{"id":"https://openalex.org/W2782724554","doi":"https://doi.org/10.1001/jamapediatrics.2017.4838","title":"Comparing Alternative Ranibizumab Dosages for Safety and Efficacy in Retinopathy of Prematurity","display_name":"Comparing Alternative Ranibizumab Dosages for Safety and Efficacy in Retinopathy of Prematurity","publication_year":2018,"publication_date":"2018-01-08","ids":{"openalex":"https://openalex.org/W2782724554","doi":"https://doi.org/10.1001/jamapediatrics.2017.4838","mag":"2782724554","pmid":"https://pubmed.ncbi.nlm.nih.gov/29309486","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5840003"},"language":"en","primary_location":{"id":"doi:10.1001/jamapediatrics.2017.4838","doi":"https://doi.org/10.1001/jamapediatrics.2017.4838","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamapediatrics.2017.4838","pdf_url":"https://jamanetwork.com/journals/jamapediatrics/articlepdf/2667558/jamapediatrics_stahl_2018_oi_170100.pdf","source":{"id":"https://openalex.org/S4210192535","display_name":"Archives of Pediatrics and Adolescent Medicine","issn_l":"1072-4710","issn":["1072-4710","1538-3628","2168-6203","2168-6211"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jamanetwork.com/journals/jamapediatrics/articlepdf/2667558/jamapediatrics_stahl_2018_oi_170100.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034062166","display_name":"Andreas Stahl","orcid":"https://orcid.org/0000-0002-8013-7597","observed_orcids":["https://orcid.org/0000-0002-8013-7597"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Andreas Stahl","raw_affiliation_strings":["Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004175910","display_name":"Tim U. Krohne","orcid":"https://orcid.org/0000-0003-2280-925X","observed_orcids":["https://orcid.org/0000-0003-2280-925X"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tim U. Krohne","raw_affiliation_strings":["Department of Ophthalmology, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037018029","display_name":"Nicole Eter","orcid":"https://orcid.org/0000-0001-5617-346X","observed_orcids":["https://orcid.org/0000-0001-5617-346X"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nicole Eter","raw_affiliation_strings":["Department of Ophthalmology, University of Muenster Medical Center, Muenster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of Muenster Medical Center, Muenster, Germany","institution_ids":["https://openalex.org/I22465464","https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055370065","display_name":"Isabel Oberacher-Velten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Isabel Oberacher-Velten","raw_affiliation_strings":["Department of Ophthalmology, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046032804","display_name":"Rainer Guthoff","orcid":"https://orcid.org/0000-0002-6038-5577","observed_orcids":["https://orcid.org/0000-0002-6038-5577"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rainer Guthoff","raw_affiliation_strings":["Department of Ophthalmology, Faculty of Medicine, University of Dusseldorf, Dusseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Faculty of Medicine, University of Dusseldorf, Dusseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102124559","display_name":"Synke Meltendorf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Synke Meltendorf","raw_affiliation_strings":["Department of Ophthalmology, Otto von Guericke University, Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Otto von Guericke University, Magdeburg, Germany","institution_ids":["https://openalex.org/I95793202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027277898","display_name":"Oliver Ehrt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver Ehrt","raw_affiliation_strings":["Department of Ophthalmology, Ludwig-Maximilian University of Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Ludwig-Maximilian University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053176467","display_name":"Sabine Aisenbrey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabine Aisenbrey","raw_affiliation_strings":["University Eye Hospital, Eberhard Karls University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Eye Hospital, Eberhard Karls University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110137134","display_name":"Johann Baptist Roider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johann Roider","raw_affiliation_strings":["Department of Ophthalmology, University of Kiel, University Medical Center, Kiel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of Kiel, University Medical Center, Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010602494","display_name":"H. Gerding","orcid":"https://orcid.org/0000-0003-3968-5601","observed_orcids":["https://orcid.org/0000-0003-3968-5601"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heinrich