{"id":"https://openalex.org/W2782012253","doi":"https://doi.org/10.1534/g3.117.300357","title":"Unintended Side Effects of Transformation Are Very Rare in Cryptococcus neoformans","display_name":"Unintended Side Effects of Transformation Are Very Rare in Cryptococcus neoformans","publication_year":2018,"publication_date":"2018-01-06","ids":{"openalex":"https://openalex.org/W2782012253","doi":"https://doi.org/10.1534/g3.117.300357","mag":"2782012253","pmid":"https://pubmed.ncbi.nlm.nih.gov/29305388","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5844303"},"language":"en","primary_location":{"id":"doi:10.1534/g3.117.300357","doi":"https://doi.org/10.1534/g3.117.300357","is_oa":true,"landing_page_url":"https://doi.org/10.1534/g3.117.300357","pdf_url":null,"source":{"id":"https://openalex.org/S109822313","display_name":"G3 Genes Genomes Genetics","issn_l":"2160-1836","issn":["2160-1836"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319844","host_organization_name":"Genetics Society of America","host_organization_lineage":["https://openalex.org/P4310319844"],"host_organization_lineage_names":["Genetics Society of America"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 Genes|Genomes|Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1534/g3.117.300357","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037912811","display_name":"Ryan Z. Friedman","orcid":"https://orcid.org/0000-0001-9013-8676","observed_orcids":["https://orcid.org/0000-0001-9013-8676"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Z Friedman","raw_affiliation_strings":["Center for Genome Sciences and Systems Biology, Washington University School of Medicine, Saint Louis, Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genome Sciences and Systems Biology, Washington University School of Medicine, Saint Louis, Missouri 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028102887","display_name":"Stacey R. Gish","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacey R Gish","raw_affiliation_strings":["Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004534683","display_name":"Holly Brown","orcid":"https://orcid.org/0009-0008-8157-5055","observed_orcids":["https://orcid.org/0009-0008-8157-5055"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Holly Brown","raw_affiliation_strings":["Center for Genome Sciences and Systems Biology, Washington University School of Medicine, Saint Louis, Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genome Sciences and Systems Biology, Washington University School of Medicine, Saint Louis, Missouri 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012767942","display_name":"Lindsey M. Brier","orcid":"https://orcid.org/0000-0002-1831-4935","observed_orcids":["https://orcid.org/0000-0002-1831-4935"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsey Brier","raw_affiliation_strings":["Center for Genome Sciences and Systems Biology, Washington University School of Medicine, Saint Louis, Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genome Sciences and Systems Biology, Washington University School of Medicine, Saint Louis, Missouri 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088483609","display_name":"Nicole C. Howard","orcid":"https://orcid.org/0000-0003-0805-5914","observed_orcids":["https://orcid.org/0000-0003-0805-5914"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole Howard","raw_affiliation_strings":["Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044812923","display_name":"Tamara Lea Doering","orcid":"https://orcid.org/0000-0002-5179-7393","observed_orcids":["https://orcid.org/0000-0002-5179-7393"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamara L Doering","raw_affiliation_strings":["Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010345611","display_name":"Michael R. Brent","orcid":"https://orcid.org/0000-0002-8689-0299","observed_orcids":["https://orcid.org/0000-0002-8689-0299"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael R Brent","raw_affiliation_strings":["Center for Genome Sciences and Systems Biology, Washington University School of Medicine, Saint Louis, Missouri 63110","Department of Computer Science and Engineering, Washington University, Saint Louis, Missouri 63130","Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genome Sciences and Systems Biology, Washington University School of Medicine, Saint Louis, Missouri 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Computer Science and Engineering, Washington University, Saint Louis, Missouri 63130","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri 63110","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010345611"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":2709,"currency":"USD","value_usd":2709},"apc_paid":{"value":2709,"currency":"USD","value_usd":2709},"fwci":0.5336,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.59872197,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"3","first_page":"815","last_page":"822"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.03620000183582306,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cryptococcus-neoformans-var-grubii","display_name":"Cryptococcus