{"id":"https://openalex.org/W2780966849","doi":"https://doi.org/10.1039/c7tx00189d","title":"Role of GSK3\u03b2/\u03b1-synuclein axis in methamphetamine-induced neurotoxicity in PC12 cells","display_name":"Role of GSK3\u03b2/\u03b1-synuclein axis in methamphetamine-induced neurotoxicity in PC12 cells","publication_year":2017,"publication_date":"2017-12-22","ids":{"openalex":"https://openalex.org/W2780966849","doi":"https://doi.org/10.1039/c7tx00189d","mag":"2780966849","pmid":"https://pubmed.ncbi.nlm.nih.gov/30090577","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6062219"},"language":"en","primary_location":{"id":"doi:10.1039/c7tx00189d","doi":"https://doi.org/10.1039/c7tx00189d","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c7tx00189d","pdf_url":"https://academic.oup.com/toxres/article-pdf/7/2/221/30114584/c7tx00189d.pdf","source":{"id":"https://openalex.org/S2494971184","display_name":"Toxicology Research","issn_l":"2045-452X","issn":["2045-452X","2045-4538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","ki-jl-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/toxres/article-pdf/7/2/221/30114584/c7tx00189d.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053237939","display_name":"Lizeng Li","orcid":"https://orcid.org/0000-0003-3237-6371","observed_orcids":["https://orcid.org/0000-0003-3237-6371"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lizeng Li","raw_affiliation_strings":["Guangzhou 510515","People's Republic of China","School of Forensic Medicine","Southern Medical University","Fax: +86 2062789046","School of Forensic Medicine, Southern Medical University, Guangzhou 510515, People's Republic of China. Tel: +86 2062789101"],"raw_orcid":"https://orcid.org/0000-0003-3237-6371","affiliations":[{"raw_affiliation_string":"Guangzhou 510515","institution_ids":[]},{"raw_affiliation_string":"People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"School of Forensic Medicine","institution_ids":[]},{"raw_affiliation_string":"Southern Medical University","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Fax: +86 2062789046","institution_ids":[]},{"raw_affiliation_string":"School of Forensic Medicine, Southern Medical University, Guangzhou 510515, People's Republic of China. Tel: +86 2062789101","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100366191","display_name":"Si Xuan Chen","orcid":"https://orcid.org/0000-0002-4196-0740","observed_orcids":["https://orcid.org/0000-0002-4196-0740"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Si Chen","raw_affiliation_strings":["Guangzhou 510515","People's Republic of China","School of Forensic Medicine","Southern Medical University","Fax: +86 2062789046","School of Forensic Medicine, Southern Medical University, Guangzhou 510515, People's Republic of China. Tel: +86 2062789101"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou 510515","institution_ids":[]},{"raw_affiliation_string":"People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"School of Forensic Medicine","institution_ids":[]},{"raw_affiliation_string":"Southern Medical University","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Fax: +86 2062789046","institution_ids":[]},{"raw_affiliation_string":"School of Forensic Medicine, Southern Medical University, Guangzhou 510515, People's Republic of China. Tel: +86 2062789101","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100371989","display_name":"Yue Wang","orcid":"https://orcid.org/0000-0002-0556-955X","observed_orcids":["https://orcid.org/0000-0002-0556-955X"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Wang","raw_affiliation_strings":["Guangzhou 510515","People's Republic of China","School of Forensic Medicine","Southern Medical University","Fax: +86 2062789046","School of Forensic Medicine, Southern Medical University, Guangzhou 510515, People's Republic of China. Tel: +86 2062789101"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou 510515","institution_ids":[]},{"raw_affiliation_string":"People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"School of Forensic Medicine","institution_ids":[]},{"raw_affiliation_string":"Southern Medical University","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Fax: +86 2062789046","institution_ids":[]},{"raw_affiliation_string":"School of Forensic Medicine, Southern Medical University, Guangzhou 510515, People's Republic of China. Tel: +86 2062789101","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106266071","display_name":"Xia Yue","orcid":"https://orcid.org/0000-0002-5842-2295","observed_orcids":["https://orcid.org/0000-0002-5842-2295"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xia Yue","raw_affiliation_strings":["Guangzhou 510515","People's Republic of China","School of Forensic Medicine","Southern Medical University","Fax: +86 2062789046","School of Forensic Medicine, Southern Medical University, Guangzhou 510515, People's Republic of China. Tel: +86 2062789101"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou 510515","institution_ids":[]},{"raw_affiliation_string":"People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"School of Forensic Medicine","institution_ids":[]},{"raw_affiliation_string":"Southern Medical