacy and safety of ombitasvir/paritaprevir/ritonavir combination therapy for genotype 1b chronic hepatitis C patients complicated with chronic kidney disease","publication_year":2018,"publication_date":"2018-01-10","ids":{"openalex":"https://openalex.org/W2783802128","doi":"https://doi.org/10.1111/hepr.13058","mag":"2783802128","pmid":"https://pubmed.ncbi.nlm.nih.gov/29316062"},"language":"en","primary_location":{"id":"doi:10.1111/hepr.13058","doi":"https://doi.org/10.1111/hepr.13058","is_oa":false,"landing_page_url":"https://doi.org/10.1111/hepr.13058","pdf_url":null,"source":{"id":"https://openalex.org/S110399111","display_name":"Hepatology Research","issn_l":"1386-6346","issn":["1386-6346","1872-034X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110757059","display_name":"Taeang Arai","orcid":"https://orcid.org/0009-0008-5817-1845","observed_orcids":["https://orcid.org/0009-0008-5817-1845"]},"institutions":[{"id":"https://openalex.org/I4210162733","display_name":"Chiba Hokusou Hospital","ror":"https://ror.org/050adm910","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210162733"]},{"id":"https://openalex.org/I80188885","display_name":"Nippon Medical School","ror":"https://ror.org/00krab219","country_code":"JP","type":"education","lineage":["https://openalex.org/I80188885"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taeang Arai","raw_affiliation_strings":["Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Japan","institution_ids":["https://openalex.org/I4210162733","https://openalex.org/I80188885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080709934","display_name":"Masanori Atsukawa","orcid":"https://orcid.org/0000-0003-3374-7111","observed_orcids":["https://orcid.org/0000-0003-3374-7111"]},"institutions":[{"id":"https://openalex.org/I4210162733","display_name":"Chiba Hokusou Hospital","ror":"https://ror.org/050adm910","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210162733"]},{"id":"https://openalex.org/I80188885","display_name":"Nippon Medical School","ror":"https://ror.org/00krab219","country_code":"JP","type":"education","lineage":["https://openalex.org/I80188885"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masanori Atsukawa","raw_affiliation_strings":["Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Japan","Department of Internal Medicine, Division of Gastroenterology and Hepatology, Nippon Medical School, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Japan","institution_ids":["https://openalex.org/I4210162733","https://openalex.org/I80188885"]},{"raw_affiliation_string":"Department of Internal Medicine, Division of Gastroenterology and Hepatology, Nippon Medical School, Tokyo, Japan","institution_ids":["https://openalex.org/I80188885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086743926","display_name":"Akihito Tsubota","orcid":"https://orcid.org/0000-0001-6860-0326","observed_orcids":["https://orcid.org/0000-0001-6860-0326"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihito Tsubota","raw_affiliation_strings":["Core Research Facilities for Basic Science, The Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Research Facilities for Basic Science, The Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077739041","display_name":"Tadashi Ikegami","orcid":"https://orcid.org/0000-0002-9216-3186","observed_orcids":["https://orcid.org/0000-0002-9216-3186"]},"institutions":[{"id":"https://openalex.org/I158929114","display_name":"Tokyo Medical University","ror":"https://ror.org/00k5j5c86","country_code":"JP","type":"education","lineage":["https://openalex.org/I158929114"]},{"id":"https://openalex.org/I4210135408","display_name":"Tokyo Medical University Ibaraki Medical Center","ror":"https://ror.org/031hmx230","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210135408"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Ikegami","raw_affiliation_strings":["Department of Internal Medicine, Division of Hepatology and Gastroenterology, Tokyo Medical University, Ibaraki Medical Center, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Hepatology and Gastroenterology, Tokyo Medical University, Ibaraki Medical Center, Ibaraki, Japan","institution_ids":["https://openalex.org/I158929114","https://openalex.org/I4210135408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111836568","display_name":"Noritomo Shimada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405256241","display_name":"Otakanomori Hospital","ror":"https://ror.org/03ygpv007","country_code":"JP","type":"government","lineage":["https://openalex.org/I4405256241"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noritomo