{"id":"https://openalex.org/W2778263369","doi":"https://doi.org/10.18632/oncotarget.23464","title":"Computational methods reveal novel functionalities of PIWI-interacting RNAs in human papillomavirus-induced head and neck squamous cell carcinoma","display_name":"Computational methods reveal novel functionalities of PIWI-interacting RNAs in human papillomavirus-induced head and neck squamous cell carcinoma","publication_year":2017,"publication_date":"2017-12-19","ids":{"openalex":"https://openalex.org/W2778263369","doi":"https://doi.org/10.18632/oncotarget.23464","mag":"2778263369","pmid":"https://pubmed.ncbi.nlm.nih.gov/29435129","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5797000"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.23464","doi":"https://doi.org/10.18632/oncotarget.23464","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.23464","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=23464&path%5B%5D=73909","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=23464&path%5B%5D=73909","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086140564","display_name":"Aswini R. Krishnan","orcid":"https://orcid.org/0000-0003-0764-5111","observed_orcids":["https://orcid.org/0000-0003-0764-5111"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aswini R. Krishnan","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, California, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091136830","display_name":"Yuanhao Qu","orcid":"https://orcid.org/0000-0002-7574-259X","observed_orcids":["https://orcid.org/0000-0002-7574-259X"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yuanhao Qu","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, California, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047081149","display_name":"Pin Xue Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pin Xue Li","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, California, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001334428","display_name":"Angela E. Zou","orcid":"https://orcid.org/0000-0002-9709-3121","observed_orcids":["https://orcid.org/0000-0002-9709-3121"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela E. Zou","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, California, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017600358","display_name":"Joseph A. Califano","orcid":"https://orcid.org/0000-0002-4715-6761","observed_orcids":["https://orcid.org/0000-0002-4715-6761"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph A. Califano","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, California, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089144595","display_name":"Jessica Wang\u2010Rodriguez","orcid":"https://orcid.org/0000-0001-7233-8105","observed_orcids":["https://orcid.org/0000-0001-7233-8105"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Wang-Rodriguez","raw_affiliation_strings":["Veterans Administration San Diego Healthcare System and Department of Pathology, University of California San Diego, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Administration San Diego Healthcare System and Department of Pathology, University of California San Diego, La Jolla, California, USA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210099595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067079844","display_name":"Weg M. Ongkeko","orcid":"https://orcid.org/0000-0002-2790-2480","observed_orcids":["https://orcid.org/0000-0002-2790-2480"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weg M. Ongkeko","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, California, USA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5086140564","https://openalex.org/A5091136830"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":0.9167,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.68591761,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"9","issue":"4","first_page":"4614","last_page":"4624"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.7139000296592712,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.7139000296592712,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.22840000689029694,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/piwi-interacting-rnas","display_name":"piRNA","score":0.8209999799728394},{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.9160000085830688},{"id":"https://openalex.org/keywords/hpv-16","display_name":"HPV16","score":0.8859999775886536},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/piwil4","display_name":"PIWIL4","score":0.968999981880188},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.7509999871253967},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.6470000147819519},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"copy number variation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7139999866485596},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.4309999942779541},{"id":"https://openalex.org/keywords/tcga-data","display_name":"TCGA data","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.8110477924346924},{"id":"https://openalex.org/C147724379","wikidata":"https://www.wikidata.org/wiki/Q2367421","display_name":"Piwi-interacting RNA","level":5,"score":0.7264648079872131},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4808979034423828},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4693114757537842},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3651212751865387},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36221033334732056},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3335159420967102},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3235545754432678},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3206629753112793},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.2939467430114746},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2932637333869934},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2929695248603821},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28336894512176514},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.2447606921195984},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1765437126159668}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.18632/oncotarget.23464","doi":"https://doi.org/10.18632/oncotarget.23464","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.23464","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=23464&path%5B%5D=73909","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4716668","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5797000","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5797000","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5797000","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Text"},{"id":"pmid:29435129","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29435129","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt5ds5170d","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/5ds5170d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oncotarget, vol 