University","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Fax: +86 2062789046","institution_ids":[]},{"raw_affiliation_string":"School of Forensic Medicine, Southern Medical University, Guangzhou 510515, People's Republic of China. Tel: +86 2062789101","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100549784","display_name":"Jingtao Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingtao Xu","raw_affiliation_strings":["Guangzhou 510515","People's Republic of China","School of Forensic Medicine","Southern Medical University","Fax: +86 2062789046","School of Forensic Medicine, Southern Medical University, Guangzhou 510515, People's Republic of China. Tel: +86 2062789101"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou 510515","institution_ids":[]},{"raw_affiliation_string":"People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"School of Forensic Medicine","institution_ids":[]},{"raw_affiliation_string":"Southern Medical University","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Fax: +86 2062789046","institution_ids":[]},{"raw_affiliation_string":"School of Forensic Medicine, Southern Medical University, Guangzhou 510515, People's Republic of China. Tel: +86 2062789101","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016512307","display_name":"Wei\u2010Bing Xie","orcid":"https://orcid.org/0000-0003-4292-3674","observed_orcids":["https://orcid.org/0000-0003-4292-3674"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weibing Xie","raw_affiliation_strings":["Guangzhou 510515","People's Republic of China","School of Forensic Medicine","Southern Medical University","Fax: +86 2062789046","School of Forensic Medicine, Southern Medical University, Guangzhou 510515, People's Republic of China. Tel: +86 2062789101"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou 510515","institution_ids":[]},{"raw_affiliation_string":"People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"School of Forensic Medicine","institution_ids":[]},{"raw_affiliation_string":"Southern Medical University","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Fax: +86 2062789046","institution_ids":[]},{"raw_affiliation_string":"School of Forensic Medicine, Southern Medical University, Guangzhou 510515, People's Republic of China. Tel: +86 2062789101","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026015910","display_name":"Pingming Qiu","orcid":"https://orcid.org/0000-0002-5579-1124","observed_orcids":["https://orcid.org/0000-0002-5579-1124"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pingming Qiu","raw_affiliation_strings":["Guangzhou 510515","People's Republic of China","School of Forensic Medicine","Southern Medical University","Fax: +86 2062789046","School of Forensic Medicine, Southern Medical University, Guangzhou 510515, People's Republic of China. Tel: +86 2062789101"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou 510515","institution_ids":[]},{"raw_affiliation_string":"People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"School of Forensic Medicine","institution_ids":[]},{"raw_affiliation_string":"Southern Medical University","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Fax: +86 2062789046","institution_ids":[]},{"raw_affiliation_string":"School of Forensic Medicine, Southern Medical University, Guangzhou 510515, People's Republic of China. Tel: +86 2062789101","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chao Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chao Liu","raw_affiliation_strings":["Guangzhou 510030","Guangzhou Forensic Science Institute","People's Republic of China","Guangzhou Forensic Science Institute, Guangzhou 510030, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou 510030","institution_ids":[]},{"raw_affiliation_string":"Guangzhou Forensic Science Institute","institution_ids":[]},{"raw_affiliation_string":"People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Guangzhou Forensic Science Institute, Guangzhou 510030, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025298452","display_name":"AiFeng Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"AiFeng Wang","raw_affiliation_strings":["Guangzhou 510515","People's Republic of China","School of Forensic Medicine","Southern Medical University","Fax: +86 2062789046","School of Forensic Medicine, Southern Medical University, Guangzhou 510515, People's Republic of China. Tel: +86 2062789101"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou 510515","institution_ids":[]},{"raw_affiliation_string":"People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"School of Forensic Medicine","institution_ids":[]},{"raw_affiliation_string":"Southern Medical University","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Fax: +86 2062789046","institution_ids":[]},{"raw_affiliation_string":"School of Forensic Medicine, Southern Medical University, Guangzhou 510515, People's Republic of China. Tel: +86 2062789101","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100416394","display_name":"Huijun Wang","orcid":"https://orcid.org/0000-0001-5414-1472","observed_orcids":["https://orcid.org/0000-0001-5414-1472","https://orcid.org/0000-0003-2590-6020","https://orcid.org/0000-0003-2026-6140"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huijun