{"id":"https://openalex.org/W2777075988","doi":"https://doi.org/10.1515/hsz-2017-0243","title":"How human serum albumin recognizes DNA and RNA","display_name":"How human serum albumin recognizes DNA and RNA","publication_year":2017,"publication_date":"2017-12-16","ids":{"openalex":"https://openalex.org/W2777075988","doi":"https://doi.org/10.1515/hsz-2017-0243","mag":"2777075988","pmid":"https://pubmed.ncbi.nlm.nih.gov/29252186"},"language":"en","primary_location":{"id":"doi:10.1515/hsz-2017-0243","doi":"https://doi.org/10.1515/hsz-2017-0243","is_oa":false,"landing_page_url":"https://doi.org/10.1515/hsz-2017-0243","pdf_url":null,"source":{"id":"https://openalex.org/S18118477","display_name":"Biological Chemistry","issn_l":"1431-6730","issn":["1431-6730","1437-4315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083382818","display_name":"Ludmila I. Alinovskaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ludmila I. Alinovskaya","raw_affiliation_strings":["Institute of Chemical Biology and Fundamental Medicine of SB RAS, 8 Lavrentiev Ave., Novosibirsk 630090, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemical Biology and Fundamental Medicine of SB RAS, 8 Lavrentiev Ave., Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I4210091979","https://openalex.org/I4210127387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108759453","display_name":"Sergey E. Sedykh","orcid":"https://orcid.org/0000-0003-0882-8171","observed_orcids":["https://orcid.org/0000-0003-0882-8171"]},"institutions":[{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Sergey E. Sedykh","raw_affiliation_strings":["Institute of Chemical Biology and Fundamental Medicine of SB RAS, 8 Lavrentiev Ave., Novosibirsk 630090, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemical Biology and Fundamental Medicine of SB RAS, 8 Lavrentiev Ave., Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I4210091979","https://openalex.org/I4210127387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076841276","display_name":"Nikita V. Ivanisenko","orcid":"https://orcid.org/0000-0002-0333-8117","observed_orcids":["https://orcid.org/0000-0002-0333-8117"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Nikita V. Ivanisenko","raw_affiliation_strings":["Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, 10 Lavrentiev Ave., 630090 Novosibirsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, 10 Lavrentiev Ave., 630090 Novosibirsk, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210116466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057914677","display_name":"Svetlana E. Soboleva","orcid":"https://orcid.org/0000-0002-7430-3683","observed_orcids":["https://orcid.org/0000-0002-7430-3683"]},"institutions":[{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Svetlana E. Soboleva","raw_affiliation_strings":["Institute of Chemical Biology and Fundamental Medicine of SB RAS, 8 Lavrentiev Ave., Novosibirsk 630090, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemical Biology and Fundamental Medicine of SB RAS, 8 Lavrentiev Ave., Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I4210091979","https://openalex.org/I4210127387"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081504559","display_name":"Georgy A. Nevinsky","orcid":"https://orcid.org/0000-0002-4988-8923","observed_orcids":["https://orcid.org/0000-0002-4988-8923"]},"institutions":[{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Georgy A. Nevinsky","raw_affiliation_strings":["Institute of Chemical Biology and Fundamental Medicine of SB RAS, 8 Lavrentiev Ave., Novosibirsk 630090, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemical Biology and Fundamental Medicine of SB RAS, 8 Lavrentiev Ave., Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I4210091979","https://openalex.org/I4210127387"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5081504559"],"corresponding_institution_ids":["https://openalex.org/I4210091979","https://openalex.org/I4210127387"],"apc_list":{"value":0,"currency":"EUR","value_usd":0},"apc_paid":null,"fwci":0.1947,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.45453448,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"399","issue":"4","first_page":"347","last_page":"360"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13187","display_name":"Diffusion and Search Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-serum-albumin","display_name":"human serum albumin","score":1.0},{"id":"https://openalex.org/keywords/nucleic-acid-binding","display_name":"nucleic acid binding","score":0.9559999704360962},{"id":"https://openalex.org/keywords/dna-binding","display_name":"DNA binding","score":0.8429999947547913},{"id":"https://openalex.org/keywords/rna-binding","display_name":"RNA binding","score":0.9990000128746033},{"id":"https://openalex.org/keywords/binding-sites","display_name":"binding sites","score":0.6729999780654907},{"id":"https://openalex.org/keywords/nucleotide-affinity","display_name":"nucleotide affinity","score":0.4090000092983246},{"id":"https://openalex.org/keywords/binding-thermodynamics","display_name":"binding