{"id":"https://openalex.org/W2780484652","doi":"https://doi.org/10.1186/s12969-017-0212-y","title":"Pharmacokinetic and safety profile of tofacitinib in children with polyarticular course juvenile idiopathic arthritis: results of a phase 1, open-label, multicenter study","display_name":"Pharmacokinetic and safety profile of tofacitinib in children with polyarticular course juvenile idiopathic arthritis: results of a phase 1, open-label, multicenter study","publication_year":2017,"publication_date":"2017-12-01","ids":{"openalex":"https://openalex.org/W2780484652","doi":"https://doi.org/10.1186/s12969-017-0212-y","mag":"2780484652","pmid":"https://pubmed.ncbi.nlm.nih.gov/29282090","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5745974"},"language":"en","primary_location":{"id":"doi:10.1186/s12969-017-0212-y","doi":"https://doi.org/10.1186/s12969-017-0212-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12969-017-0212-y","pdf_url":null,"source":{"id":"https://openalex.org/S121831025","display_name":"Pediatric Rheumatology","issn_l":"1546-0096","issn":["1546-0096"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Rheumatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12969-017-0212-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080140512","display_name":"Nicolino Ruperto","orcid":"https://orcid.org/0000-0001-8407-7782","observed_orcids":["https://orcid.org/0000-0001-8407-7782"]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Nicolino Ruperto","raw_affiliation_strings":["Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy. nicolaruperto@gaslini.org","Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy. nicolaruperto@gaslini.org","institution_ids":["https://openalex.org/I2801463291"]},{"raw_affiliation_string":"Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy","institution_ids":["https://openalex.org/I2801463291"]}]},{"author_position":"middle","author":{"id":null,"display_name":"the Pediatric Rheumatology Collaborative Study Group (PRCSG)","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"the Pediatric Rheumatology Collaborative Study Group (PRCSG)","raw_affiliation_strings":["Cincinnati Children's Hospital Medical Center, PRCSG, Cincinnati, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital Medical Center, PRCSG, Cincinnati, OH, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021386589","display_name":"Hermine I. Brunner","orcid":"https://orcid.org/0000-0001-9478-2987","observed_orcids":["https://orcid.org/0000-0001-9478-2987"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hermine I. Brunner","raw_affiliation_strings":["Cincinnati Children's Hospital Medical Center, PRCSG, Cincinnati, OH, USA","St Louis Children's Hospital ODS Rheumatology and Neurology, Krakow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital Medical Center, PRCSG, Cincinnati, OH, USA","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"St Louis Children's Hospital ODS Rheumatology and Neurology, Krakow, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012015082","display_name":"Zbigniew Micha\u0142 \u017buber","orcid":"https://orcid.org/0000-0001-9581-0601","observed_orcids":["https://orcid.org/0000-0001-9581-0601"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zbigniew Zuber","raw_affiliation_strings":["St Louis Children's Hospital ODS Rheumatology and Neurology, Krakow, Poland","Pediatric Rheumatology Research Institute, Bad Bramstedt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Louis Children's Hospital ODS Rheumatology and Neurology, Krakow, Poland","institution_ids":[]},{"raw_affiliation_string":"Pediatric Rheumatology Research Institute, Bad Bramstedt, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054063371","display_name":"Nikolay Tzaribachev","orcid":"https://orcid.org/0000-0001-9215-0783","observed_orcids":["https://orcid.org/0000-0001-9215-0783"]},"institutions":[{"id":"https://openalex.org/I4210104586","display_name":"Randall Children's Hospital at Legacy Emanuel","ror":"https://ror.org/00x2q5f89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I163879017","https://openalex.org/I4210104586"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikolay Tzaribachev","raw_affiliation_strings":["Pediatric Rheumatology Research Institute, Bad Bramstedt, Germany","Randall Children's Hospital, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Rheumatology Research Institute, Bad Bramstedt, Germany","institution_ids":[]},{"raw_affiliation_string":"Randall Children's Hospital, Portland, OR, USA","institution_ids":["https://openalex.org/I4210104586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034764312","display_name":"Daniel