{"id":"https://openalex.org/W2779110738","doi":"https://doi.org/10.3389/fphar.2017.00930","title":"Role of \u03b2-Interferon Inducer (DEAE-Dextran) in Tumorigenesis by VEGF and NOTCH1 Inhibition along with Apoptosis Induction","display_name":"Role of \u03b2-Interferon Inducer (DEAE-Dextran) in Tumorigenesis by VEGF and NOTCH1 Inhibition along with Apoptosis Induction","publication_year":2017,"publication_date":"2017-12-19","ids":{"openalex":"https://openalex.org/W2779110738","doi":"https://doi.org/10.3389/fphar.2017.00930","mag":"2779110738","pmid":"https://pubmed.ncbi.nlm.nih.gov/29311933"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2017.00930","doi":"https://doi.org/10.3389/fphar.2017.00930","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2017.00930","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2017.00930/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphar.2017.00930/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010353436","display_name":"Anita K. Bakrania","orcid":"https://orcid.org/0000-0002-8487-3946","observed_orcids":["https://orcid.org/0000-0002-8487-3946"]},"institutions":[{"id":"https://openalex.org/I165831266","display_name":"Nirma University","ror":"https://ror.org/05qkq7x38","country_code":"IN","type":"education","lineage":["https://openalex.org/I165831266"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Anita K. Bakrania","raw_affiliation_strings":["Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, India","institution_ids":["https://openalex.org/I165831266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001132909","display_name":"Bhavesh C. Variya","orcid":"https://orcid.org/0000-0002-8734-8186","observed_orcids":["https://orcid.org/0000-0002-8734-8186"]},"institutions":[{"id":"https://openalex.org/I165831266","display_name":"Nirma University","ror":"https://ror.org/05qkq7x38","country_code":"IN","type":"education","lineage":["https://openalex.org/I165831266"]},{"id":"https://openalex.org/I4210132663","display_name":"Zydus Lifesciences Limited (India)","ror":"https://ror.org/03ktyvw44","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210132663"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Bhavesh C. Variya","raw_affiliation_strings":["Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, India","Zydus Research Centre, Ahmedabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, India","institution_ids":["https://openalex.org/I165831266"]},{"raw_affiliation_string":"Zydus Research Centre, Ahmedabad, India","institution_ids":["https://openalex.org/I4210132663"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087002800","display_name":"Snehal Sanjay Patel","orcid":"https://orcid.org/0000-0002-5002-7530","observed_orcids":["https://orcid.org/0000-0002-5002-7530"]},"institutions":[{"id":"https://openalex.org/I165831266","display_name":"Nirma University","ror":"https://ror.org/05qkq7x38","country_code":"IN","type":"education","lineage":["https://openalex.org/I165831266"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Snehal S. Patel","raw_affiliation_strings":["Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, India","institution_ids":["https://openalex.org/I165831266"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010353436","https://openalex.org/A5087002800"],"corresponding_institution_ids":["https://openalex.org/I165831266"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.1941,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.50485125,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":null,"first_page":"930","last_page":"930"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deae-dextran","display_name":"DEAE-dextran","score":0.949999988079071},{"id":"https://openalex.org/keywords/interferon-inducers","display_name":"interferon inducers","score":0.7319999933242798},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9580000042915344},{"id":"https://openalex.org/keywords/angiogenesis-inhibitors","display_name":"angiogenesis inhibitors","score":0.8349999785423279},{"id":"https://openalex.org/keywords/vegf-inhibition","display_name":"VEGF inhibition","score":0.9279999732971191},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8980000019073486},{"id":"https://openalex.org/keywords/ros-scavenging","display_name":"reactive oxygen species