thermodynamics","score":0.6890000104904175},{"id":"https://openalex.org/keywords/orthophosphate","display_name":"orthophosphate","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.7187603712081909},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7055655717849731},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.6556327939033508},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.587852954864502},{"id":"https://openalex.org/C2778597219","wikidata":"https://www.wikidata.org/wiki/Q11721976","display_name":"Human serum albumin","level":2,"score":0.49085336923599243},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.47840532660484314},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.45378774404525757},{"id":"https://openalex.org/C2777132085","wikidata":"https://www.wikidata.org/wiki/Q46220103","display_name":"Phosphate","level":2,"score":0.4469982087612152},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4424007534980774},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29299575090408325},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11133530735969543}],"mesh":[{"descriptor_ui":"D000075462","descriptor_name":"Serum Albumin, Human","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000075462","descriptor_name":"Serum Albumin, Human","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1515/hsz-2017-0243","doi":"https://doi.org/10.1515/hsz-2017-0243","is_oa":false,"landing_page_url":"https://doi.org/10.1515/hsz-2017-0243","pdf_url":null,"source":{"id":"https://openalex.org/S18118477","display_name":"Biological Chemistry","issn_l":"1431-6730","issn":["1431-6730","1437-4315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:29252186","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29252186","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W250794222","https://openalex.org/W328694624","https://openalex.org/W1584476217","https://openalex.org/W1591316722","https://openalex.org/W1818561672","https://openalex.org/W1965228991","https://openalex.org/W1968819700","https://openalex.org/W1971026058","https://openalex.org/W1971806083","https://openalex.org/W1972127529","https://openalex.org/W1991056917","https://openalex.org/W2008294344","https://openalex.org/W2009095852","https://openalex.org/W2010598175","https://openalex.org/W2016401253","https://openalex.org/W2017131081","https://openalex.org/W2032783971","https://openalex.org/W2036050531","https://openalex.org/W2039872984","https://openalex.org/W2041145998","https://openalex.org/W2041780922","https://openalex.org/W2056677038","https://openalex.org/W2062143679","https://openalex.org/W2063877076","https://openalex.org/W2076710572","https://openalex.org/W2078744599","https://openalex.org/W2088900329","https://openalex.org/W2093431378","https://openalex.org/W2143846339","https://openalex.org/W2302448475","https://openalex.org/W2411004031","https://openalex.org/W2418964727","https://openalex.org/W6639751288"],"related_works":["https://openalex.org/W2090427843","https://openalex.org/W1986508464","https://openalex.org/W2050602316","https://openalex.org/W2918064266","https://openalex.org/W2524689808","https://openalex.org/W2073068322","https://openalex.org/W2016401253","https://openalex.org/W7134110188","https://openalex.org/W2157438880","https://openalex.org/W2010602998"],"abstract_inverted_index":{"We":[0],"show":[1],"here":[2],"for":[3,31,40,87,94,154,196],"the":[4,18,22,73,80,107,127,130,144,155,160,181],"first":[5,81,156],"time":[6],"that":[7],"HSA":[8,197],"possesses":[9],"two":[10],"nucleic":[11],"acid-(NA)":[12],"binding":[13,33,47],"sites":[14,34,48,84,164],"and":[15,37,52,59,62,67,82,90,111,120,159],"we":[16],"estimated":[17],"relative":[19],"contributions":[20],"of":[21,25,45,76,99,165,184,188],"nucleotide":[23,89,97,186],"links":[24],"(pN)n":[26,100],"to":[27,72,79,129,192],"their":[28,193],"total":[29,74,194],"affinity":[30,39,75,131,153,172,195],"these":[32,46],"with":[35,102,174],"higher":[36],"lower":[38,93,171],"NAs.":[41],"The":[42,177],"minimal":[43],"ligands":[44],"are":[49],"orthophosphate":[50],"(Kd=3.0":[51],"20.0":[53],"mm),":[54],"various":[55],"dNMPs":[56],"(5.6-400":[57],"\u03bcm":[58,66],"0.063-18":[60],"mm)":[61],"different":[63],"rNMPs":[64],"(4.9-30":[65],"14-250":[68],"\u03bcm).":[69],"Maximal":[70],"contribution":[71,108,128,145,183],"all":[77,114,149,189],"NAs":[78,168],"second":[83,161],"was":[85,91,134],"observed":[86],"one":[88],"remarkably":[92],"three":[95],"additional":[96],"units":[98],"(n=1-4)":[101],"a":[103,122,140],"significant":[104],"decrease":[105,125],"in":[106,126,143],"at":[109,112,132,146],"n=5-6,":[110],"n\u22657-8":[113],"dependencies":[115],"reached":[116],"plateaus.":[117],"For":[118],"d(pA)n":[119],"r(pA)n":[121],"relatively":[123],"gradual":[124],"n=1-6":[133],"observed,":[135],"while":[136],"several":[137],"d(pN)n,":[138],"demonstrated":[139,151],"sharp":[141],"increase":[142],"n=2-4.":[147],"Finally,":[148],"(pN)n>10":[150],"high":[152],"(1.4-150":[157],"nm)":[158,163],"(80-2400":[162],"HSA.":[166],"Double-stranded":[167],"showed":[169],"significantly":[170],"comparing":[173],"single-stranded":[175],"ligands.":[176],"thermodynamic":[178],"parameters":[179],"characterizing":[180],"specific":[182],"every":[185],"link":[187],"(pN)1-9":[190],"(\u0394G\u00b0)":[191],"were":[198],"estimated.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-01-05T00:00:00"}
