{"id":"https://openalex.org/W2780970587","doi":"https://doi.org/10.3390/md15120391","title":"LC-MS/MS Detection of Karlotoxins Reveals New Variants in Strains of the Marine Dinoflagellate Karlodinium veneficum from the Ebro Delta (NW Mediterranean)","display_name":"LC-MS/MS Detection of Karlotoxins Reveals New Variants in Strains of the Marine Dinoflagellate Karlodinium veneficum from the Ebro Delta (NW Mediterranean)","publication_year":2017,"publication_date":"2017-12-18","ids":{"openalex":"https://openalex.org/W2780970587","doi":"https://doi.org/10.3390/md15120391","mag":"2780970587","pmid":"https://pubmed.ncbi.nlm.nih.gov/29258236","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5742851"},"language":"en","primary_location":{"id":"doi:10.3390/md15120391","doi":"https://doi.org/10.3390/md15120391","is_oa":true,"landing_page_url":"https://doi.org/10.3390/md15120391","pdf_url":"https://www.mdpi.com/1660-3397/15/12/391/pdf?version=1513587080","source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1660-3397/15/12/391/pdf?version=1513587080","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035818452","display_name":"Bernd Krock","orcid":"https://orcid.org/0000-0003-4022-9101","observed_orcids":["https://orcid.org/0000-0003-4022-9101"]},"institutions":[{"id":"https://openalex.org/I127251866","display_name":"Alfred-Wegener-Institut Helmholtz-Zentrum f\u00fcr Polar- und Meeresforschung","ror":"https://ror.org/032e6b942","country_code":"DE","type":"facility","lineage":["https://openalex.org/I127251866","https://openalex.org/I1305996414"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Bernd Krock","raw_affiliation_strings":["Alfred Wegener Institut-Helmholtz Zentrum f\u00fcr Polar- und Meeresforschung, Chemische \u00d6kologie, Am Handelshafen 12, 27570 Bremerhaven, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alfred Wegener Institut-Helmholtz Zentrum f\u00fcr Polar- und Meeresforschung, Chemische \u00d6kologie, Am Handelshafen 12, 27570 Bremerhaven, Germany","institution_ids":["https://openalex.org/I127251866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112618053","display_name":"Julia Busch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127251866","display_name":"Alfred-Wegener-Institut Helmholtz-Zentrum f\u00fcr Polar- und Meeresforschung","ror":"https://ror.org/032e6b942","country_code":"DE","type":"facility","lineage":["https://openalex.org/I127251866","https://openalex.org/I1305996414"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia Busch","raw_affiliation_strings":["Alfred Wegener Institut-Helmholtz Zentrum f\u00fcr Polar- und Meeresforschung, Chemische \u00d6kologie, Am Handelshafen 12, 27570 Bremerhaven, Germany","Common Wadden Sea Secretariat, Virchowstr. 1, 26382 Wilhelmshaven, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alfred Wegener Institut-Helmholtz Zentrum f\u00fcr Polar- und Meeresforschung, Chemische \u00d6kologie, Am Handelshafen 12, 27570 Bremerhaven, Germany","institution_ids":["https://openalex.org/I127251866"]},{"raw_affiliation_string":"Common Wadden Sea Secretariat, Virchowstr. 1, 26382 Wilhelmshaven, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039623501","display_name":"Urban Tillmann","orcid":"https://orcid.org/0000-0002-8207-4382","observed_orcids":["https://orcid.org/0000-0002-8207-4382"]},"institutions":[{"id":"https://openalex.org/I127251866","display_name":"Alfred-Wegener-Institut Helmholtz-Zentrum f\u00fcr Polar- und Meeresforschung","ror":"https://ror.org/032e6b942","country_code":"DE","type":"facility","lineage":["https://openalex.org/I127251866","https://openalex.org/I1305996414"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Urban Tillmann","raw_affiliation_strings":["Alfred Wegener Institut-Helmholtz Zentrum f\u00fcr Polar- und Meeresforschung, Chemische \u00d6kologie, Am Handelshafen 12, 27570 Bremerhaven, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alfred Wegener Institut-Helmholtz Zentrum f\u00fcr Polar- und Meeresforschung, Chemische \u00d6kologie, Am Handelshafen 12, 27570 