{"id":"https://openalex.org/W2777075185","doi":"https://doi.org/10.1111/ajco.12822","title":"Efficacy and safety of oxycodone/naloxone as add\u2010on therapy to gabapentin or pregabalin for the management of chemotherapy\u2010induced peripheral neuropathy in Korea","display_name":"Efficacy and safety of oxycodone/naloxone as add\u2010on therapy to gabapentin or pregabalin for the management of chemotherapy\u2010induced peripheral neuropathy in Korea","publication_year":2017,"publication_date":"2017-12-27","ids":{"openalex":"https://openalex.org/W2777075185","doi":"https://doi.org/10.1111/ajco.12822","mag":"2777075185","pmid":"https://pubmed.ncbi.nlm.nih.gov/29280313"},"language":"en","primary_location":{"id":"doi:10.1111/ajco.12822","doi":"https://doi.org/10.1111/ajco.12822","is_oa":false,"landing_page_url":"https://doi.org/10.1111/ajco.12822","pdf_url":null,"source":{"id":"https://openalex.org/S77500791","display_name":"Asia-Pacific Journal of Clinical Oncology","issn_l":"1743-7555","issn":["1743-7555","1743-7563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asia-Pacific Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051312069","display_name":"Bong\u2010Seog Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101595","display_name":"Veterans Health Service Medical Center","ror":"https://ror.org/00xhz2q61","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210101595","https://openalex.org/I4210129722"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Bong\u2010Seog Kim","raw_affiliation_strings":["Division of Hemato\u2010Oncology VHS Medical Center  Seoul South Korea","Division of Hemato-Oncology VHS Medical Center Seoul South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hemato\u2010Oncology VHS Medical Center  Seoul South Korea","institution_ids":["https://openalex.org/I4210101595"]},{"raw_affiliation_string":"Division of Hemato-Oncology VHS Medical Center Seoul South Korea","institution_ids":["https://openalex.org/I4210101595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013483628","display_name":"Jong\u2010Youl Jin","orcid":"https://orcid.org/0000-0001-9106-3194","observed_orcids":["https://orcid.org/0000-0001-9106-3194"]},"institutions":[{"id":"https://openalex.org/I4210133166","display_name":"The Catholic University of Korea Bucheon St. Mary's Hospital","ror":"https://ror.org/0443jbw36","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210133166","https://openalex.org/I4405260414","https://openalex.org/I87111246"]},{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong\u2010Youl Jin","raw_affiliation_strings":["Division of Hemato\u2010Oncology Bucheon St. Mary's Hospital The Catholic University of Korea  Bucheon South Korea","Division of Hemato-Oncology Bucheon St. Mary's Hospital The Catholic University of Korea Bucheon South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hemato\u2010Oncology Bucheon St. Mary's Hospital The Catholic University of Korea  Bucheon South Korea","institution_ids":["https://openalex.org/I4210133166","https://openalex.org/I87111246"]},{"raw_affiliation_string":"Division of Hemato-Oncology Bucheon St. Mary's Hospital The Catholic University of Korea Bucheon South Korea","institution_ids":["https://openalex.org/I4210133166","https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041556537","display_name":"Jung Hye Kwon","orcid":"https://orcid.org/0000-0002-5965-3204","observed_orcids":["https://orcid.org/0000-0002-5965-3204"]},"institutions":[{"id":"https://openalex.org/I146824383","display_name":"Hallym University","ror":"https://ror.org/03sbhge02","country_code":"KR","type":"education","lineage":["https://openalex.org/I146824383"]},{"id":"https://openalex.org/I4210147999","display_name":"Kangdong Sacred Heart Hospital","ror":"https://ror.org/05mx1gf76","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210147999"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jung Hye Kwon","raw_affiliation_strings":["Division of Hemato\u2010Oncology Kangdong Sacred Heart Hospital Hallym University  Seoul South Korea","Division of Hemato-Oncology Kangdong Sacred Heart Hospital Hallym University Seoul South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hemato\u2010Oncology Kangdong Sacred Heart Hospital Hallym University  Seoul South Korea","institution_ids":["https://openalex.org/I146824383","https://openalex.org/I4210147999"]},{"raw_affiliation_string":"Division of Hemato-Oncology Kangdong Sacred Heart Hospital Hallym University Seoul South Korea","institution_ids":["https://openalex.org/I146824383","https://openalex.org/I4210147999"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067439762","display_name":"In Sook Woo","orcid":"https://orcid.org/0000-0001-8220-2260","observed_orcids":["https://orcid.org/0000-0001-8220-2260"]},"institutions":[{"id":"https://openalex.org/I4210109336","display_name":"The Catholic University of Korea Yeouido St. Mary's Hospital","ror":"https://ror.org/0229xaa13","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210109336","https://openalex.org/I4405260414","https://openalex.org/I87111246"]},{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"In