{"id":"https://openalex.org/W2777085303","doi":"https://doi.org/10.1016/j.pharmthera.2017.12.012","title":"Selective estrogen receptor modulators (SERMs) and selective estrogen receptor degraders (SERDs) in cancer treatment","display_name":"Selective estrogen receptor modulators (SERMs) and selective estrogen receptor degraders (SERDs) in cancer treatment","publication_year":2017,"publication_date":"2017-12-28","ids":{"openalex":"https://openalex.org/W2777085303","doi":"https://doi.org/10.1016/j.pharmthera.2017.12.012","mag":"2777085303","pmid":"https://pubmed.ncbi.nlm.nih.gov/29289555"},"language":"en","primary_location":{"id":"doi:10.1016/j.pharmthera.2017.12.012","doi":"https://doi.org/10.1016/j.pharmthera.2017.12.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.pharmthera.2017.12.012","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0163725817303108/pdf","source":{"id":"https://openalex.org/S83493678","display_name":"Pharmacology & Therapeutics","issn_l":"0163-7258","issn":["0163-7258","1879-016X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology & Therapeutics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0163725817303108/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104110851","display_name":"Hitisha Patel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093176","display_name":"Radius Health (United States)","ror":"https://ror.org/00m2x3q29","country_code":"US","type":"company","lineage":["https://openalex.org/I4210093176"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hitisha K. Patel","raw_affiliation_strings":["Radius Health, Inc, Waltham, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radius Health, Inc, Waltham, MA, USA","institution_ids":["https://openalex.org/I4210093176"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073955009","display_name":"Teeru Bihani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093176","display_name":"Radius Health (United States)","ror":"https://ror.org/00m2x3q29","country_code":"US","type":"company","lineage":["https://openalex.org/I4210093176"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Teeru Bihani","raw_affiliation_strings":["Radius Health, Inc, Waltham, MA, USA. Electronic address: tbihani@radiuspharm.com","Radius Health, Inc, Waltham, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radius Health, Inc, Waltham, MA, USA. Electronic address: tbihani@radiuspharm.com","institution_ids":["https://openalex.org/I4210093176"]},{"raw_affiliation_string":"Radius Health, Inc, Waltham, MA, USA","institution_ids":["https://openalex.org/I4210093176"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5073955009"],"corresponding_institution_ids":["https://openalex.org/I4210093176"],"apc_list":{"value":5660,"currency":"USD","value_usd":5660},"apc_paid":{"value":5660,"currency":"USD","value_usd":5660},"fwci":3.008,"has_fulltext":true,"cited_by_count":536,"citation_normalized_percentile":{"value":0.95035461,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"186","issue":null,"first_page":"1","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8637999892234802,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8637999892234802,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.1145000010728836,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/selective-estrogen-receptor-modulators","display_name":"selective estrogen receptor modulators","score":0.9980000257492065},{"id":"https://openalex.org/keywords/selective-estrogen-receptor-degrader","display_name":"selective estrogen receptor degrader","score":1.0},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.8700000047683716},{"id":"https://openalex.org/keywords/endocrine-resistance","display_name":"endocrine therapy resistance","score":0.7099999785423279},{"id":"https://openalex.org/keywords/antiestrogens","display_name":"antiestrogens","score":0.7310000061988831},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C2777944059","wikidata":"https://www.wikidata.org/wiki/Q903917","display_name":"Selective estrogen receptor