{"id":"https://openalex.org/W2777461561","doi":"https://doi.org/10.1001/jamaoncol.2017.4427","title":"Clinical and Molecular Characteristics Associated With Survival Among Patients Treated With Checkpoint Inhibitors for Advanced Non\u2013Small Cell Lung Carcinoma","display_name":"Clinical and Molecular Characteristics Associated With Survival Among Patients Treated With Checkpoint Inhibitors for Advanced Non\u2013Small Cell Lung Carcinoma","publication_year":2017,"publication_date":"2017-12-21","ids":{"openalex":"https://openalex.org/W2777461561","doi":"https://doi.org/10.1001/jamaoncol.2017.4427","mag":"2777461561","pmid":"https://pubmed.ncbi.nlm.nih.gov/29270615","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5838598"},"language":"en","primary_location":{"id":"doi:10.1001/jamaoncol.2017.4427","doi":"https://doi.org/10.1001/jamaoncol.2017.4427","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamaoncol.2017.4427","pdf_url":"https://jamanetwork.com/journals/jamaoncology/articlepdf/2666760/jamaoncology_lee_2017_oi_170079.pdf","source":{"id":"https://openalex.org/S2756165422","display_name":"JAMA Oncology","issn_l":"2374-2437","issn":["2374-2437","2374-2445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Oncology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jamanetwork.com/journals/jamaoncology/articlepdf/2666760/jamaoncology_lee_2017_oi_170079.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071066396","display_name":"Chee Khoon Lee","orcid":"https://orcid.org/0000-0003-2955-9820","observed_orcids":["https://orcid.org/0000-0003-2955-9820"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I4210123059","display_name":"St George Hospital","ror":"https://ror.org/02pk13h45","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210123059"]},{"id":"https://openalex.org/I42131985","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70","country_code":"AU","type":"government","lineage":["https://openalex.org/I2801453606","https://openalex.org/I3149551504","https://openalex.org/I42131985"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Chee Khoon Lee","raw_affiliation_strings":["Cancer Care Centre, St George Hospital, Sydney, New South Wales, Australia","National Health and Medical Research Council Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Care Centre, St George Hospital, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I4210123059"]},{"raw_affiliation_string":"National Health and Medical Research Council Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I42131985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059121058","display_name":"Johnathan Man","orcid":"https://orcid.org/0000-0002-8505-1506","observed_orcids":["https://orcid.org/0000-0002-8505-1506"]},"institutions":[{"id":"https://openalex.org/I4210123059","display_name":"St George Hospital","ror":"https://ror.org/02pk13h45","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210123059"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Johnathan Man","raw_affiliation_strings":["Cancer Care Centre, St George Hospital, Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Care Centre, St George Hospital, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I4210123059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052465499","display_name":"Sarah J. Lord","orcid":"https://orcid.org/0000-0003-2763-5949","observed_orcids":["https://orcid.org/0000-0003-2763-5949"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I42131985","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70","country_code":"AU","type":"government","lineage":["https://openalex.org/I2801453606","https://openalex.org/I3149551504","https://openalex.org/I42131985"]},{"id":"https://openalex.org/I93396115","display_name":"The University of Notre Dame Australia","ror":"https://ror.org/02stey378","country_code":"AU","type":"education","lineage":["https://openalex.org/I93396115"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sally Lord","raw_affiliation_strings":["National Health and Medical Research Council Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia","School of Medicine, The University of Norte Dame, Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Health and Medical Research Council Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I42131985"]},{"raw_affiliation_string":"School of Medicine, The University of Norte Dame, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I93396115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073324156","display_name":"Wendy