{"id":"https://openalex.org/W2783123733","doi":"https://doi.org/10.18632/oncotarget.24039","title":"CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in C. elegans","display_name":"CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in C. elegans","publication_year":2018,"publication_date":"2018-01-06","ids":{"openalex":"https://openalex.org/W2783123733","doi":"https://doi.org/10.18632/oncotarget.24039","mag":"2783123733","pmid":"https://pubmed.ncbi.nlm.nih.gov/29515755"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.24039","doi":"https://doi.org/10.18632/oncotarget.24039","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.24039","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=24039&path%5B%5D=75582","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=24039&path%5B%5D=75582","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yujie Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Yujie Li","raw_affiliation_strings":["Department of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074268733","display_name":"Sandra Finkbeiner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Sandra Finkbeiner","raw_affiliation_strings":["Department of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051651825","display_name":"Athina Ganner","orcid":"https://orcid.org/0000-0002-6455-5641","observed_orcids":["https://orcid.org/0000-0002-6455-5641"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Athina Ganner","raw_affiliation_strings":["Department of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046940836","display_name":"Julia P. Gerber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I189991","display_name":"University of Veterinary Medicine Hannover, Foundation","ror":"https://ror.org/015qjqf64","country_code":"DE","type":"education","lineage":["https://openalex.org/I189991"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia Gerber","raw_affiliation_strings":["Department of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany","Department of Physiology, University of Veterinary Medicine Hannover, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]},{"raw_affiliation_string":"Department of Physiology, University of Veterinary Medicine Hannover, Hannover, Germany","institution_ids":["https://openalex.org/I189991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056896127","display_name":"Marinella Klein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marinella Klein","raw_affiliation_strings":["Department of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009920528","display_name":"Manuel Grafe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Manuel Grafe","raw_affiliation_strings":["Department of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028890790","display_name":"Jakob Kandzia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jakob Kandzia","raw_affiliation_strings":["Department of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033723353","display_name":"Antje Thien","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Antje Thien","raw_affiliation_strings":["Bioinformatics and Molecular Genetics, Faculty of Biology, Albert-Ludwigs-University Freiburg, Freiburg, Germany","Department of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Molecular Genetics, Faculty of Biology, Albert-Ludwigs-University Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Department of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047471814","display_name":"Kathrin Thedieck","orcid":"https://orcid.org/0000-0002-9069-2930","observed_orcids":["https://orcid.org/0000-0002-9069-2930"]},"institutions":[{"id":"https://openalex.org/I129877168","display_name":"Carl von Ossietzky Universit\u00e4t Oldenburg","ror":"https://ror.org/033n9gh91","country_code":"DE","type":"education","lineage":["https://openalex.org/I129877168"]},{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["DE","NL"],"is_corresponding":false,"raw_author_name":"Kathrin Thedieck","raw_affiliation_strings":["Bioinformatics and Molecular Genetics, Faculty of Biology, Albert-Ludwigs-University Freiburg, Freiburg, Germany","Department for Neuroscience, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany","Department of Pediatrics, Section Systems Medicine of Metabolism and Signaling, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Molecular Genetics, Faculty of Biology, Albert-Ludwigs-University Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Department for Neuroscience, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany","institution_ids":["https://openalex.org/I129877168"]},{"raw_affiliation_string":"Department of Pediatrics, Section Systems Medicine of Metabolism and Signaling, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079506557","display_name":"G. Breves","orcid":"https://orcid.org/0000-0003-2871-3064","observed_orcids":["https://orcid.org/0000-0003-2871-3064"]},"institutions":[{"id":"https://openalex.org/I189991","display_name":"University of Veterinary Medicine Hannover, Foundation","ror":"https://ror.org/015qjqf64","country_code":"DE","type":"education","lineage":["https://openalex.org/I189991"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerhard Breves","raw_affiliation_strings":["Department