Bremerhaven, Germany","institution_ids":["https://openalex.org/I127251866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079449902","display_name":"Francisco Garc\u00eda-Camacho","orcid":"https://orcid.org/0000-0001-6168-3632","observed_orcids":["https://orcid.org/0000-0001-6168-3632","https://orcid.org/0000-0001-6076-3390"]},"institutions":[{"id":"https://openalex.org/I52354020","display_name":"University of Almer\u00eda","ror":"https://ror.org/003d3xx08","country_code":"ES","type":"education","lineage":["https://openalex.org/I52354020"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco Garc\u00eda-Camacho","raw_affiliation_strings":["Chemical Engineering Area, University of Almer\u00eda, 04120 La Ca\u00f1ada, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Engineering Area, University of Almer\u00eda, 04120 La Ca\u00f1ada, Spain","institution_ids":["https://openalex.org/I52354020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030983447","display_name":"A. S\u00e1nchez\u2010Mir\u00f3n","orcid":"https://orcid.org/0000-0001-5119-8035","observed_orcids":["https://orcid.org/0000-0001-5119-8035"]},"institutions":[{"id":"https://openalex.org/I52354020","display_name":"University of Almer\u00eda","ror":"https://ror.org/003d3xx08","country_code":"ES","type":"education","lineage":["https://openalex.org/I52354020"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Asterio S\u00e1nchez-Mir\u00f3n","raw_affiliation_strings":["Chemical Engineering Area, University of Almer\u00eda, 04120 La Ca\u00f1ada, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Engineering Area, University of Almer\u00eda, 04120 La Ca\u00f1ada, Spain","institution_ids":["https://openalex.org/I52354020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042189932","display_name":"Juan Jos\u00e9 Gallardo-Rodr\u00edguez","orcid":"https://orcid.org/0000-0003-2953-7699","observed_orcids":["https://orcid.org/0000-0003-2953-7699"]},"institutions":[{"id":"https://openalex.org/I172787465","display_name":"University of Concepci\u00f3n","ror":"https://ror.org/0460jpj73","country_code":"CL","type":"education","lineage":["https://openalex.org/I172787465"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Juan Gallardo-Rodr\u00edguez","raw_affiliation_strings":["Department of Chemical Engineering, Faculty of Engineering, University of Concepci\u00f3n, Concepci\u00f3n 4030000, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Faculty of Engineering, University of Concepci\u00f3n, Concepci\u00f3n 4030000, Chile","institution_ids":["https://openalex.org/I172787465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023833294","display_name":"L. L\u00f3pez\u2010Rosales","orcid":"https://orcid.org/0000-0001-5881-6086","observed_orcids":["https://orcid.org/0000-0001-5881-6086"]},"institutions":[{"id":"https://openalex.org/I52354020","display_name":"University of Almer\u00eda","ror":"https://ror.org/003d3xx08","country_code":"ES","type":"education","lineage":["https://openalex.org/I52354020"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Lorenzo L\u00f3pez-Rosales","raw_affiliation_strings":["Chemical Engineering Area, University of Almer\u00eda, 04120 La Ca\u00f1ada, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Engineering Area, University of Almer\u00eda, 04120 La Ca\u00f1ada, Spain","institution_ids":["https://openalex.org/I52354020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072312036","display_name":"Karl Blyth Andree","orcid":"https://orcid.org/0000-0001-6564-0015","observed_orcids":["https://orcid.org/0000-0001-6564-0015"]},"institutions":[{"id":"https://openalex.org/I4210100913","display_name":"Institute of Agrifood Research and Technology","ror":"https://ror.org/012zh9h13","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210100913","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Karl Andree","raw_affiliation_strings":["Institut de Recerca i Tecnologia Agroaliment\u00e0ries (IRTA), Ctra Poble Nou km 5.5, 43540 Sant Carles de la Rapita, Tarragona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recerca i Tecnologia Agroaliment\u00e0ries (IRTA), Ctra Poble