Sook Woo","raw_affiliation_strings":["Yeouido St. Mary's Hospital College of Medicine The Catholic University of Korea  Seoul South Korea","Yeouido St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yeouido St. Mary's Hospital College of Medicine The Catholic University of Korea  Seoul South Korea","institution_ids":["https://openalex.org/I4210109336","https://openalex.org/I87111246"]},{"raw_affiliation_string":"Yeouido St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul South Korea","institution_ids":["https://openalex.org/I4210109336","https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076585994","display_name":"Yoon Ho Ko","orcid":"https://orcid.org/0000-0002-2506-3740","observed_orcids":["https://orcid.org/0000-0002-2506-3740"]},"institutions":[{"id":"https://openalex.org/I4210106953","display_name":"The Catholic University of Korea Uijeongbu St. Mary's Hospital","ror":"https://ror.org/02ezaf703","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210106953","https://openalex.org/I4405260414","https://openalex.org/I87111246"]},{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yoon Ho Ko","raw_affiliation_strings":["Division of Oncology Uijeongbu St. Mary's Hospital The Catholic University of Korea  Uijeongbu South Korea","Division of Oncology Uijeongbu St. Mary's Hospital The Catholic University of Korea Uijeongbu South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology Uijeongbu St. Mary's Hospital The Catholic University of Korea  Uijeongbu South Korea","institution_ids":["https://openalex.org/I4210106953","https://openalex.org/I87111246"]},{"raw_affiliation_string":"Division of Oncology Uijeongbu St. Mary's Hospital The Catholic University of Korea Uijeongbu South Korea","institution_ids":["https://openalex.org/I4210106953","https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102149485","display_name":"Suk-Young Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111267","display_name":"The Catholic University of Korea Daejeon St. Mary's Hospital","ror":"https://ror.org/01tck1990","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210111267","https://openalex.org/I4405260414","https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Suk\u2010Young Park","raw_affiliation_strings":["Division of Oncology Daejeon St. Mary's Hospital The Catholic University of Korea  Daejeon South Korea","Division of Oncology Daejeon St. Mary's Hospital The Catholic University of Korea Daejeon South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology Daejeon St. Mary's Hospital The Catholic University of Korea  Daejeon South Korea","institution_ids":["https://openalex.org/I4210111267"]},{"raw_affiliation_string":"Division of Oncology Daejeon St. Mary's Hospital The Catholic University of Korea Daejeon South Korea","institution_ids":["https://openalex.org/I4210111267"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005991609","display_name":"Hye\u2010Jeong Park","orcid":"https://orcid.org/0000-0001-8243-079X","observed_orcids":["https://orcid.org/0000-0001-8243-079X"]},"institutions":[{"id":"https://openalex.org/I4210119895","display_name":"Mundipharma (South Korea)","ror":"https://ror.org/02bb52086","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210117898","https://openalex.org/I4210119895"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hye\u2010Jeong Park","raw_affiliation_strings":["Medical Affairs Mundipharma Korea Ltd.  Seoul South Korea","Medical Affairs Mundipharma Korea Ltd. Seoul South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Affairs Mundipharma Korea Ltd.  Seoul South Korea","institution_ids":["https://openalex.org/I4210119895"]},{"raw_affiliation_string":"Medical Affairs Mundipharma Korea Ltd. Seoul South Korea","institution_ids":["https://openalex.org/I4210119895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047320061","display_name":"Jin\u2010Hyoung Kang","orcid":"https://orcid.org/0000-0003-3845-7260","observed_orcids":["https://orcid.org/0000-0003-3845-7260"]},"institutions":[{"id":"https://openalex.org/I4210160144","display_name":"The Catholic University of Korea Seoul St. Mary's Hospital","ror":"https://ror.org/056cn0e37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210160144","https://openalex.org/I4405260414","https://openalex.org/I87111246"]},{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jin Hyung Kang","raw_affiliation_strings":["Division of Medical Oncology Seoul St. Mary's Hospital The Catholic University of Korea  Seoul South Korea","Division of Medical Oncology Seoul St. Mary's Hospital The Catholic University of Korea Seoul South Korea"],"raw_orcid":"https://orcid.org/0000-0003-3845-7260","affiliations":[{"raw_affiliation_string":"Division of Medical Oncology Seoul St. Mary's Hospital The Catholic University of Korea  Seoul South Korea","institution_ids":["https://openalex.org/I4210160144","https://openalex.org/I87111246"]},{"raw_affiliation_string":"Division of Medical Oncology Seoul St. Mary's Hospital The Catholic University of Korea