neoformans var. grubii","score":0.9449999928474426},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.9089999794960022},{"id":"https://openalex.org/keywords/genome-editing","display_name":"genome editing","score":0.593999981880188},{"id":"https://openalex.org/keywords/compensatory-mutations","display_name":"compensatory mutations","score":0.6990000009536743},{"id":"https://openalex.org/keywords/gene-deletion","display_name":"gene deletion","score":0.8529999852180481},{"id":"https://openalex.org/keywords/drug-resistance-markers","display_name":"drug resistance markers","score":0.6520000100135803},{"id":"https://openalex.org/keywords/gene-expression-changes","display_name":"gene expression changes","score":0.8709999918937683},{"id":"https://openalex.org/keywords/fungal-genome","display_name":"fungal genome","score":0.3479999899864197}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7925264835357666},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.7460584044456482},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7172691822052002},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7014107704162598},{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.6842687726020813},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.6765535473823547},{"id":"https://openalex.org/C2777893358","wikidata":"https://www.wikidata.org/wiki/Q131924","display_name":"Cryptococcus neoformans","level":2,"score":0.6433990597724915},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.4583626687526703},{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.4269183278083801},{"id":"https://openalex.org/C24432333","wikidata":"https://www.wikidata.org/wiki/Q2068526","display_name":"Whole genome sequencing","level":4,"score":0.42369043827056885},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.41696518659591675},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003455","descriptor_name":"Cryptococcus neoformans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003455","descriptor_name":"Cryptococcus neoformans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003455","descriptor_name":"Cryptococcus neoformans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014170","descriptor_name":"Transformation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014170","descriptor_name":"Transformation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014170","descriptor_name":"Transformation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016254","descriptor_name":"Mutagenesis, Insertional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016254","descriptor_name":"Mutagenesis, Insertional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016254","descriptor_name":"Mutagenesis, Insertional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016681","descriptor_name":"Genome, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016681","descriptor_name":"Genome, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016681","descriptor_name":"Genome, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059386","descriptor_name":"Reverse Genetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059386","descriptor_name":"Reverse Genetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059386","descriptor_name":"Reverse Genetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1534/g3.117.300357","doi":"https://doi.org/10.1534/g3.117.300357","is_oa":true,"landing_page_url":"https://doi.org/10.1534/g3.117.300357","pdf_url":null,"source":{"id":"https://openalex.org/S109822313","display_name":"G3 Genes Genomes Genetics","issn_l":"2160-1836","issn":["2160-1836"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319844","host_organization_name":"Genetics Society of America","host_organization_lineage":["https://openalex.org/P4310319844"],"host_organization_lineage_names":["Genetics Society of America"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 Genes|Genomes|Genetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5844303","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5844303","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 (Bethesda)","raw_type":"Text"},{"id":"pmid:29305388","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29305388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 (Bethesda, Md.)","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.wustl.edu:open_access_pubs-7637","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wustl.edu/open_access_pubs/6624","pdf_url":"https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=7637&context=open_access_pubs","source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:7d068d646ee04403ba4cbfca5f838b36","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7d068d646ee04403ba4cbfca5f838b36","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"G3: Genes, Genomes, Genetics, Vol 8, Iss 3, Pp 815-822 