{"id":"https://openalex.org/W2776355388","doi":"https://doi.org/10.3389/fmed.2017.00232","title":"Removal of the C-Terminal Domains of ADAMTS13 by Activated Coagulation Factor XI induces Platelet Adhesion on Endothelial Cells under Flow Conditions","display_name":"Removal of the C-Terminal Domains of ADAMTS13 by Activated Coagulation Factor XI induces Platelet Adhesion on Endothelial Cells under Flow Conditions","publication_year":2017,"publication_date":"2017-12-20","ids":{"openalex":"https://openalex.org/W2776355388","doi":"https://doi.org/10.3389/fmed.2017.00232","mag":"2776355388","pmid":"https://pubmed.ncbi.nlm.nih.gov/29326937","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5742325"},"language":"en","primary_location":{"id":"doi:10.3389/fmed.2017.00232","doi":"https://doi.org/10.3389/fmed.2017.00232","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2017.00232","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmed.2017.00232/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fmed.2017.00232/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032869216","display_name":"Kathleen S. Garland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen S. Garland","raw_affiliation_strings":["Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, OR, United States","Division of Pediatric Hematology/Oncology, School of Medicine, Oregon Health & Science University, Portland, OR, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, OR, United States","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Division of Pediatric Hematology/Oncology, School of Medicine, Oregon Health & Science University, Portland, OR, United States","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008848687","display_name":"St\u00e9phanie E. Reitsma","orcid":"https://orcid.org/0000-0002-7058-5038","observed_orcids":["https://orcid.org/0000-0002-7058-5038"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"St\u00e9phanie E. Reitsma","raw_affiliation_strings":["Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, OR, United States","Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, OR, United States","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112070250","display_name":"Toshiaki Shirai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Toshiaki Shirai","raw_affiliation_strings":["Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, OR, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, OR, United States","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006803418","display_name":"Jevgenia Zilberman\u2010Rudenko","orcid":"https://orcid.org/0000-0001-9862-9285","observed_orcids":["https://orcid.org/0000-0001-9862-9285"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jevgenia Zilberman-Rudenko","raw_affiliation_strings":["Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, OR, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, OR, United States","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011450008","display_name":"Erik I. Tucker","orcid":"https://orcid.org/0000-0003-0532-113X","observed_orcids":["https://orcid.org/0000-0003-0532-113X"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I4210094792","display_name":"Aronora (United States)","ror":"https://ror.org/00vrz7m04","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erik I. Tucker","raw_affiliation_strings":["Aronora, Inc., Portland, OR, United States","Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, OR, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aronora, Inc., Portland, OR, United States","institution_ids":["https://openalex.org/I4210094792"]},{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, OR, United States","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021496734","display_name":"David Gailani","orcid":"https://orcid.org/0000-0001-8142-8014","observed_orcids":["https://orcid.org/0000-0001-8142-8014"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Gailani","raw_affiliation_strings":["Vanderbilt University School of Medicine, Nashville, TN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University School of Medicine, Nashville, TN, United States","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036237322","display_name":"Andr\u00e1s Gruber","orcid":"https://orcid.org/0000-0001-6212-2247","observed_orcids":["https://orcid.org/0000-0001-6212-2247"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I4210094792","display_name":"Aronora (United States)","ror":"https://ror.org/00vrz7m04","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andr\u00e1s Gruber","raw_affiliation_strings":["Aronora, Inc., Portland, OR, United States","Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, OR, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aronora, Inc., Portland, OR, United States","institution_ids":["https://openalex.org/I4210094792"]},{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, OR, United States","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050978437","display_name":"Owen J. T. McCarty","orcid":"https://orcid.org/0000-0001-9481-0124","observed_orcids":["https://orcid.org/0000-0001-9481-0124"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Owen J. T. McCarty","raw_affiliation_strings":["Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, OR, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, OR, United States","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074003801","display_name":"Cristina Puy","orcid":"https://orcid.org/0000-0002-5911-8156","observed_orcids":["https://orcid.org/0000-0002-5911-8156"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cristina Puy","raw_affiliation_strings":["Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, OR, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, OR, United States","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5074003801"],"corresponding_institution_ids":["https://openalex.org/I165690674"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.6313,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.72900014,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"4","issue":null,"first_page":"232","last_page":"232"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adamts13","display_name":"ADAMTS13","score":1.0},{"id":"https://openalex.org/keywords/cub-domain","display_name":"CUB