of Physiology, University of Veterinary Medicine Hannover, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Veterinary Medicine Hannover, Hannover, Germany","institution_ids":["https://openalex.org/I189991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080600755","display_name":"Thomas Jank","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Jank","raw_affiliation_strings":["Institute for Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053004770","display_name":"Ralf Baumeister","orcid":"https://orcid.org/0000-0002-1632-4777","observed_orcids":["https://orcid.org/0000-0002-1632-4777"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ralf Baumeister","raw_affiliation_strings":["Bioinformatics and Molecular Genetics, Faculty of Biology, Albert-Ludwigs-University Freiburg, Freiburg, Germany","Centre for Biological Signaling Studies (BIOSS), Albert-Ludwigs-University of Freiburg, Freiburg, Germany","Centre for Biological Systems Analysis (ZBSA), Albert-Ludwigs-University Freiburg, Freiburg, Germany","ZBMZ Centre for Biochemistry and Molecular Cell Research, Faculty of Medicine, Albert-Ludwigs-University Freiburg, Freiburg, Germany","Department of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Molecular Genetics, Faculty of Biology, Albert-Ludwigs-University Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Centre for Biological Signaling Studies (BIOSS), Albert-Ludwigs-University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Centre for Biological Systems Analysis (ZBSA), Albert-Ludwigs-University Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"ZBMZ Centre for Biochemistry and Molecular Cell Research, Faculty of Medicine, Albert-Ludwigs-University Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Department of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048410197","display_name":"Gerd Walz","orcid":"https://orcid.org/0000-0002-4950-9946","observed_orcids":["https://orcid.org/0000-0002-4950-9946"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerd Walz","raw_affiliation_strings":["Centre for Biological Signaling Studies (BIOSS), Albert-Ludwigs-University of Freiburg, Freiburg, Germany","Department of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Biological Signaling Studies (BIOSS), Albert-Ludwigs-University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Department of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051513539","display_name":"Elke Neumann\u2010Haefelin","orcid":"https://orcid.org/0000-0001-5893-4293","observed_orcids":["https://orcid.org/0000-0001-5893-4293"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Elke Neumann-Haefelin","raw_affiliation_strings":["Department of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5074268733"],"corresponding_institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"],"apc_list":null,"apc_paid":null,"fwci":0.2847,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.46845124,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":"11","first_page":"9581","last_page":"9595"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mtorc1-signaling","display_name":"mTORC1 signaling","score":0.9509999752044678},{"id":"https://openalex.org/keywords/rheb","display_name":"Rheb","score":0.9169999957084656},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7649999856948853},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.8069999814033508},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8999999761581421},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.4440000057220459},{"id":"https://openalex.org/keywords/tor-signaling","display_name":"TOR signaling","score":0.44999998807907104},{"id":"https://openalex.org/keywords/torc2","display_name":"TORC2","score":0.421999990940094}],"concepts":[{"id":"https://openalex.org/C2778937405","wikidata":"https://www.wikidata.org/wiki/Q18031127","display_name":"RHEB","level":5,"score":0.9348104000091553},{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.9003666043281555},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.715654194355011},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.663780689239502},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6608664989471436},{"id":"https://openalex.org/C107846503","wikidata":"https://www.wikidata.org/wiki/Q14876061","display_name":"mTORC2","level":5,"score":0.5968644022941589},{"id":"https://openalex.org/C2909523446","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"TOR signaling","level":3,"score":0.5496873259544373},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5404537320137024},{"id":"https://openalex.org/C104202773","wikidata":"https://www.wikidata.org/wiki/Q18031289","display_name":"P70-S6 Kinase 1","level":4,"score":0.5189582705497742},{"id":"https://openalex.org/C2777949483","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"Mechanistic target of