J. Kingsbury","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104586","display_name":"Randall Children's Hospital at Legacy Emanuel","ror":"https://ror.org/00x2q5f89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I163879017","https://openalex.org/I4210104586"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. Kingsbury","raw_affiliation_strings":["Randall Children's Hospital, Portland, OR, USA","Hamburger Zentrum f\u00fcr Kinder- und Jugendrheumatologie, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Randall Children's Hospital, Portland, OR, USA","institution_ids":["https://openalex.org/I4210104586"]},{"raw_affiliation_string":"Hamburger Zentrum f\u00fcr Kinder- und Jugendrheumatologie, Hamburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020603336","display_name":"Ivan Foeldvari","orcid":"https://orcid.org/0000-0003-0659-5298","observed_orcids":["https://orcid.org/0000-0003-0659-5298"]},"institutions":[{"id":"https://openalex.org/I4210128171","display_name":"Asklepios Klinik Sankt Augustin","ror":"https://ror.org/038v5jv72","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210128171"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ivan Foeldvari","raw_affiliation_strings":["Hamburger Zentrum f\u00fcr Kinder- und Jugendrheumatologie, Hamburg, Germany","Centre of General Pediatrics and Neonatology, Asklepios Klinik, Sankt Augustin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hamburger Zentrum f\u00fcr Kinder- und Jugendrheumatologie, Hamburg, Germany","institution_ids":[]},{"raw_affiliation_string":"Centre of General Pediatrics and Neonatology, Asklepios Klinik, Sankt Augustin, Germany","institution_ids":["https://openalex.org/I4210128171"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053719643","display_name":"Gerd Horneff","orcid":"https://orcid.org/0000-0001-5491-7832","observed_orcids":["https://orcid.org/0000-0001-5491-7832"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]},{"id":"https://openalex.org/I4210128171","display_name":"Asklepios Klinik Sankt Augustin","ror":"https://ror.org/038v5jv72","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210128171"]}],"countries":["DE","PL"],"is_corresponding":false,"raw_author_name":"Gerd Horneff","raw_affiliation_strings":["Centre of General Pediatrics and Neonatology, Asklepios Klinik, Sankt Augustin, Germany","Department of Pediatric Rheumatology, Medical University of Lodz, Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre of General Pediatrics and Neonatology, Asklepios Klinik, Sankt Augustin, Germany","institution_ids":["https://openalex.org/I4210128171"]},{"raw_affiliation_string":"Department of Pediatric Rheumatology, Medical University of Lodz, Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009579378","display_name":"El\u017cbieta Barbara Smolewska","orcid":"https://orcid.org/0000-0002-8421-0448","observed_orcids":["https://orcid.org/0000-0002-8421-0448"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]},{"id":"https://openalex.org/I4210166300","display_name":"University of Minnesota Children's Hospital","ror":"https://ror.org/05jc5ee02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1309104334","https://openalex.org/I4210166300"]}],"countries":["PL","US"],"is_corresponding":false,"raw_author_name":"Elzbieta Smolewska","raw_affiliation_strings":["Department of Pediatric Rheumatology, Medical University of Lodz, Lodz, Poland","University of Minnesota Masonic Children's Hospital, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Rheumatology, Medical University of Lodz, Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]},{"raw_affiliation_string":"University of Minnesota Masonic Children's Hospital, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210166300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063503884","display_name":"Richard K. Vehe","orcid":"https://orcid.org/0000-0003-4679-8305","observed_orcids":["https://orcid.org/0000-0003-4679-8305"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I4210166300","display_name":"University of Minnesota Children's Hospital","ror":"https://ror.org/05jc5ee02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1309104334","https://openalex.org/I4210166300"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard K. Vehe","raw_affiliation_strings":["University of Minnesota Masonic Children's Hospital, Minneapolis, MN, USA","Pfizer Inc, Collegeville, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota Masonic Children's Hospital, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210166300"]},{"raw_affiliation_string":"Pfizer Inc, Collegeville, PA, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108882392","display_name":"Anasuya