Nou km 5.5, 43540 Sant Carles de la Rapita, Tarragona, Spain","institution_ids":["https://openalex.org/I4210100913"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079829482","display_name":"Margarita Fern\u00e1ndez\u2010Tejedor","orcid":"https://orcid.org/0000-0002-2875-1135","observed_orcids":["https://orcid.org/0000-0002-2875-1135"]},"institutions":[{"id":"https://openalex.org/I4210100913","display_name":"Institute of Agrifood Research and Technology","ror":"https://ror.org/012zh9h13","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210100913","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Margarita Fern\u00e1ndez-Tejedor","raw_affiliation_strings":["Institut de Recerca i Tecnologia Agroaliment\u00e0ries (IRTA), Ctra Poble Nou km 5.5, 43540 Sant Carles de la Rapita, Tarragona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recerca i Tecnologia Agroaliment\u00e0ries (IRTA), Ctra Poble Nou km 5.5, 43540 Sant Carles de la Rapita, Tarragona, Spain","institution_ids":["https://openalex.org/I4210100913"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058055103","display_name":"Matthias Witt","orcid":"https://orcid.org/0000-0001-6007-0527","observed_orcids":["https://orcid.org/0000-0001-6007-0527"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthias Witt","raw_affiliation_strings":["Bruker Daltonik GmbH, Fahrenheitstr. 4, 28359 Bremen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bruker Daltonik GmbH, Fahrenheitstr. 4, 28359 Bremen, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008577519","display_name":"Allan Douglas Cembella","orcid":"https://orcid.org/0000-0002-1297-2240","observed_orcids":["https://orcid.org/0000-0002-1297-2240"]},"institutions":[{"id":"https://openalex.org/I127251866","display_name":"Alfred-Wegener-Institut Helmholtz-Zentrum f\u00fcr Polar- und Meeresforschung","ror":"https://ror.org/032e6b942","country_code":"DE","type":"facility","lineage":["https://openalex.org/I127251866","https://openalex.org/I1305996414"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Allan Cembella","raw_affiliation_strings":["Alfred Wegener Institut-Helmholtz Zentrum f\u00fcr Polar- und Meeresforschung, Chemische \u00d6kologie, Am Handelshafen 12, 27570 Bremerhaven, Germany"],"raw_orcid":"https://orcid.org/0000-0002-1297-2240","affiliations":[{"raw_affiliation_string":"Alfred Wegener Institut-Helmholtz Zentrum f\u00fcr Polar- und Meeresforschung, Chemische \u00d6kologie, Am Handelshafen 12, 27570 Bremerhaven, Germany","institution_ids":["https://openalex.org/I127251866"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071135069","display_name":"Allen R. Place","orcid":"https://orcid.org/0000-0003-4692-2388","observed_orcids":["https://orcid.org/0000-0003-4692-2388"]},"institutions":[{"id":"https://openalex.org/I149521062","display_name":"University of Maryland Center for Environmental Science","ror":"https://ror.org/04dqdxm60","country_code":"US","type":"education","lineage":["https://openalex.org/I149521062"]},{"id":"https://openalex.org/I4405261322","display_name":"Institute of Marine and Environmental Technology","ror":"https://ror.org/05431kn12","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405261322"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allen Place","raw_affiliation_strings":["Institute of Marine and Environmental Technology, UMCES, Baltimore, MD 21613, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Marine and Environmental Technology, UMCES, Baltimore, MD 21613, USA","institution_ids":["https://openalex.org/I149521062","https://openalex.org/I4405261322"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5035818452"],"corresponding_institution_ids":["https://openalex.org/I127251866"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":1.254,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.7539557,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"15","issue":"12","first_page":"391","last_page":"391"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11985","display_name":"Marine Toxins and Detection