{"id":"https://openalex.org/W2776880279","doi":null,"title":"Current Concepts With Video Illustrations Platelet-Rich Plasma: A Milieu of Bioactive Factors","display_name":"Current Concepts With Video Illustrations Platelet-Rich Plasma: A Milieu of Bioactive Factors","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2776880279","mag":"2776880279"},"language":"en","primary_location":{"id":"mag:2776880279","doi":null,"is_oa":false,"landing_page_url":"https://www.briancolemd.com/wp-content/themes/ypo-theme/pdf/yjar.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056890310","display_name":"Stacie G. Boswell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stacie G. Boswell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064391561","display_name":"Brian J. Cole","orcid":"https://orcid.org/0000-0002-4006-2113","observed_orcids":["https://orcid.org/0000-0002-4006-2113"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian J. Cole","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4006-2113","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048156485","display_name":"Emily A. Sundman","orcid":"https://orcid.org/0000-0001-7949-4266","observed_orcids":["https://orcid.org/0000-0001-7949-4266"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emily A. Sundman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067157002","display_name":"Vasili Karas","orcid":"https://orcid.org/0000-0003-4464-1179","observed_orcids":["https://orcid.org/0000-0003-4464-1179"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vasili Karas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059515326","display_name":"Lisa A. Fortier","orcid":"https://orcid.org/0000-0003-1072-5059","observed_orcids":["https://orcid.org/0000-0003-1072-5059"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisa A. Fortier","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1072-5059","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2439,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.55344468,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-rich-plasma","display_name":"platelet-rich plasma","score":1.0},{"id":"https://openalex.org/keywords/platelet-concentrates","display_name":"platelet concentrates","score":0.753000020980835},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.6809999942779541},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/alpha-granules","display_name":"alpha-granules","score":0.8259999752044678},{"id":"https://openalex.org/keywords/dense-bodies","display_name":"dense bodies","score":0.847000002861023},{"id":"https://openalex.org/keywords/lysosomes","display_name":"lysosomes","score":0.890999972820282},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.7630000114440918},{"id":"https://openalex.org/keywords/musculoskeletal-tissue-regeneration","display_name":"musculoskeletal regeneration","score":0.8130000233650208},{"id":"https://openalex.org/keywords/sports-medicine","display_name":"sports medicine","score":0.5929999947547913},{"id":"https://openalex.org/keywords/orthopedics","display_name":"orthopedics","score":0.9110000133514404},{"id":"https://openalex.org/keywords/leukocytes","display_name":"leukocytes","score":0.6930000185966492},{"id":"https://openalex.org/keywords/erythrocytes","display_name":"erythrocytes","score":0.9459999799728394},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C2780076745","wikidata":"https://www.wikidata.org/wiki/Q613879","display_name":"Platelet-rich plasma","level":3,"score":0.9021872282028198},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.7140167355537415},{"id":"https://openalex.org/C2778589496","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostasis","level":2,"score":0.6552060842514038},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5555004477500916},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5025835037231445},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.46744880080223083},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4558774530887604},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.45088115334510803},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4197543263435364},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40793144702911377},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33739539980888367},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2471400797367096},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24141255021095276}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2776880279","doi":null,"is_oa":false,"landing_page_url":"https://www.briancolemd.com/wp-content/themes/ypo-theme/pdf/yjar.