9, iss 4","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt8nr7b71n","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/8nr7b71n","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oncotarget, vol 9, iss 4","raw_type":"article"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.23464","doi":"https://doi.org/10.18632/oncotarget.23464","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.23464","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=23464&path%5B%5D=73909","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8804402898","display_name":"Non-coding RNAs in salivary gland tumor","funder_award_id":"R21DE023242","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2778263369.pdf","grobid_xml":"https://content.openalex.org/works/W2778263369.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1965766554","https://openalex.org/W1972353480","https://openalex.org/W1990654003","https://openalex.org/W2002201590","https://openalex.org/W2005439008","https://openalex.org/W2007607256","https://openalex.org/W2008211165","https://openalex.org/W2010928038","https://openalex.org/W2011499737","https://openalex.org/W2041306541","https://openalex.org/W2060532519","https://openalex.org/W2060588565","https://openalex.org/W2060763328","https://openalex.org/W2062312459","https://openalex.org/W2065031087","https://openalex.org/W2074636681","https://openalex.org/W2074675420","https://openalex.org/W2077053535","https://openalex.org/W2084811286","https://openalex.org/W2088685363","https://openalex.org/W2105666596","https://openalex.org/W2120456037","https://openalex.org/W2125352919","https://openalex.org/W2130410032","https://openalex.org/W2149166037","https://openalex.org/W2162547088","https://openalex.org/W2165290876","https://openalex.org/W2166558639","https://openalex.org/W2234938965","https://openalex.org/W2272578559","https://openalex.org/W2295954653","https://openalex.org/W2404460484","https://openalex.org/W2438457922","https://openalex.org/W2563376882"],"related_works":["https://openalex.org/W4250543733","https://openalex.org/W2741621103","https://openalex.org/W2253552256","https://openalex.org/W2563376882","https://openalex.org/W4289444516","https://openalex.org/W2500349205","https://openalex.org/W7162871808","https://openalex.org/W2908568928","https://openalex.org/W4396842361","https://openalex.org/W4361302403"],"abstract_inverted_index":{"//":[0],"Aswini":[1],"R.":[2],"Krishnan":[3],"1,":[4,9],"*":[5,10,71],",":[6,11,16,21,26,271,273,276],"Yuanhao":[7],"Qu":[8],"Pin":[12],"Xue":[13],"Li":[14],"1":[15,20,25,34,35],"Angela":[17],"E.":[18],"Zou":[19],"Joseph":[22],"A.":[23],"Califano":[24],"Jessica":[27],"Wang-Rodriguez":[28],"2":[29,51],"and":[30,39,58,115,143,163,225,274,307,322,329],"Weg":[31,81],"M.":[32,82],"Ongkeko":[33],"Department":[36,59],"of":[37,43,60,63,113,138,158,170,182,191,205,241,251,266,301],"Otolaryngology-Head":[38],"Neck":[40],"Surgery,":[41],"University":[42,62],"California":[44,64],"San":[45,54,65],"Diego,":[46,66],"La":[47,67],"Jolla,":[48,68],"California,":[49,69],"USA":[50,70],"Veterans":[52],"Administration":[53],"Diego":[55],"Healthcare":[56],"System":[57],"Pathology,":[61],"These":[72],"authors":[73],"contributed":[74],"equally":[75],"to":[76,133,193,244,255],"this":[77,261],"work":[78],"Correspondence":[79],"to:":[80],"Ongkeko,":[83],"email:":[84],"wongkeko@ucsd.edu":[85],"Keywords:":[86],"piRNA;":[87],"HNSCC;":[88],"ncRNA;":[89],"HPV":[90],"Received:":[91],"August":[92],"21,":[93],"2017":[94,98,102],"Accepted:":[95],"November":[96],"28,":[97],"Published:":[99],"December":[100],"19,":[101],"ABSTRACT":[103],"Human":[104],"papillomavirus":[105],"(HPV)":[106],"infection":[107],"is":[108],"the":[109,178,196,202,238,312],"fastest":[110],"growing":[111],"cause":[112],"head":[114],"neck":[116],"squamous":[117],"cell":[118,291],"carcinoma":[119],"(HNSCC)":[120],"today,":[121],"but":[122],"its":[123],"role":[124],"in":[125,145,185,229,248,253,260,279,285,304,326],"malignant":[126],"transformation":[127],"remains":[128],"unclear.":[129],"This":[130],"study":[131,296],"aimed":[132],"conduct":[134],"a":[135,168,298],"comprehensive":[136],"investigation":[137,300],"PIWI-interacting":[139],"RNA":[140],"(piRNA)":[141],"alterations":[142],"functionalities":[144],"HPV-induced":[146,186],"HNSCC.":[147],"Using":[148],"77":[149],"RNA-sequencing":[150],"datasets":[151],"from":[152],"TCGA,":[153],"we":[154],"examined":[155],"differential":[156,264],"expression":[157,265,284],"piRNAs":[159,192,243],"between":[160],"HPV16(+)":[161],"HNSCC":[162,230,234,252],"HPV(\u2013)":[164,289],"Normal":[165],"samples,":[166],"identifying":[167,188],"panel":[169,190],"30":[171],"HPV-dysregulated":[172,217],"piRNAs.":[173],"We":[174,213],"then":[175],"computationally":[176],"investigated":[177],"potential":[179,239],"mechanistic":[180],"significances":[181],"these":[183,315],"transcripts":[184,218,318],"HNSCC,":[187,306],"our":[189,242,294],"associate":[194],"with":[195,222],"protein":[197],"PIWIL4":[198],"as":[199,201,231,233],"well":[200,232],"RTL":[203],"family":[204],"retrotransposon-like":[206],"genes,":[207],"possibly":[208],"through":[209],"direct":[210],"binding":[211],"interactions.":[212],"also":[214],"recognized":[215],"several":[216],"for":[219],"their":[220,256],"correlations":[221],"well-documented":[223],"mutations":[224],"copy":[226],"number":[227],"variations":[228],"clinical":[235],"variables,":[236],"demonstrating":[237],"ability":[240],"play":[245,320],"important":[246],"roles":[247,325],"large-scale":[249],"modulation":[250],"addition":[254],"direct,":[257],"smaller-scale":[258],"interactions":[259],"malignancy.":[262],"The":[263],"key":[267],"piRNAs,":[268],"including":[269],"NONHSAT077364":[270],"NONHSAT102574":[272],"NONHSAT128479":[275],"was":[277],"verified":[278],"vitro":[280],"by":[281],"evaluating":[282],"endogenous":[283],"HPV(+)":[286],"cancer":[287],"vs.":[288],"normal":[290],"lines.":[292],"Overall,":[293],"novel":[295],"provides":[297],"rigorous":[299],"piRNA":[302],"dysregulation":[303],"HPV-related":[305],"lends":[308],"critical":[309],"insight":[310],"into":[311],"idea":[313],"that":[314],"small":[316],"regulatory":[317],"may":[319],"crucial":[321],"previously":[323],"unidentified":[324],"tumor":[327],"pathogenesis":[328],"progression.":[330]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-01-05T00:00:00"}