{"id":"https://openalex.org/W2776861637","doi":"https://doi.org/10.4142/jvs.2017.18.4.431","title":"Pharmacokinetics of tilmicosin in healthy pigs and in pigs experimentally infected withHaemophilus parasuis","display_name":"Pharmacokinetics of tilmicosin in healthy pigs and in pigs experimentally infected withHaemophilus parasuis","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2776861637","doi":"https://doi.org/10.4142/jvs.2017.18.4.431","mag":"2776861637","pmid":"https://pubmed.ncbi.nlm.nih.gov/28385011","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5746435"},"language":"en","primary_location":{"id":"doi:10.4142/jvs.2017.18.4.431","doi":"https://doi.org/10.4142/jvs.2017.18.4.431","is_oa":true,"landing_page_url":"https://doi.org/10.4142/jvs.2017.18.4.431","pdf_url":"http://vetsci.org/Synapse/Data/PDFData/0118JVS/jvs-18-431.pdf","source":{"id":"https://openalex.org/S116496814","display_name":"Journal of Veterinary Science","issn_l":"1229-845X","issn":["1229-845X","1976-555X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","kci-registered","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319499","host_organization_name":"Korean Society of Veterinary Science","host_organization_lineage":["https://openalex.org/P4310319499"],"host_organization_lineage_names":["Korean Society of Veterinary Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://vetsci.org/Synapse/Data/PDFData/0118JVS/jvs-18-431.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100450757","display_name":"Ling Zhang","orcid":"https://orcid.org/0000-0003-0520-7249","observed_orcids":["https://orcid.org/0000-0003-0520-7249"]},"institutions":[{"id":"https://openalex.org/I102208913","display_name":"Shihezi University","ror":"https://ror.org/04x0kvm78","country_code":"CN","type":"education","lineage":["https://openalex.org/I102208913"]},{"id":"https://openalex.org/I2801312332","display_name":"Xinjiang Production and Construction Corps","ror":"https://ror.org/03hcmxw73","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I2801312332"]},{"id":"https://openalex.org/I3129293551","display_name":"Tarim University","ror":"https://ror.org/05202v862","country_code":"CN","type":"education","lineage":["https://openalex.org/I3129293551"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Zhang","raw_affiliation_strings":["College of Animal Science & Technology, Shihezi University, Shihezi 832000, China","College of Animal Science and Technology, Tarim University, Alar 843300, China","Key Laboratory of Tarim Animal Husbandry Science and Technology of Xinjiang Production & Construction Corps, Alar 843300, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science & Technology, Shihezi University, Shihezi 832000, China","institution_ids":["https://openalex.org/I102208913"]},{"raw_affiliation_string":"College of Animal Science and Technology, Tarim University, Alar 843300, China","institution_ids":["https://openalex.org/I3129293551"]},{"raw_affiliation_string":"Key Laboratory of Tarim Animal Husbandry Science and Technology of Xinjiang Production & Construction Corps, Alar 843300, China","institution_ids":["https://openalex.org/I2801312332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101867963","display_name":"Li Zhao","orcid":"https://orcid.org/0000-0002-5537-2165","observed_orcids":["https://orcid.org/0000-0002-5537-2165"]},"institutions":[{"id":"https://openalex.org/I2801312332","display_name":"Xinjiang Production and Construction Corps","ror":"https://ror.org/03hcmxw73","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I2801312332"]},{"id":"https://openalex.org/I3129293551","display_name":"Tarim University","ror":"https://ror.org/05202v862","country_code":"CN","type":"education","lineage":["https://openalex.org/I3129293551"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Zhao","raw_affiliation_strings":["College of Animal Science and Technology, Tarim University, Alar 843300, China","Key Laboratory of Tarim Animal Husbandry Science and Technology of Xinjiang Production & Construction Corps, Alar 843300, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science and Technology, Tarim University, Alar 843300, China","institution_ids":["https://openalex.org/I3129293551"]},{"raw_affiliation_string":"Key Laboratory of Tarim Animal Husbandry Science and Technology of Xinjiang Production & Construction Corps, Alar 843300, China","institution_ids":["https://openalex.org/I2801312332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100620734","display_name":"Yonghong Liu","orcid":"https://orcid.org/0000-0003-4432-9433","observed_orcids":["https://orcid.org/0000-0003-4432-9433"]},"institutions":[{"id":"https://openalex.org/I2801312332","display_name":"Xinjiang Production and Construction Corps","ror":"https://ror.org/03hcmxw73","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I2801312332"]},{"id":"https://openalex.org/I3129293551","display_name":"Tarim University","ror":"https://ror.org/05202v862","country_code":"CN","type":"education","lineage":["https://openalex.org/I3129293551"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yonghong Liu","raw_affiliation_strings":["College of Animal Science and Technology, Tarim University, Alar 843300, China","Key Laboratory of Tarim Animal Husbandry Science and Technology of Xinjiang Production & Construction Corps, Alar 843300, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science and Technology, Tarim University, Alar 843300, China","institution_ids":["https://openalex.org/I3129293551"]},{"raw_affiliation_string":"Key Laboratory of Tarim Animal Husbandry Science and Technology of Xinjiang Production & Construction Corps, Alar 843300, China","institution_ids":["https://openalex.org/I2801312332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100339322","display_name":"Junfeng Liu","orcid":"https://orcid.org/0000-0002-8079-145X","observed_orcids":["https://orcid.org/0000-0002-8079-145X","https://orcid.org/0000-0001-6868-7900"]},"institutions":[{"id":"https://openalex.org/I2801312332","display_name":"Xinjiang Production and Construction Corps","ror":"https://ror.org/03hcmxw73","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I2801312332"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junfeng Liu","raw_affiliation_strings":["Key Laboratory of Tarim Animal Husbandry Science and Technology of Xinjiang Production & Construction Corps, Alar 843300, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Tarim Animal Husbandry Science and Technology of Xinjiang Production & Construction Corps, Alar 843300, China","institution_ids":["https://openalex.org/I2801312332"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101547505","display_name":"Xianqiang Li","orcid":"https://orcid.org/0000-0002-7296-7179","observed_orcids":["https://orcid.org/0000-0002-7296-7179"]},"institutions":[{"id":"https://openalex.org/I2801312332","display_name":"Xinjiang Production and Construction Corps","ror":"https://ror.org/03hcmxw73","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I2801312332"]},{"id":"https://openalex.org/I3129293551","display_name":"Tarim University","ror":"https://ror.org/05202v862","country_code":"CN","type":"education","lineage":["https://openalex.org/I3129293551"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xianqiang Li","raw_affiliation_strings":["College of Animal Science and Technology, Tarim University, Alar 843300, China","Key Laboratory of Tarim Animal Husbandry Science and Technology of Xinjiang Production & Construction Corps, Alar 843300, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science and Technology, Tarim University, Alar 843300, China","institution_ids":["https://openalex.org/I3129293551"]},{"raw_affiliation_string":"Key Laboratory of Tarim Animal Husbandry Science and Technology of Xinjiang Production & Construction Corps, Alar 843300, China","institution_ids":["https://openalex.org/I2801312332"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101547505"],"corresponding_institution_ids":["https://openalex.org/I2801312332","https://openalex.org/I3129293551"],"apc_list":{"value":300,"currency":"USD","value_usd":300},"apc_paid":{"value":300,"currency":"USD","value_usd":300},"fwci":5.2914,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.96026409,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"18","issue":"4","first_page":"431","last_page":"431"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13791","display_name":"Veterinary medicine and infectious diseases","score":0.3610999882221222,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13791","display_name":"Veterinary medicine and infectious