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":85,"referenced_works":["https://openalex.org/W50662716","https://openalex.org/W144741449","https://openalex.org/W191217823","https://openalex.org/W1500447113","https://openalex.org/W1597610606","https://openalex.org/W1616572587","https://openalex.org/W1915179576","https://openalex.org/W1927609136","https://openalex.org/W1963591185","https://openalex.org/W1971810132","https://openalex.org/W1974818527","https://openalex.org/W1984461161","https://openalex.org/W1987236019","https://openalex.org/W1989677590","https://openalex.org/W1990786414","https://openalex.org/W1992447985","https://openalex.org/W1993547964","https://openalex.org/W1993905453","https://openalex.org/W1995111560","https://openalex.org/W1997617980","https://openalex.org/W2002503130","https://openalex.org/W2003720335","https://openalex.org/W2004269649","https://openalex.org/W2005611861","https://openalex.org/W2009471315","https://openalex.org/W2010746754","https://openalex.org/W2015639954","https://openalex.org/W2016774778","https://openalex.org/W2021372224","https://openalex.org/W2021805943","https://openalex.org/W2024088469","https://openalex.org/W2027666746","https://openalex.org/W2033379517","https://openalex.org/W2036802630","https://openalex.org/W2039025407","https://openalex.org/W2040447899","https://openalex.org/W2041207935","https://openalex.org/W2043647716","https://openalex.org/W2043956496","https://openalex.org/W2045362817","https://openalex.org/W2047030440","https://openalex.org/W2049237667","https://openalex.org/W2052823603","https://openalex.org/W2054389140","https://openalex.org/W2055478328","https://openalex.org/W2058195651","https://openalex.org/W2067896463","https://openalex.org/W2069786094","https://openalex.org/W2077504541","https://openalex.org/W2081602516","https://openalex.org/W2084589854","https://openalex.org/W2086495275","https://openalex.org/W2088045079","https://openalex.org/W2088986145","https://openalex.org/W2089782191","https://openalex.org/W2091643263","https://openalex.org/W2092156139","https://openalex.org/W2096005052","https://openalex.org/W2099713463","https://openalex.org/W2102477006","https://openalex.org/W2103085892","https://openalex.org/W2105193603","https://openalex.org/W2105885710","https://openalex.org/W2108451044","https://openalex.org/W2112102525","https://openalex.org/W2115315237","https://openalex.org/W2118688587","https://openalex.org/W2124525370","https://openalex.org/W2126939899","https://openalex.org/W2130679926","https://openalex.org/W2131187552","https://openalex.org/W2134795024","https://openalex.org/W2135696229","https://openalex.org/W2139523975","https://openalex.org/W2140861987","https://openalex.org/W2143110295","https://openalex.org/W2149142235","https://openalex.org/W2154054061","https://openalex.org/W2155683738","https://openalex.org/W2158213350","https://openalex.org/W2163206176","https://openalex.org/W2163780750","https://openalex.org/W2164505387","https://openalex.org/W2164816019","https://openalex.org/W2170089982"],"related_works":["https://openalex.org/W1983106010","https://openalex.org/W2314712370","https://openalex.org/W2522064491","https://openalex.org/W1453073937","https://openalex.org/W4402546874","https://openalex.org/W2544139843","https://openalex.org/W2135789366","https://openalex.org/W3137237500","https://openalex.org/W1990045708","https://openalex.org/W4320010145"],"abstract_inverted_index":{"Platelet":[0],"concentrates":[1],"such":[2],"as":[3,122],"platelet-rich":[4],"plasma":[5,130],"(PRP)":[6],"have":[7,76],"gained":[8],"popularity":[9],"in":[10,73,114,117,144,148,171,197],"sports":[11],"medicine":[12],"and":[13,20,32,48,84,94,108,128,137,140,146,151],"orthopaedics":[14],"to":[15,22,36,45,64,174,192,200],"promote":[16],"accelerated":[17],"physiologic":[18],"healing":[19],"return":[21],"function.":[23],"Each":[24],"PRP":[25,52,115,145,183],"product":[26],"varies":[27],"depending":[28],"on":[29,57,177],"patient":[30],"factors":[31,97],"the":[33,59,62,67,159,178,185,193],"system":[34],"used":[35],"generate":[37],"it.":[38],"Blood":[39],"from":[40,98,105],"some":[41],"patients":[42],"may":[43],"fail":[44],"make":[46],"PRP,":[47],"most":[49],"clinicians":[50],"use":[51,187],"without":[53],"performing":[54],"cell":[55],"counts":[56],"either":[58],"blood":[60],"or":[61,91],"preparation":[63],"confirm":[65],"that":[66,79,162],"solution":[68],"is":[69],"truly":[70],"PRP.":[71,175],"Components":[72],"this":[74],"milieu":[75],"bioactive":[77],"functions":[78],"affect":[80],"musculoskeletal":[81,125],"tissue":[82],"regeneration":[83],"healing.":[85],"Platelets":[86],"are":[87,103,132,142,167],"activated":[88],"by":[89],"collagen":[90],"other":[92],"molecules":[93],"release":[95],"growth":[96],"alpha":[99],"granules.":[100],"Additional":[101],"substances":[102],"released":[104],"dense":[106],"bodies":[107],"lysosomes.":[109],"Soluble":[110],"proteins":[111],"also":[112],"present":[113,143],"function":[116,147],"hemostasis,":[118],"whereas":[119],"others":[120],"serve":[121],"biomarkers":[123],"of":[124,181],"injury.":[126],"Electrolytes":[127],"soluble":[129],"hormones":[131],"required":[133],"for":[134],"cellular":[135,153],"signaling":[136,154],"regulation.":[138],"Leukocytes":[139],"erythrocytes":[141],"inflammation,":[149],"immunity,":[150],"additional":[152],"pathways.":[155],"This":[156],"article":[157],"supports":[158],"emerging":[160],"paradigm":[161],"more":[163],"than":[164],"just":[165],"platelets":[166],"playing":[168],"a":[169,182],"role":[170],"clinical":[172,186,202],"responses":[173],"Depending":[176],"specific":[179],"constituents":[180],"preparation,":[184],"can":[188],"theoretically":[189],"be":[190],"matched":[191],"pathology":[194],"being":[195],"treated":[196],"an":[198],"effort":[199],"improve":[201],"efficacy.":[203]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-01-05T00:00:00"}