{"id":"https://openalex.org/W2783145995","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.14129","title":"Arsenic trioxide in patients with hepatocellular carcinoma: A phase II trial","display_name":"Arsenic trioxide in patients with hepatocellular carcinoma: A phase II trial","publication_year":2006,"publication_date":"2006-06-20","ids":{"openalex":"https://openalex.org/W2783145995","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.14129","mag":"2783145995"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2006.24.18_suppl.14129","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.14129","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2006.24.18_suppl.14129","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055129224","display_name":"Chung\u2010Wu Lin","orcid":"https://orcid.org/0000-0001-5042-0503","observed_orcids":["https://orcid.org/0000-0001-5042-0503"]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"C. Lin","raw_affiliation_strings":["National Taiwan University Hospital, Taipei, Taiwan Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Taiwan University Hospital, Taipei, Taiwan Republic of China","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113799370","display_name":"C-H. Hsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"C. Hsu","raw_affiliation_strings":["National Taiwan University Hospital, Taipei, Taiwan Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Taiwan University Hospital, Taipei, Taiwan Republic of China","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113799370","display_name":"C-H. Hsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"C. Hsu","raw_affiliation_strings":["National Taiwan University Hospital, Taipei, Taiwan Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Taiwan University Hospital, Taipei, Taiwan Republic of China","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027838493","display_name":"Wen\u2010Ming Hsu","orcid":"https://orcid.org/0000-0002-5145-9538","observed_orcids":["https://orcid.org/0000-0002-5145-9538"]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"W. Hsu","raw_affiliation_strings":["National Taiwan University Hospital, Taipei, Taiwan Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Taiwan University Hospital, Taipei, Taiwan Republic of China","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017953971","display_name":"Ann\u2010Lii Cheng","orcid":"https://orcid.org/0000-0002-9152-6512","observed_orcids":["https://orcid.org/0000-0002-9152-6512"]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"A. Cheng","raw_affiliation_strings":["National Taiwan University Hospital, Taipei, Taiwan Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Taiwan University Hospital, Taipei, Taiwan Republic of China","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055074037","display_name":"James Chih\u2010Hsin Yang","orcid":"https://orcid.org/0000-0002-5586-5138","observed_orcids":["https://orcid.org/0000-0002-5586-5138"]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"C. Yang","raw_affiliation_strings":["National Taiwan University Hospital, Taipei, Taiwan Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Taiwan University Hospital, Taipei, Taiwan Republic of China","institution_ids":["https://openalex.org/I4210131804"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210131804"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"18_suppl","first_page":"14129","last_page":"14129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10710","display_name":"Arsenic contamination and mitigation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arsenic-trioxide","display_name":"arsenic trioxide","score":1.0},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9729999899864197},{"id":"https://openalex.org/keywords/single-agent-chemotherapy","display_name":"single-agent chemotherapy","score":0.8519999980926514},{"id":"https://openalex.org/keywords/stable-disease","display_name":"stable disease","score":0.7099999785423279},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9010000228881836},{"id":"https://openalex.org/keywords/advanced-liver-cancer","display_name":"advanced liver cancer","score":0.6019999980926514},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.6200000047683716},{"id":"https://openalex.org/keywords/dosing-regimen","display_name":"dosing regimen","score":0.5139999985694885},{"id":"https://openalex.org/keywords/toxicity","display_name":"toxicity","score":0.3240000009536743}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.930793285369873},{"id":"https://openalex.org/C2780386689","wikidata":"https://www.wikidata.org/wiki/Q7739","display_name":"Arsenic trioxide","level":3,"score":0.8980708718299866},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6729671359062195},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6365029811859131},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6359734535217285},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5712271332740784},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.48972466588020325},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.4561750590801239},{"id":"https://openalex.org/C2992208098","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function","level":2,"score":0.4500657320022583},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4416847825050354},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4074632525444031},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.36953213810920715},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.34782305359840393},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3118245601654053},{"id":"https://openalex.org/C502230775","wikidata":"https://www.wikidata.org/wiki/Q871","display_name":"Arsenic","level":2,"score":0.21907374262809753},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2006.24.18_suppl.14129","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.14129","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2006.24.18_suppl.14129","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2590601018","https://openalex.org/W2388579949","https://openalex.org/W2379611374","https://openalex.org/W2377020768","https://openalex.org/W2413359697","https://openalex.org/W1993056328","https://openalex.org/W2388995947","https://openalex.org/W2520267970","https://openalex.org/W2368286676","https://openalex.org/W2999936267"],"abstract_inverted_index":{"14129":[0],"Background:":[1],"Arsenic":[2],"trioxide":[3,31,62,166],"induces":[4],"growth":[5],"inhibition":[6],"and":[7,26,55,154],"apoptosis":[8],"in":[9,32],"human":[10],"hepatocellular":[11],"carcinoma":[12],"(HCC)":[13],"cell":[14],"lines.":[15],"A":[16],"phase":[17],"II":[18],"trial":[19],"was":[20,79,86,139,148,161],"conducted":[21],"to":[22,43,182],"evaluate":[23],"the":[24],"efficacy":[25],"toxicity":[27],"of":[28,88,112],"single-agent":[29],"arsenic":[30,61,165],"patients":[33,42,89,96,125],"with":[34,90,103],"HCC.":[35],"Methods:":[36],"Inclusion":[37],"criteria":[38],"included":[39],"advanced":[40,105,175],"HCC":[41,108,176],"whom":[44],"no":[45],"standard":[46],"palliative":[47],"treatment":[48],"can":[49],"be":[50],"offered,":[51],"good":[52],"organ":[53],"function":[54,57],"liver":[56],"reserve.":[58],"Patients":[59],"received":[60,109],"0.16\u20130.24":[63],"mg/kg/day":[64],"for":[65,70,129],"5\u20136":[66],"days":[67],"per":[68],"week":[69],"3\u20134":[71],"weeks":[72],"followed":[73],"by":[74,158],"one-week":[75],"rest.":[76],"Tumor":[77],"response":[78],"accessed":[80],"every":[81],"2":[82],"months.":[83,133],"Primary":[84],"endpoint":[85],"percentage":[87],"6-month":[91,135],"disease":[92,127],"stabilization.":[93],"Results:":[94],"Twenty-nine":[95],"(M/F":[97],"=":[98],"24:5;":[99],"median":[100,145],"age:":[101],"59)":[102],"locally":[104],"or":[106],"metastatic":[107],"a":[110],"total":[111],"61":[113],"cycles":[114],"(median,":[115],"2;":[116],"range,":[117],"1\u20136).":[118],"One":[119],"patient":[120],"had":[121,126],"partial":[122],"remission.":[123],"Three":[124],"stabilization":[128,137],"at":[130],"least":[131],"six":[132],"The":[134,144],"tumor":[136],"rate":[138],"14%":[140],"(95%":[141,151],"CI,":[142,152],"1\u201327).":[143],"overall":[146],"survival":[147,156],"4.8":[149],"months":[150],"1.4\u20138.2)":[153],"one-year":[155],"estimated":[157],"Kaplan-Meier":[159],"methodology":[160],"30%.":[162],"Conclusions:":[163],"Single-agent":[164],"using":[167],"this":[168],"dose":[169],"schedule":[170],"is":[171],"not":[172],"active":[173],"against":[174],"patients.":[177],"No":[178],"significant":[179],"financial":[180],"relationships":[181],"disclose.":[183]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2018-01-26T00:00:00"}