modulator","level":5,"score":0.8310925960540771},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7732313871383667},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.7373200058937073},{"id":"https://openalex.org/C2776067312","wikidata":"https://www.wikidata.org/wiki/Q50429983","display_name":"Antiestrogen","level":5,"score":0.6595878601074219},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5926085710525513},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5502601861953735},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.5051046013832092},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4905025362968445},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.44849586486816406},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.41949281096458435},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34935083985328674},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34572067856788635},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22267720103263855}],"mesh":[{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020845","descriptor_name":"Selective Estrogen Receptor Modulators","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020845","descriptor_name":"Selective Estrogen Receptor Modulators","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D020845","descriptor_name":"Selective Estrogen Receptor Modulators","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D065171","descriptor_name":"Estrogen Receptor Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D065171","descriptor_name":"Estrogen Receptor Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D065171","descriptor_name":"Estrogen Receptor Antagonists","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.pharmthera.2017.12.012","doi":"https://doi.org/10.1016/j.pharmthera.2017.12.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.pharmthera.2017.12.012","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0163725817303108/pdf","source":{"id":"https://openalex.org/S83493678","display_name":"Pharmacology & Therapeutics","issn_l":"0163-7258","issn":["0163-7258","1879-016X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology & Therapeutics","raw_type":"journal-article"},{"id":"pmid:29289555","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29289555","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology & therapeutics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.pharmthera.2017.12.012","doi":"https://doi.org/10.1016/j.pharmthera.2017.12.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.pharmthera.2017.12.012","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0163725817303108/pdf","source":{"id":"https://openalex.org/S83493678","display_name":"Pharmacology & Therapeutics","issn_l":"0163-7258","issn":["0163-7258","1879-016X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology & Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320316098","display_name":"Radius Health","ror":"https://ror.org/00m2x3q29"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2777085303.pdf","grobid_xml":"https://content.openalex.org/works/W2777085303.grobid-xml"},"referenced_works_count":401,"referenced_works":["https://openalex.org/W317155238","https://openalex.org/W779403461","https://openalex.org/W840607072","https://openalex.org/W1004286510","https://openalex.org/W1505828315","https://openalex.org/W1506399025","https://openalex.org/W1520764408","https://openalex.org/W1560075141","https://openalex.org/W1562190372","https://openalex.org/W1562784453","https://openalex.org/W1565310327","https://openalex.org/W1590666178","https://openalex.org/W1606189458","https://openalex.org/W1618493953","https://openalex.org/W1646536031","https://openalex.org/W1656816575","https://openalex.org/W1738416205","https://openalex.org/W1761610861","https://openalex.org/W1792508556","https://openalex.org/W1829247853","https://openalex.org/W1849884743","https://openalex.org/W1850971480","https://openalex.org/W1855644411","https://openalex.org/W1862864205","https://openalex.org/W1878298203","https://openalex.org/W1894067668","https