A. Cooper","orcid":"https://orcid.org/0000-0001-5418-4229","observed_orcids":["https://orcid.org/0000-0001-5418-4229"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2799732068","display_name":"Royal Prince Alfred Hospital","ror":"https://ror.org/05gpvde20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799732068"]},{"id":"https://openalex.org/I63525965","display_name":"Western Sydney University","ror":"https://ror.org/03t52dk35","country_code":"AU","type":"education","lineage":["https://openalex.org/I63525965"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Wendy Cooper","raw_affiliation_strings":["Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia","School of Medicine, Western Sydney University, Sydney, New South Wales, Australia","Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I2799732068"]},{"raw_affiliation_string":"School of Medicine, Western Sydney University, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I63525965"]},{"raw_affiliation_string":"Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000275974","display_name":"Matthew Jon Links","orcid":"https://orcid.org/0000-0003-3779-3705","observed_orcids":["https://orcid.org/0000-0003-3779-3705"]},"institutions":[{"id":"https://openalex.org/I4210123059","display_name":"St George Hospital","ror":"https://ror.org/02pk13h45","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210123059"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Matthew Links","raw_affiliation_strings":["Cancer Care Centre, St George Hospital, Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Care Centre, St George Hospital, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I4210123059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023743013","display_name":"Val Gebski","orcid":"https://orcid.org/0000-0001-8748-1844","observed_orcids":["https://orcid.org/0000-0001-8748-1844"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I42131985","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70","country_code":"AU","type":"government","lineage":["https://openalex.org/I2801453606","https://openalex.org/I3149551504","https://openalex.org/I42131985"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Val Gebski","raw_affiliation_strings":["National Health and Medical Research Council Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Health and Medical Research Council Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I42131985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008593691","display_name":"Roy S. Herbst","orcid":"https://orcid.org/0000-0003-2535-5847","observed_orcids":["https://orcid.org/0000-0003-2535-5847"]},"institutions":[{"id":"https://openalex.org/I2802730090","display_name":"Yale Cancer Center","ror":"https://ror.org/03j7sze86","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802730090","https://openalex.org/I4210117499","https://openalex.org/I4210165192"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210165192","display_name":"Smilow Cancer Hospital","ror":"https://ror.org/05q3szf80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117499","https://openalex.org/I4210165192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roy S. Herbst","raw_affiliation_strings":["Smilow Cancer Hospital, New Haven, Connecticut","Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Smilow Cancer Hospital, New Haven, Connecticut","institution_ids":["https://openalex.org/I4210165192"]},{"raw_affiliation_string":"Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I2802730090","https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048487071","display_name":"Richard J. Gralla","orcid":"https://orcid.org/0000-0001-7963-3086","observed_orcids":["https://orcid.org/0000-0001-7963-3086"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I2800364127","display_name":"Jacobi Medical Center","ror":"https://ror.org/05hcfns23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800364127"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard J. Gralla","raw_affiliation_strings":["Department of Medicine (Oncology), Albert Einstein College of Medicine, New York, New York","Hematology-Oncology Division, Jacobi Medical Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Oncology), Albert Einstein College of Medicine, New York, New York","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Hematology-Oncology Division, Jacobi Medical Center, New York, New York","institution_ids":["https://openalex.org/I2800364127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066717752","display_name":"Tony