Wang","raw_affiliation_strings":["Guangzhou 510515","People's Republic of China","School of Forensic Medicine","Southern Medical University","Fax: +86 2062789046","School of Forensic Medicine, Southern Medical University, Guangzhou 510515, People's Republic of China. Tel: +86 2062789101"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou 510515","institution_ids":[]},{"raw_affiliation_string":"People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"School of Forensic Medicine","institution_ids":[]},{"raw_affiliation_string":"Southern Medical University","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Fax: +86 2062789046","institution_ids":[]},{"raw_affiliation_string":"School of Forensic Medicine, Southern Medical University, Guangzhou 510515, People's Republic of China. Tel: +86 2062789101","institution_ids":["https://openalex.org/I58200834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025298452","https://openalex.org/A5100416394"],"corresponding_institution_ids":["https://openalex.org/I58200834"],"apc_list":{"value":2560,"currency":"USD","value_usd":2560},"apc_paid":null,"fwci":1.5146,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.82303256,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"7","issue":"2","first_page":"221","last_page":"234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methamphetamine","display_name":"methamphetamine","score":0.9589999914169312},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.9610000252723694},{"id":"https://openalex.org/keywords/gsk-3beta","display_name":"GSK3\u03b2","score":0.9459999799728394},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.921999990940094},{"id":"https://openalex.org/keywords/tau-phosphorylation","display_name":"tau phosphorylation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.7770000100135803},{"id":"https://openalex.org/keywords/glucocerebrosidase","display_name":"glucocerebrosidase","score":0.9629999995231628},{"id":"https://openalex.org/keywords/limp-2","display_name":"LIMP-2","score":0.9919999837875366},{"id":"https://openalex.org/keywords/lithium-chloride","display_name":"lithium chloride","score":0.8199999928474426},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.925000011920929},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.6899999976158142},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.7559999823570251},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.8786457180976868},{"id":"https://openalex.org/C2780376393","wikidata":"https://www.wikidata.org/wiki/Q191924","display_name":"Methamphetamine","level":2,"score":0.7974791526794434},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47854194045066833},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41760846972465515},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40583133697509766},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3478918671607971},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2413959503173828},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23092061281204224},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.2027755081653595}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1039/c7tx00189d","doi":"https://doi.org/10.1039/c7tx00189d","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c7tx00189d","pdf_url":"https://academic.oup.com/toxres/article-pdf/7/2/221/30114584/c7tx00189d.pdf","source":{"id":"https://openalex.org/S2494971184","display_name":"Toxicology Research","issn_l":"2045-452X","issn":["2045-452X","2045-4538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","ki-jl-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5271755","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6062219","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6062219","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6062219","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicol Res (Camb)","raw_type":"Text"},{"id":"pmid:30090577","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30090577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1039/c7tx00189d","doi":"https://doi.org/10.1039/c7tx00189d","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c7tx00189d","pdf_url":"https://academic.oup.com/toxres/article-pdf/7/2/221/30114584/c7tx00189d.pdf","source":{"id":"https://openalex.org/S2494971184","display_name":"Toxicology Research","issn_l":"2045-452X","issn":["2045-452X","2045-4538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","ki-jl-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2329117242","display_name":null,"funder_award_id":"Grant No. 2015A030310434","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G4503323154","display_name":null,"funder_award_id":"Grant No. 81501628","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2780966849.pdf","grobid_xml":"https://content.openalex.org/works/W2780966849.