://openalex.org/W1897679170","https://openalex.org/W1898692666","https://openalex.org/W1919901534","https://openalex.org/W1944448503","https://openalex.org/W1953419452","https://openalex.org/W1961026612","https://openalex.org/W1965660226","https://openalex.org/W1966216790","https://openalex.org/W1967021280","https://openalex.org/W1967288816","https://openalex.org/W1969870046","https://openalex.org/W1971628094","https://openalex.org/W1974167857","https://openalex.org/W1974841944","https://openalex.org/W1975402264","https://openalex.org/W1975472851","https://openalex.org/W1975781791","https://openalex.org/W1978282886","https://openalex.org/W1979413406","https://openalex.org/W1979903836","https://openalex.org/W1980040001","https://openalex.org/W1981125500","https://openalex.org/W1981801066","https://openalex.org/W1983481205","https://openalex.org/W1984705614","https://openalex.org/W1986364825","https://openalex.org/W1987029023","https://openalex.org/W1987458731","https://openalex.org/W1987557987","https://openalex.org/W1988508767","https://openalex.org/W1989757783","https://openalex.org/W1992523140","https://openalex.org/W1992534638","https://openalex.org/W1993031979","https://openalex.org/W1994401414","https://openalex.org/W1994783207","https://openalex.org/W1995360221","https://openalex.org/W1995388182","https://openalex.org/W1995475389","https://openalex.org/W1996191291","https://openalex.org/W1996200093","https://openalex.org/W1997006452","https://openalex.org/W1998040747","https://openalex.org/W1999142127","https://openalex.org/W1999183598","https://openalex.org/W1999426074","https://openalex.org/W1999911762","https://openalex.org/W2000973033","https://openalex.org/W2001652125","https://openalex.org/W2002339899","https://openalex.org/W2002514277","https://openalex.org/W2003686815","https://openalex.org/W2003996771","https://openalex.org/W2004867710","https://openalex.org/W2006860223","https://openalex.org/W2009551388","https://openalex.org/W2010440101","https://openalex.org/W2010925208","https://openalex.org/W2012502745","https://openalex.org/W2012877952","https://openalex.org/W2013564634","https://openalex.org/W2013809140","https://openalex.org/W2014115970","https://openalex.org/W2014324176","https://openalex.org/W2015257936","https://openalex.org/W2015473392","https://openalex.org/W2016406592","https://openalex.org/W2017333359","https://openalex.org/W2017402038","https://openalex.org/W2018157403","https://openalex.org/W2019311111","https://openalex.org/W2019454154","https://openalex.org/W2019627697","https://openalex.org/W2019695814","https://openalex.org/W2020508605","https://openalex.org/W2020547886","https://openalex.org/W2021145743","https://openalex.org/W2022742795","https://openalex.org/W2023077979","https://openalex.org/W2023586989","https://openalex.org/W2025784247","https://openalex.org/W2026383074","https://openalex.org/W2026579016","https://openalex.org/W2027442209","https://openalex.org/W2027918295","https://openalex.org/W2028691872","https://openalex.org/W2029055202","https://openalex.org/W2031113361","https://openalex.org/W2032497885","https://openalex.org/W2032654223","https://openalex.org/W2033527965","https://openalex.org/W2033872262","https://openalex.org/W2034753152","https://openalex.org/W2037965527","https://openalex.org/W2039864977","https://openalex.org/W2039871782","https://openalex.org/W2041155982","https://openalex.org/W2042162210","https://openalex.org/W2042487706","https://openalex.org/W2042714596","https://openalex.org/W2043433390","https://openalex.org/W2044497664","https://openalex.org/W2044869180","https://openalex.org/W2045389096","https://openalex.org/W2046410395","https://openalex.org/W2047246104","https://openalex.org/W2048257551","https://openalex.org/W2048610237","https://openalex.org/W2048624904","https://openalex.org/W2049679696","https://openalex.org/W2050870515","https://openalex.org/W2051676088","https://openalex.org/W2052074532","https://openalex.org/W2052266277","https://openalex.org/W2052631876","https://openalex.org/W2053252897","https://openalex.org/W2054372078","https://openalex.org/W2054564508","https://openalex.org/W2055047420","https://openalex.org/W2055421714","https://openalex.org/W2056155028","https://openalex.org/W2056404763","https://openalex.org/W2057185405","https://openalex.org/W2057553101","https://openalex.org/W2058338331","https://openalex.org/W2058771273","https://openalex.org/W2060011282","https://openalex.org/W2060324598","https://openalex.org/W2060404556","https://openalex.org/W2060756680","https://openalex.org/W2061111218","https://openalex.org/W2061671852","https://openalex.org/W2061739720","https://openalex.org/W2061818721","https://openalex.org/W2062073156","https://openalex.org/W2062798076","https://openalex.org/W2062870076","https://openalex.org/W2066058476","https://openalex.org/W2066441904","https://openalex.org/W2066609234","https://openalex.org/W2067980525","https://openalex.org/W2068501866","https://openalex.org/W2068659150","https://openalex.org/W2068733105","https://openalex.org/W2070367875","https://openalex.org/W2070541537","https://openalex.org/W2071164190","https://openalex.org/W2074062119","https://openalex.org/W2074335085","https://openalex.org/W2074903810","https://openalex.org/W2076294660","https://openalex.org/W2076910309","https://openalex.org/W2078168707","https://openalex.org/W2080463492","https://openalex.org/W2081098900","https://openalex.org/W2082604451","https://openalex.org/W2082963913","https://openalex.org/W2083576875","https://openalex.org/W2087273432","https://openalex.org/W2087552682","https://openalex.org/W2089738145","https://openalex.org/W2091462791","https://openalex.org/W2092677214","https://openalex.org/W2095092592","https://openalex.org/W2097255042","https://openalex.org/W2098270787","https://openalex.org/W2099254042","https://openalex.org/W2099493846","https://openalex.org/W2100531260","https://openalex.org/W2100874814","https://openalex.org/W2100980757","https://openalex.org/W2101738855","https://openalex.org/W2101844536","https://openalex.org/W2103791567","https://openalex.org/W2103829266","https://openalex.org/W2104561097","https://openalex.org/W2104775804","https://openalex.org/W2105084636","https://openalex.org/W2106605842","https://openalex.org/W2106955083","https://openalex.org/W2109388713","https://openalex.org/W2109941680","https://openalex.org/W2110061970","https://openalex.org/W2110315198","https://openalex.org/W2110767908","https://openalex.org/W2110812946","https://openalex.org/W2111650618","https://openalex.org/W2112577860","https://openalex.org/W2112620293","https://openalex.org/W2112620415","https://openalex.org/W2112831138","https://openalex.org/W2113315372","https://openalex.org/W2113458582","https://openalex.org/W2114457800","https://openalex.org/W2115020988","https://openalex.org/W2115602827","https://openalex.org/W2115950635","https://openalex.org/W2116397033","https://openalex.org/W2116937653","https://openalex.org/W2117357260","https://openalex.org/W2118003113","https://openalex.org/W2118229928","https://openalex.org/W2118728607","https://openalex.org/W2118918129","https://openalex.org/W2120344853","https://openalex.org/W2121207995","https://openalex.org/W2121311779","https://openalex.org/W2121454015","https://openalex.org/W2121656289","https://openalex.org/W2122148679","https://openalex.org/W2123006593","https://openalex.org/W2123498358","https://openalex.org/W2124358769","https://openalex.org/W2125713798","https://openalex.org/W2125765400","https://openalex.org/W2126275835","https://openalex.org/W2127487694","https://openalex.org/W2128003724","https://openalex.org/W2128456807","https://openalex.org/W2128458647","https://openalex.org/W2128613144","https://openalex.org/W2129757272","https://openalex.org/W2130868107","https://openalex.org/W2131195026","https://openalex.org/W2131394541","https://openalex.org/W2131994307","https://openalex.org/W2133667885","https://openalex.org/W2134062048","https://openalex.org/W2134427809","https://openalex.org/W2134605638","https://openalex.org/W2134762354","https://openalex.org/W2135944809","https://openalex.org/W2136