Shimada","raw_affiliation_strings":["Department of Internal Medicine, Division of Gastroenterology and Hepatology, Otakanomori Hospital, Kashiwa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Gastroenterology and Hepatology, Otakanomori Hospital, Kashiwa, Japan","institution_ids":["https://openalex.org/I4405256241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101415226","display_name":"Keizo Kato","orcid":"https://orcid.org/0000-0003-2184-6016","observed_orcids":["https://orcid.org/0000-0003-2184-6016"]},"institutions":[{"id":"https://openalex.org/I4210137170","display_name":"Shinmatsudo Central General Hospital","ror":"https://ror.org/038estk42","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137170"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keizo Kato","raw_affiliation_strings":["Department of Internal Medicine, Division of Gastroenterology and Hepatology, Shinmatsudo Central General Hospital, Matsudo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Gastroenterology and Hepatology, Shinmatsudo Central General Hospital, Matsudo, Japan","institution_ids":["https://openalex.org/I4210137170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102918516","display_name":"Hiroshi Abe","orcid":"https://orcid.org/0000-0003-1106-9524","observed_orcids":["https://orcid.org/0000-0003-1106-9524"]},"institutions":[{"id":"https://openalex.org/I4210137170","display_name":"Shinmatsudo Central General Hospital","ror":"https://ror.org/038estk42","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137170"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Abe","raw_affiliation_strings":["Department of Internal Medicine, Division of Gastroenterology and Hepatology, Shinmatsudo Central General Hospital, Matsudo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Gastroenterology and Hepatology, Shinmatsudo Central General Hospital, Matsudo, Japan","institution_ids":["https://openalex.org/I4210137170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049568375","display_name":"Tomomi Okubo","orcid":"https://orcid.org/0000-0003-1244-4736","observed_orcids":["https://orcid.org/0000-0003-1244-4736"]},"institutions":[{"id":"https://openalex.org/I4210162733","display_name":"Chiba Hokusou Hospital","ror":"https://ror.org/050adm910","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210162733"]},{"id":"https://openalex.org/I80188885","display_name":"Nippon Medical School","ror":"https://ror.org/00krab219","country_code":"JP","type":"education","lineage":["https://openalex.org/I80188885"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomomi Okubo","raw_affiliation_strings":["Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Japan","institution_ids":["https://openalex.org/I4210162733","https://openalex.org/I80188885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009103376","display_name":"Norio Itokawa","orcid":"https://orcid.org/0009-0002-2390-6692","observed_orcids":["https://orcid.org/0009-0002-2390-6692"]},"institutions":[{"id":"https://openalex.org/I4210162733","display_name":"Chiba Hokusou Hospital","ror":"https://ror.org/050adm910","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210162733"]},{"id":"https://openalex.org/I80188885","display_name":"Nippon Medical School","ror":"https://ror.org/00krab219","country_code":"JP","type":"education","lineage":["https://openalex.org/I80188885"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norio Itokawa","raw_affiliation_strings":["Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Japan","institution_ids":["https://openalex.org/I4210162733","https://openalex.org/I80188885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000519458","display_name":"Chisa Kondo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80188885","display_name":"Nippon Medical School","ror":"https://ror.org/00krab219","country_code":"JP","type":"education","lineage":["https://openalex.org/I80188885"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chisa Kondo","raw_affiliation_strings":["Department of Internal Medicine, Division of Gastroenterology and Hepatology, Nippon Medical School, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Gastroenterology and Hepatology, Nippon Medical School, Tokyo, Japan","institution_ids":["https://openalex.org/I80188885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051397464","display_name":"Shigeru Mikami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13045471","display_name":"Kikkoman (Japan)","ror":"https://ror.org/00z0d6447","country_code":"JP","type":"company","lineage":["https://openalex.org/I13045471"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeru Mikami","raw_affiliation_strings":["Department of Internal Medicine, Division of Gastroenterology, Kikkoman General Hospital, Noda, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Gastroenterology, Kikkoman General Hospital, Noda, Japan","institution_ids":["https://openalex.org/I13045471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017304406","display_name":"Toru Asano","orcid":"https://orcid.org/0000-0002-1148-1634","observed_orcids":["https://orcid.org/0000-0002-1148-1634"]},"institutions":[{"id":"https://openalex.org/I4210103327","display_name":"Tokyo Metropolitan Bokutoh Hospital","ror":"https://ror.org/01dk3f134","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210103327"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru Asano","raw_affiliation_strings":["Department of Internal Medicine, Division of Gastroenterology and Hepatology, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Gastroenterology and Hepatology, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan","institution_ids":["https://openalex.org/I4210103327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021400044","display_name":"Yoshimichi Chuganji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103327","display_name":"Tokyo Metropolitan Bokutoh Hospital","ror":"https://ror.org/01dk3f134","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210103327"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshimichi Chuganji","raw_affiliation_strings":["Department of Internal Medicine, Division of Gastroenterology and Hepatology, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Gastroenterology and Hepatology, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan","institution_ids":["https://openalex.org/I4210103327"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yasushi Matsuzaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158929114","display_name":"Tokyo Medical University","ror":"https://ror.org/00k5j5c86","country_code":"JP","type":"education","lineage":["https://openalex.org/I158929114"]},{"id":"https://openalex.org/I4210135408","display_name":"Tokyo Medical University Ibaraki Medical Center","ror":"https://ror.org/031hmx230","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210135408"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasushi Matsuzaki","raw_affiliation_strings":["Department of Internal Medicine, Division of Hepatology and Gastroenterology, Tokyo Medical University, Ibaraki Medical Center, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Hepatology and Gastroenterology, Tokyo Medical University, Ibaraki Medical Center, Ibaraki, Japan","institution_ids":["https://openalex.org/I158929114","https://openalex.org/I4210135408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026964230","display_name":"Hidenori Toyoda","orcid":"https://orcid.org/0000-0002-1652-6168","observed_orcids":["https://orcid.org/0000-0002-1652-6168"]},"institutions":[{"id":"https://openalex.org/I4210123703","display_name":"Ogaki Municipal Hospital","ror":"https://ror.org/0266t0867","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210123703"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidenori Toyoda","raw_affiliation_strings":["Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan","institution_ids":["https://openalex.org/I4210123703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043762552","display_name":"Takashi Kumada","orcid":"https://orcid.org/0000-0003-2211-495X","observed_orcids":["https://orcid.org/0000-0003-2211-495X","https://orcid.org/0000-0001-5871-3802"]},"institutions":[{"id":"https://openalex.org/I4210123703","display_name":"Ogaki Municipal Hospital","ror":"https://ror.org/0266t0867","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210123703"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Kumada","raw_affiliation_strings":["Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan","institution_ids":["https://openalex.org/I4210123703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077530077","display_name":"Etsuko Iio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Etsuko Iio","raw_affiliation_strings":["Department of Virology and Liver Unit, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology and Liver Unit, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009887722","display_name":"Yasuhito Tanaka","orcid":"https://orcid.org/0000-0002-2473-6966","observed_orcids":["https://orcid.org/0000-0002-2473-6966","https://orcid.org/0000-0002-7658-3690"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhito Tanaka","raw_affiliation_strings":["Department of Virology and Liver Unit, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology and Liver Unit, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058841198","display_name":"Katsuhiko Iwakiri","orcid":"https://orcid.org/0000-0002-5558-6104","observed_orcids":["https://orcid.org/0000-0002-5558-6104"]},"institutions":[{"id":"https://openalex.org/I80188885","display_name":"Nippon Medical School","ror":"https://ror.org/00krab219","country_code":"JP","type":"education","lineage":["https://openalex.org/I80188885"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuhiko Iwakiri","raw_affiliation_strings":["Department of Internal Medicine, Division of Gastroenterology and Hepatology, Nippon Medical School, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Gastroenterology and Hepatology, Nippon Medical School, Tokyo, Japan","institution_ids":["https://openalex.org/I80188885"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5080709934"],"corresponding_institution_ids":["https://openalex.org/I4210162733","https://openalex.org/I80188885"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":2.8448,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.9104973,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"48","issue":"7","first_page":"549","last_page":"555"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ombitasvir-paritaprevir-ritonavir","display_name":"ombitasvir/paritaprevir/ritonavir","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hcv-genotype-1b","display_name":"HCV genotype 1b","score":0.8299999833106995},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9549999833106995},{"id":"https://openalex.org/keywords/pre-dialysis-patients","display_name":"predialysis","score":0.8820000290870667},{"id":"https://openalex.org/keywords/direct-acting-antivirals","display_name":"direct-acting antivirals","score":0.8930000066757202},{"id":"https://openalex.org/keywords/sustained-virologic-response","display_name":"sustained virological response","score":0.9179999828338623},{"id":"https://openalex.org/keywords/rapid-virologic-response","display_name":"rapid virological response","score":0.9129999876022339},{"id":"https://openalex.org/keywords/treatment-emergent-adverse-events","display_name":"treatment-emergent adverse events","score":0.8759999871253967},{"id":"https://openalex.org/keywords/renal-safety","display_name":"renal safety","score":0.5490000247955322},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8703014850616455},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7707933187484741},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.760312557220459},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.68850177526474},{"id":"https://openalex.org/C2777100407","wikidata":"https://www.wikidata.org/wiki/Q19598175","display_name":"Ombitasvir","level":5,"score":0.6551334857940674},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5368751883506775},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5307630896568298},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5145922899246216},{"id":"https://openalex.org/C2779298103","wikidata":"https://www.wikidata.org/wiki/Q422618","display_name":"Ritonavir","level":5,"score":0.5073661208152771},{"id":"https://openalex.org/C2778867932","wikidata":"https://www.wikidata.org/wiki/Q16824572","display_name":"Paritaprevir","level":5,"score":0.4754202961921692},{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.4569249153137207},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4128468334674835},{"id":"https://openalex.org/C3020491458","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Chronic hepatitis","level":3,"score":0.28838491439819336},{"id":"https://openalex.org/C2780040827","wikidata":"https://www.wikidata.org/wiki/Q421862","display_name":"Ribavirin","level":4,"score":0.21256625652313232},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15824851393699646},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.13981252908706665},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.06547343730926514},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.04475146532058716}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1111/hepr.13058","doi":"https://doi.org/10.1111/hepr.13058","is_oa":false,"landing_page_url":"https://doi.org/10.1111/hepr.13058","pdf_url":null,"source":{"id":"https://openalex.org/S110399111","display_name":"Hepatology