{"id":"https://openalex.org/W2783545767","doi":"https://doi.org/10.1164/rccm.201708-1755oc","title":"HIV gp120 in the Lungs of Antiretroviral Therapy\u2013treated Individuals Impairs Alveolar Macrophage Responses to Pneumococci","display_name":"HIV gp120 in the Lungs of Antiretroviral Therapy\u2013treated Individuals Impairs Alveolar Macrophage Responses to Pneumococci","publication_year":2018,"publication_date":"2018-01-24","ids":{"openalex":"https://openalex.org/W2783545767","doi":"https://doi.org/10.1164/rccm.201708-1755oc","mag":"2783545767","pmid":"https://pubmed.ncbi.nlm.nih.gov/29365279","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6006400"},"language":"en","primary_location":{"id":"doi:10.1164/rccm.201708-1755oc","doi":"https://doi.org/10.1164/rccm.201708-1755oc","is_oa":false,"landing_page_url":"https://doi.org/10.1164/rccm.201708-1755oc","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6006400","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030964686","display_name":"Paul Collini","orcid":"https://orcid.org/0000-0001-6696-6826","observed_orcids":["https://orcid.org/0000-0001-6696-6826"]},"institutions":[{"id":"https://openalex.org/I4210102902","display_name":"Sheffield Teaching Hospitals NHS Foundation Trust","ror":"https://ror.org/018hjpz25","country_code":"GB","type":"funder","lineage":["https://openalex.org/I4210102902"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Paul J. Collini","raw_affiliation_strings":["Academic Directorate of Communicable Diseases and Specialised Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom","The Florey Institute for Host-Pathogen Interactions and Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield Medical School, Sheffield, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-6696-6826","affiliations":[{"raw_affiliation_string":"Academic Directorate of Communicable Diseases and Specialised Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I4210102902"]},{"raw_affiliation_string":"The Florey Institute for Host-Pathogen Interactions and Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield Medical School, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041349371","display_name":"Martin A. Bewley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martin A. Bewley","raw_affiliation_strings":["The Florey Institute for Host-Pathogen Interactions and Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield Medical School, Sheffield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Florey Institute for Host-Pathogen Interactions and Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield Medical School, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mohamed Mohasin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mohamed Mohasin","raw_affiliation_strings":["The Florey Institute for Host-Pathogen Interactions and Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield Medical School, Sheffield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Florey Institute for Host-Pathogen Interactions and Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield Medical School, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052083569","display_name":"Helen M. Marriott","orcid":"https://orcid.org/0000-0003-1070-0054","observed_orcids":["https://orcid.org/0000-0003-1070-0054"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Helen M. Marriott","raw_affiliation_strings":["The Florey Institute for Host-Pathogen Interactions and Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield Medical School, Sheffield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Florey Institute for Host-Pathogen Interactions and Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield Medical School, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102906879","display_name":"Robert F. Miller","orcid":"https://orcid.org/0000-0003-2067-4291","observed_orcids":["https://orcid.org/0000-0003-2067-4291"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert F. Miller","raw_affiliation_strings":["Research Department of Infection and Population Health, Institute of Epidemiology & Health Care, Faculty of Population Health Sciences, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Department of Infection and Population Health, Institute of Epidemiology & Health Care, Faculty of Population Health Sciences, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054324011","display_name":"Anna Mar\u00eda Geretti","orcid":"https://orcid.org/0000-0002-3670-6588","observed_orcids":["https://orcid.org/0000-0002-3670-6588"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anna-Maria Geretti","raw_affiliation_strings":["Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006129426","display_name":"Apostolos I. Beloukas","orcid":"https://orcid.org/0000-0001-5639-0528","observed_orcids":["https://orcid.org/0000-0001-5639-0528"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Apostolos Beloukas","raw_affiliation_strings":["Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086326029","display_name":"Athanasios