020634","https://openalex.org/W2136136792","https://openalex.org/W2137177885","https://openalex.org/W2137355132","https://openalex.org/W2137579997","https://openalex.org/W2137620209","https://openalex.org/W2138036445","https://openalex.org/W2138314001","https://openalex.org/W2138692147","https://openalex.org/W2138748691","https://openalex.org/W2139657953","https://openalex.org/W2139726760","https://openalex.org/W2140442588","https://openalex.org/W2141137976","https://openalex.org/W2141232624","https://openalex.org/W2141647078","https://openalex.org/W2142334766","https://openalex.org/W2142429005","https://openalex.org/W2142957794","https://openalex.org/W2143659344","https://openalex.org/W2144013834","https://openalex.org/W2144790402","https://openalex.org/W2144811587","https://openalex.org/W2145476705","https://openalex.org/W2146378328","https://openalex.org/W2146522405","https://openalex.org/W2146615732","https://openalex.org/W2147371405","https://openalex.org/W2148320836","https://openalex.org/W2148345265","https://openalex.org/W2149307998","https://openalex.org/W2149636926","https://openalex.org/W2151227939","https://openalex.org/W2153954237","https://openalex.org/W2154377786","https://openalex.org/W2155391261","https://openalex.org/W2156009048","https://openalex.org/W2156455256","https://openalex.org/W2157995673","https://openalex.org/W2158961508","https://openalex.org/W2159206513","https://openalex.org/W2159924849","https://openalex.org/W2160584021","https://openalex.org/W2161387798","https://openalex.org/W2161551022","https://openalex.org/W2161977537","https://openalex.org/W2162255983","https://openalex.org/W2163684297","https://openalex.org/W2164121917","https://openalex.org/W2164541907","https://openalex.org/W2164803063","https://openalex.org/W2165378843","https://openalex.org/W2166026840","https://openalex.org/W2166297054","https://openalex.org/W2166500526","https://openalex.org/W2166760402","https://openalex.org/W2166969772","https://openalex.org/W2167072194","https://openalex.org/W2167151693","https://openalex.org/W2167356378","https://openalex.org/W2168292296","https://openalex.org/W2168931759","https://openalex.org/W2169318796","https://openalex.org/W2169449395","https://openalex.org/W2170796746","https://openalex.org/W2172185687","https://openalex.org/W2202331296","https://openalex.org/W2243467818","https://openalex.org/W2255638054","https://openalex.org/W2258559299","https://openalex.org/W2280263946","https://openalex.org/W2290950904","https://openalex.org/W2291124025","https://openalex.org/W2315368724","https://openalex.org/W2322520357","https://openalex.org/W2323521900","https://openalex.org/W2323968754","https://openalex.org/W2330022227","https://openalex.org/W2332737325","https://openalex.org/W2342819511","https://openalex.org/W2343623791","https://openalex.org/W2345534652","https://openalex.org/W2346465624","https://openalex.org/W2374277491","https://openalex.org/W2384234396","https://openalex.org/W2395038895","https://openalex.org/W2401713021","https://openalex.org/W2404884142","https://openalex.org/W2407339950","https://openalex.org/W2409321377","https://openalex.org/W2411335118","https://openalex.org/W2413654632","https://openalex.org/W2415372857","https://openalex.org/W2416163692","https://openalex.org/W2418100713","https://openalex.org/W2423565878","https://openalex.org/W2461551798","https://openalex.org/W2467112370","https://openalex.org/W2468302041","https://openalex.org/W2470394874","https://openalex.org/W2488747917","https://openalex.org/W2514511766","https://openalex.org/W2514824518","https://openalex.org/W2516966009","https://openalex.org/W2530784802","https://openalex.org/W2558360748","https://openalex.org/W2560635244","https://openalex.org/W2564891497","https://openalex.org/W2565707423","https://openalex.org/W2569695585","https://openalex.org/W2570235257","https://openalex.org/W2581347009","https://openalex.org/W2590052154","https://openalex.org/W2593123457","https://openalex.org/W2598503582","https://openalex.org/W2608386464","https://openalex.org/W2609928112","https