{"id":"https://openalex.org/W2783550737","doi":"https://doi.org/10.3390/ijerph15010139","title":"Trypsin Binding with Copper Ions Scavenges Superoxide: Molecular Dynamics-Based Mechanism Investigation","display_name":"Trypsin Binding with Copper Ions Scavenges Superoxide: Molecular Dynamics-Based Mechanism Investigation","publication_year":2018,"publication_date":"2018-01-15","ids":{"openalex":"https://openalex.org/W2783550737","doi":"https://doi.org/10.3390/ijerph15010139","mag":"2783550737","pmid":"https://pubmed.ncbi.nlm.nih.gov/29342974"},"language":"en","primary_location":{"id":"doi:10.3390/ijerph15010139","doi":"https://doi.org/10.3390/ijerph15010139","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijerph15010139","pdf_url":"https://www.mdpi.com/1660-4601/15/1/139/pdf?version=1516032797","source":{"id":"https://openalex.org/S15239247","display_name":"International Journal of Environmental Research and Public Health","issn_l":"1660-4601","issn":["1660-4601","1661-7827"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","medline","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Environmental Research and Public Health","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1660-4601/15/1/139/pdf?version=1516032797","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101717612","display_name":"Xin Li","orcid":"https://orcid.org/0000-0002-5976-2988","observed_orcids":["https://orcid.org/0000-0002-5976-2988","https://orcid.org/0000-0002-7570-1712","https://orcid.org/0000-0001-8291-7557"]},"institutions":[{"id":"https://openalex.org/I167383011","display_name":"Henan University of Science and Technology","ror":"https://ror.org/05d80kz58","country_code":"CN","type":"education","lineage":["https://openalex.org/I167383011"]},{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xin Li","raw_affiliation_strings":["College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China","Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, Lanzhou University, Lanzhou 730000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China","institution_ids":["https://openalex.org/I167383011"]},{"raw_affiliation_string":"Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, Lanzhou University, Lanzhou 730000, China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073873450","display_name":"Yongliang Zhong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I167383011","display_name":"Henan University of Science and Technology","ror":"https://ror.org/05d80kz58","country_code":"CN","type":"education","lineage":["https://openalex.org/I167383011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongliang Zhong","raw_affiliation_strings":["College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China","institution_ids":["https://openalex.org/I167383011"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101608345","display_name":"Chunyan Zhao","orcid":"https://orcid.org/0000-0003-4163-1848","observed_orcids":["https://orcid.org/0000-0003-4163-1848"]},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunyan Zhao","raw_affiliation_strings":["School of Pharmacy, Lanzhou University, Lanzhou 730000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Lanzhou University, Lanzhou 730000, China","institution_ids":["https://openalex.org/I76214153"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101717612"],"corresponding_institution_ids":["https://openalex.org/I167383011","https://openalex.org/I76214153"],"apc_list":{"value":2500,"currency":"CHF","value_usd":3016},"apc_paid":{"value":2500,"currency":"CHF","value_usd":3016},"fwci":0.4707,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.57242105,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"15","issue":"1","first_page":"139","last_page":"139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.02160000056028366,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trypsin","display_name":"trypsin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/superoxide-radical-scavenging","display_name":"superoxide radical scavenging","score":0.9340000152587891},{"id":"https://openalex.org/keywords/copper-ions","display_name":"copper ions","score":0.9589999914169312},{"id":"https://openalex.org/keywords/polychlorinated-biphenyls","display_name":"polychlorinated biphenyls","score":0.9599999785423279},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.7720000147819519},{"id":"https://openalex.org/keywords/beta-sheet-formation","display_name":"\u03b2-sheet formation","score":0.5299999713897705},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.8709999918937683},{"id":"https://openalex.org/keywords/serine-protease","display_name":"serine