Gerding","raw_affiliation_strings":["Augenzentrum Pallas Kliniken, Olten, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Augenzentrum Pallas Kliniken, Olten, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049938906","display_name":"C. Jandeck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claudia Jandeck","raw_affiliation_strings":["Artemis Eye Clinic, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Artemis Eye Clinic, Frankfurt, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091304323","display_name":"Lois E. H. Smith","orcid":"https://orcid.org/0000-0001-7644-6410","observed_orcids":["https://orcid.org/0000-0001-7644-6410"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lois E. H. Smith","raw_affiliation_strings":["Department of Ophthalmology, Harvard Medical School, Boston Children\u2019s Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Harvard Medical School, Boston Children\u2019s Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058428156","display_name":"Johanna M. Pfeil","orcid":"https://orcid.org/0000-0002-2731-6094","observed_orcids":["https://orcid.org/0000-0002-2731-6094"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johanna M. Walz","raw_affiliation_strings":["Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany","Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]},{"raw_affiliation_string":"Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"last","author":{"id":null,"display_name":"for the Comparing Alternative Ranibizumab Dosages for Safety and Efficacy in Retinopathy of Prematurity (CARE-ROP) Study Group","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"for the Comparing Alternative Ranibizumab Dosages for Safety and Efficacy in Retinopathy of Prematurity (CARE-ROP) Study Group","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5034062166"],"corresponding_institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"],"apc_list":null,"apc_paid":null,"fwci":16.1136,"has_fulltext":true,"cited_by_count":155,"citation_normalized_percentile":{"value":0.99657146,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"172","issue":"3","first_page":"278","last_page":"278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12484","display_name":"Retinopathy of Prematurity Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12484","display_name":"Retinopathy of Prematurity Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinopathy-of-prematurity","display_name":"retinopathy of prematurity","score":0.9259999990463257},{"id":"https://openalex.org/keywords/ranibizumab","display_name":"ranibizumab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.9350000023841858},{"id":"https://openalex.org/keywords/dose-comparison","display_name":"dose comparison","score":0.6859999895095825},{"id":"https://openalex.org/keywords/plus-disease","display_name":"plus disease","score":0.9319999814033508},{"id":"https://openalex.org/keywords/salvage-therapy","display_name":"salvage therapy","score":0.8309999704360962},{"id":"https://openalex.org/keywords/plasma-vegf-levels","display_name":"plasma VEGF levels","score":0.8119999766349792},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.4580000042915344},{"id":"https://openalex.org/keywords/infants","display_name":"infants","score":0.5270000100135803},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.7879999876022339},{"id":"https://openalex.org/keywords/rop-recurrence","display_name":"ROP recurrence","score":0.460999995470047},{"id":"https://openalex.org/keywords/neonatal-eye-disease","display_name":"neonatal eye disease","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9748587608337402},{"id":"https://openalex.org/C2779918416","wikidata":"https://www.wikidata.org/wiki/Q1423087","display_name":"Retinopathy of prematurity","level":4,"score":0.9096364974975586},{"id":"https://openalex.org/C2781100027","wikidata":"https://www.wikidata.org/wiki/Q414270","display_name":"Ranibizumab","level":4,"score":0.8592019081115723},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.6342177391052246},{"id":"https://openalex.org/C162156334","wikidata":"https://www.wikidata.org/wiki/Q473420","display_name":"Dose","level":2,"score":0.6320701241493225},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5760440826416016},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5115340948104858},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.5094521641731262},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.48560041189193726},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.399029940366745},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.38973137736320496},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3572760224342346},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28122901916503906},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.2562328577041626},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.17832952737808228},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.07879889011383057},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000069579","descriptor_name":"Ranibizumab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005858","descriptor_name":"Germany","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012178","descriptor_name":"Retinopathy