Hazra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anasuya Hazra","raw_affiliation_strings":["Pfizer Inc, Collegeville, PA, USA","Pfizer Inc, Groton, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Inc, Collegeville, PA, USA","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Pfizer Inc, Groton, CT, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100324884","display_name":"Rong Wang","orcid":"https://orcid.org/0000-0002-2169-4174","observed_orcids":["https://orcid.org/0000-0002-2169-4174"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong Wang","raw_affiliation_strings":["Pfizer Inc, Groton, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Inc, Groton, CT, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Charles A. Mebus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles A. Mebus","raw_affiliation_strings":["Pfizer Inc, Groton, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Inc, Groton, CT, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054965158","display_name":"Christine W. Alvey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Alvey","raw_affiliation_strings":["Pfizer Inc, Groton, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Inc, Groton, CT, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109461164","display_name":"Manisha Lamba","orcid":"https://orcid.org/0009-0001-1480-0792","observed_orcids":["https://orcid.org/0009-0001-1480-0792"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manisha Lamba","raw_affiliation_strings":["Pfizer Inc, Groton, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Inc, Groton, CT, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111963131","display_name":"Sriram Krishnaswami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sriram Krishnaswami","raw_affiliation_strings":["Pfizer Inc, Groton, CT, USA","Pfizer Inc, Collegeville, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Inc, Groton, CT, USA","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Pfizer Inc, Collegeville, PA, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041090241","display_name":"Thomas C. Stock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas C. Stock","raw_affiliation_strings":["Pfizer Inc, Collegeville, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Inc, Collegeville, PA, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Min Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Wang","raw_affiliation_strings":["Pfizer Inc, Collegeville, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Inc, Collegeville, PA, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043600384","display_name":"Ricardo Maisse Suehiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Ricardo Suehiro","raw_affiliation_strings":["Pfizer Inc, Collegeville, PA, USA","Istituto Giannina Gaslini, Direzione Scientifica, Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Inc, Collegeville, PA, USA","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Istituto Giannina Gaslini, Direzione Scientifica, Genoa, Italy","institution_ids":["https://openalex.org/I2801463291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027612338","display_name":"Alberto Martini","orcid":"https://orcid.org/0000-0001-7642-1459","observed_orcids":["https://orcid.org/0000-0001-7642-1459"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Alberto Martini","raw_affiliation_strings":["Istituto Giannina Gaslini, Direzione Scientifica, Genoa, Italy","Cincinnati Children's Hospital Medical Center, PRCSG, Cincinnati, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Giannina Gaslini, Direzione Scientifica, Genoa, Italy","institution_ids":["https://openalex.org/I2801463291"]},{"raw_affiliation_string":"Cincinnati Children's Hospital Medical Center, PRCSG, Cincinnati, OH, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068517463","display_name":"Daniel J. Lovell","orcid":"https://orcid.org/0000-0003-1604-0130","observed_orcids":["https://orcid.org/0000-0003-1604-0130"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. Lovell","raw_affiliation_strings":["Cincinnati Children's Hospital Medical Center, PRCSG, Cincinnati, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital Medical Center, PRCSG, Cincinnati, OH, USA","institution_ids":["https://openalex.org/I1285204247"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5080140512"],"corresponding_institution_ids":["https://openalex.org/I2801463291"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":5.3698,"has_fulltext":false,"cited_by_count":98,"citation_normalized_percentile":{"value":0.96480901,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"15","issue":"1","first_page":"86","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.015599999576807022,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tofacitinib","display_name":"tofacitinib","score":0.9779999852180481},{"id":"https://openalex.org/keywords/juvenile-idiopathic-arthritis","display_name":"juvenile idiopathic arthritis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9639999866485596},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.5569999814033508},{"id":"https://openalex.org/keywords/taste-acceptability","display_name":"taste acceptability","score":0.7039999961853027},{"id":"https://openalex.org/keywords/oral-solution","display_name":"oral solution","score":0.7950000166893005},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6850000023841858},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.5149999856948853},{"id":"https://openalex.org/keywords/oral-jak-inhibitor","display_name":"oral JAK inhibitor","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9414966106414795},{"id":"https://openalex.org/C2778886723","wikidata":"https://www.wikidata.org/wiki/Q3530324","display_name":"Tofacitinib","level":3,"score":0.7913165092468262},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.7447076439857483},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.6153095364570618},{"id":"https://openalex.org/C115961737","wikidata":"https://www.wikidata.org/wiki/Q1516282","display_name":"Juvenile","level":2,"score":0.5654876232147217},{"id":"https://openalex.org/C3019800554","wikidata":"https://www.wikidata.org/wiki/Q3813242","display_name":"Open label","level":3,"score":0.557604193687439},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5431311726570129},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.541355311870575},{"id":"https://openalex.org/C3018359032","wikidata":"https://www.wikidata.org/wiki/Q1550789","display_name":"Safety profile","level":3,"score":0.4818519353866577},{"id":"https://openalex.org/C2992435398","wikidata":"https://www.wikidata.org/wiki/Q6934595","display_name":"Multicenter study","level":3,"score":0.4386306703090668},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.2770691514015198},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.13137692213058472},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.07962390780448914},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001171","descriptor_name":"Arthritis, Juvenile","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D013649","descriptor_name":"Taste","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1186/s12969-017-0212-y","doi":"https://doi.org/10.1186/s12969-017-0212-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12969-017-0212-y","pdf_url":null,"source":{"id":"https://openalex.org/S121831025","display_name":"Pediatric Rheumatology","issn_l":"1546-0096","issn":["1546-0096"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Rheumatology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4665402","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5745974","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5745974","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5745974","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatr Rheumatol Online J","raw_type":"Text"},{"id":"pmid:29282090","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29282090","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric rheumatology online journal","raw_type":"Clinical Trial, Phase I"},{"id":"pmh:oai:boa.unimib.it:10281/544283","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10281/544283","pdf_url":null,"source":{"id":"https://openalex.org/S4306401259","display_name":"BOA (University of Milano-Bicocca)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:8b41efdbbeb34a4f96be87df88800a71","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/8b41efdbbeb34a4f96be87df88800a71","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pediatric Rheumatology Online Journal, Vol 15, Iss 1, Pp 1-10 (2017)","raw_type":"article"},{"id":"pmh:oai:iris.unige.it:11567/965360","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11567/965360","pdf_url":null,"source":{"id":"https://openalex.org/S4377196291","display_name":"CINECA IRIS Institutial Research Information System (University of Genoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I83816512","host_organization_name":"University of Genoa","host_organization_lineage":["https://openalex.org/I83816512"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s12969-017-0212-y","doi":"https://doi.org/10.1186/s12969-017-0212-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12969-017-0212-y","pdf_url":null,"source":{"id":"https://openalex.org/S121831025","display_name":"Pediatric