Seoul South Korea","institution_ids":["https://openalex.org/I4210160144","https://openalex.org/I87111246"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5047320061"],"corresponding_institution_ids":["https://openalex.org/I4210160144","https://openalex.org/I87111246"],"apc_list":{"value":3700,"currency":"USD","value_usd":3700},"apc_paid":null,"fwci":0.7572,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.74121632,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"14","issue":"5","first_page":"e448","last_page":"e454"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxycodone-naloxone","display_name":"oxycodone/naloxone","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chemotherapy-induced-peripheral-neuropathy","display_name":"chemotherapy-induced peripheral neuropathy","score":0.9509999752044678},{"id":"https://openalex.org/keywords/gabapentin","display_name":"gabapentin","score":0.9319999814033508},{"id":"https://openalex.org/keywords/pregabalin","display_name":"pregabalin","score":1.0},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.9100000262260437},{"id":"https://openalex.org/keywords/taxane-based-chemotherapy","display_name":"taxane-based chemotherapy","score":0.9039999842643738},{"id":"https://openalex.org/keywords/korean-patients","display_name":"Korean patients","score":0.621999979019165},{"id":"https://openalex.org/keywords/fact-gog-ntx","display_name":"FACT/GOG-Ntx","score":0.7229999899864197},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C2776468701","wikidata":"https://www.wikidata.org/wiki/Q412174","display_name":"Pregabalin","level":2,"score":0.9202880859375},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9019879102706909},{"id":"https://openalex.org/C2776608144","wikidata":"https://www.wikidata.org/wiki/Q410352","display_name":"Gabapentin","level":3,"score":0.8400270342826843},{"id":"https://openalex.org/C2776029756","wikidata":"https://www.wikidata.org/wiki/Q407535","display_name":"Oxycodone","level":4,"score":0.7185428738594055},{"id":"https://openalex.org/C2779289229","wikidata":"https://www.wikidata.org/wiki/Q17153857","display_name":"Chemotherapy-induced peripheral neuropathy","level":4,"score":0.5907713770866394},{"id":"https://openalex.org/C2778750930","wikidata":"https://www.wikidata.org/wiki/Q4540629","display_name":"(+)-Naloxone","level":4,"score":0.5850881934165955},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5600905418395996},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5470455884933472},{"id":"https://openalex.org/C2780052408","wikidata":"https://www.wikidata.org/wiki/Q4967024","display_name":"Brief Pain Inventory","level":3,"score":0.4677678942680359},{"id":"https://openalex.org/C2779901536","wikidata":"https://www.wikidata.org/wiki/Q945238","display_name":"Peripheral neuropathy","level":3,"score":0.4577760398387909},{"id":"https://openalex.org/C2780435969","wikidata":"https://www.wikidata.org/wiki/Q5625186","display_name":"Gynecologic oncology","level":2,"score":0.4161831736564636},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3670874834060669},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.25508913397789},{"id":"https://openalex.org/C2781118164","wikidata":"https://www.wikidata.org/wiki/Q1088113","display_name":"Chronic pain","level":2,"score":0.18299487233161926},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.1518062949180603},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069583","descriptor_name":"Pregabalin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000069583","descriptor_name":"Pregabalin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000069583","descriptor_name":"Pregabalin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000077206","descriptor_name":"Gabapentin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000077206","descriptor_name":"Gabapentin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000077206","descriptor_name":"Gabapentin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009270","descriptor_name":"Naloxone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009270","descriptor_name":"Naloxone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009270","descriptor_name":"Naloxone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010098","descriptor_name":"Oxycodone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010098","descriptor_name":"Oxycodone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010098","descriptor_name":"Oxycodone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D056910","descriptor_name":"Republic of Korea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056910","descriptor_name":"Republic of Korea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056910","descriptor_name":"Republic of Korea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059408","descriptor_name":"Pain Management","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059408","descriptor_name":"Pain Management","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059408","descriptor_name":"Pain