scavenging","score":0.9710000157356262},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.4129999876022339},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.8029999732971191},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.8740000128746033},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.7080000042915344},{"id":"https://openalex.org/keywords/cd31","display_name":"CD31","score":0.6330000162124634},{"id":"https://openalex.org/keywords/transfection-agents","display_name":"transfection agents","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C2777339698","wikidata":"https://www.wikidata.org/wiki/Q423123","display_name":"Dextran","level":2,"score":0.7624385952949524},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6391991376876831},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5432941913604736},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5176835060119629},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.514593243598938},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46793195605278015},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.42330342531204224},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42298638820648193},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.41846901178359985},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.41846203804016113},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3097034692764282},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2800951600074768},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23415857553482056},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fphar.2017.00930","doi":"https://doi.org/10.3389/fphar.2017.00930","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2017.00930","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2017.00930/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmid:29311933","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29311933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4669655","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5742137","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5742137","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5742137","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:5d0d8d8d82b94f37904ab2cccaea513e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5d0d8d8d82b94f37904ab2cccaea513e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 8 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2017.00930","doi":"https://doi.org/10.3389/fphar.2017.00930","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2017.00930","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2017.00930/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7900000214576721,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320328433","display_name":"Nirma University","ror":"https://ror.org/05qkq7x38"},{"id":"https://openalex.org/F4320337281","display_name":"Institute of Pharmacy, Nirma University","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2779110738.pdf","grobid_xml":"https://content.openalex.org/works/W2779110738.grobid-xml"},"referenced_works_count":91,"referenced_works":["https://openalex.org/W43675158","https://openalex.org/W853270325","https://openalex.org/W1554815317","https://openalex.org/W1570141158","https://openalex.org/W1574675143","https://openalex.org/W1962741441","https://openalex.org/W1966886766","https://openalex.org/W1969761720","https://openalex.org/W1975766026","https://openalex.org/W1979361881","https://openalex.org/W1981752846","https://openalex.org/W1983742719","https://openalex.org/W1985712533","https://openalex.org/W2000292756","https://openalex.org/W2001780798","https://openalex.org/W2002746961","https://openalex.org/W2006612491","https://openalex.org/W2007431287","https://openalex.org/W2010476650","https://openalex.org/W2011338138","https://openalex.org/W2011660637","https://openalex.org/W2020355892","https://openalex.org/W2025029151","https://openalex.org/W2025142983","https://openalex.org/W2026126577","https://openalex.org/W2027157544","https://openalex.org/W2032630075","https://openalex.org/W2037150903","https://openalex.org/W2037473273","https://openalex.org/W2040587518","https://openalex.org/W2041577685","https://openalex.org/W2042811848","https://openalex.org/W2043842211","https://openalex.org/W2046839020","https://openalex.org/W2048607324","https://openalex.org/W2049856484","https://openalex.org/W2050276508","https://openalex.org/W2050555289","https://openalex.org/W2053335915","https://openalex.org/W2054958270","https://openalex.org/W2055157840","https://openalex.org/W2055567331","https://openalex.org/W2057257609","https://openalex.org/W2057521345","https://openalex.org/W2060075925","https://openalex.org/W2062711358