rapamycin","level":4,"score":0.5139445662498474},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.4668351411819458},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27324700355529785},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.07581689953804016}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.18632/oncotarget.24039","doi":"https://doi.org/10.18632/oncotarget.24039","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.24039","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=24039&path%5B%5D=75582","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmid:29515755","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29515755","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"},{"id":"pmh:oai:pure.rug.nl:openaire/533ff641-46d4-4d96-8a7a-ad915be351e5","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/533ff641-46d4-4d96-8a7a-ad915be351e5","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Li, Y, Finkbeiner, S, Ganner, A, Gerber, J, Klein, M, Grafe, M, Kandzia, J, Thien, A, Thedieck, K, Breves, G, Jank, T, Baumeister, R, Walz, G & Neumann-Haefelin, E 2018, 'CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in', Oncotarget, vol. 9, no. 11, pp. 9581-9595. https://doi.org/10.18632/oncotarget.24039","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:4750237","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5839386","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5839386","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5839386","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oncotarget","raw_type":"Text"},{"id":"pmh:oai:bibliographie.ub.uni-due.de:ubo_mods_00230195","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pubmed/29515755","pdf_url":null,"source":{"id":"https://openalex.org/S7407055102","display_name":"Universit\u00e4tsbibliographie, Universit\u00e4t Duisburg-Essen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/533ff641-46d4-4d96-8a7a-ad915be351e5","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/533ff641-46d4-4d96-8a7a-ad915be351e5","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oncotarget, 9(11), 9581 - 9595. Impact Journals LLC","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.24039","doi":"https://doi.org/10.18632/oncotarget.24039","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.24039","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=24039&path%5B%5D=75582","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/14","display_name":"Life below water","score":0.6600000262260437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G114216032","display_name":null,"funder_award_id":"CRC1140","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2543069916","display_name":null,"funder_award_id":"CRC746","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2764835898","display_name":"e:Med - Modul II - Verbundprojekt: MAPTor-Net - Personalisierte Therapie pankreatischer neuroendokriner Tumoren basierend auf mathematischen Modellen des MAPK-mTOR Netzwerkes - Teilprojekt B","funder_award_id":"031A426B","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G56445926","display_name":null,"funder_award_id":"DFG CRC1140","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G592703221","display_name":null,"funder_award_id":"TH 1358/3-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6042863912","display_name":null,"funder_award_id":"KFO201","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320309636","display_name":"University of Minnesota","ror":"https://ror.org/03grvy078"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320320933","display_name":"Rijksuniversiteit Groningen","ror":"https://ror.org/012p63287"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320338080","display_name":"European Social Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2783123733.pdf","grobid_xml":"https://content.openalex.org/works/W2783123733.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W15253933","https://openalex.org/W1523693806","https://openalex.org/W1921244251","https://openalex.org/W1967588638","https://openalex.org/W1977077130","https://openalex.org/W1977787135","https://openalex.org/W1990960113","https://openalex.org/W1994305081","https://openalex.org/W2001259221","https://openalex.org/W2002741326","https://openalex.org/W2011859278","https://openalex.org/W2012865029","https://openalex.org/W2015173256","https://openalex.org/W2023819606","https://openalex.org/W2024168218","https://openalex.org/W2024222958","https://openalex.org/W2024919274","https://openalex.org/W2029989060","https://openalex.org/W2038120788","https://openalex.org/W2039196160","https://openalex.org/W2044621729","https://openalex.org/W2045201133","https://openalex.org/W2047750593","https://openalex.org/W2048376025","https://openalex.org/W2055194692","https://openalex.org/W2056137479","https://openalex.org/W2058484936","https://openalex.org/W2060607801","https://openalex.org/W2061091970","https://openalex.org/W2064609969","https://openalex.org/W2066660409","https://openalex.org/W2083089496","https://openalex.org/W2086292277","https://openalex.org/W2089632625","https://openalex.org/W2109263914","https://openalex.org/W2111822899","https://openalex.org/W2112769897","https://openalex.org/W2114570899","https://openalex.org/W2116450149","https://openalex.org/W2127063807","https://openalex.org/W2132493451","https://openalex.org/W2134138119","https://openalex.org/W2138474054","https://openalex.org/W2148242921","https://openalex.org/W2153607816","https://openalex.org/W2167408228","https://openalex