diseases","score":0.3610999882221222,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.3537999987602234,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.2093999981880188,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tilmicosin","display_name":"tilmicosin","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9810000061988831},{"id":"https://openalex.org/keywords/glaesserella-parasuis","display_name":"Haemophilus parasuis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/pigs","display_name":"pigs","score":0.7960000038146973},{"id":"https://openalex.org/keywords/experimental-infection","display_name":"experimental infection","score":0.7039999961853027},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.7639999985694885},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.6489999890327454},{"id":"https://openalex.org/keywords/macrolide-antibiotics","display_name":"macrolide antibiotics","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8500313758850098},{"id":"https://openalex.org/C2776231263","wikidata":"https://www.wikidata.org/wiki/Q722387","display_name":"Tilmicosin","level":3,"score":0.8427226543426514},{"id":"https://openalex.org/C2776402342","wikidata":"https://www.wikidata.org/wiki/Q311275","display_name":"Haemophilus","level":3,"score":0.5355755090713501},{"id":"https://openalex.org/C139254425","wikidata":"https://www.wikidata.org/wiki/Q1332167","display_name":"Volume of distribution","level":3,"score":0.46470656991004944},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.45560115575790405},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.43128055334091187},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4271323084831238},{"id":"https://openalex.org/C192670549","wikidata":"https://www.wikidata.org/wiki/Q5361061","display_name":"Elimination rate constant","level":4,"score":0.42558610439300537},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3474966883659363},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.332241415977478},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.30368661880493164},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3034283518791199},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.2774408757686615},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.07932212948799133},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006192","descriptor_name":"Haemophilus Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006192","descriptor_name":"Haemophilus Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006192","descriptor_name":"Haemophilus Infections","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044137","descriptor_name":"Haemophilus parasuis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.4142/jvs.2017.18.4.431","doi":"https://doi.org/10.4142/jvs.2017.18.4.431","is_oa":true,"landing_page_url":"https://doi.org/10.4142/jvs.2017.18.4.431","pdf_url":"http://vetsci.org/Synapse/Data/PDFData/0118JVS/jvs-18-431.pdf","source":{"id":"https://openalex.org/S116496814","display_name":"Journal of Veterinary Science","issn_l":"1229-845X","issn":["1229-845X","1976-555X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","kci-registered","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319499","host_organization_name":"Korean Society of Veterinary Science","host_organization_lineage":["https://openalex.org/P4310319499"],"host_organization_lineage_names":["Korean Society of Veterinary Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Science","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4666928","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5746435","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:28385011","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28385011","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of veterinary science","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5746435","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5746435/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Vet Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.4142/jvs.2017.18.4.431","doi":"https://doi.org/10.4142/jvs.2017.18.4.431","is_oa":true,"landing_page_url":"https://doi.org/10.4142/jvs.2017.18.4.431","pdf_url":"http://vetsci.org/Synapse/Data/PDFData/0118JVS/jvs-18-431.pdf","source":{"id":"https://openalex.org/S116496814","display_name":"Journal of Veterinary