","https://openalex.org/W2064126710","https://openalex.org/W2067948812","https://openalex.org/W2067968941","https://openalex.org/W2069132215","https://openalex.org/W2072747624","https://openalex.org/W2073379232","https://openalex.org/W2074605890","https://openalex.org/W2082887122","https://openalex.org/W2086858852","https://openalex.org/W2089298737","https://openalex.org/W2090025028","https://openalex.org/W2090099837","https://openalex.org/W2096950793","https://openalex.org/W2106054392","https://openalex.org/W2107040566","https://openalex.org/W2109637975","https://openalex.org/W2112870074","https://openalex.org/W2117046140","https://openalex.org/W2118863472","https://openalex.org/W2121891790","https://openalex.org/W2123239648","https://openalex.org/W2124088761","https://openalex.org/W2125192217","https://openalex.org/W2126486896","https://openalex.org/W2129124160","https://openalex.org/W2129860749","https://openalex.org/W2134230584","https://openalex.org/W2134768631","https://openalex.org/W2142491513","https://openalex.org/W2146907762","https://openalex.org/W2156596432","https://openalex.org/W2157343124","https://openalex.org/W2160281835","https://openalex.org/W2163565167","https://openalex.org/W2168362647","https://openalex.org/W2171367003","https://openalex.org/W2298375517","https://openalex.org/W2326732193","https://openalex.org/W2330526016","https://openalex.org/W2332317850","https://openalex.org/W2410606281","https://openalex.org/W2493010869","https://openalex.org/W2761925117","https://openalex.org/W3121948843","https://openalex.org/W6641358924"],"related_works":["https://openalex.org/W2075734225","https://openalex.org/W2042474810","https://openalex.org/W2592007767","https://openalex.org/W2026862129","https://openalex.org/W2361980913","https://openalex.org/W2361962797","https://openalex.org/W2160904476","https://openalex.org/W2363178760","https://openalex.org/W2253642286","https://openalex.org/W2351699250"],"abstract_inverted_index":{"As":[0,103],"a":[1,21,27,104],"novel":[2],"target":[3],"for":[4,24,36,45],"breast":[5,130],"cancer,":[6],"interferon":[7,86],"inducers":[8],"have":[9],"found":[10,57],"its":[11],"role":[12],"as":[13,26,41,51,71,94,96,190,207,209],"anti-angiogenic":[14,53],"agents":[15],"with":[16,47,134,181,195,201],"diethylaminoethyl":[17],"dextran":[18],"(DEAE-Dextran)":[19],"being":[20],"molecule":[22],"used":[23],"centuries":[25],"transfection":[28],"agent.":[29],"Our":[30],"results":[31,185],"herein":[32],"offer":[33],"an":[34,42,52,72,135,191],"explanation":[35],"the":[37,64,155],"emergence":[38],"of":[39,89,101,106,119,142,144,150,157,177,188],"DEAE-Dextran":[40,55,74,90,109,124,151,189],"anti-tumor":[43,193],"agent":[44,194],"TNBC":[46],"in-depth":[48],"mechanistic":[49],"approach":[50],"molecule.":[54],"has":[56,75],"to":[58,77,171,198,214],"possess":[59,78],"cytotoxic":[60],"activity":[61],"demonstrated":[62],"during":[63],"various":[65],"in":[66,123,129,137,163,166,217],"vitro":[67],"cytotoxicity":[68],"assays;":[69],"moreover,":[70],"anti-oxidant,":[73],"shown":[76],"excellent":[79],"reactive":[80],"oxygen":[81],"species":[82],"scavenging":[83],"activity.":[84],"The":[85],"inducing":[87],"capacity":[88],"was":[91,152,179],"determined":[92,174],"qualitatively":[93],"well":[95,208],"quantitatively":[97],"specifically":[98],"demonstrating":[99],"overexpression":[100,118],"\u03b2-interferon.":[102],"measure":[105],"anti-proliferative":[107],"activity,":[108],"exhibited":[110],"reduced":[111],"ki67,":[112],"p53,":[113],"and":[114,121,146,160,165,204],"PCNA":[115],"levels.":[116],"Also,":[117],"CK5/6":[120],"p63":[122],"treated":[125],"animals":[126],"indicated":[127],"improvement":[128,136],"cell":[131],"morphology":[132],"along":[133],"cell\u2013cell":[138],"adhesion":[139],"by":[140,154,175],"virtue":[141],"upregulation":[143],"\u03b2-catenin":[145],"E-cadherin.":[147],"Anti-angiogenic":[148],"property":[149],"concluded":[153],"downregulation":[156,176],"CD31,":[158],"VEGF,":[159],"NOTCH1":[161,205],"both":[162],"vivo":[164],"vitro.":[167],"Further,":[168],"apoptosis":[169,210],"due":[170],"DEAE-Dextran,":[172],"initially":[173],"Bcl2,":[178],"confirmed":[180],"flow":[182],"cytometry.":[183],"Overall,":[184],"are":[186],"defensive":[187],"emerging":[192],"mechanisms":[196],"pertaining":[197],"\u03b2-interferon":[199],"induction":[200],"probable":[202],"VEGF":[203],"inhibition":[206],"which":[211],"still":[212],"needs":[213],"be":[215],"studied":[216],"further":[218],"depth.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}