S.K. Mok","orcid":"https://orcid.org/0000-0002-8251-0551","observed_orcids":["https://orcid.org/0000-0002-8251-0551"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Tony Mok","raw_affiliation_strings":["Hong Kong Cancer Institute, Department of Clinical Oncology, Chinese University of Hong Kong, Shatin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hong Kong Cancer Institute, Department of Clinical Oncology, Chinese University of Hong Kong, Shatin, China","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055074037","display_name":"James Chih\u2010Hsin Yang","orcid":"https://orcid.org/0000-0002-5586-5138","observed_orcids":["https://orcid.org/0000-0002-5586-5138"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"James Chih-Hsin Yang","raw_affiliation_strings":["Department of Oncology, National Taiwan University Hospital, Taipei City, Taiwan","Graduate Institute of Oncology, National Taiwan University, Taipei City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, National Taiwan University Hospital, Taipei City, Taiwan","institution_ids":["https://openalex.org/I4210131804"]},{"raw_affiliation_string":"Graduate Institute of Oncology, National Taiwan University, Taipei City, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5071066396"],"corresponding_institution_ids":["https://openalex.org/I129604602","https://openalex.org/I4210123059","https://openalex.org/I42131985"],"apc_list":null,"apc_paid":null,"fwci":5.1294,"has_fulltext":true,"cited_by_count":598,"citation_normalized_percentile":{"value":0.97618388,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"4","issue":"2","first_page":"210","last_page":"210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5098000168800354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5098000168800354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.45559999346733093,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9779999852180481},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.9269999861717224},{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":0.843999981880188},{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"pembrolizumab","score":1.0},{"id":"https://openalex.org/keywords/atezolizumab","display_name":"atezolizumab","score":1.0},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9259999990463257},{"id":"https://openalex.org/keywords/egfr-mutation-status","display_name":"EGFR mutation status","score":0.7080000042915344},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.843999981880188},{"id":"https://openalex.org/keywords/second-line-treatment","display_name":"second-line therapy","score":0.7799999713897705},{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.6589999794960022},{"id":"https://openalex.org/keywords/pd-1-pd-l1-inhibitors","display_name":"PD-1/PD-L1 inhibitors","score":0.6069999933242798},{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.7490000128746033},{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9110269546508789},{"id":"https://openalex.org/C2775949291","wikidata":"https://www.wikidata.org/wiki/Q20707748","display_name":"Atezolizumab","level":5,"score":0.8388672471046448},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.816814124584198},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.7740755677223206},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.7077881097793579},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6979084014892578},{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.6952828764915466},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5617219805717468},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5064340829849243},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4897890090942383},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.427436888217926},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2839023768901825},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.25922876596450806},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.2057953178882599},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.10987028479576111},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D059447","descriptor_name":"Cell Cycle Checkpoints","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059447","descriptor_name":"Cell Cycle Checkpoints","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1001/jamaoncol.2017.4427","doi":"https://doi.org/10.1001/jamaoncol.2017.4427","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamaoncol.2017.4427","pdf_url":"https://jamanetwork.com/journals/jamaoncology/articlepdf/2666760/jamaoncology_lee_2017_oi_170079.pdf","source":{"id":"https://openalex.org/S2756165422","display_name":"JAMA