Rheumatology","issn_l":"1546-0096","issn":["1546-0096"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Rheumatology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1969936299","https://openalex.org/W1987733166","https://openalex.org/W1998366883","https://openalex.org/W1998725696","https://openalex.org/W2006557592","https://openalex.org/W2016380386","https://openalex.org/W2017213437","https://openalex.org/W2038992287","https://openalex.org/W2058491189","https://openalex.org/W2075591761","https://openalex.org/W2097149228","https://openalex.org/W2098706915","https://openalex.org/W2133462208","https://openalex.org/W2134389576","https://openalex.org/W2135974703","https://openalex.org/W2138049450","https://openalex.org/W2145557630","https://openalex.org/W2162618915","https://openalex.org/W2168958406","https://openalex.org/W2221264044","https://openalex.org/W2512179350","https://openalex.org/W2584430503","https://openalex.org/W4362561699"],"related_works":["https://openalex.org/W2551673566","https://openalex.org/W4391442488","https://openalex.org/W3122929167","https://openalex.org/W3212215487","https://openalex.org/W4379521459","https://openalex.org/W4297065559","https://openalex.org/W4283692637","https://openalex.org/W4399427565","https://openalex.org/W6902463388","https://openalex.org/W3049641500"],"abstract_inverted_index":{"Juvenile":[0],"idiopathic":[1],"arthritis":[2],"(JIA)":[3],"is":[4],"the":[5,26,134,310],"most":[6],"common":[7],"pediatric":[8,312],"rheumatic":[9],"disease":[10],"and":[11,29,91,105,128,168,218,229,234,241,259,301],"a":[12],"leading":[13],"cause":[14],"of":[15,20,32,50,73,133,186,261],"childhood":[16],"disability.":[17],"The":[18,173],"objective":[19],"this":[21,290],"study":[22,49,291],"was":[23,62,100,122,137,207,226,253,268,285],"to":[24,71,80,87,95,103,250,279],"characterize":[25],"PK,":[27],"safety,":[28],"taste":[30,303],"acceptability":[31,132,284],"tofacitinib":[33,51,163,176,311],"in":[34,52,178,210,215,221,238,245,292,306],"patients":[35,53,140],"with":[36,54,264,271,294],"JIA.":[37],"This":[38],"Phase":[39],"1,":[40,78,127,148,212],"open-label,":[41],"multiple-dose":[42],"(twice":[43],"daily":[44],"[BID]":[45],"for":[46,304],"5":[47,57],"days)":[48],"active":[55],"(\u2265":[56],"joints)":[58],"polyarticular":[59,295],"course":[60,296],"JIA":[61,297],"conducted":[63],"from":[64,289],"March":[65],"2013\u2013December":[66],"2015.":[67],"Patients":[68],"were":[69,116,145,165,236],"allocated":[70],"one":[72],"three":[74],"age-based":[75],"cohorts:":[76],"Cohort":[77,84,92,147,152,157,179,182,197,211,216,222,246],"12":[79,89],"<":[81,88,96],"18":[82],"years;":[83,90],"2,":[85,153,217],"6":[86,97],"3,":[93,158,242],"2":[94,183,198,240],"years.":[98],"Tofacitinib":[99,267],"administered":[101],"according":[102],"age":[104],"body":[106],"weight":[107],"as":[108],"tablets":[109],"or":[110,276],"oral":[111,135],"solution":[112,136],"(grape":[113],"flavor).":[114],"PK":[115,194,287],"assessed":[117,123],"on":[118],"Day":[119,126,129],"5;":[120],"safety":[121],"at":[124,203],"screening,":[125],"5.":[130],"Taste":[131,283],"evaluated.":[138],"Twenty-six":[139],"(age":[141],"range":[142],"2\u201317":[143],"years)":[144],"enrolled:":[146],"N":[149,154,159],"=":[150,155,160],"8;":[151],"9;":[156,161],"median":[162,175],"doses":[164],"5.0,":[166],"2.5,":[167],"3.0":[169],"mg":[170],"BID,":[171],"respectively.":[172,231],"higher":[174,244],"dose":[177],"3":[180],"versus":[181],"reflected":[184],"implementation":[185],"an":[187,192],"amended":[188],"dosing":[189,299],"scheme":[190],"following":[191],"interim":[193],"analysis":[195],"after":[196],"recruitment.":[199],"Geometric":[200],"mean":[201],"AUC":[202],"steady":[204],"state":[205],"(AUCtau)":[206],"156.6":[208],"ng\u2022h/mL":[209,214,220],"118.8":[213],"142.5":[219],"3;":[223],"Cmax":[224,251],"(ng/mL)":[225],"47.0,":[227],"41.7,":[228],"66.2,":[230],"Ctrough,":[232],"Cmin,":[233],"t1/2":[235],"similar":[237,254],"Cohorts":[239],"but":[243],"1.":[247],"Median":[248],"time":[249],"(Tmax)":[252],"between":[255],"cohorts.":[256],"Apparent":[257],"clearance":[258],"volume":[260],"distribution":[262],"decreased":[263],"decreasing":[265],"age.":[266],"well":[269],"tolerated,":[270],"no":[272],"serious":[273],"adverse":[274,280],"events":[275,281],"discontinuations":[277],"due":[278],"reported.":[282],"confirmed.":[286],"findings":[288],"children":[293],"established":[298],"regimens":[300],"acceptable":[302],"use":[305],"subsequent":[307],"studies":[308],"within":[309],"development":[313],"program.":[314],"ClinicalTrials.gov:":[315],"NCT01513902":[316],".":[317]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-01-05T00:00:00"}