Methods","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11985","display_name":"Marine Toxins and Detection Methods","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10032","display_name":"Marine Plankton and Biogeochemistry","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1910","display_name":"Oceanography"},"field":{"id":"https://openalex.org/fields/19","display_name":"Earth and Planetary Sciences"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/karlodinium-veneficum","display_name":"Karlodinium veneficum","score":1.0},{"id":"https://openalex.org/keywords/dinoflagellate-toxins","display_name":"dinoflagellate toxins","score":0.8370000123977661},{"id":"https://openalex.org/keywords/multiple-reaction-monitoring","display_name":"multiple reaction monitoring","score":0.7649999856948853},{"id":"https://openalex.org/keywords/lc-ms-ms-method-development","display_name":"LC-MS/MS method development","score":0.824999988079071},{"id":"https://openalex.org/keywords/toxin-variants","display_name":"toxin variants","score":0.37400001287460327},{"id":"https://openalex.org/keywords/ebro-delta","display_name":"Ebro Delta","score":0.6949999928474426},{"id":"https://openalex.org/keywords/alfacs-bay","display_name":"Alfacs Bay","score":0.9869999885559082},{"id":"https://openalex.org/keywords/collision-induced-dissociation","display_name":"collision-induced dissociation","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C2780204098","wikidata":"https://www.wikidata.org/wiki/Q120490","display_name":"Dinoflagellate","level":2,"score":0.8528946042060852},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.49848079681396484},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.4623033106327057},{"id":"https://openalex.org/C5072461","wikidata":"https://www.wikidata.org/wiki/Q49506","display_name":"Delta","level":2,"score":0.4499184489250183},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.44399237632751465},{"id":"https://openalex.org/C115880899","wikidata":"https://www.wikidata.org/wiki/Q1124247","display_name":"Bay","level":2,"score":0.42968010902404785},{"id":"https://openalex.org/C64489805","wikidata":"https://www.wikidata.org/wiki/Q873864","display_name":"Liquid chromatography\u2013mass spectrometry","level":3,"score":0.4264039397239685},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.41311734914779663},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40805768966674805},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39858269691467285},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.23664799332618713},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.10882353782653809},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10322302579879761},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.08990541100502014},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004141","descriptor_name":"Dinoflagellida","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004141","descriptor_name":"Dinoflagellida","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008387","descriptor_name":"Marine Toxins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008522","descriptor_name":"Mediterranean Sea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011090","descriptor_name":"Polyenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011714","descriptor_name":"Pyrans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059001","descriptor_name":"Aquatic Organisms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.3390/md15120391","doi":"https://doi.org/10.3390/md15120391","is_oa":true,"landing_page_url":"https://doi.org/10.3390/md15120391","pdf_url":"https://www.mdpi.com/1660-3397/15/12/391/pdf?version=1513587080","source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4656089","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5742851","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5742851","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5742851","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mar Drugs","raw_type":"Text"},{"id":"pmid:29258236","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29258236","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine drugs","raw_type":"Journal Article"},{"id":"pmh:oai:epic.awi.de:46079","doi":null,"is_oa":false,"landing_page_url":"https://epic.awi.de/id/eprint/46079/1/Krock_2017.pdf","pdf_url":"https://epic.awi.de/id/eprint/46079/1/Krock_2017.pdf","source":{"id":"https://openalex.org/S4306400378","display_name":"Helmholtz-Zentrum f\u00fcr Polar-und Meeresforschung (Alfred-Wegener-Institut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799732068","host_organization_name":"Royal Prince Alfred Hospital","host_organization_lineage":["https://openalex.org/I2799732068"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:repositori.irta.cat:20.500.12327/1849","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12327/1849","pdf_url":"https://repositori.irta.cat/bitstream/20.500.12327/1849/1/Krock_LcMs_2017.pdf","source":{"id":"https://openalex.org/S4306401920","display_name":"IRTA (Institut de Recerca i Tecnologia Agroalimentaries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210100913","host_organization_name":"Institute of Agrifood Research and Technology","host_organization_lineage":["https://openalex.org/I4210100913"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dnet:riualreposit::1d5649d082c3e9b44d73a7b6906ec059","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10835/7325","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:281eae6bd4bd437a8179dea6b70f51f9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/281eae6bd4bd437a8179dea6b70f51f9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Marine Drugs, Vol 15, Iss 12, p 391 (2017)","raw_type":"article"},{"id":"pmh:oai:repositorio.ual.es:10835/7325","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10835/7325","pdf_url":null,"source":{"id":"https://openalex.org/S4306400756","display_name":"Repositorio de Patentes de la Universidad de Almer\u00eda (Universidad de Almer\u00eda)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/md15120391","doi":"https://doi.org/10.3390/md15120391","is_oa":true,"landing_page_url":"https://doi.org/10.3390/md15120391","pdf_url":"https://www.mdpi.com/1660-3397/15/12/391/pdf?version=1513587080","source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2041438762","display_name":null,"funder_award_id":"SAF2011-28883-C03-02","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G256251933","display_name":null,"funder_award_id":"NOAA-NOS-NCCOS-2012-2002987","funder_id":"https://openalex.org/F4320332181","funder_display_name":"National Oceanic and Atmospheric Administration"},{"id":"https://openalex.org/G3840495656","display_name":null,"funder_award_id":"CTQ2014-55888-C3-02","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G4034572470","display_name":null,"funder_award_id":"CTQ2014","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G8094374727","display_name":"Translation regulation of gene expression in toxic dinoflagellates","funder_award_id":"R01ES021949","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G8372636845","display_name":null,"funder_award_id":"CTQ2014-55888-C3-02","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G873436557","display_name":null,"funder_award_id":"SAF2011-28883-C03-02","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"}],"funders":[{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332181","display_name":"National Oceanic and Atmospheric Administration","ror":"https://ror.org/02z5nhe81"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337947","display_name":"National Centers for Coastal Ocean Science","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2780970587.pdf","grobid_xml":"https://content.openalex.org/works/W2780970587.