Science","issn_l":"1229-845X","issn":["1229-845X","1976-555X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","kci-registered","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319499","host_organization_name":"Korean Society of Veterinary Science","host_organization_lineage":["https://openalex.org/P4310319499"],"host_organization_lineage_names":["Korean Society of Veterinary Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4628862289","display_name":"\u6c1f\u82ef\u5c3c\u8003\u5bf9\u732a\u94fe\u7403\u83cc\u7684\u836f\u52a8\u5b66-\u836f\u6548\u5b66\u540c\u6b65\u6a21\u578b\u7814\u7a76","funder_award_id":"31660729","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2776861637.pdf","grobid_xml":"https://content.openalex.org/works/W2776861637.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W119036543","https://openalex.org/W750232306","https://openalex.org/W1491948868","https://openalex.org/W1550186467","https://openalex.org/W1966395979","https://openalex.org/W1997234474","https://openalex.org/W1997774470","https://openalex.org/W2007616013","https://openalex.org/W2029252255","https://openalex.org/W2030152377","https://openalex.org/W2050876696","https://openalex.org/W2051350672","https://openalex.org/W2063096966","https://openalex.org/W2074746839","https://openalex.org/W2076186995","https://openalex.org/W2079461103","https://openalex.org/W2106576332","https://openalex.org/W2109313325","https://openalex.org/W2113557034","https://openalex.org/W2128031707","https://openalex.org/W2135021243","https://openalex.org/W2150083832","https://openalex.org/W2158873021","https://openalex.org/W2227158198","https://openalex.org/W2234153860","https://openalex.org/W2278970772","https://openalex.org/W2321409638","https://openalex.org/W2418193357","https://openalex.org/W2549020367"],"related_works":["https://openalex.org/W2949876655","https://openalex.org/W3043981739","https://openalex.org/W79455121","https://openalex.org/W2050876696","https://openalex.org/W2158873021","https://openalex.org/W2321409638","https://openalex.org/W2800283439","https://openalex.org/W2915541151","https://openalex.org/W2389952587","https://openalex.org/W3010115718"],"abstract_inverted_index":{"A":[0],"comparative":[1],"in":[2,12,84,177],"vivo":[3],"pharmacokinetic":[4],"(PK)":[5],"study":[6,163],"of":[7,29,82,102,107,113,160,175],"tilmicosin":[8],"(TIL)":[9],"was":[10,37],"conducted":[11],"6":[13,18],"crossbred":[14,19],"healthy":[15,85,179],"pigs":[16,20,89],"and":[17,42,49,86,111,150,180],"infected":[21,35],"with":[22,63],"Haemophilus":[23],"(H.)":[24],"parasuis":[25],"following":[26],"oral":[27],"administration":[28],"a":[30,57],"single":[31],"40":[32],"mg/kg":[33],"dose.The":[34],"model":[36],"established":[38],"by":[39,44,56,72],"intranasal":[40],"inoculation":[41],"confirmed":[43],"clinical":[45],"signs,":[46],"blood":[47],"biochemistry,":[48],"microscopic":[50],"examinations.Plasma":[51],"TIL":[52,76,83,176],"concentrations":[53],"were":[54,70,90,117,167],"determined":[55],"validated":[58],"high-performance":[59],"liquid":[60],"chromatography":[61],"method":[62],"ultraviolet":[64],"detection":[65],"at":[66],"285":[67],"nm.PK":[68],"parameters":[69,81],"calculated":[71],"using":[73],"WinNonlin":[74],"software.After":[75],"administration,":[77],"the":[78,95,103,108,114,172,178],"main":[79],"PK":[80,173],"H.":[87,181],"parasuis-infected":[88,182],"as":[91],"follows:":[92],"Area":[93],"under":[94],"concentration-time":[96],"curve,":[97],"maximal":[98],"drug":[99],"concentration,":[100],"half-life":[101,106,112],"absorption":[104],"phase,":[105,110],"distribution":[109],"elimination":[115],"phase":[116],"34.86":[118],"\u00b1":[119,123,127,131,135,139,143,147,152],"9.69":[120],"vs.":[121,129,137,145,154],"28.73":[122],"6.18":[124],"\uf06dg\u318dh/mL,":[125],"1.77":[126],"0.33":[128],"1.67":[130],"0.28":[132],"\uf06dg/mL,":[133],"2.27":[134],"0.45":[136],"2.24":[138],"0.44":[140],"h,":[141,149,157],"5.35":[142],"1.40":[144],"4.61":[146],"0.35":[148],"43.53":[151],"8.17":[153],"42.05\u00b1":[155],"9.36":[156],"respectively.These":[158],"results":[159],"this":[161],"exploratory":[162],"suggest":[164],"that":[165],"there":[166],"no":[168],"significant":[169],"differences":[170],"between":[171],"profiles":[174],"pigs.":[183]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-01-05T00:00:00"}