Papadimitropoulos","orcid":"https://orcid.org/0000-0001-9822-4931","observed_orcids":["https://orcid.org/0000-0001-9822-4931"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Athanasios Papadimitropoulos","raw_affiliation_strings":["Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088538717","display_name":"Robert Charles Read","orcid":"https://orcid.org/0000-0002-4297-6728","observed_orcids":["https://orcid.org/0000-0002-4297-6728"]},"institutions":[{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013"]},{"id":"https://openalex.org/I4210118229","display_name":"NIHR Southampton Biomedical Research Centre","ror":"https://ror.org/01qqpzg67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2802965805","https://openalex.org/I4210118229","https://openalex.org/I43439940"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robert C. Read","raw_affiliation_strings":["Academic Unit of Clinical and Experimental Sciences, University of Southampton and National Institute for Health Research Southampton Biomedical Research Centre, Southampton, United Kingdom; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academic Unit of Clinical and Experimental Sciences, University of Southampton and National Institute for Health Research Southampton Biomedical Research Centre, Southampton, United Kingdom; and","institution_ids":["https://openalex.org/I34931013","https://openalex.org/I4210118229","https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015508529","display_name":"Mahdad Noursadeghi","orcid":"https://orcid.org/0000-0002-4774-0853","observed_orcids":["https://orcid.org/0000-0002-4774-0853"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mahdad Noursadeghi","raw_affiliation_strings":["Division of Infection & Immunity, Faculty of Medical Sciences, University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infection & Immunity, Faculty of Medical Sciences, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014938248","display_name":"David Harold Dockrell","orcid":"https://orcid.org/0000-0002-2718-4861","observed_orcids":["https://orcid.org/0000-0002-2718-4861"]},"institutions":[{"id":"https://openalex.org/I4210102902","display_name":"Sheffield Teaching Hospitals NHS Foundation Trust","ror":"https://ror.org/018hjpz25","country_code":"GB","type":"funder","lineage":["https://openalex.org/I4210102902"]},{"id":"https://openalex.org/I4210151647","display_name":"Centre for Inflammation Research","ror":"https://ror.org/05wcr1b38","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210151647","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David H. Dockrell","raw_affiliation_strings":["Academic Directorate of Communicable Diseases and Specialised Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom","MRC/UoE Centre for Inflammation Research, The University of Edinburgh, Edinburgh, United Kingdom","The Florey Institute for Host-Pathogen Interactions and Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield Medical School, Sheffield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academic Directorate of Communicable Diseases and Specialised Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I4210102902"]},{"raw_affiliation_string":"MRC/UoE Centre for Inflammation Research, The University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I4210151647","https://openalex.org/I98677209"]},{"raw_affiliation_string":"The Florey Institute for Host-Pathogen Interactions and Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield Medical School, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5030964686"],"corresponding_institution_ids":["https://openalex.org/I4210102902","https://openalex.org/I91136226"],"apc_list":null,"apc_paid":null,"fwci":2.4063,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.88510638,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"197","issue":"12","first_page":"1604","last_page":"1615"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-gp120","display_name":"HIV-1 gp120","score":0.8880000114440918},{"id":"https://openalex.org/keywords/alveolar-macrophages","display_name":"alveolar macrophages","score":0.9190000295639038},{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":0.9110000133514404},{"id":"https://openalex.org/keywords/invasive-pneumococcal-disease","display_name":"invasive pneumococcal disease","score":0.9599999785423279},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.9610000252723694},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.531000018119812},{"id":"https://openalex.org/keywords/mitochondrial-ros","display_name":"mitochondrial reactive oxygen species","score":0.8650000095367432},{"id":"https://openalex.org/keywords/mcl-1","display_name":"Mcl-1","score":0.8790000081062317},{"id":"https://openalex.org/keywords/monocyte-derived-macrophages","display_name":"monocyte-derived macrophages","score":0.8370000123977661},{"id":"https://openalex.org/keywords/innate-immune-defects","display_name":"innate immune defects","score":0.5820000171661377},{"id":"https://openalex.org/keywords/hiv-associated-lung-disease","display_name":"HIV-associated lung