{"id":"https://openalex.org/W2780241272","doi":"https://doi.org/10.1016/j.bpj.2017.10.006","title":"Atomistic Insights into Structural Differences between E3 and E4 Isoforms of Apolipoprotein E","display_name":"Atomistic Insights into Structural Differences between E3 and E4 Isoforms of Apolipoprotein E","publication_year":2017,"publication_date":"2017-12-01","ids":{"openalex":"https://openalex.org/W2780241272","doi":"https://doi.org/10.1016/j.bpj.2017.10.006","mag":"2780241272","pmid":"https://pubmed.ncbi.nlm.nih.gov/29262361","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5770556"},"language":"en","primary_location":{"id":"doi:10.1016/j.bpj.2017.10.006","doi":"https://doi.org/10.1016/j.bpj.2017.10.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2017.10.006","pdf_url":"http://www.cell.com/article/S0006349517310937/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0006349517310937/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006836914","display_name":"Angana Ray","orcid":"https://orcid.org/0000-0002-5785-9188","observed_orcids":["https://orcid.org/0000-0002-5785-9188"]},"institutions":[{"id":"https://openalex.org/I11947397","display_name":"Tata Institute of Fundamental Research","ror":"https://ror.org/03ht1xw27","country_code":"IN","type":"education","lineage":["https://openalex.org/I11947397","https://openalex.org/I2799351866","https://openalex.org/I3149292468"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Angana Ray","raw_affiliation_strings":["Tata Institute of Fundamental Research, Hyderabad, Telangana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tata Institute of Fundamental Research, Hyderabad, Telangana, India","institution_ids":["https://openalex.org/I11947397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002919238","display_name":"Navjeet Ahalawat","orcid":"https://orcid.org/0000-0002-9665-8709","observed_orcids":["https://orcid.org/0000-0002-9665-8709"]},"institutions":[{"id":"https://openalex.org/I11947397","display_name":"Tata Institute of Fundamental Research","ror":"https://ror.org/03ht1xw27","country_code":"IN","type":"education","lineage":["https://openalex.org/I11947397","https://openalex.org/I2799351866","https://openalex.org/I3149292468"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Navjeet Ahalawat","raw_affiliation_strings":["Tata Institute of Fundamental Research, Hyderabad, Telangana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tata Institute of Fundamental Research, Hyderabad, Telangana, India","institution_ids":["https://openalex.org/I11947397"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091368395","display_name":"Jagannath Mondal","orcid":"https://orcid.org/0000-0003-1090-5199","observed_orcids":["https://orcid.org/0000-0003-1090-5199"]},"institutions":[{"id":"https://openalex.org/I11947397","display_name":"Tata Institute of Fundamental Research","ror":"https://ror.org/03ht1xw27","country_code":"IN","type":"education","lineage":["https://openalex.org/I11947397","https://openalex.org/I2799351866","https://openalex.org/I3149292468"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Jagannath Mondal","raw_affiliation_strings":["Tata Institute of Fundamental Research, Hyderabad, Telangana, India. Electronic address: jmondal@tifrh.res.in","Tata Institute of Fundamental Research, Hyderabad, Telangana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tata Institute of Fundamental Research, Hyderabad, Telangana, India. Electronic address: jmondal@tifrh.res.in","institution_ids":["https://openalex.org/I11947397"]},{"raw_affiliation_string":"Tata Institute of Fundamental Research, Hyderabad, Telangana, India","institution_ids":["https://openalex.org/I11947397"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5091368395"],"corresponding_institution_ids":["https://openalex.org/I11947397"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.9233,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.69642125,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"113","issue":"12","first_page":"2682","last_page":"2694"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.5156000256538391,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.5156000256538391,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.4787999987602234,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9729999899864197},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.9369999766349792},{"id":"https://openalex.org/keywords/apoe3","display_name":"APOE3","score":0.9890000224113464},{"id":"https://openalex.org/keywords/alzheimer-s-disease-risk","display_name":"Alzheimer's disease risk","score":0.7599999904632568},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.527999997138977},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.5350000262260437},{"id":"https://openalex.org/keywords/molten-globule","display_name":"molten globule","score":0.8560000061988831},{"id":"https://openalex.org/keywords/folding-intermediates","display_name":"folding intermediates","score":0.8209999799728394},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.8259999752044678},{"id":"https://openalex.org/keywords/monomeric-protein","display_name":"monomeric protein","score":0.5730000138282776},{"id":"https://openalex.org/keywords/atomistic-simulation","display_name":"atomistic