{"id":"https://openalex.org/W2777832155","doi":"https://doi.org/10.1002/bdr2.1182","title":"Neurobiology of substance use in adolescents and potential therapeutic effects of exercise for prevention and treatment of substance use disorders","display_name":"Neurobiology of substance use in adolescents and potential therapeutic effects of exercise for prevention and treatment of substance use disorders","publication_year":2017,"publication_date":"2017-12-01","ids":{"openalex":"https://openalex.org/W2777832155","doi":"https://doi.org/10.1002/bdr2.1182","mag":"2777832155","pmid":"https://pubmed.ncbi.nlm.nih.gov/29251846"},"language":"en","primary_location":{"id":"doi:10.1002/bdr2.1182","doi":"https://doi.org/10.1002/bdr2.1182","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bdr2.1182","pdf_url":null,"source":{"id":"https://openalex.org/S23975315","display_name":"Birth Defects Research","issn_l":"2472-1727","issn":["2472-1727"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth Defects Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5751741","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038780091","display_name":"Nora L. Nock","orcid":"https://orcid.org/0000-0002-6476-6692","observed_orcids":["https://orcid.org/0000-0002-6476-6692"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nora L. Nock","raw_affiliation_strings":["Department of Epidemiology and Biostatistics Case Western Reserve University Cleveland Ohio","Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio"],"raw_orcid":"https://orcid.org/0000-0002-6476-6692","affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics Case Western Reserve University Cleveland Ohio","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041186270","display_name":"Sonia Minnes","orcid":"https://orcid.org/0000-0002-0132-4678","observed_orcids":["https://orcid.org/0000-0002-0132-4678"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonia Minnes","raw_affiliation_strings":["Jack, Joseph and Morton Mandel School of Applied Sciences Case Western Reserve University Cleveland Ohio","Jack, Joseph and Morton Mandel School of Applied Sciences, Case Western Reserve University, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jack, Joseph and Morton Mandel School of Applied Sciences Case Western Reserve University Cleveland Ohio","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Jack, Joseph and Morton Mandel School of Applied Sciences, Case Western Reserve University, Cleveland, Ohio","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016841050","display_name":"Jay L. Alberts","orcid":"https://orcid.org/0000-0002-9379-3630","observed_orcids":["https://orcid.org/0000-0002-9379-3630"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay L. Alberts","raw_affiliation_strings":["Department of Biomedical Engineering Cleveland Clinic Cleveland Ohio","Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering Cleveland Clinic Cleveland Ohio","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038780091"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":{"value":3700,"currency":"USD","value_usd":3700},"apc_paid":null,"fwci":2.4093,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.89418617,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"109","issue":"20","first_page":"1711","last_page":"1729"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adolescent-substance-use","display_name":"adolescent substance use","score":0.9940000176429749},{"id":"https://openalex.org/keywords/substance-use-disorders","display_name":"substance use disorders","score":0.9950000047683716},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.6190000176429749},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.921999990940094},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.7670000195503235},{"id":"https://openalex.org/keywords/reward-sensitivity","display_name":"reward sensitivity","score":0.875},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cannabis-use","display_name":"cannabis use","score":0.7710000276565552},{"id":"https://openalex.org/keywords/opioid-use","display_name":"opioid use","score":0.8489999771118164},{"id":"https://openalex.org/keywords/substance-abuse-prevention","display_name":"substance use prevention","score":0.6050000190734863},{"id":"https://openalex.org/keywords/addiction-treatment","display_name":"addiction treatment","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6521743535995483},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.5642443299293518},{"id":"https://openalex.org/C36951298","wikidata":"https://www.wikidata.org/wiki/Q379784","display_name":"Arousal","level":2,"score":0.5021858215332031},{"id":"https://openalex.org/C143661069","wikidata":"https://www.wikidata.org/wiki/Q670713","display_name":"Reward system","level":2,"score":0.4817959666252136},{"id":"https://openalex.org/C2777193897","wikidata":"https://www.wikidata.org/wiki/Q179452","display_name":"Amphetamine","level":3,"score":0.4748951494693756},{"id":"https://openalex.org/C2991912374","wikidata":"https://www.wikidata.org/wiki/Q400711","display_name":"Substance