disease","score":0.4449999928474426}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9238595962524414},{"id":"https://openalex.org/C2778012055","wikidata":"https://www.wikidata.org/wiki/Q448687","display_name":"Alveolar macrophage","level":4,"score":0.7682603001594543},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.6342203617095947},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5966660976409912},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5249179005622864},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.4515291452407837},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.375236839056015},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.31277576088905334},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016676","descriptor_name":"Macrophages, Alveolar","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D044966","descriptor_name":"Anti-Retroviral Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D044966","descriptor_name":"Anti-Retroviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D060467","descriptor_name":"Disease Resistance","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1164/rccm.201708-1755oc","doi":"https://doi.org/10.1164/rccm.201708-1755oc","is_oa":false,"landing_page_url":"https://doi.org/10.1164/rccm.201708-1755oc","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5261187","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6006400","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6006400","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6006400","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Respir Crit Care Med","raw_type":"Text"},{"id":"pmid:29365279","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29365279","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.whiterose.ac.uk:126027","doi":null,"is_oa":false,"landing_page_url":"http://eprints.whiterose.ac.uk/126027/1/Collini_gp120Spn_Blue-201708-1755OC_Manuscript_R1_Clean.pdf","pdf_url":"http://eprints.whiterose.ac.uk/126027/1/Collini_gp120Spn_Blue-201708-1755OC_Manuscript_R1_Clean.pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:eprints.soton.ac.uk:422255","doi":null,"is_oa":true,"landing_page_url":"http://doi.org/10.1164/rccm.201708-1755OC>).","pdf_url":"https://eprints.soton.ac.uk/422255/1/Collini_gp120Spn_Blue_201708_1755OC_Manuscript_R1_Clean_1.pdf","source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:art.torvergata.it:2108/410310","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2108/410310","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10042368","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10042368/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine , 197 (12) pp. 1604-1615. (2018)","raw_type":"Article"},{"id":"pmh:oai:pure.ed.ac.uk:openaire/eae4a6b2-5175-4170-a966-15d57ae7d61d","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.11820/eae4a6b2-5175-4170-a966-15d57ae7d61d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Collini, P, Bewley, M A, Mohasin, M, Marriott, H M, Miller, R F, Geretti, A M, Beloukas, A, Papadimitropoulos, A, Read, R C, Noursadeghi, M & Dockrell, D H 2018, 'HIV gp120 in the lungs of antiretroviral therapy\u2013treated Individuals impairs alveolar macrophage responses to pneumococci', American Journal of Respiratory and Critical Care Medicine, vol. 197, no. 12, pp. 1604\u20131615. https://doi.org/10.1164/rccm.201708-1755OC","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5261187","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6006400","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1957150380","display_name":"Integrated multi-dimensional molecular organ imaging","funder_award_id":"MR/K015710/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2480738000","display_name":"A genetically modified nasopharyngeal commensal as a platform for human bacteriotherapy","funder_award_id":"MR/N013204/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G4219199536","display_name":"Optimising Innate Host Defence to Combat Antimicrobial Resistance","funder_award_id":"MR/N02995X/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7187647332","display_name":"Pathfinder:Experimental Human Challenge with Genetically Modified Commensals to Investigate Respiratory Tract Mucosal Immunity and Colonisation","funder_award_id":"MR/N026993/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7957563180","display_name":"NIHR Senior Investigator Award","funder_award_id":"NF-SI-0617-10010","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G8765071762","display_name":null,"funder_award_id":"MRNO2995X/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320307856","display_name":"World Health Organization","ror":"https://ror.org/01f80g185"},{"id":"https://openalex.org/F4320310142","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320325311","display_name":"University College London Hospitals NHS Foundation Trust","ror":"https://ror.org/042fqyp44"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320336679","display_name":"NIHR Sheffield Clinical Research Facility","ror":"https://ror.org/03e9axr45"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2783545767.pdf","grobid_xml":"https://content.openalex.org/works/W2783545767.