{"id":"https://openalex.org/W2781679092","doi":"https://doi.org/10.1128/jvi.01848-17","title":"Cleavage of the C-Terminal Fragment of Reovirus \u03bc1 Is Required for Optimal Infectivity","display_name":"Cleavage of the C-Terminal Fragment of Reovirus \u03bc1 Is Required for Optimal Infectivity","publication_year":2018,"publication_date":"2018-01-03","ids":{"openalex":"https://openalex.org/W2781679092","doi":"https://doi.org/10.1128/jvi.01848-17","mag":"2781679092","pmid":"https://pubmed.ncbi.nlm.nih.gov/29298891","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5827373"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.01848-17","doi":"https://doi.org/10.1128/jvi.01848-17","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.01848-17","pdf_url":"https://jvi.asm.org/content/jvi/92/6/e01848-17.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jvi.asm.org/content/jvi/92/6/e01848-17.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086981588","display_name":"Anthony J. Snyder","orcid":"https://orcid.org/0000-0002-2551-9461","observed_orcids":["https://orcid.org/0000-0002-2551-9461"]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony J. Snyder","raw_affiliation_strings":["Department of Biology, Indiana University, Bloomington, Indiana, USA"],"raw_orcid":"https://orcid.org/0000-0002-2551-9461","affiliations":[{"raw_affiliation_string":"Department of Biology, Indiana University, Bloomington, Indiana, USA","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051237839","display_name":"Pranav Danthi","orcid":"https://orcid.org/0000-0001-6199-6022","observed_orcids":["https://orcid.org/0000-0001-6199-6022"]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pranav Danthi","raw_affiliation_strings":["Department of Biology, Indiana University, Bloomington, Indiana, USA"],"raw_orcid":"https://orcid.org/0000-0001-6199-6022","affiliations":[{"raw_affiliation_string":"Department of Biology, Indiana University, Bloomington, Indiana, USA","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1335,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.75259758,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"92","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":0.7782999873161316,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":0.7782999873161316,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.09080000221729279,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.04349999874830246,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reovirus","display_name":"reovirus","score":0.8220000267028809},{"id":"https://openalex.org/keywords/c-terminal-cleavage","display_name":"C-terminal cleavage","score":0.8799999952316284},{"id":"https://openalex.org/keywords/pore-formation","display_name":"pore formation","score":0.6549999713897705},{"id":"https://openalex.org/keywords/membrane-damage","display_name":"membrane damage","score":0.6769999861717224},{"id":"https://openalex.org/keywords/virus-entry","display_name":"viral entry","score":0.7350000143051147},{"id":"https://openalex.org/keywords/endosomal-membrane","display_name":"endosomal membrane","score":0.5410000085830688},{"id":"https://openalex.org/keywords/host-cell-infection","display_name":"host cell infection","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6941378712654114},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6247119307518005},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.6074641942977905},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.6025490760803223},{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.5985154509544373},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5918179154396057},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.583649754524231},{"id":"https://openalex.org/C193469717","wikidata":"https://www.wikidata.org/wiki/Q6556349","display_name":"Lipid-anchored protein","level":4,"score":0.5317560434341431},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5125296115875244},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.49899935722351074},{"id":"https://openalex.org/C97380033","wikidata":"https://www.wikidata.org/wiki/Q994215","display_name":"Viral