Research","issn_l":"1386-6346","issn":["1386-6346","1872-034X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology Research","raw_type":"journal-article"},{"id":"pmid:29316062","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29316062","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology research : the official journal of the Japan Society of Hepatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3822241261","display_name":"Integrating multiple omics analysis for understanding the pathological mechanism of chronic hepatitis B virus infection and identifying potential molecular targets using humanized chimeric mice","funder_award_id":"15K06810","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1973675889","https://openalex.org/W2005895808","https://openalex.org/W2010430849","https://openalex.org/W2043193067","https://openalex.org/W2043976325","https://openalex.org/W2044349000","https://openalex.org/W2044629657","https://openalex.org/W2061364273","https://openalex.org/W2068946470","https://openalex.org/W2075038444","https://openalex.org/W2085618156","https://openalex.org/W2088337379","https://openalex.org/W2101598010","https://openalex.org/W2110280174","https://openalex.org/W2113428683","https://openalex.org/W2114985397","https://openalex.org/W2125076558","https://openalex.org/W2131025687","https://openalex.org/W2132581252","https://openalex.org/W2142660384","https://openalex.org/W2151695776","https://openalex.org/W2155238509","https://openalex.org/W2197649852","https://openalex.org/W2234102010","https://openalex.org/W2272258032","https://openalex.org/W2284028703","https://openalex.org/W2296452901","https://openalex.org/W2465804291","https://openalex.org/W2566350519","https://openalex.org/W2567208426","https://openalex.org/W2591292326","https://openalex.org/W2608685329","https://openalex.org/W3184412694","https://openalex.org/W4206176002","https://openalex.org/W4241616429","https://openalex.org/W4242579539"],"related_works":["https://openalex.org/W3153287087","https://openalex.org/W2896127610","https://openalex.org/W2896996128","https://openalex.org/W4321368048","https://openalex.org/W4400387078","https://openalex.org/W2567208426","https://openalex.org/W2608685329","https://openalex.org/W3094338795","https://openalex.org/W2777886565","https://openalex.org/W3162117366"],"abstract_inverted_index":{"AIM:":[0],"The":[1,198],"aim":[2],"of":[3,13,61,70,83,89,185,207],"this":[4],"study":[5,200],"was":[6,178],"to":[7,191,223],"clarify":[8],"the":[9,81,105,109,121,125,142,147,163,166,174,183,194,203],"effects":[10,204],"and":[11,34,54,75,93,101,116,132,158,205],"safety":[12,206],"ombitasvir/paritaprevir/ritonavir":[14],"(OBT/PTV/r)":[15],"therapy":[16,209],"in":[17,39,47,141,182,210,225],"genotype":[18,211],"1b":[19,212],"chronic":[20,26,213],"hepatitis":[21,214],"C":[22,215],"patients":[23,40,48,56,72,77,216,226],"with":[24,41,45,57,78,217],"non-dialysis":[25,218],"kidney":[27],"disease":[28],"(CKD).":[29],"METHODS:":[30],".":[31],"Virologic":[32],"responses":[33],"treatment-emergent":[35],"adverse":[36],"events":[37],"(TEAEs)":[38],"CKD":[42,74,123,164,219],"were":[43,67,98,111,127,137,220],"compared":[44],"those":[46,224],"without":[49,73,227],"CKD.":[50,79,228],"RESULTS:":[51],"Two":[52],"hundred":[53],"thirty-five":[55],"a":[58],"median":[59],"age":[60],"67":[62],"years":[63],"(range,":[64],"27-89":[65],"years)":[66],"enrolled,":[68],"consisting":[69],"181":[71,106],"54":[76,122],"Overall,":[80],"rates":[82,110,126,145],"rapid":[84],"virologic":[85,95,143],"response":[86,91,96,144],"(RVR),":[87],"end":[88],"treatment":[90,175,188],"(ETR),":[92],"sustained":[94],"(SVR)":[97],"78.7%,":[99],"98.7%,":[100,102],"respectively.":[103,119,135],"Among":[104,120],"non-CKD":[107],"patients,":[108,124],"77.3%":[112],"(140/181),":[113],"98.9%":[114,117],"(179/181),":[115,118],"83.3%":[128],"(45/54),":[129],"98.1%":[130,133],"(53/54),":[131,134],"There":[136,177],"no":[138,179],"significant":[139,180],"differences":[140],"between":[146,193],"two":[148,195],"groups":[149],"(P":[150],"=":[151],"0.449":[152],"for":[153,156,160],"RVR,":[154],"0.545":[155,159],"ETR,":[157],"SVR).":[161],"In":[162],"group,":[165],"eGFR":[167],"level":[168],"did":[169],"not":[170,221],"significantly":[171],"change":[172],"throughout":[173],"period.":[176],"difference":[181],"incidence":[184],"TEAEs":[186,192],"or":[187],"discontinuation":[189],"due":[190],"groups.":[196],"CONCLUSION:":[197],"present":[199],"showed":[201],"that":[202],"OBV/PTV/r":[208],"inferior":[222]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2018-01-26T00:00:00"}