simulation","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.783019483089447},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.6180974245071411},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.4985218048095703},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.49545085430145264},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.45654818415641785},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.44136565923690796},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.4269426167011261},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4053305983543396},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33501362800598145},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2744516432285309},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26612403988838196},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.19903403520584106},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17293816804885864},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15256646275520325},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.1361246407032013},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06259062886238098},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053318","descriptor_name":"Apolipoprotein E3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053318","descriptor_name":"Apolipoprotein E3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053327","descriptor_name":"Apolipoprotein E4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053327","descriptor_name":"Apolipoprotein E4","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.bpj.2017.10.006","doi":"https://doi.org/10.1016/j.bpj.2017.10.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2017.10.006","pdf_url":"http://www.cell.com/article/S0006349517310937/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5265846","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5770556","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5770556","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5770556","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophys J","raw_type":"Text"},{"id":"pmid:29262361","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29262361","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical journal","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1016/j.bpj.2017.10.006","doi":"https://doi.org/10.1016/j.bpj.2017.10.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2017.10.006","pdf_url":"http://www.cell.com/article/S0006349517310937/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5633072660","display_name":null,"funder_award_id":"PDF/2016/002712","funder_id":"https://openalex.org/F4320334771","funder_display_name":"Science and Engineering Research Board"}],"funders":[{"id":"https://openalex.org/F4320320715","display_name":"Tata Institute of Fundamental Research","ror":"https://ror.org/03ht1xw27"},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2780241272.pdf"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W98152484","https://openalex.org/W1031578623","https://openalex.org/W1490077018","https://openalex.org/W1529259401","https://openalex.org/W1559121591","https://openalex.org/W1624860839","https://openalex.org/W1964882696","https://openalex.org/W1973065853","https://openalex.org/W1973264045","https://openalex.org/W1976821598","https://openalex.org/W1986986500","https://openalex.org/W1987327282","https://openalex.org/W1990016625","https://openalex.org/W1994543234","https://openalex.org/W2006409771","https://openalex.org/W2006599070","https://openalex.org/W2007282102","https://openalex.org/W2008708467","https://openalex.org/W2012029966","https://openalex.org/W2016579573","https://openalex.org/W2021520922","https://openalex.org/W2023100445","https://openalex.org/W2024762727","https://openalex.org/W2025625972","https://openalex.org/W2030947664","https://openalex.org/W2032132732","https://openalex.org/W2034724732","https://openalex.org/W2035589234","https://openalex.org/W2036785198","https://openalex.org/W2041562692","https://openalex.org/W2048884904","https://openalex.org/W2051394059","https://openalex.org/W2052735470","https://openalex.org/W2059995793","https://openalex.org/W2060872117","https://openalex.org/W2061916198","https://openalex.org/W2065281489","https://openalex.org/W2066644955","https://openalex.org/W2067160010","https://openalex.org/W2067976699","https://openalex.org/W2069118296","https://openalex.org/W2076775566","https://openalex.org/W2077219082","https://openalex.org/W2081693079","https://openalex.org/W2085213650","https://openalex.org/W2087532566","https://openalex.org/W2090271811","https://openalex.org/W2090688839","https://openalex.org/W2094007252","https://openalex.org/W2100736103","https://openalex.org/W2103945336","https://openalex.org/W2104630281","https://openalex.org/W2111307154","https://openalex.org/W2112154906","https://openalex.org/W2128276019","https://openalex.org/W2128572087","https://openalex.org/W2130448290","https://openalex.org/W2132262459","https://openalex.org/W2143592395","https://openalex.org/W2146411229","https://openalex.org/W2149272953","https://openalex.org/W2150593711","https://openalex.org/W2155559959","https://openalex.org/W2169892526","https://openalex.org/W2186102849","https://openalex.org/W2206954826","https://openalex.org/W2226825552","https://openalex.org/W2317777064","https://openalex.org/W2325931377","https://openalex.org/W2401829918","https://openalex.org/W2560393860","https://openalex.org/W2574219503","https://openalex.org/W2618913695","https://openalex.org/W3100810942"],"related_works":["https://openalex.org/W6925613464","https://openalex.org/W2034724732","https://openalex.org/W4319333065","https://openalex.org/W2056451248","https://openalex.org/W7018158307","https://openalex.org/W4319930125","https://openalex.org/W2022800519","https://openalex.org/W2943773301","https://openalex.org/W2119291357","https://openalex.org/W2574219503"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-01-05T00:00:00"}