envelope","level":3,"score":0.48139145970344543},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.4782751500606537},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.4542087912559509},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.43979504704475403},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3439920246601105},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.297066330909729},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2818331718444824},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.2322511374950409},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2067224383354187},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12655207514762878},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012088","descriptor_name":"Reoviridae Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012088","descriptor_name":"Reoviridae Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012088","descriptor_name":"Reoviridae Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D030102","descriptor_name":"Orthoreovirus, Mammalian","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030102","descriptor_name":"Orthoreovirus, Mammalian","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.01848-17","doi":"https://doi.org/10.1128/jvi.01848-17","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.01848-17","pdf_url":"https://jvi.asm.org/content/jvi/92/6/e01848-17.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5050936","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5827373","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5827373","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5827373","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:29298891","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29298891","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/jvi.01848-17","doi":"https://doi.org/10.1128/jvi.01848-17","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.01848-17","pdf_url":"https://jvi.asm.org/content/jvi/92/6/e01848-17.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6575179084","display_name":"Characterizing the Role of Specific Host Lipids during Reovirus Cell Entry","funder_award_id":"F32AI126643","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000873611","display_name":"Regulating the Detection of Reovirus Infection","funder_award_id":"R01AI110637","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2781679092.pdf"},"referenced_works_count":88,"referenced_works":["https://openalex.org/W113368119","https://openalex.org/W184342374","https://openalex.org/W1495951828","https://openalex.org/W1517980685","https://openalex.org/W1536475774","https://openalex.org/W1556205825","https://openalex.org/W1556533824","https://openalex.org/W1556957020","https://openalex.org/W1570356840","https://openalex.org/W1573050949","https://openalex.org/W1574277876","https://openalex.org/W1575702291","https://openalex.org/W1592046893","https://openalex.org/W1654444165","https://openalex.org/W1756615966","https://openalex.org/W1759684705","https://openalex.org/W1795397659","https://openalex.org/W1867247140","https://openalex.org/W1958095582","https://openalex.org/W1966455695","https://openalex.org/W1969261348","https://openalex.org/W1969533384","https://openalex.org/W1970863640","https://openalex.org/W1974225254","https://openalex.org/W1977270787","https://openalex.org/W1979127187","https://openalex.org/W1984355682","https://openalex.org/W1992261249","https://openalex.org/W1998803987","https://openalex.org/W1999853046","https://openalex.org/W2001197606","https://openalex.org/W2001276190","https://openalex.org/W2007841228","https://openalex.org/W2008110664","https://openalex.org/W2008217463","https://openalex.org/W2008328787","https://openalex.org/W2014432612","https://openalex.org/W2019067040","https://openalex.org/W2022712238","https://openalex.org/W2027980197","https://openalex.org/W2028658614","https://openalex.org/W2030140181","https://openalex.org/W2030683115","https://openalex.org/W2032148650","https://openalex.org/W2036258571","https://openalex.org/W2036378627","https://openalex.org/W2042559521","https://openalex.org/W2062111121","https://openalex.org/W2067013875","https://openalex.org/W2067042270","https://openalex.org/W2070556034","https://openalex.org/W2082471681","https://openalex.org/W2083345819","https://openalex.org/W2090821297","https://openalex.org/W2092199562","https://openalex.org/W2094252315","https://openalex.org/W2094396570","https://openalex.org/W2095433366","https://openalex.org/W2096498694","https://openalex.org/W2101200006","https://openalex.org/W2101711240","https://openalex.org/W2103409030","https://openalex.org/W2110596532","https://openalex.org/W2111496511","https://openalex.org/W2114283220","https://openalex.org/W2114570899","https://openalex.org/W2115994196","https://openalex.org/W2116055960","https://openalex.org/W2116380451","https://openalex.org/W2117582775","https://openalex.org/W2122170158","https://openalex.org/W2127939214","https://openalex.org/W2129778565","https://openalex.org/W2131553729","https://openalex.org/W2132702239","https://openalex.org/W2139756641","https://openalex.org/W2142630646","https://openalex.org/W2145386287","https://openalex.