{"id":"https://openalex.org/W2783333436","doi":null,"title":"Use of novel biomarkers to explore cardiovascular risk and drug effects","display_name":"Use of novel biomarkers to explore cardiovascular risk and drug effects","publication_year":2017,"publication_date":"2017-12-01","ids":{"openalex":"https://openalex.org/W2783333436","mag":"2783333436"},"language":"en","primary_location":{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/357193","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/357193","pdf_url":"https://dspace.library.uu.nl/handle/1874/357193","source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.library.uu.nl/handle/1874/357193","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028788640","display_name":"Daniel Kofink","orcid":"https://orcid.org/0000-0002-0223-8608","observed_orcids":["https://orcid.org/0000-0002-0223-8608"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Daniel Kofink","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0223-8608","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5028788640"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.25440001487731934,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.25440001487731934,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.21469999849796295,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.1720999926328659,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiovascular-biomarkers","display_name":"cardiovascular biomarkers","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cardiovascular-risk-prediction","display_name":"cardiovascular risk prediction","score":0.9229999780654907},{"id":"https://openalex.org/keywords/childhood-obesity","display_name":"childhood obesity","score":0.7110000252723694},{"id":"https://openalex.org/keywords/monocyte-gene-expression","display_name":"monocyte gene expression","score":0.9789999723434448},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.972000002861023},{"id":"https://openalex.org/keywords/atherosclerotic-plaque-characteristics","display_name":"atherosclerotic plaque characteristics","score":0.8930000066757202},{"id":"https://openalex.org/keywords/endarterectomy","display_name":"endarterectomy","score":0.9369999766349792},{"id":"https://openalex.org/keywords/recurrent-vascular-events","display_name":"recurrent vascular events","score":0.7910000085830688},{"id":"https://openalex.org/keywords/hematological-parameters","display_name":"hematological parameters","score":0.925000011920929},{"id":"https://openalex.org/keywords/metabolic-profiling","display_name":"metabolite profiling","score":0.8090000152587891},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.8610000014305115},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9150000214576721},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.9769999980926514},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction","display_name":"left ventricular ejection fraction","score":0.996999979019165},{"id":"https://openalex.org/keywords/pravastatin","display_name":"pravastatin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/statin-therapy","display_name":"statin therapy","score":0.5630000233650208},{"id":"https://openalex.org/keywords/drug-effects-on-metabolism","display_name":"drug effects on metabolism","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7458617687225342},{"id":"https://openalex.org/C2779519902","wikidata":"https://www.wikidata.org/wiki/Q1240093","display_name":"Pravastatin","level":3,"score":0.6257506012916565},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.5948413610458374},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5917729735374451},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5004329681396484},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.48787975311279297},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48682230710983276},{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.4676387310028076},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.43554794788360596},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3599677085876465},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.15085303783416748},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09344422817230225},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/357193","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/357193","pdf_url":"https://dspace.library.uu.nl/handle/1874/357193","source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:oai:dspace.library.uu.nl:1874/357193","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/357193","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/357193","doi":null,"is_oa":false,"landing_page_url":"http://dspace.library.uu.nl/handle/1874/357193","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:2783333436","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/357193","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/357193","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/357193","pdf_url":"https://dspace.library.uu.nl/handle/1874/357193","source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323596","display_name":"Center for Translational Molecular Medicine","ror":"https://ror.org/047wvvg23"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2783333436.pdf","grobid_xml":"https://content.openalex.org/works/W2783333436.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1972696558","https://openalex.org/W1987645827","https://openalex.org/W1992748772","https://openalex.org/W1993646603","https://openalex.org/W2009013500","https://openalex.org/W2014377708","https://openalex.org/W2014541905","https://openalex.org/W2017298577","https://openalex.org/W2040290929","https://openalex.org/W2061357887","https://openalex.org/W2071114782","https://openalex.org/W2082704080","https://openalex.org/W2084194797","https://openalex.org/W2103308668","https://openalex.org/W2127427274","https://openalex.org/W2148583670","https://openalex.org/W2149892026","https://openalex.org/W2155121555","https://openalex.org/W2296625401","https://openalex.org/W2310542696","https://openalex.org/W2320260993","https://openalex.org/W2338349399","https://openalex.org/W2563201188","https://openalex.org/W2587991149","https://openalex.org/W2693222384"],"related_works":["https://openalex.org/W78608181","https://openalex.org/W1974438296","https://openalex.org/W2467440938","https://openalex.org/W2275605164","https://openalex.org/W4389957037","https://openalex.org/W2120107049","https://openalex.org/W3000235757","https://openalex.org/W2802785901","https://openalex.org/W2475608060","https://openalex.org/W7100388044"],"abstract_inverted_index":{"Cardiovascular":[0],"disease":[1,39,64],"causes":[2],"immense":[3],"health":[4],"care":[5],"costs":[6],"and":[7,29,83,158,165],"production":[8],"losses,":[9],"underscoring":[10],"the":[11,34,72,91,151,178],"need":[12],"to":[13,24,30,47,62,98,149,159],"identify":[14,25],"individuals":[15],"at":[16],"risk":[17],"requiring":[18],"preventive":[19],"treatment.":[20],"This":[21],"thesis":[22],"aims":[23],"novel":[26],"cardiovascular":[27,38,139],"biomarkers":[28,133,161],"advance":[31],"understanding":[32],"of":[33,74,76,93,101,125,137,153,162,181],"pathophysiological":[35],"mechanisms":[36],"underlying":[37],"progression.":[40],"Moreover,":[41],"we":[42,131,144,176],"used":[43],"high-throughput":[44],"metabolic":[45,114,156,185],"profiling":[46,115],"study":[48,124,160],"molecular":[49],"drug":[50],"effects.":[51],"Chapter":[52,69,88,117,142,174],"2":[53],"relates":[54],"altered":[55],"monocyte":[56],"gene":[57],"expression":[58],"in":[59,66,105,129],"childhood":[60],"obesity":[61],"atherosclerotic":[63,80],"complexity":[65],"adult":[67],"patients.":[68,107],"3":[70],"investigates":[71],"association":[73],"loss":[75],"chromosome":[77],"Y":[78],"with":[79],"plaque":[81],"characteristics":[82],"clinical":[84,146,192],"outcome":[85],"after":[86,170],"endarterectomy.":[87],"4":[89],"explores":[90],"ability":[92],"routinely":[94],"measured":[95],"hematological":[96],"parameters":[97],"improve":[99,135],"prediction":[100,136],"recurrent":[102],"vascular":[103,106],"events":[104],"The":[108],"remaining":[109],"chapters":[110],"report":[111],"results":[112],"from":[113,121,189],"studies.":[116],"5":[118],"presents":[119],"findings":[120],"a":[122,190],"prospective":[123],"two":[126],"angiographic":[127],"cohorts,":[128],"which":[130],"identified":[132],"that":[134],"subsequent":[138],"events.":[140],"In":[141,173],"6,":[143],"use":[145],"trial":[147],"data":[148,188],"explore":[150],"effect":[152,180],"metformin":[154],"on":[155,184],"profiles":[157],"infarct":[163],"size":[164],"left":[166],"ventricular":[167],"ejection":[168],"fraction":[169],"myocardial":[171],"infarction.":[172],"7,":[175],"investigate":[177],"longitudinal":[179],"pravastatin":[182],"treatment":[183],"profiles,":[186],"using":[187],"randomized":[191],"trial.":[193]},"counts_by_year":[],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2018-01-26T00:00:00"}