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W962303251","https://openalex.org/W1453749980","https://openalex.org/W1963964735","https://openalex.org/W1964369099","https://openalex.org/W1975663903","https://openalex.org/W1982917597","https://openalex.org/W1984381843","https://openalex.org/W1985148010","https://openalex.org/W1988770789","https://openalex.org/W1990766751","https://openalex.org/W1994471277","https://openalex.org/W2011702233","https://openalex.org/W2013358605","https://openalex.org/W2020539203","https://openalex.org/W2021708856","https://openalex.org/W2023450466","https://openalex.org/W2031712417","https://openalex.org/W2034306495","https://openalex.org/W2035714583","https://openalex.org/W2063453578","https://openalex.org/W2066208599","https://openalex.org/W2070563113","https://openalex.org/W2071753201","https://openalex.org/W2074504557","https://openalex.org/W2074731222","https://openalex.org/W2075341087","https://openalex.org/W2081328670","https://openalex.org/W2086217848","https://openalex.org/W2087989091","https://openalex.org/W2089903742","https://openalex.org/W2090504536","https://openalex.org/W2115471318","https://openalex.org/W2122698930","https://openalex.org/W2157008267","https://openalex.org/W2317476304","https://openalex.org/W2323259190","https://openalex.org/W2473664811","https://openalex.org/W2586506051","https://openalex.org/W2604591414","https://openalex.org/W2619132735","https://openalex.org/W2970999560","https://openalex.org/W4244236213"],"related_works":["https://openalex.org/W2066208599","https://openalex.org/W2511269569","https://openalex.org/W2034306495","https://openalex.org/W2074504557","https://openalex.org/W2020539203","https://openalex.org/W4414299261","https://openalex.org/W2324435544","https://openalex.org/W2053882159","https://openalex.org/W4407230414","https://openalex.org/W18597846"],"abstract_inverted_index":{"A":[0],"liquid":[1],"chromatography-tandem":[2],"mass":[3],"spectrometry":[4],"(LC-MS/MS)":[5],"method":[6,25,71,189],"was":[7,26,74],"developed":[8],"for":[9,72,98],"the":[10,17,29,48,69,114,148,155,168,195,202],"detection":[11,67],"and":[12,41,62,132,135],"quantitation":[13],"of":[14,31,44,47,66,68,85,95,104,113,141,144,186,197,204,208,212],"karlotoxins":[15,33,88,124,172],"in":[16,154,158,194,201],"selected":[18],"reaction":[19],"monitoring":[20],"(SRM)":[21],"mode.":[22],"This":[23],"novel":[24,171],"based":[27],"upon":[28],"analysis":[30],"purified":[32,209],"(KcTx-1,":[34],"KmTx-2,":[35],"44-oxo-KmTx-2,":[36],"KmTx-5),":[37],"one":[38,160],"amphidinol":[39],"(AM-18),":[40],"unpurified":[42],"extracts":[43],"bulk":[45],"cultures":[46,103],"marine":[49],"dinoflagellate":[50],"Karlodinium":[51],"veneficum":[52,106,146],"strain":[53,107],"CCMP2936":[54],"from":[55,110,147,162,178],"Delaware":[56],"(Eastern":[57],"USA),":[58],"which":[59],"produces":[60],"KmTx-1":[61],"KmTx-3.":[63],"The":[64],"limit":[65],"SRM":[70],"KmTx-2":[73],"determined":[75],"as":[76],"2.5":[77],"ng":[78],"on-column.":[79],"Collision":[80],"induced":[81],"dissociation":[82],"(CID)":[83],"spectra":[84],"all":[86],"putative":[87,123,170,198],"were":[89,173],"recorded":[90],"to":[91,138],"present":[92],"fragmentation":[93],"patterns":[94],"each":[96],"compound":[97],"their":[99],"unambiguous":[100],"identification.":[101],"Bulk":[102],"K.":[105,145],"K10":[108],"isolated":[109],"an":[111,191],"embayment":[112],"Ebro":[115,149],"Delta,":[116],"NW":[117],"Mediterranean,":[118],"yielded":[119],"five":[120,169],"previously":[121],"unreported":[122],"with":[125],"molecular":[126],"masses":[127],"1280,":[128],"1298,":[129],"1332,":[130],"1356,":[131],"1400":[133],"Da,":[134],"similar":[136],"fragments":[137],"KmTx-5.":[139],"Analysis":[140],"several":[142,176],"isolates":[143,177],"Delta":[150],"revealed":[151],"small-scale":[152],"diversity":[153],"karlotoxin":[156],"spectrum":[157,207],"that":[159],"isolate":[161],"Fangar":[163],"Bay":[164],"produced":[165],"KmTx-5,":[166],"whereas":[167],"found":[174],"among":[175],"nearby,":[179],"but":[180],"hydrographically":[181],"distinct":[182],"Alfacs":[183],"Bay.":[184],"Application":[185],"this":[187],"LC-MS/MS":[188],"represents":[190],"incremental":[192],"advance":[193],"determination":[196],"karlotoxins,":[199],"particularly":[200],"absence":[203],"a":[205],"complete":[206],"analytical":[210],"standards":[211],"known":[213],"specific":[214],"potency.":[215]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-01-05T00:00:00"}