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1568547943","https://openalex.org/W1781589933","https://openalex.org/W1853829787","https://openalex.org/W1857710144","https://openalex.org/W1918446975","https://openalex.org/W1920153897","https://openalex.org/W1941174210","https://openalex.org/W1943881540","https://openalex.org/W1949329543","https://openalex.org/W1964989462","https://openalex.org/W1969232124","https://openalex.org/W1971804401","https://openalex.org/W1972506621","https://openalex.org/W1977039417","https://openalex.org/W1983295563","https://openalex.org/W1983316303","https://openalex.org/W1986427619","https://openalex.org/W1994416115","https://openalex.org/W1995088695","https://openalex.org/W2002816700","https://openalex.org/W2006385863","https://openalex.org/W2011134834","https://openalex.org/W2022092903","https://openalex.org/W2036235452","https://openalex.org/W2041126931","https://openalex.org/W2042270105","https://openalex.org/W2043933094","https://openalex.org/W2051635573","https://openalex.org/W2053252472","https://openalex.org/W2074208925","https://openalex.org/W2075174537","https://openalex.org/W2076893605","https://openalex.org/W2119240876","https://openalex.org/W2150196371","https://openalex.org/W2152799266","https://openalex.org/W2156752460","https://openalex.org/W2158025821","https://openalex.org/W2158720649","https://openalex.org/W2160718594","https://openalex.org/W2161132506","https://openalex.org/W2162166699","https://openalex.org/W2169496824","https://openalex.org/W2587299118","https://openalex.org/W2617197254","https://openalex.org/W4253150653"],"related_works":["https://openalex.org/W2026874492","https://openalex.org/W7017965591","https://openalex.org/W4297906274","https://openalex.org/W2161132506","https://openalex.org/W2160718594","https://openalex.org/W2036235452","https://openalex.org/W1994308024","https://openalex.org/W2595473260","https://openalex.org/W3124894116","https://openalex.org/W4417325329"],"abstract_inverted_index":{"Abstract":[0],"Rationale":[1],"People":[2],"living":[3,178],"with":[4,63,78,82,87,179],"HIV":[5,180],"are":[6,44],"at":[7],"significantly":[8],"increased":[9,209],"risk":[10],"of":[11,130,201],"invasive":[12],"pneumococcal":[13,133,138,193,217,239],"disease,":[14],"despite":[15],"long-term":[16,61],"antiretroviral":[17],"therapy":[18],"(ART).":[19],"The":[20],"mechanism":[21],"explaining":[22],"this":[23],"observation":[24],"remains":[25],"undefined.":[26],"Objectives":[27],"To":[28],"determine":[29],"if":[30],"apoptosis-associated":[31],"microbicidal":[32,234],"mechanisms,":[33,235],"required":[34],"to":[35,184,238],"clear":[36],"intracellular":[37],"pneumococci":[38],"that":[39],"survive":[40],"initial":[41],"phagolysosomal":[42],"killing,":[43],"perturbed.":[45],"Methods":[46],"Alveolar":[47],"macrophages":[48,69],"(AM)":[49],"were":[50,71,85,116],"obtained":[51,72],"by":[52,135],"BAL":[53,149],"from":[54,73,145,151,176],"healthy":[55,74,185,196],"donors":[56,59,75],"or":[57,80,162],"HIV-1\u2013seropositive":[58,147],"on":[60],"ART":[62],"undetectable":[64],"plasma":[65],"viral":[66],"load.":[67],"Monocyte-derived":[68],"(MDM)":[70],"and":[76,93,101,113,122,132,160,208],"infected":[77],"HIV-1BaL":[79,125],"treated":[81],"gp120.":[83],"Macrophages":[84],"challenged":[86],"opsonized":[88],"serotype":[89],"2":[90],"Streptococcus":[91],"pneumoniae":[92],"assessed":[94],"for":[95],"apoptosis,":[96,128],"bactericidal":[97],"activity,":[98],"protein":[99],"expression,":[100],"mitochondrial":[102],"reactive":[103],"oxygen":[104],"species":[105],"(mROS).":[106],"AM":[107,144,173,233],"phenotyping,":[108],"ultrasensitive":[109],"HIV-1":[110,163],"RNA":[111,164],"quantification,":[112],"gp120":[114,161,188,213],"measurement":[115],"also":[117,141,166,214],"performed":[118],"in":[119,143,172,192,195,219,232],"BAL.":[120],"Measurements":[121],"Main":[123],"Results":[124],"infection":[126],"impaired":[127],"induction":[129],"mROS,":[131],"killing":[134,139,194,218],"MDM.":[136,220],"Apoptosis-associated":[137],"was":[140,165,181],"reduced":[142],"ART-treated":[146],"donors.":[148],"fluid":[150],"these":[152],"individuals":[153],"demonstrated":[154],"persistent":[155],"lung":[156],"CD8+":[157],"T":[158],"lymphocytosis,":[159],"detected.":[167],"Despite":[168,222],"this,":[169],"transcriptional":[170],"activity":[171],"freshly":[174],"isolated":[175],"people":[177],"broadly":[182],"similar":[183],"volunteers.":[186],"Instead,":[187],"phenocopied":[189],"the":[190],"defect":[191],"MDM":[197],"through":[198],"post-translational":[199],"modification":[200],"Mcl-1,":[202],"preventing":[203],"apoptosis":[204],"induction,":[205],"caspase":[206],"activation,":[207],"mROS":[210],"generation.":[211],"Moreover,":[212],"inhibited":[215],"mROS-dependent":[216],"Conclusions":[221],"ART,":[223],"HIV-1,":[224],"via":[225],"gp120,":[226],"drives":[227],"persisting":[228],"innate":[229],"immune":[230],"defects":[231],"enhancing":[236],"susceptibility":[237],"disease.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2018-01-26T00:00:00"}