.org/W2170319238","https://openalex.org/W4242986207"],"related_works":["https://openalex.org/W2154106855","https://openalex.org/W2118120822","https://openalex.org/W1977883755","https://openalex.org/W1566520694","https://openalex.org/W4200610622","https://openalex.org/W1533284996","https://openalex.org/W3176831692","https://openalex.org/W3166437080","https://openalex.org/W1492770473","https://openalex.org/W1576208079"],"abstract_inverted_index":{"//":[0],"Yujie":[1],"Li":[2],"1,":[3,8,17,34,60],"*":[4,9,194],",":[5,10,14,19,23,27,31,36,42,46,50,57,355,360],"Sandra":[6],"Finkbeiner":[7],"Athina":[11],"Ganner":[12],"1":[13,22,26,30,65,66],"Julia":[15],"Gerber":[16],"9":[18,45,183],"Marinella":[20],"Klein":[21],"Manuel":[24],"Grafe":[25],"Jakob":[28],"Kandzia":[29],"Antje":[32],"Thien":[33],"2":[35,77],"Kathrin":[37],"Thedieck":[38],"2,":[39,53],"3,":[40],"4":[41,110],"Gerhard":[43],"Breves":[44],"Thomas":[47],"Jank":[48],"5":[49,127],"Ralf":[51],"Baumeister":[52],"6,":[54],"7,":[55],"8":[56,167],"Gerd":[58],"Walz":[59],"6":[61,144],"and":[62,79,98,117,131,134,172,240,242,255,274,303,317,325,332,335,361,390,405,435,440],"Elke":[63],"Neumann-Haefelin":[64],"Department":[67,90,111,184],"of":[68,73,83,91,96,101,115,137,140,152,177,185,188,232,261,288,301,305,369,417],"Nephrology,":[69],"Medical":[70,104],"Center,":[71],"University":[72,100,103,123,187],"Freiburg,":[74,75,86,87,141,142,153,154,164,165,180,181],"Germany":[76,88,126,143,155,166,182,193],"Bioinformatics":[78],"Molecular":[80,173],"Genetics,":[81],"Faculty":[82,136,176],"Biology,":[84],"Albert-Ludwigs-University":[85,139,151,163,179],"3":[89],"Pediatrics,":[92],"Section":[93],"Systems":[94,160],"Medicine":[95,116,190],"Metabolism":[97],"Signaling,":[99],"Groningen,":[102,106,107],"Center":[105],"The":[108,229,321],"Netherlands":[109],"for":[112,129,146,158,170,329,375,410,432],"Neuroscience,":[113],"School":[114],"Health":[118],"Sciences,":[119],"Carl":[120],"von":[121],"Ossietzky":[122],"Oldenburg,":[124,125],"Institute":[128],"Experimental":[130],"Clinical":[132],"Pharmacology":[133],"Toxicology,":[135],"Medicine,":[138,178],"Centre":[145,157,169],"Biological":[147,159],"Signaling":[148],"Studies":[149],"(BIOSS),":[150],"7":[156],"Analysis":[161],"(ZBSA),":[162],"ZBMZ":[168],"Biochemistry":[171],"Cell":[174],"Research,":[175],"Physiology,":[186],"Veterinary":[189],"Hannover,":[191,192],"These":[195,427],"authors":[196],"contributed":[197],"equally":[198],"to":[199,238,270],"this":[200,278],"work":[201],"Correspondence":[202],"to:":[203],"Neumann-Haefelin,":[204],"email:":[205],"elke.neumann-haefelin@uniklinik-freiburg.de":[206],"Keywords:":[207],"mTORC1":[208,254,262,266,306,373,391,407,421],"signaling;":[209],"Rheb;":[210],"aging;":[211],"stress":[212,319,333],"response;":[213],"C.":[214,285,309,381],"elegans":[215,286,310,382],"Received:":[216],"September":[217],"30,":[218],"2017":[219,223],"Accepted:":[220],"November":[221],"15,":[222],"Published:":[224],"January":[225],"06,":[226],"2018":[227],"ABSTRACT":[228],"mechanistic":[230],"target":[231],"rapamycin":[233],"(mTOR)":[234],"kinase":[235,358],"is":[236,296,366,378,386,424],"central":[237,372],"metabolism":[239],"growth,":[241],"has":[243],"a":[244,297,371],"conserved":[245],"role":[246],"in":[247,251,308,340,349,380,398,419,438],"aging.":[248],"mTOR":[249,357,433],"functions":[250,348,434],"two":[252],"complexes,":[253],"mTORC2.":[256],"In":[257,277,393],"diverse":[258],"eukaryotes,":[259],"inhibition":[260],"signaling":[263,307,422,436],"increases":[264],"lifespan.":[265],"transduces":[267],"anabolic":[268],"signals":[269],"stimulate":[271],"protein":[272,376,411],"synthesis":[273,412],"inhibits":[275],"autophagy.":[276],"study,":[279],"we":[280,395],"demonstrate":[281],"that":[282,346,397,414],"CGEF-1,":[283],"the":[284,289,350,356,415,420],"homolog":[287],"human":[290,399],"guanine":[291],"nucleotide":[292],"exchange":[293],"factor":[294],"Dbl,":[295],"novel":[298],"binding":[299],"partner":[300],"RHEB-1":[302],"activator":[304],".":[311,383],"cgef-1":[312,341,347,365,389],"mutants":[313],"display":[314],"prolonged":[315],"lifespan":[316],"enhanced":[318],"resistance.":[320],"transcription":[322],"factors":[323],"DAF-16/FoxO":[324],"SKN-1/Nrf":[326],"are":[327],"required":[328],"increased":[330,387],"longevity":[331],"tolerance,":[334],"induce":[336],"protective":[337],"gene":[338],"expression":[339],"mutants.":[342],"Genetic":[343],"evidence":[344],"indicates":[345],"same":[351],"pathway":[352,423],"with":[353,403],"rheb-1":[354],"let-363":[359],"daf-15":[362],"/Raptor.":[363],"When":[364],"inactivated,":[367],"phosphorylation":[368],"4E-BP,":[370],"substrate":[374],"translation":[377],"reduced":[379],"Moreover,":[384],"autophagy":[385],"upon":[388],"inhibition.":[392],"addition,":[394],"show":[396],"cells":[400],"Dbl":[401],"associates":[402],"Rheb":[404],"stimulates":[406],"downstream":[408],"targets":[409],"suggesting":[413],"function":[416],"CGEF-1/Dbl":[418],"evolutionarily":[425],"conserved.":[426],"findings":[428],"have":[429],"important":[430],"implications":[431],"mechanisms":[437],"aging":[439],"age-related":[441],"diseases.":[442]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2018-01-26T00:00:00"}