://openalex.org/W2611953519","https://openalex.org/W2613492884","https://openalex.org/W2790952449","https://openalex.org/W2901368272","https://openalex.org/W2952009971","https://openalex.org/W3016908890","https://openalex.org/W3198500581","https://openalex.org/W4237889359","https://openalex.org/W4238388542","https://openalex.org/W4241276954","https://openalex.org/W4244519136","https://openalex.org/W4252714226","https://openalex.org/W4255313539","https://openalex.org/W4299862621","https://openalex.org/W6610948010","https://openalex.org/W6636308156","https://openalex.org/W6639914564","https://openalex.org/W6640187128","https://openalex.org/W6645348866","https://openalex.org/W6646853684","https://openalex.org/W6677061289","https://openalex.org/W6678256546","https://openalex.org/W6680601435","https://openalex.org/W6681330882","https://openalex.org/W6713711633","https://openalex.org/W6714275268"],"related_works":["https://openalex.org/W2058229569","https://openalex.org/W4368374182","https://openalex.org/W4221134652","https://openalex.org/W7161822139","https://openalex.org/W1511371042","https://openalex.org/W4307904570","https://openalex.org/W3200278202","https://openalex.org/W7129495598","https://openalex.org/W3094721087","https://openalex.org/W4289527757"],"abstract_inverted_index":{"Breast":[0],"cancer":[1,7,16,75,96,168,219],"is":[2,77,125,221],"the":[3,27,36,54,69,100,117,145,165,179,189,199,202,211],"most":[4],"frequently":[5],"diagnosed":[6],"in":[8,33,127,184,198,217],"women,":[9],"with":[10,53,116],"estrogen":[11,58,64],"receptor":[12,59,65],"positive":[13],"(ER+)":[14],"breast":[15,23,74,135,148,167,208],"making":[17,89],"up":[18],"approximately":[19],"75%":[20],"of":[21,46,56,86,105,120,147,156,173,181,192,201,206,213],"all":[22],"cancers":[24],"diagnosed.":[25],"Given":[26],"dependence":[28,70],"on":[29,71],"active":[30],"ER":[31,52,72,90,141,182],"signaling":[32],"these":[34],"tumors,":[35],"predominant":[37],"treatment":[38,131,146],"strategy":[39],"has":[40],"been":[41],"to":[42,109,175],"inhibit":[43],"various":[44,140],"aspects":[45],"this":[47,95,111],"pathway":[48],"including":[49],"directly":[50],"antagonizing":[51],"use":[55,163,180],"selective":[57,63],"modulators":[60],"(SERMs)":[61],"and":[62,98,103,153,177,188,215],"degraders":[66],"(SERDs).":[67],"Interestingly,":[68],"for":[73,94,133,144],"growth":[76],"often":[78],"retained":[79],"even":[80],"after":[81],"progression":[82],"through":[83],"several":[84],"lines":[85],"antiestrogen":[87],"therapy,":[88],"a":[91,128],"bonafide":[92],"biomarker":[93],"subtype":[97],"driving":[99],"continued":[101],"research":[102],"development":[104,191],"novel":[106,193],"ER-targeted":[107],"therapeutics":[108],"treat":[110],"patient":[112],"population.":[113],"This,":[114],"combined":[115],"continuous":[118],"discovery":[119],"mechanisms":[121,155,172],"underlying":[122],"endocrine":[123],"resistance,":[124],"resulting":[126],"continually":[129],"evolving":[130],"landscape":[132,205],"ER+":[134,166,207],"cancer.":[136,209],"This":[137],"review":[138],"discusses":[139],"antagonists":[142,183],"investigated":[143],"cancer,":[149],"outlining":[150],"their":[151,161],"pharmacological":[152],"tissue-specific":[154],"action":[157],"as":[158,160],"well":[159],"specified":[162],"within":[164],"setting.":[169],"In":[170],"addition,":[171],"resistance":[174],"SERMs":[176,214],"SERDs,":[178],"combination":[185],"therapy":[186],"strategies,":[187],"ongoing":[190],"drugs":[194],"are":[195],"also":[196,222],"reviewed":[197],"context":[200],"changing":[203],"clinical":[204],"Lastly,":[210],"role":[212],"SERDs":[216],"non-breast":[218],"indications":[220],"discussed.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":65},{"year":2025,"cited_by_count":75},{"year":2024,"cited_by_count":85},{"year":2023,"cited_by_count":79},{"year":2022,"cited_by_count":77},{"year":2021,"cited_by_count":66},{"year":2020,"cited_by_count":48},{"year":2019,"cited_by_count":31},{"year":2018,"cited_by_count":8}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-01-05T00:00:00"}