protease","score":0.6570000052452087},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.593999981880188}],"concepts":[{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.8908442258834839},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.8237665891647339},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7570047378540039},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5081822872161865},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.4999244213104248},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.445231556892395},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.43365705013275146},{"id":"https://openalex.org/C2777807008","wikidata":"https://www.wikidata.org/wiki/Q87324999","display_name":"Serine protease","level":4,"score":0.41533926129341125},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.33781787753105164}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007477","descriptor_name":"Ions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007477","descriptor_name":"Ions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007477","descriptor_name":"Ions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014362","descriptor_name":"Trypsinogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014362","descriptor_name":"Trypsinogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014362","descriptor_name":"Trypsinogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051116","descriptor_name":"Receptors, Scavenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051116","descriptor_name":"Receptors, Scavenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051116","descriptor_name":"Receptors, Scavenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.3390/ijerph15010139","doi":"https://doi.org/10.3390/ijerph15010139","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijerph15010139","pdf_url":"https://www.mdpi.com/1660-4601/15/1/139/pdf?version=1516032797","source":{"id":"https://openalex.org/S15239247","display_name":"International Journal of Environmental Research and Public Health","issn_l":"1660-4601","issn":["1660-4601","1661-7827"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","medline","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Environmental Research and Public Health","raw_type":"journal-article"},{"id":"pmid:29342974","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29342974","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of environmental research and public health","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5800238","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5800238","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Int J Environ Res Public Health","raw_type":"Text"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/196282","doi":null,"is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/196282","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/262445","doi":null,"is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/262445","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"\u671f\u520a\u8bba\u6587"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/277880","doi":null,"is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/277880","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/288956","doi":null,"is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/288956","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/373881","doi":null,"is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/373881","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:RePEc:gam:jijerp:v:15:y:2018:i:1:p:139-:d:127063","doi":null,"is_oa":false,"landing_page_url":"https://www.mdpi.com/1660-4601/15/1/139/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:0d58b5c2a48d4fd4a05ccfbeae12828b","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/0d58b5c2a48d4fd4a05ccfbeae12828b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Environmental Research and Public Health, Vol 15, Iss 1, p 139 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijerph15010139","doi":"https://doi.org/10.3390/ijerph15010139","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijerph15010139","pdf_url":"https://www.mdpi.com/1660-4601/15/1/139/pdf?version=1516032797","source":{"id":"https://openalex.org/S15239247","display_name":"International Journal of Environmental Research and Public Health","issn_l":"1660-4601","issn":["1660-4601","1661-7827"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","medline","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Environmental Research and Public