Oncology","issn_l":"2374-2437","issn":["2374-2437","2374-2445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5269501","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5838598","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5838598","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5838598","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Oncol","raw_type":"Text"},{"id":"pmid:29270615","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29270615","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA oncology","raw_type":"Journal Article"},{"id":"pmh:oai:research-repository.griffith.edu.au:10072/385019","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10072/385019","pdf_url":null,"source":{"id":"https://openalex.org/S7407064376","display_name":"Griffith Research Online","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1001/jamaoncol.2017.4427","doi":"https://doi.org/10.1001/jamaoncol.2017.4427","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamaoncol.2017.4427","pdf_url":"https://jamanetwork.com/journals/jamaoncology/articlepdf/2666760/jamaoncology_lee_2017_oi_170079.pdf","source":{"id":"https://openalex.org/S2756165422","display_name":"JAMA Oncology","issn_l":"2374-2437","issn":["2374-2437","2374-2445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[{"id":"https://openalex.org/G9000905448","display_name":"Yale Clinical and Translational Science Award","funder_award_id":"UL1TR001863","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320309086","display_name":"Celgene","ror":"https://ror.org/0527yg379"},{"id":"https://openalex.org/F4320311653","display_name":"Taiho Pharmaceutical","ror":"https://ror.org/02v50dx14"},{"id":"https://openalex.org/F4320315087","display_name":"Clovis Oncology","ror":"https://ror.org/04ps4d441"},{"id":"https://openalex.org/F4320322148","display_name":"Eisai","ror":"https://ror.org/04vvh7p27"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320333682","display_name":"Ignyta","ror":"https://ror.org/05mmnft02"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2777461561.pdf","grobid_xml":"https://content.openalex.org/works/W2777461561.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1982488143","https://openalex.org/W2049553585","https://openalex.org/W2071865120","https://openalex.org/W2104347254","https://openalex.org/W2124427232","https://openalex.org/W2130652363","https://openalex.org/W2131876608","https://openalex.org/W2134667653","https://openalex.org/W2143488876","https://openalex.org/W2145411470","https://openalex.org/W2147592245","https://openalex.org/W2156353875","https://openalex.org/W2160549455","https://openalex.org/W2198093519","https://openalex.org/W2235523093","https://openalex.org/W2293064244","https://openalex.org/W2293531514","https://openalex.org/W2296947286","https://openalex.org/W2342639474","https://openalex.org/W2400514548","https://openalex.org/W2416791964","https://openalex.org/W2538232731","https://openalex.org/W2557730509","https://openalex.org/W2560367415","https://openalex.org/W2560704457","https://openalex.org/W2561459036","https://openalex.org/W2567564314","https://openalex.org/W2572174216","https://openalex.org/W2614502842","https://openalex.org/W2683488101","https://openalex.org/W2741903474","https://openalex.org/W2787467961","https://openalex.org/W2891360169","https://openalex.org/W2892012167","https://openalex.org/W4406564638"],"related_works":["https://openalex.org/W2793719304","https://openalex.org/W2589103622","https://openalex.org/W2981771279","https://openalex.org/W2286173468","https://openalex.org/W2506710765","https://openalex.org/W2947501460","https://openalex.org/W4292661229","https://openalex.org/W2947577031","https://openalex.org/W2415283090","https://openalex.org/W2538232731"],"abstract_inverted_index":{"IMPORTANCE:":[0],"Checkpoint":[1,225,395],"inhibitors":[2,226,428],"have":[3,437],"replaced":[4],"docetaxel":[5,43,222,235],"as":[6],"the":[7,24,36,64,77,111,170,183,249,264,286,301,449],"new":[8],"standard":[9],"second-line":[10,408],"therapy":[11,409],"in":[12,46,76,108,199,248,263,285,300,407,410,448,457],"advanced":[13,195],"non-small":[14],"cell":[15],"lung":[16],"carcinoma":[17],"(NSCLC),":[18],"but":[19,261,298],"little":[20],"is":[21],"known":[22],"about":[23],"potential":[25],"predictive":[26],"value":[27],"of":[28,39,68,115,124,128,160,414,442,453],"clinical":[29,73,91],"and":[30,45