of Prematurity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1001/jamapediatrics.2017.4838","doi":"https://doi.org/10.1001/jamapediatrics.2017.4838","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamapediatrics.2017.4838","pdf_url":"https://jamanetwork.com/journals/jamapediatrics/articlepdf/2667558/jamapediatrics_stahl_2018_oi_170100.pdf","source":{"id":"https://openalex.org/S4210192535","display_name":"Archives of Pediatrics and Adolescent Medicine","issn_l":"1072-4710","issn":["1072-4710","1538-3628","2168-6203","2168-6211"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Pediatrics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4831804","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5840003","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5840003","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5840003","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Pediatr","raw_type":"Text"},{"id":"pmid:29309486","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29309486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA pediatrics","raw_type":"Comparative Study"},{"id":"pmh:oai:epub.uni-regensburg.de:47410","doi":null,"is_oa":false,"landing_page_url":"https://epub.uni-regensburg.de/47410/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1001/jamapediatrics.2017.4838","doi":"https://doi.org/10.1001/jamapediatrics.2017.4838","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamapediatrics.2017.4838","pdf_url":"https://jamanetwork.com/journals/jamapediatrics/articlepdf/2667558/jamapediatrics_stahl_2018_oi_170100.pdf","source":{"id":"https://openalex.org/S4210192535","display_name":"Archives of Pediatrics and Adolescent Medicine","issn_l":"1072-4710","issn":["1072-4710","1538-3628","2168-6203","2168-6211"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Pediatrics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G4415044112","display_name":"Novel therapies to inhibit Diabetic Retinopathy","funder_award_id":"R24EY024864","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G5829768055","display_name":"Boston Intellectual and Developmental Disabilities Research Center","funder_award_id":"U54HD090255","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G9000920623","display_name":"Dietary control of angiogenesis in retinopathy models","funder_award_id":"R01EY017017","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320321112","display_name":"Eberhard Karls Universit\u00e4t T\u00fcbingen","ror":"https://ror.org/03a1kwz48"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2782724554.pdf","grobid_xml":"https://content.openalex.org/works/W2782724554.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W106587198","https://openalex.org/W200771558","https://openalex.org/W1073469074","https://openalex.org/W1578008435","https://openalex.org/W1656028612","https://openalex.org/W1965819844","https://openalex.org/W1990201092","https://openalex.org/W1998726711","https://openalex.org/W2021381232","https://openalex.org/W2031875923","https://openalex.org/W2047069236","https://openalex.org/W2053098204","https://openalex.org/W2062756251","https://openalex.org/W2069036016","https://openalex.org/W2078546898","https://openalex.org/W2081930185","https://openalex.org/W2083538148","https://openalex.org/W2096547439","https://openalex.org/W2113170046","https://openalex.org/W2160177190","https://openalex.org/W2222356193","https://openalex.org/W2298072637","https://openalex.org/W2317196257","https://openalex.org/W2324499954","https://openalex.org/W2334508015","https://openalex.org/W2396111793","https://openalex.org/W2413795004","https://openalex.org/W2490167875","https://openalex.org/W2578733585","https://openalex.org/W2593221228","https://openalex.org/W2608826714","https://openalex.org/W3147843683","https://openalex.org/W3148465273","https://openalex.org/W4296167288"],"related_works":["https://openalex.org/W2972706767","https://openalex.org/W4200164386","https://openalex.org/W4411975946","https://openalex.org/W2317196257","https://openalex.org/W4224312400","https://openalex.org/W2021381232","https://openalex.org/W4308950458","https://openalex.org/W4392388364","https://openalex.org/W4384518804","https://openalex.org/W4394389240"],"abstract_inverted_index":{"Importance:":[0],"Anti-vascular":[1],"endothelial":[2],"growth":[3],"factor":[4],"(VEGF)":[5],"therapies":[6],"are":[7,23],"a":[8,35,38,364],"novel":[9],"treatment":[10],"option":[11],"in":[12,63,74,98,108,142,228,234,247,257,272,292,304,318],"retinopathy":[13],"of":[14,30,68,144,163,182,190,221,325,341,348],"prematurity":[15],"(ROP).":[16],"Data":[17],"on":[18],"dosing,":[19],"efficacy,":[20],"and":[21,50,118,125,154,185,194,232,251,308,322,376],"safety":[22],"insufficient.":[24],"Objective:":[25],"To":[26],"investigate":[27],"lower":[28,353],"doses":[29,67,268],"anti-VEGF":[31],"therapy":[32,170],"with":[33,37,76,84,88,93,105,203,345],"ranibizumab,":[34],"substance":[36],"significantly":[39],"shorter":[40],"systemic":[41,366],"half-life":[42],"than":[43],"the":[44,161,225,229,235,239,248,258,293,326,342,352],"standard":[45,327],"treatment,":[46,216],"bevacizumab.":[47],"Design,":[48],"Setting,":[49],"Participants:":[51],"This":[52,310],"randomized,":[53],"multicenter,":[54],"double-blind,":[55],"investigator-initiated":[56],"trial":[57],"at":[58,148,171,214],"9":[59],"academic":[60],"medical":[61],"centers":[62],"Germany":[64],"compared":[65],"ranibizumab":[66,135,267,315,349],"0.12":[69,346],"mg":[70,73,347],"vs":[71],"0.20":[72],"infants":[75,122,131,164,202],"bilateral":[77],"aggressive":[78],"posterior":[79,109],"ROP;":[80],"ROP":[81,102,145,191,204,275,321],"stage":[82,103],"1":[83,133],"plus":[85,89,96,106],"disease,":[86,90],"2":[87,233],"or":[91,94,101],"3":[92,104,220],"without":[95],"disease":[97,107],"zone":[99,110],"I;":[100],"II.":[111],"Patients":[112],"were":[113,123,127,140,192,205,269,300],"recruited":[114],"between":[115],"September":[116],"2014":[117],"August":[119],"2016.":[120],"Twenty":[121],"screened":[124],"19":[126],"randomized.":[128],"Interventions:":[129],"All":[130],"received":[132],"baseline":[134],"injection":[136],"per":[137],"eye.":[138],"Reinjections":[139],"allowed":[141],"case":[143],"recurrence":[146],"after":[147,369],"least":[149],"28":[150],"days.":[151],"Main":[152],"Outcomes":[153],"Measures:":[155],"The":[156,296],"primary":[157],"end":[158,176],"point":[159,362],"was":[160,290],"number":[162],"who":[165],"did":[166,261],"not":[167,262,301],"require":[168,263],"rescue":[169,264],"24":[172],"weeks.":[173],"Key":[174],"secondary":[175],"points":[177],"included":[178],"time-to-event":[179],"analyses,":[180],"progression":[181],"physiologic":[183],"vascularization,":[184],"plasma":[186,298,359],"VEGF":[187,297,360],"levels.":[188],"Stages":[189],"photodocumented":[193],"reviewed":[195],"by":[196],"an":[197],"expert":[198],"committee.":[199],"Results:":[200],"Nineteen":[201],"enrolled":[206],"(9":[207],"[47.4%]":[208],"female;":[209],"median":[210],"[range]":[211],"postmenstrual":[212],"age":[213],"first":[215],"36.4":[217],"[34.7-39.7]":[218],"weeks),":[219],"whom":[222],"died":[223],"during":[224],"study":[226,312],"(1":[227],"0.12-mg":[230,249,294],"group":[231,250,260],"0.20-mg":[236,259],"group).":[237],"Of":[238],"surviving":[240],"infants,":[241],"8":[242],"(88.9%)":[243],"(17":[244],"eyes":[245,255],"[94.4%])":[246],"6":[252],"(85.7%)":[253],"(13":[254],"[92.9%])":[256],"therapy.":[265],"Both":[266],"equally":[270,333],"successful":[271],"controlling":[273,319],"acute":[274,320],"(Cochran-Mantel-Haenszel":[276],"analysis;":[277],"odds":[278],"ratio,":[279],"1.88;":[280],"95%":[281],"CI,":[282],"0.26-13.49;":[283],"P":[284],"=":[285],".53).":[286],"Physiologic":[287],"intraretinal":[288],"vascularization":[289,340],"superior":[291],"group.":[295,306],"levels":[299,361],"systematically":[302],"altered":[303],"either":[305],"Conclusions":[307],"Relevance:":[309],"pilot":[311],"demonstrates":[313],"that":[314,323,351],"is":[316],"effective":[317,334],"24%":[324],"adult":[328],"dose":[329,354],"(0.12":[330],"mg)":[331],"appears":[332],"as":[335],"40%":[336],"(0.20":[337],"mg).":[338],"Superior":[339],"peripheral":[343],"retina":[344],"indicates":[350],"may":[355],"be":[356],"favorable.":[357],"Unchanged":[358],"toward":[363],"limited":[365],"drug":[367],"exposure":[368],"ranibizumab.":[370],"Trial":[371],"Registration:":[372],"clinicaltrials.gov":[373],"Identifier:":[374,378],"NCT02134457":[375],"clinicaltrialsregister.eu":[377],"2013-002539-13.":[379]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":27},{"year":2022,"cited_by_count":26},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":11}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-01-26T00:00:00"}