Health","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3472121117","display_name":"H2O2\u53c2\u4e0e\u7684\u7ec6\u83cc\u95f4\u4f53\u5728\u7ec6\u80de\u5206\u88c2\u4e0e\u7ec6\u80de\u635f\u4f24\u4e2d\u7684\u529f\u80fd\u53ca\u5176\u5206\u5b50\u673a\u5236\u7814\u7a76","funder_award_id":"31000017","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3852055869","display_name":null,"funder_award_id":"lzujbky-2017-200","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G5940844331","display_name":null,"funder_award_id":"KF2015-17","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G6718038","display_name":null,"funder_award_id":"2016-01","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7751656537","display_name":"\u57fa\u4e8e\u5206\u5b50\u6a21\u62df\u548c\u4f53\u5916\u5b9a\u70b9\u7a81\u53d8\u6280\u672f\u7684\u5355\u6838\u82f7\u9178\u591a\u6001\u6027\u6838\u53d7\u4f53\u4e0e\u7c7b\u56fa\u9187\u7c7b\u5185\u5206\u6ccc\u5e72\u6270\u7269\u4f5c\u7528\u7684\u5206\u5b50\u673a\u5236\u7814\u7a76","funder_award_id":"21207056","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8789723682","display_name":null,"funder_award_id":"lzujbky-2017-kb05","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320326969","display_name":"State Key Laboratory of Environmental Chemistry and Ecotoxicology","ror":"https://ror.org/003v6nj12"},{"id":"https://openalex.org/F4320327659","display_name":"Gansu University of Chinese Medicine","ror":"https://ror.org/00g741v42"},{"id":"https://openalex.org/F4320335505","display_name":"Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences","ror":"https://ror.org/03rpsvy57"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2783550737.pdf","grobid_xml":"https://content.openalex.org/works/W2783550737.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1503099155","https://openalex.org/W1558622111","https://openalex.org/W1564125081","https://openalex.org/W1967684285","https://openalex.org/W1972404844","https://openalex.org/W1976951513","https://openalex.org/W1978459297","https://openalex.org/W1984782432","https://openalex.org/W1989652481","https://openalex.org/W2000619268","https://openalex.org/W2003277364","https://openalex.org/W2009351040","https://openalex.org/W2032881767","https://openalex.org/W2038727752","https://openalex.org/W2041275298","https://openalex.org/W2057146784","https://openalex.org/W2062709989","https://openalex.org/W2063629588","https://openalex.org/W2070399086","https://openalex.org/W2073229964","https://openalex.org/W2093732951","https://openalex.org/W2097181554","https://openalex.org/W2100541923","https://openalex.org/W2102998463","https://openalex.org/W2106918975","https://openalex.org/W2117934496","https://openalex.org/W2128981481","https://openalex.org/W2136959524","https://openalex.org/W2139363713","https://openalex.org/W2154817985","https://openalex.org/W2241760375","https://openalex.org/W2332642772","https://openalex.org/W2336126569","https://openalex.org/W2544764777","https://openalex.org/W2607638621","https://openalex.org/W2610610193","https://openalex.org/W2611775283","https://openalex.org/W2617895952"],"related_works":["https://openalex.org/W2336126569","https://openalex.org/W2466016252","https://openalex.org/W2021163071","https://openalex.org/W4200192018","https://openalex.org/W1972560754","https://openalex.org/W4309353051","https://openalex.org/W2008305082","https://openalex.org/W3048569867","https://openalex.org/W2883654761","https://openalex.org/W2367312412"],"abstract_inverted_index":{"Trypsin":[0],"is":[1],"a":[2,11,64,70],"serine":[3],"protease,":[4],"which":[5,78,112],"has":[6],"been":[7],"proved":[8,99],"to":[9],"be":[10,24,133],"novel":[12],"superoxide":[13,18,47,141],"scavenger.":[14],"The":[15,39],"burst":[16],"of":[17,36,46,49,61,84,90,119,140],"induced":[19],"by":[20,26,54],"polychlorinated":[21],"biphenyls":[22],"can":[23],"impeded":[25],"trypsin":[27,50,105,127],"in":[28,73,104,115],"both":[29],"wild":[30],"type":[31],"and":[32,95,125],"sod":[33],"knockout":[34],"mutants":[35],"Escherichia":[37],"coli.":[38],"experimental":[40],"results":[41],"demonstrated":[42],"that":[43,100],"the":[44,59,74,82,96,101,120,138],"activities":[45],"scavenging":[48],"were":[51],"significantly":[52,136],"accelerated":[53],"Cu":[55,62,102,130],"ions.":[56],"Also,":[57],"with":[58,87,129],"addition":[60],"ions,":[63],"new":[65],"\u03b2-sheet":[66],"(\u03b27)":[67],"transited":[68],"from":[69],"random":[71],"coil":[72],"Cu(II)-trypsin":[75],"(TP)":[76],"system,":[77],"was":[79],"favorable":[80],"for":[81,135],"formation":[83],"more":[85],"contacts":[86],"other":[88],"sheets":[89],"trypsin.":[91],"Residue\u2013residue":[92],"network":[93],"analysis":[94],"porcupine":[97],"plots":[98],"ion":[103],"strengthened":[106],"some":[107],"native":[108],"interactions":[109],"among":[110],"residues,":[111],"ultimately":[113],"resulted":[114],"much":[116],"greater":[117],"stability":[118],"Cu(II)-TP":[121],"system.":[122],"Moreover,":[123],"compact":[124],"stable":[126],"structures":[128],"ions":[131],"might":[132],"responsible":[134],"provoking":[137],"activity":[139],"scavenging.":[142]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}