,57,63,84,126,158,166,173,280,451,456],"molecular":[31],"characteristics.":[32,51],"OBJECTIVE:":[33],"To":[34],"estimate":[35],"relative":[37,318],"efficacy":[38],"checkpoint":[40,96,129,209,427],"inhibitor":[41,97,130,210],"vs":[42,331,345,358,371,384],"overall":[44,171,231,246,283,405,416],"subgroups":[47,174],"defined":[48],"by":[49],"clinicopathological":[50,121],"DATA":[52,147],"SOURCES:":[53],"This":[54],"systematic":[55],"review":[56],"meta-analysis":[58,444],"searched":[59],"MEDLINE,":[60],"Embase,":[61],"PubMed,":[62],"Cochrane":[65],"Central":[66],"Register":[67],"Controlled":[69],"Trials":[70],"for":[71,135,169,419],"randomized":[72,205],"trials":[74,92,190,455],"published":[75],"English":[78],"language":[79],"between":[80],"January":[81,85],"1,":[82],"1996,":[83],"30,":[86],"2017.":[87,146],"STUDY":[88],"SELECTION:":[89],"Randomized":[90],"that":[93,426],"compared":[94,233,397],"a":[95,208],"(nivolumab,":[98,211],"pembrolizumab,":[99,214],"or":[100,117,217,221,379],"atezolizumab)":[101],"with":[102,194,229,234,398,402,421],"docetaxel.":[103],"For":[104],"each":[105],"trial":[106,112],"included":[107,198],"this":[109,136,200,443],"study,":[110],"name,":[113],"year":[114],"publication":[116],"conference":[118],"presentation,":[119],"patients'":[120],"characteristics,":[122],"type":[123,127],"chemotherapy,":[125],"were":[131,175,180,197,204,227,321],"extracted.":[132,176],"Data":[133],"collection":[134],"study":[137,154],"took":[138],"place":[139],"from":[140],"February":[141],"1":[142,346],"to":[143,206,324],"March":[144],"31,":[145],"EXTRACTION":[148],"AND":[149,393],"SYNTHESIS:":[150],"Two":[151],"reviewers":[152],"performed":[153],"selection,":[155],"data":[156],"abstraction,":[157],"risk":[159],"bias":[161],"assessment.":[162],"Hazard":[163],"ratios":[164],"(HR)":[165],"95%":[167,238,255,270,292,307],"CIs":[168],"population":[172],"Pooled":[177],"treatment":[178,319],"estimates":[179],"calculated":[181],"using":[182],"inverse-variance-weighted":[184],"method.":[185],"RESULTS:":[186],"In":[187],"total,":[188],"5":[189],"involving":[191],"3025":[192],"patients":[193,203,420],"NSCLC":[196],"meta-analysis.":[201],"These":[202],"receive":[207],"427":[212],"[14.1%];":[213],"691":[215],"[22.8%];":[216],"atezolizumab,":[218],"569":[219],"[18.8%])":[220],"(1338":[223],"[44.2%]).":[224],"associated":[228,401],"prolonged":[230,245,282],"survival,":[232],"(HR,":[236,253,268,290,305],"0.69;":[237],"CI,":[239,256,271,293,308],"0.63-0.75;":[240],"P":[241,258,273,277,295,310,314,337,350,364,376,389],"<":[242,259],".001).":[243],"They":[244],"survival":[247,284,406,417],"EGFR":[250,265,422],"wild-type":[251,303],"subgroup":[252,267,289,304],"0.67;":[254],"0.60-0.75;":[257],".001),":[260],"not":[262,299],"mutant":[266,288,423],"1.11;":[269],"0.80-1.53;":[272],"=":[274,278,296,311,315,338,351,365,377,390],".54;":[275],"interaction,":[276,313,336,349,363,375,388],".005),":[279],"they":[281],"KRAS":[287,302],"0.65;":[291],"0.44-0.97;":[294],".03)":[297],"0.86;":[306],"0.67-1.11;":[309],".24;":[312],".24).":[316],"The":[317,412,440],"benefits":[320],"similar":[322],"according":[323],"smoking":[325],"status":[326,341],"(never":[327],"smokers":[328,333],"[HR,":[329,334,343,347,356,361,369,373,382,386],"0.79]":[330],"ever":[332],"0.69];":[335,362],".40),":[339],"performance":[340],"(0":[342],"0.69]":[344,383],"0.68];":[348],".85),":[352],"age":[353],"(<65":[354],"years":[355,360],"0.71]":[357],"\u226565":[359],".74),":[366],"histology":[367],"(squamous":[368],"0.67]":[370],"nonsquamous":[372],"0.70];":[374,387],".71),":[378],"sex":[380],"(male":[381],"female":[385],".82).":[391],"CONCLUSION":[392],"RELEVANCE:":[394],"inhibitors,":[396],"docetaxel,":[399],"are":[400],"significantly":[403],"prolong":[404],"NSCLC.":[411],"finding":[413],"no":[415],"benefit":[418],"tumors":[424],"suggests":[425],"should":[429],"be":[430],"considered":[431],"only":[432],"after":[433],"other":[434],"effective":[435],"therapies":[436],"been":[438],"exhausted.":[439],"findings":[441],"could":[445],"also":[446],"assist":[447],"design":[450],"interpretation":[452],"future":[454],"economic":[458],"analyses.":[459]},"counts_by_year":[{"year":2026,"cited_by_count":30},{"year":2025,"cited_by_count":47},{"year":2024,"cited_by_count":87},{"year":2023,"cited_by_count":64},{"year":2022,"cited_by_count":98},{"year":2021,"cited_by_count":93},{"year":2020,"cited_by_count":80},{"year":2019,"cited_by_count":57},{"year":2018,"cited_by_count":42}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-01-05T00:00:00"}