Management","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/ajco.12822","doi":"https://doi.org/10.1111/ajco.12822","is_oa":false,"landing_page_url":"https://doi.org/10.1111/ajco.12822","pdf_url":null,"source":{"id":"https://openalex.org/S77500791","display_name":"Asia-Pacific Journal of Clinical Oncology","issn_l":"1743-7555","issn":["1743-7555","1743-7563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asia-Pacific Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:29280313","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29280313","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asia-Pacific journal of clinical oncology","raw_type":"Clinical Trial, Phase IV"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7799999713897705}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320335978","display_name":"Mundipharma Korea Ltd","ror":"https://ror.org/02bb52086"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1775697053","https://openalex.org/W1966998000","https://openalex.org/W1976365920","https://openalex.org/W1984689348","https://openalex.org/W1997328578","https://openalex.org/W1999130958","https://openalex.org/W2005452896","https://openalex.org/W2039898366","https://openalex.org/W2052389332","https://openalex.org/W2057662279","https://openalex.org/W2059190124","https://openalex.org/W2066829799","https://openalex.org/W2082275407","https://openalex.org/W2082276527","https://openalex.org/W2090637590","https://openalex.org/W2095756305","https://openalex.org/W2096491215","https://openalex.org/W2114050808","https://openalex.org/W2114458368","https://openalex.org/W2128848460","https://openalex.org/W2132309748","https://openalex.org/W2141505882","https://openalex.org/W2149603226","https://openalex.org/W2161055573","https://openalex.org/W2169071518","https://openalex.org/W2580868502","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2090637590","https://openalex.org/W2955941728","https://openalex.org/W1991677473","https://openalex.org/W4386947978","https://openalex.org/W2890033595","https://openalex.org/W2115451671","https://openalex.org/W2766439546","https://openalex.org/W2048164399","https://openalex.org/W1495096574","https://openalex.org/W2912163764"],"abstract_inverted_index":{"AIMS:":[0],"To":[1],"investigate":[2],"the":[3,180],"efficacy":[4],"and":[5,94,197,234],"safety":[6,95,245],"of":[7,87,105,185],"oxycodone/naloxone":[8,64,106],"in":[9,76,138,172,179,217,237],"patients":[10,34,60,146,207,239],"with":[11,18,35,39,240],"chemotherapy-induced":[12],"peripheral":[13],"neuropathy":[14],"(CIPN)":[15],"inadequately":[16,37],"controlled":[17,38],"pregabalin":[19,40,54,227],"or":[20,41,55,220,228],"gabapentin.":[21],"METHODS:":[22],"This":[23],"4-week,":[24],"multicenter,":[25],"interventional,":[26],"single-arm":[27],"phase":[28],"IV":[29],"study":[30],"included":[31,84],"72":[32],"Korean":[33,238],"CIPN":[36],"gabapentin":[42,56,229],"(Numeric":[43],"Rating":[44],"Scale":[45],"0-10;":[46],"NRS":[47,77,115,139],"\u22654":[48],"at":[49,57,141],"baseline).":[50],"In":[51],"addition":[52],"to":[53,66,145,226],"existing":[58],"doses,":[59],"received":[61],"20/10":[62],"mg/day":[63,68],"(up-titrated":[65],"80/40":[67],"as":[69],"needed).":[70],"The":[71,98],"primary":[72],"endpoint":[73],"was":[74,107,118],"change":[75,137],"score":[78,116,140],"after":[79],"4":[80,143],"weeks.":[81],"Secondary":[82],"endpoints":[83],"Functional":[85],"Assessment":[86],"Cancer":[88],"Therapy/Gynecologic":[89],"Oncology":[90],"Group-Neurotoxicity":[91],"(FACT/GOG-NTX)":[92],"scores":[93],"assessments.":[96],"RESULTS:":[97],"mean":[99,136],"\u00b1":[100,109,120,151,158,188,192,200],"standard":[101],"deviation":[102],"(SD)":[103],"dose":[104],"23.3":[108],"7.5":[110],"mg/day.":[111],"At":[112],"week":[113,142],"4,":[114],"reduction":[117],"1.29":[119],"1.84":[121],"points":[122],"(21.4%":[123],"reduction;":[124],"P":[125,163,194,202],"<":[126,203],"0.0001).":[127,204],"Patients":[128],"on":[129,147],"taxane-based":[130],"chemotherapy":[131,149],"experienced":[132],"a":[133],"significantly":[134],"smaller":[135],"compared":[144],"other":[148],"(-0.63":[150],"1.54":[152],"[n":[153,160],"=":[154,161,164,195],"30]":[155],"vs.":[156],"-1.83":[157],"1.00":[159],"36];":[162],"0.0072).":[165],"Although":[166],"there":[167],"were":[168,177,212],"no":[169,213],"significant":[170,215,244],"changes":[171,216],"FACT/GOG-NTX":[173],"total":[174],"scores,":[175],"improvements":[176],"observed":[178],"neurotoxicity":[181],"subscale":[182],"measuring":[183],"numbness/tingling":[184],"hands":[186],"(mean":[187],"SD":[189],"change:":[190],"-0.27":[191],"1.04;":[193],"0.0427)":[196],"feet":[198],"(-0.60":[199],"1.09;":[201],"Forty-two":[205],"(58.3%)":[206],"reported":[208],"adverse":[209],"events.":[210],"There":[211],"clinically":[214,243],"laboratory":[218],"tests":[219],"vital":[221],"signs.":[222],"CONCLUSION:":[223],"Oxycodone/naloxone":[224],"added":[225],"provided":[230],"additional":[231],"pain":[232],"relief":[233],"symptom":[235],"control":[236],"CIPN,":[241],"without":[242],"concerns.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}