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W114737604","https://openalex.org/W628958324","https://openalex.org/W1173809700","https://openalex.org/W1495904497","https://openalex.org/W1542222030","https://openalex.org/W1561899360","https://openalex.org/W1572032866","https://openalex.org/W1579214214","https://openalex.org/W1585155225","https://openalex.org/W1964350538","https://openalex.org/W1968812021","https://openalex.org/W1970330967","https://openalex.org/W1977224722","https://openalex.org/W1993327095","https://openalex.org/W1993871977","https://openalex.org/W2001764117","https://openalex.org/W2003448331","https://openalex.org/W2012879006","https://openalex.org/W2020167843","https://openalex.org/W2031365272","https://openalex.org/W2033062161","https://openalex.org/W2037923368","https://openalex.org/W2039571337","https://openalex.org/W2040691826","https://openalex.org/W2041497611","https://openalex.org/W2044446578","https://openalex.org/W2047677635","https://openalex.org/W2051728587","https://openalex.org/W2071871730","https://openalex.org/W2079994150","https://openalex.org/W2093891050","https://openalex.org/W2106796327","https://openalex.org/W2110494223","https://openalex.org/W2114800281","https://openalex.org/W2118940054","https://openalex.org/W2131978771","https://openalex.org/W2134898475","https://openalex.org/W2140529212","https://openalex.org/W2144140825","https://openalex.org/W2147906131","https://openalex.org/W2154345916","https://openalex.org/W2164778558","https://openalex.org/W2169923780","https://openalex.org/W2189621653","https://openalex.org/W2226005455","https://openalex.org/W2316647542","https://openalex.org/W2327459035","https://openalex.org/W2415987739","https://openalex.org/W2466907804","https://openalex.org/W2515345382","https://openalex.org/W2562372517","https://openalex.org/W2577340531","https://openalex.org/W2752326209","https://openalex.org/W4293242696"],"related_works":["https://openalex.org/W3006815996","https://openalex.org/W3015547199","https://openalex.org/W2991185479","https://openalex.org/W3127292896","https://openalex.org/W3177210303","https://openalex.org/W1997709410","https://openalex.org/W3201455550","https://openalex.org/W2943419283","https://openalex.org/W3036227946","https://openalex.org/W2905491748"],"abstract_inverted_index":{"Methamphetamine":[0],"(METH)":[1],"is":[2],"well-known":[3],"as":[4],"a":[5,50,265],"potent":[6],"psychostimulant":[7],"of":[8,44,53,58,71,164,181,202],"abuse":[9],"worldwide.":[10],"METH":[11,39,98,157,203,224],"administration":[12,99],"can":[13],"cause":[14,52],"neurotoxicity":[15,237],"and":[16,31,77,91,102,136,140,150,166,169,177,214,218,238,246,254,260],"neurodegenerative":[17,26,239],"injury,":[18],"which":[19],"are":[20],"similar":[21],"to":[22,257,268],"the":[23,42,56,69,107,125,132,153,159,170,182,200,211,223,250],"two":[24],"prevalent":[25],"disorders":[27],"Alzheimer's":[28],"disease":[29,33],"(AD)":[30],"Parkinson's":[32],"(PD).":[34],"Recent":[35],"results":[36,83],"suggested":[37],"that":[38,47,85,122,145,230],"exposure":[40],"increased":[41,96,210],"level":[43],"\u03b1-synuclein":[45],"(\u03b1-syn)":[46],"could":[48],"be":[49,264],"possible":[51],"neurotoxicity.":[54,81],"However,":[55],"mechanism":[57],"METH-induced":[59,80,236,270],"neurodegeneration":[60],"remains":[61],"unclear.":[62],"This":[63],"study":[64],"was":[65,173],"aimed":[66],"at":[67],"examining":[68],"effects":[70],"glycogen":[72],"synthase":[73],"kinase3\u03b2":[74],"(GSK3\u03b2),":[75],"\u03b1-syn,":[76,90],"tau":[78],"on":[79],"Our":[82],"indicated":[84],"P-GSK3\u03b2":[86,146],"(Tyr216),":[87],"P-Tau":[88,149],"(Ser396),":[89],"P-\u03b1-syn":[92],"(Ser129)":[93],"levels":[94],"were":[95,117],"after":[97],"in":[100,235],"dose-":[101],"time-dependent":[103],"manners.":[104],"Upon":[105],"inhibiting":[106],"GSK3\u03b2":[108,231,262],"activity":[109],"with":[110,148,188,199],"LiCl":[111,123,176,215],"or":[112],"GSK3\u03b2-siRNA,":[113],"these":[114],"protein":[115,194,244],"expressions":[116,180,220],"significantly":[118],"decreased.":[119],"We":[120,142],"observed":[121],"protected":[124],"cells":[126],"from":[127],"METH-caused":[128],"cytotoxicity":[129],"by":[130,152,162,175,222,241],"weakening":[131],"cell":[133,138,258],"morphological":[134],"damage":[135],"preventing":[137],"apoptosis":[139,259],"death.":[141,261],"also":[143],"found":[144],"colocalized":[147],"\u03b1-syn":[151,212,247],"immunofluorescence":[154],"method.":[155],"Further,":[156],"disrupted":[158,221],"cellular":[160,171],"autophagy":[161,172],"upregulation":[163],"LC3-II":[165],"P62":[167],"proteins,":[168],"restored":[174,216],"GSK3\u03b2-siRNA.":[178],"The":[179,205],"\u03b1-syn-specific":[183],"degradative":[184],"enzyme":[185],"glucocerebrosidase":[186],"(GCase)":[187],"its":[189],"regulator":[190],"lysosomal":[191],"integral":[192],"membrane":[193],"type-2":[195],"(LIMP-2)":[196],"decreased":[197],"inversely":[198],"doses":[201],"treatment.":[204,225],"GCase":[206,217],"inhibitor":[207],"conduritol-\u03b2-epoxide":[208],"(C\u03b2E)":[209],"levels,":[213],"LIMP-2":[219],"In":[226],"summary,":[227],"we":[228],"conclude":[229],"plays":[232],"key":[233],"roles":[234],"injury":[240],"promoting":[242],"abnormal":[243],"phosphorylation":[245],"accumulation,":[248],"blocking":[249],"autophagy-lysosomal":[251],"degradation":[252],"pathway,":[253],"finally":[255],"leading":[256],"may":[263],"potential":[266],"target":[267],"prevent":[269],"neurodegeneration.":[271]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2018-01-05T00:00:00"}