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1534/g3.117.300357","doi":"https://doi.org/10.1534/g3.117.300357","is_oa":true,"landing_page_url":"https://doi.org/10.1534/g3.117.300357","pdf_url":null,"source":{"id":"https://openalex.org/S109822313","display_name":"G3 Genes Genomes Genetics","issn_l":"2160-1836","issn":["2160-1836"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319844","host_organization_name":"Genetics Society of America","host_organization_lineage":["https://openalex.org/P4310319844"],"host_organization_lineage_names":["Genetics Society of America"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 Genes|Genomes|Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.800000011920929,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5295506991","display_name":"CAPSULE REGULATION AND VIRULENCE IN CRYPTOCOCCUS NEOFORMANS","funder_award_id":"R01AI087794","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000906309","display_name":"Principles in Pulmonary Research","funder_award_id":"T32HL007317","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1496662040","https://openalex.org/W1535354154","https://openalex.org/W1551144904","https://openalex.org/W1596062789","https://openalex.org/W1872803163","https://openalex.org/W1913132555","https://openalex.org/W1966985102","https://openalex.org/W1984029089","https://openalex.org/W1999888715","https://openalex.org/W1999917330","https://openalex.org/W2018152833","https://openalex.org/W2018416742","https://openalex.org/W2025868705","https://openalex.org/W2051624901","https://openalex.org/W2052948442","https://openalex.org/W2070218828","https://openalex.org/W2082120419","https://openalex.org/W2095680943","https://openalex.org/W2095699986","https://openalex.org/W2097065948","https://openalex.org/W2099636105","https://openalex.org/W2106578986","https://openalex.org/W2108234281","https://openalex.org/W2108973381","https://openalex.org/W2111350087","https://openalex.org/W2117507471","https://openalex.org/W2120277859","https://openalex.org/W2124985265","https://openalex.org/W2126005128","https://openalex.org/W2132378736","https://openalex.org/W2134526812","https://openalex.org/W2136801189","https://openalex.org/W2140948740","https://openalex.org/W2141290892","https://openalex.org/W2142437744","https://openalex.org/W2150506261","https://openalex.org/W2152239989","https://openalex.org/W2170551349","https://openalex.org/W2341852238","https://openalex.org/W2546667113","https://openalex.org/W2557592747","https://openalex.org/W2611697423","https://openalex.org/W2678625059","https://openalex.org/W2773927394","https://openalex.org/W4232677247"],"related_works":["https://openalex.org/W2025868705","https://openalex.org/W3211050020","https://openalex.org/W2001999711","https://openalex.org/W2018416742","https://openalex.org/W2522950276","https://openalex.org/W3120886071","https://openalex.org/W3009325507","https://openalex.org/W2785844090","https://openalex.org/W4397005765","https://openalex.org/W2111794554"],"abstract_inverted_index":{"Abstract":[0],"Received":[1],"wisdom":[2],"in":[3,135],"the":[4,11,35,40,50,64,150,171,176],"field":[5],"of":[6,13,39,42,52,72,159,166,175],"fungal":[7,46],"biology":[8],"holds":[9],"that":[10,26,70,99,144],"process":[12],"editing":[14],"a":[15,45,87,94,97,105,114,141,160],"genome":[16,47,173],"by":[17,48,76,81,156],"transformation":[18,43,71,95],"and":[19,55,84,138,153],"homologous":[20,82],"recombination":[21,83],"is":[22,28,90],"inherently":[23],"mutagenic.":[24],"However,":[25],"belief":[27],"based":[29],"on":[30,44,126],"circumstantial":[31],"evidence.":[32],"We":[33,128],"provide":[34,170],"first":[36],"direct":[37],"measurement":[38],"effects":[41],"sequencing":[49],"genomes":[51],"29":[53],"transformants":[54],"30":[56],"untransformed":[57],"controls":[58],"with":[59],"high":[60],"coverage.":[61],"Contrary":[62],"to":[63],"received":[65],"wisdom,":[66],"our":[67,167],"results":[68],"show":[69],"DNA":[73],"segments":[74],"flanked":[75],"long":[77],"targeting":[78],"sequences,":[79],"followed":[80],"selection":[85],"for":[86,104,133],"drug":[88,161],"marker,":[89],"extremely":[91],"safe.":[92],"If":[93],"deletes":[96],"gene,":[98,115],"may":[100],"create":[101],"selective":[102],"pressure":[103],"few":[106,142],"compensatory":[107],"mutations,":[108],"but":[109],"even":[110],"when":[111],"we":[112,116,169],"deleted":[113],"found":[117,139],"fewer":[118],"than":[119],"two":[120],"point":[121],"mutations":[122],"per":[123],"deletion":[124],"strain,":[125],"average.":[127],"also":[129],"tested":[130],"these":[131],"strains":[132,154],"changes":[134],"gene":[136],"expression":[137],"only":[140],"genes":[143],"were":[145],"consistently":[146],"differentially":[147],"expressed":[148],"between":[149],"wild":[151],"type":[152],"modified":[155],"genomic":[157],"insertion":[158],"resistance":[162],"marker.":[163],"As":[164],"part":[165],"report,":[168],"assembled":[172],"sequence":[174],"commonly":[177],"used":[178],"laboratory":[179],"strain":[180,185],"Cryptococcus":[181],"neoformans":[182],"var.":[183],"grubii":[184],"KN99\u03b1.":[186]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2018-01-12T00:00:00"}