use","level":2,"score":0.4519767463207245},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.4502488970756531},{"id":"https://openalex.org/C40010229","wikidata":"https://www.wikidata.org/wiki/Q3184856","display_name":"Substance abuse","level":2,"score":0.44058889150619507},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.4296766221523285},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3990052342414856},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3636385202407837},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.3583414554595947},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.34446606040000916},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32616788148880005}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005081","descriptor_name":"Exercise Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005081","descriptor_name":"Exercise Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005081","descriptor_name":"Exercise Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009446","descriptor_name":"Neurobiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009446","descriptor_name":"Neurobiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009446","descriptor_name":"Neurobiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019966","descriptor_name":"Substance-Related Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D019966","descriptor_name":"Substance-Related Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D019966","descriptor_name":"Substance-Related Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D019966","descriptor_name":"Substance-Related Disorders","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D019966","descriptor_name":"Substance-Related Disorders","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D019966","descriptor_name":"Substance-Related Disorders","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/bdr2.1182","doi":"https://doi.org/10.1002/bdr2.1182","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bdr2.1182","pdf_url":null,"source":{"id":"https://openalex.org/S23975315","display_name":"Birth Defects Research","issn_l":"2472-1727","issn":["2472-1727"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth Defects Research","raw_type":"journal-article"},{"id":"pmid:29251846","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29251846","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth defects research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5234503","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5751741","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5751741","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5751741","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Birth Defects Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5751741","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5751741","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Birth Defects Res","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7300000190734863}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000109086","display_name":null,"funder_award_id":"R01 CA175100","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G995833159","display_name":null,"funder_award_id":"R01 CA175100","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":240,"referenced_works":["https://openalex.org/W41435160","https://openalex.org/W61126686","https://openalex.org/W61407429","https://openalex.org/W121458920","https://openalex.org/W781134833","https://openalex.org/W1085529922","https://openalex.org/W1496608909","https://openalex.org/W1554794777","https://openalex.org/W1584054336","https://openalex.org/W1612438756","https://openalex.org/W1612905571","https://openalex.org/W1614035160","https://openalex.org/W1783744578","https://openalex.org/W1889973532","https://openalex.org/W1917991818","https://openalex.org/W1918421874","https://openalex.org/W1950975821","https://openalex.org/W1959902108","https://openalex.org/W1966023927","https://openalex.org/W1967838338","https://openalex.org/W1970142274","https://openalex.org/W1970672886","https://openalex.org/W1971126815","https://openalex.org/W1972071141","https://openalex.org/W1974888964","https://openalex.org/W1977045531","https://openalex.org/W1977311786","https://openalex.org/W1979044287","https://openalex.org/W1981262111","https://openalex.org/W1981886643","https://openalex.org/W1982231133","https://openalex.org/W1983083446","https://openalex.org/W1990752036","https://openalex.org/W1991558321","https://openalex.org/W1991620901","https://openalex.org/W1992582005","https://openalex.org/W1992615559","https://openalex.org/W1992630689","https://openalex.org/W1994058548","https://openalex.org/W1995614778","https://openalex.org/W1997258305","https://openalex.org/W2002704498","https://openalex.org/W2004241184","https://openalex.org/W2004286315","https://openalex.org/W2004445171","https://openalex.org/W2006999172","https://openalex.org/W2009578511","https://openalex.org/W2010747514","https://openalex.org/W2011160896","https://openalex.org/W2012403948","https://openalex.org/W2012470325","https://openalex.org/W2014911395","https://openalex.org/W2015851283","https://openalex.org/W2016899938","https://openalex.org/W2017102173","https://openalex.org/W2019093706","https://openalex.org/W2021114620","https://openalex.org/W2022197189","https://openalex.org/W2022988410","https://openalex.org/W2024010938","https://openalex.org/W2027094758","https://openalex.org/W2028025236","https://openalex.org/W2028869668","https://openalex.org/W2029416914","https://openalex.org/W2030865268","https://openalex.org/W2031354288","https://openalex.org/W2031371066","https://openalex.org/W2032752029","https://openalex.org/W2033420105","https://openalex.org/W2033602780","https://openalex.org/W2033843929","https://openalex.org/W2033923862","https://openalex.org/W2037996845","https://openalex.org/W2041894636","https://openalex.org/W2044543427","https://openalex.org/W2045890739","https://openalex.org/W2046713808","https://openalex.org/W2046805670","https://openalex.org/W2047262956","https://openalex.org/W2047725278","https://openalex.org/W2051649809","https://openalex.org/W2054929297","https://openalex.org/W2059498859","https://openalex.org/W2060177832","https://openalex.org/W2060950031","https://openalex.org/W2063132177","https://openalex.org/W2063743699","https://openalex.org/W2068715462","https://openalex.org/W2068888057","https://openalex.org/W2070234875","https://openalex.org/W2070368610","https://openalex.org/W2070593149","https://openalex.org/W2072995293","https://openalex.org/W2073606822","https://openalex.org/W2075272849","https://openalex.org/W2080193524","https://openalex.org/W2082722104","https://openalex.org/W2083083744","https://openalex.org/W2084315829","https://openalex.org/W2084711515","https://openalex.org/W2086785212","https://openalex.org/W2087158314","https://openalex.org/W2087253534","https://openalex.org/W2088365036","https://openalex.org/W2089189793","https://openalex.org/W2091910506","https://openalex.org/W2092527697","https://openalex.org/W2093934222","https://openalex.org/W2097045418","https://openalex.org/W2097666580","https://openalex.org/W2098582456","https://openalex.org/W2098645160","https://openalex.org/W2099899980","https://openalex.org/W2100022970","https://openalex.org/W2100164454","https://openalex.org/W2101514929","https://openalex.org/W2101715439","https://openalex.org/W2102081573","https://openalex.org/W2104792456","https://openalex.org/W2105177783","https://openalex.org/W2107246469","https://openalex.org/W2109565047","https://openalex.org/W2111203133","https://openalex.org/W2111986556","https://openalex.org/W2113512304","https://openalex.org/W2115650553","https://openalex.org/W2115946485","https://openalex.org/W2115996482","https://openalex.org/W2116454997","https://openalex.org/W2118921112","https://openalex.org/W2120077675","https://openalex.org/W2120117522","https://openalex.org/W2120731293","https://openalex.org/W2121880736","https://openalex.org/W2121945096","https://openalex.org/W2126432364","https://openalex.org/W2128214707","https://openalex.org/W2131004597","https://openalex.org/W2131196982","https://openalex.org/W2131615411","https://openalex.org/W2131675069","https://openalex.org/W2133032983","https://openalex.org/W2133290977","https://openalex.org/W2135293200","https://openalex.org/W2139354336","https://openalex.org/W2139716393","https://openalex.org/W2141037528","https://openalex.org/W2141636993","https://openalex.org/W2142332813","https://openalex.org/W2143443600","https://openalex.org/W2144586633","https://openalex.org/W2146501028","https://openalex.org/W2152838366","https://openalex.org/W2154041895","https://openalex.org/W2154503388","https://openalex.org/W2156581621","https://openalex.org/W2156606713","https://openalex.org/W2157430062","https://openalex.org/W2159202946","https://openalex.org/W2162097818","https://openalex.org/W2167785125","https://openalex.org/W2167914321","https://openalex.org/W2169340948","https://openalex.org/W2172106147","https://openalex.org/W2173720074","https://openalex.org/W2176764139","https://openalex.org/W2178113230","https://openalex.org/W2182351705","https://openalex.org/W2188993485","https://openalex.org/W2189658019","https://openalex.org/W2192766098","https://openalex.org/W2196810774","https://openalex.org/W2207035985","https://openalex.org/W2207847464","https://openalex.org/W2218776046","https://openalex.org/W2224980508","https://openalex.org/W2252122829","https://openalex.org/W2265131300","https://openalex.org/W2276111811","https://openalex.org/W2284400566","https://openalex.org/W2289337645","https://openalex.org/W2322145489","https://openalex.org/W2324437443","https://openalex.org/W2325726379","https://openalex.org/W2337581563","https://openalex.org/W2338084070","https://openalex.org/W2342965781","https://openalex.org/W2344773776","https://openalex.org/W2344912416","https://openalex.org/W2396745871","https://openalex.org/W2396881340","https://openalex.org/W2402756356","https://openalex.org/W2413604909","https://openalex.org/W2416469128","https://openalex.org/W2442142031","https://openalex.org/W2460283291","https://openalex.org/W2464005840","https://openalex.org/W2473481878","https://openalex.org/W2486855689","https://openalex.org/W2507207243","https://openalex.org/W2508516692","https://openalex.org/W2509218837","https://openalex.org/W2509254921","https://openalex.org/W2510367665","https://openalex.org/W2510608890","https://openalex.org/W2512289010","https://openalex.org/W2514618653","https://openalex.org/W2526484688","https://openalex.org/W2530789400","https://openalex.org/W2533242073","https://openalex.org/W2545577063","https://openalex.org/W2554795142","https://openalex.org/W2556467699","https://openalex.org/W2563658156","https://openalex.org/W2571910151","https://openalex.org/W2581801442","https://openalex.org/W2588307613","https://openalex.org/W2588644346","https://openalex.org/W2588760064","https://openalex.org/W2593295944","https://openalex.org/W2604090325","https://openalex.org/W2605675783","https://openalex.org/W2614480952","https://openalex.org/W2622171988","https://openalex.org/W2623736013","https://openalex.org/W2624100118","https://openalex.org/W2664396468","https://openalex.org/W2736518658","https://openalex.org/W2761157994","https://openalex.org/W2762078336","https://openalex.org/W2765763788","https://openalex.org/W2776665798","https://openalex.org/W2892472506","https://openalex.org/W2915602714","https://openalex.org/W3007560529","https://openalex.org/W4242124043","https://openalex.org/W4245435298","https://openalex.org/W4247092534","https://openalex.org/W4294843269","https://openalex.org/W6689099169"],"related_works":["https://openalex.org/W4220977990","https://openalex.org/W2072920560","https://openalex.org/W2803873201","https://openalex.org/W2260609888","https://openalex.org/W2066864925","https://openalex.org/W2315192691","https://openalex.org/W2890860077","https://openalex.org/W2021735217","https://openalex.org/W329183168","https://openalex.org/W2063604509"],"abstract_inverted_index":{"Substance":[0,38,102],"use":[1,8,39,51,57,70,77,88,103,209],"(e.g.,":[2],"alcohol,":[3],"marijuana,":[4],"opioids,":[5],"cocaine.,":[6],"etc,)":[7],"often":[9],"initiates":[10],"during":[11,40,238],"adolescence,":[12,239],"a":[13,46,240],"critical":[14],"period":[15],"of":[16,49,68,89,203,207,217,243,256],"physiological":[17],"and":[18,71,98,112,124,132,138,154,169,178,193,212,232,247,253],"social":[19,194],"development":[20],"marked":[21],"by":[22],"an":[23,201],"increase":[24],"in":[25,28,54,83,94,104,148,172,210,229],"risk-taking":[26],"due,":[27],"part,":[29],"to":[30,33,128,159],"heightened":[31,130,244],"motivation":[32],"obtain":[34],"arousal":[35],"from":[36,174,182],"rewards.":[37],"adolescence":[41,105,173],"has":[42,81,91,106],"been":[43,107],"associated":[44,108],"with":[45,109],"greater":[47],"risk":[48],"substance":[50,208],"disorders":[52],"(SUD)":[53],"adulthood.":[55],"Although":[56],"rates":[58],"for":[59,214,250],"most":[60],"substances":[61],"have":[62,224],"remained":[63],"relatively":[64],"stable,":[65],"the":[66,72,86,95,119,161,175,204,215,251],"frequency":[67],"marijuana":[69,76],"perception":[73],"that":[74,142],"regular":[75],"is":[78],"not":[79],"harmful":[80],"increased":[82],"adolescents.":[84],"Furthermore,":[85],"nonmedical":[87],"opioids":[90],"increased,":[92],"particularly":[93,219],"South,":[96],"Midwest,":[97],"rural":[99],"low-income":[100],"communities.":[101],"adverse":[110],"structural":[111],"functional":[113],"brain":[114,235],"changes":[115],"and,":[116],"may":[117,157,233],"exacerbate":[118],"natural":[120],"\"imbalance\"":[121],"between":[122,166],"frontal/regulatory":[123],"cortical-subcortical":[125,230],"circuits,":[126],"leading":[127],"further":[129],"impulsive":[131],"reward-driven":[133],"behaviors.":[134],"Exercise":[135,156],"increases":[136,226],"growth":[137],"brain-derived":[139],"neurotrophic":[140],"factors":[141],"stimulate":[143],"endogenous":[144],"dopaminergic":[145],"systems":[146],"that,":[147],"turn,":[149],"enhance":[150],"general":[151],"plasticity,":[152,249],"learning,":[153],"memory.":[155],"help":[158],"reinforce":[160],"\"na\u00efve\"":[162],"or":[163],"underdeveloped":[164],"connections":[165],"neurological":[167],"reward":[168,180,245],"regulatory":[170],"processes":[171],"\"bottom":[176],"up\"":[177],"\"offset\"":[179],"seeking":[181],"substances,":[183],"while":[184],"concomitantly":[185],"improving":[186],"cardiovascular":[187],"health,":[188],"as":[189,191],"well":[190],"academic":[192],"achievement.":[195],"In":[196],"this":[197],"review,":[198],"we":[199,223],"provide":[200],"overview":[202],"current":[205],"state":[206],"adolescents":[211],"rationale":[213],"utilization":[216],"exercise,":[218,221],"\"assisted\"":[220],"which":[222],"shown":[225],"neural":[227,248],"activity":[228],"regions":[231],"modulate":[234],"dopamine":[236],"levels":[237],"unique":[241],"window":[242],"sensitivity":[246],"prevention":[252],"adjunctive":[254],"treatment":[255],"SUD.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