org/W2146428253","https://openalex.org/W2153532750","https://openalex.org/W2158062405","https://openalex.org/W2160360322","https://openalex.org/W2165022170","https://openalex.org/W2168736735","https://openalex.org/W2258585930","https://openalex.org/W2523890065","https://openalex.org/W2551044271","https://openalex.org/W4322697540"],"related_works":["https://openalex.org/W1958095582","https://openalex.org/W2117582775","https://openalex.org/W2744792139","https://openalex.org/W6992829151","https://openalex.org/W2096498694","https://openalex.org/W4387597391","https://openalex.org/W2007841228","https://openalex.org/W2070556034","https://openalex.org/W2145386287","https://openalex.org/W2811325608"],"abstract_inverted_index":{"ABSTRACT":[0],"The":[1,87,257],"mammalian":[2,258],"orthoreovirus":[3,259],"(reovirus)":[4,260],"outer":[5,261,302],"capsid,":[6],"which":[7,64,161,270],"is":[8,39,70,91,112,139,162],"composed":[9],"of":[10,17,23,100,130,136,171,178,183,193,244,266,277,289,311,322,331],"200":[11],"\u03bc1/\u03c33":[12],"heterohexamers":[13],"and":[14,32,44,103,107,174,207,254,275,307,337],"a":[15,55,74,146,219,264,339],"maximum":[16],"12":[18],"\u03c31":[19],"trimers,":[20],"contains":[21],"all":[22],"the":[24,49,65,80,84,98,123,127,134,169,176,181,187,199,245,278,287,290,301,309,320,332],"proteins":[25],"that":[26,149,205,222],"are":[27,249],"necessary":[28],"for":[29,165,341],"attaching":[30],"to":[31,78,114,151,180,210,240,313],"entering":[33],"host":[34,85,194,343],"cells.":[35],"Following":[36],"attachment,":[37],"reovirus":[38,148,211,333],"internalized":[40],"by":[41,118,251],"receptor-mediated":[42],"endocytosis":[43],"acid-dependent":[45],"cathepsin":[46],"proteases":[47],"degrade":[48],"\u03c33":[50],"protein.":[51],"This":[52],"process":[53],"generates":[54],"metastable":[56],"intermediate,":[57],"called":[58,92],"infectious":[59],"subviral":[60],"particle":[61,90],"(ISVP),":[62],"in":[63,97,133,156,295],"\u03bc1":[66,101,155],"membrane":[67,235,238,305],"penetration":[68],"protein":[69],"exposed.":[71],"ISVPs":[72],"undergo":[73],"second":[75],"structural":[76],"rearrangement":[77],"deposit":[79],"genome-containing":[81],"core":[82,116],"into":[83],"cytoplasm.":[86],"conformationally":[88],"altered":[89],"ISVP*.":[93],"ISVP-to-ISVP*":[94,166],"conversion":[95],"culminates":[96],"release":[99],"N-":[102],"C-terminal":[104],"fragments,":[105],"\u03bc1N":[106,111,206],"\u03a6,":[108,131],"respectively.":[109],"Released":[110],"thought":[113],"facilitate":[115],"delivery":[117,276],"generating":[119],"size-selective":[120],"pores":[121],"within":[122],"endosomal":[124],"membrane,":[125],"whereas":[126],"precise":[128],"role":[129,288],"particularly":[132],"context":[135],"viral":[137,279],"entry,":[138],"undefined.":[140],"In":[141,282],"this":[142,227,283],"report,":[143,284],"we":[144,285],"characterize":[145,286],"recombinant":[147],"fails":[150],"cleave":[152],"\u03a6":[153,159,188,208,293,298,317],"from":[154,300],"vitro":[157],".":[158],"cleavage,":[160],"not":[163],"required":[164],"conversion,":[167],"enhances":[168,304],"disruption":[170,306],"liposomal":[172],"membranes":[173,217],"facilitates":[175,308],"recruitment":[177,310],"ISVP*s":[179],"site":[182],"pore":[184,212,273,296,334],"formation.":[185,297],"Moreover,":[186,316],"cleavage-deficient":[189],"strain":[190],"initiates":[191],"infection":[192],"cells":[195],"less":[196],"efficiently":[197],"than":[198],"parental":[200],"strain.":[201],"These":[202,247],"results":[203,326],"indicate":[204],"contribute":[209],"forming":[213,335],"activity.":[214],"IMPORTANCE":[215],"Host":[216],"represent":[218],"physical":[220],"barrier":[221],"prevents":[223],"infection.":[224,323],"To":[225],"overcome":[226],"barrier,":[228],"viruses":[229],"utilize":[230],"diverse":[231],"strategies,":[232],"such":[233],"as":[234],"fusion":[236],"or":[237],"disruption,":[239],"access":[241],"internal":[242],"components":[243],"cell.":[246],"strategies":[248],"characterized":[250],"discrete":[252],"protein-protein":[253],"protein-lipid":[255],"interactions.":[256],"capsid":[262,303],"undergoes":[263],"series":[265],"well-defined":[267],"conformational":[268],"changes,":[269],"conclude":[271],"with":[272],"formation":[274],"genetic":[280],"material.":[281],"small,":[291],"reovirus-derived":[292],"peptide":[294],"cleavage":[299,318],"virions":[312],"membrane-associated":[314],"pores.":[315],"promotes":[319],"initiation":[321],"Together,":[324],"these":[325],"reveal":[327],"an":[328],"additional":[329],"component":[330],"apparatus":[336],"highlight":[338],"strategy":[340],"penetrating":[342],"membranes.":[344]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-01-12T00:00:00"}