{"id":"https://openalex.org/W2776881908","doi":"https://doi.org/10.1021/acs.jmedchem.7b01645","title":"Mind Your Ears: A New Antidote to Aminoglycoside Toxicity?","display_name":"Mind Your Ears: A New Antidote to Aminoglycoside Toxicity?","publication_year":2017,"publication_date":"2017-12-19","ids":{"openalex":"https://openalex.org/W2776881908","doi":"https://doi.org/10.1021/acs.jmedchem.7b01645","mag":"2776881908","pmid":"https://pubmed.ncbi.nlm.nih.gov/29256598"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jmedchem.7b01645","doi":"https://doi.org/10.1021/acs.jmedchem.7b01645","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.7b01645","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010491978","display_name":"Mary E. O\u2019Sullivan","orcid":"https://orcid.org/0000-0002-8700-6047","observed_orcids":["https://orcid.org/0000-0002-8700-6047"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary E. O\u2019Sullivan","raw_affiliation_strings":["Stanford University, 801 Welch Road, Palo Alto, California 94305, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, 801 Welch Road, Palo Alto, California 94305, United States","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085521686","display_name":"Alan Gi-Lun Cheng","orcid":"https://orcid.org/0000-0002-4702-8401","observed_orcids":["https://orcid.org/0000-0002-4702-8401","https://orcid.org/0000-0003-3193-3818"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alan G. Cheng","raw_affiliation_strings":["Stanford University, 801 Welch Road, Palo Alto, California 94305, United States"],"raw_orcid":"https://orcid.org/0000-0002-4702-8401","affiliations":[{"raw_affiliation_string":"Stanford University, 801 Welch Road, Palo Alto, California 94305, United States","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085521686"],"corresponding_institution_ids":["https://openalex.org/I97018004"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"61","issue":"1","first_page":"81","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aminoglycoside-toxicity","display_name":"aminoglycoside toxicity","score":0.9470000267028809},{"id":"https://openalex.org/keywords/cochlear-hair-cells","display_name":"cochlear hair cells","score":0.7680000066757202},{"id":"https://openalex.org/keywords/hearing-loss","display_name":"hearing loss","score":0.6769999861717224},{"id":"https://openalex.org/keywords/zebrafish-lateral-line","display_name":"zebrafish lateral line","score":0.8109999895095825},{"id":"https://openalex.org/keywords/drug-screening","display_name":"drug screening","score":0.9070000052452087},{"id":"https://openalex.org/keywords/rat-cochlea","display_name":"rat cochlea","score":0.8500000238418579},{"id":"https://openalex.org/keywords/ototoxicity","display_name":"ototoxicity","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C2777787772","wikidata":"https://www.wikidata.org/wiki/Q45355603","display_name":"Aminoglycoside","level":3,"score":0.942577064037323},{"id":"https://openalex.org/C2780130748","wikidata":"https://www.wikidata.org/wiki/Q317857","display_name":"Cochlea","level":2,"score":0.8152430057525635},{"id":"https://openalex.org/C2778534666","wikidata":"https://www.wikidata.org/wiki/Q1351381","display_name":"Ototoxicity","level":4,"score":0.7735698223114014},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6614779829978943},{"id":"https://openalex.org/C2779365888","wikidata":"https://www.wikidata.org/wiki/Q194168","display_name":"Antidote","level":3,"score":0.6454992294311523},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.6044481992721558},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5841768980026245},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.5490678548812866},{"id":"https://openalex.org/C2778585322","wikidata":"https://www.wikidata.org/wiki/Q1566641","display_name":"Hair cell","level":3,"score":0.5370537042617798},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5184125900268555},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4950048327445984},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.451816588640213},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4132958650588989},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.3473628759384155},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21272802352905273},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15552747249603271},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13002386689186096},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1295112669467926},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.08989092707633972},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.06881710886955261},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000617","descriptor_name":"Aminoglycosides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000931","descriptor_name":"Antidotes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007758","descriptor_name":"Ear, Inner","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007758","descriptor_name":"Ear, Inner","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007758","descriptor_name":"Ear, Inner","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jmedchem.7b01645","doi":"https://doi.org/10.1021/acs.jmedchem.7b01645","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.7b01645","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:29256598","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29256598","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6811437448","display_name":"Designing new aminoglycosides to alleviate inner ear toxicity","funder_award_id":"R01DC014720","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G8568137215","display_name":"Cochlear Mechanics","funder_award_id":"R01DC001910","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"}],"funders":[{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"},{"id":"https://openalex.org/F4320338337","display_name":"H2020 Marie Sk\u0142odowska-Curie Actions","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1981014336","https://openalex.org/W1983544635","https://openalex.org/W1994467395","https://openalex.org/W2005775837","https://openalex.org/W2007551053","https://openalex.org/W2014208948","https://openalex.org/W2081906798","https://openalex.org/W2131308754","https://openalex.org/W2137701107","https://openalex.org/W2153102800","https://openalex.org/W2751142656","https://openalex.org/W2761759723","https://openalex.org/W2764007778","https://openalex.org/W2766221660","https://openalex.org/W3031010947"],"related_works":["https://openalex.org/W7161542906","https://openalex.org/W2079631684","https://openalex.org/W2319333243","https://openalex.org/W2778638554","https://openalex.org/W2761759723","https://openalex.org/W2800332644","https://openalex.org/W2014208948","https://openalex.org/W2945433498","https://openalex.org/W2006018333","https://openalex.org/W3046074300"],"abstract_inverted_index":{"Aminoglycoside":[0],"antibiotics":[1],"are":[2],"known":[3],"toxins":[4],"to":[5],"cochlear":[6],"hair":[7],"cells,":[8],"causing":[9],"permanent":[10],"hearing":[11,44],"loss.":[12,45],"Using":[13],"the":[14,29],"zebrafish":[15],"lateral":[16],"line":[17],"system":[18],"as":[19],"a":[20,38],"platform":[21],"for":[22],"drug":[23],"screen":[24],"and":[25],"subsequent":[26],"validation":[27],"in":[28,32],"rat":[30],"cochlea":[31],"vivo,":[33],"Chowdhury":[34],"et":[35],"al.":[36],"characterized":[37],"novel":[39],"otoprotectant":[40],"working":[41],"against":[42],"aminoglycoside-induced":[43]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2018-01-05T00:00:00"}