domain","score":0.8510000109672546},{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.8769999742507935},{"id":"https://openalex.org/keywords/platelet-adhesion","display_name":"platelet adhesion","score":0.8450000286102295},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.6729999780654907},{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":0.5759999752044678},{"id":"https://openalex.org/keywords/plasmin","display_name":"plasmin","score":1.0},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.8510000109672546},{"id":"https://openalex.org/keywords/platelet-deposition","display_name":"platelet deposition","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C2780921031","wikidata":"https://www.wikidata.org/wiki/Q14873945","display_name":"ADAMTS13","level":4,"score":0.8666194677352905},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.7048482894897461},{"id":"https://openalex.org/C167814343","wikidata":"https://www.wikidata.org/wiki/Q419341","display_name":"Thrombospondin","level":4,"score":0.6616504788398743},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.633145809173584},{"id":"https://openalex.org/C2778259572","wikidata":"https://www.wikidata.org/wiki/Q407908","display_name":"Disintegrin","level":4,"score":0.602766215801239},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.5624246001243591},{"id":"https://openalex.org/C2781071845","wikidata":"https://www.wikidata.org/wiki/Q21173374","display_name":"Plasmin","level":3,"score":0.5375404357910156},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.5239372849464417},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.517723023891449},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.5067253708839417},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.4699184000492096},{"id":"https://openalex.org/C19014433","wikidata":"https://www.wikidata.org/wiki/Q5130995","display_name":"Cleave","level":3,"score":0.43759018182754517},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33256077766418457},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33006322383880615},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.256544291973114},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22799918055534363},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21413850784301758},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15460047125816345}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fmed.2017.00232","doi":"https://doi.org/10.3389/fmed.2017.00232","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2017.00232","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmed.2017.00232/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4674698","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5742325","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5742325","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5742325","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Med (Lausanne)","raw_type":"Text"},{"id":"pmid:29326937","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29326937","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:928aa220bde04d2a920061c1a8f9496b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/928aa220bde04d2a920061c1a8f9496b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Medicine, Vol 4 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmed.2017.00232","doi":"https://doi.org/10.3389/fmed.2017.00232","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2017.00232","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmed.2017.00232/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1363003109","display_name":"Role of FXI in Thrombohemorrhagic Complications","funder_award_id":"F31HL136230","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1999487110","display_name":"Oregon Clinical and Translational Research Institute","funder_award_id":"UL1TR000128","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2246901851","display_name":"Factor XI inhibitor for thrombosis","funder_award_id":"R44HL106919","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7070462608","display_name":"FXI and Sepsis","funder_award_id":"R01GM116184","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000913381","display_name":"Characterization of Coagulation Factor-platelet Interactions: Role of FXI","funder_award_id":"R01HL101972","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332578","display_name":"Oregon Clinical and Translational Research Institute","ror":"https://ror.org/009avj582"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2776355388.pdf","grobid_xml":"https://content.openalex.org/works/W2776355388.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W164651796","https://openalex.org/W276645119","https://openalex.org/W1504530782","https://openalex.org/W1536015903","https://openalex.org/W1831354387","https://openalex.org/W1860833529","https://openalex.org/W1967765437","https://openalex.org/W1972595265","https://openalex.org/W1973642951","https://openalex.org/W1979338133","https://openalex.org/W1998399069","https://openalex.org/W1999881321","https://openalex.org/W2013031367","https://openalex.org/W2014250508","https://openalex.org/W2017309331","https://openalex.org/W2019151399","https://openalex.org/W2027322928","https://openalex.org/W2042466479","https://openalex.org/W2044505929","https://openalex.org/W2051131128","https://openalex.org/W2052418612","https://openalex.org/W2062894803","https://openalex.org/W2079133863","https://openalex.org/W2079416873","https://openalex.org/W2100451345","https://openalex.org/W2102719739","https://openalex.org/W2103700658","https://openalex.org/W2110059705","https://openalex.org/W2128727430","https://openalex.org/W2157764784","https://openalex.org/W2157956748","https://openalex.org/W2158841686","https://openalex.org/W2162977739","https://openalex.org/W2313344452","https://openalex.org/W2338854794","https://openalex.org/W2401660990","https://openalex.org/W2412230954","https://openalex.org/W2584813174","https://openalex.org/W2588749321"],"related_works":["https://openalex.org/W2980237255","https://openalex.org/W3205937921","https://openalex.org/W2052418612","https://openalex.org/W1539971791","https://openalex.org/W2887973855","https://openalex.org/W2559621605","https://openalex.org/W2042998092","https://openalex.org/W2563473028","https://openalex.org/W2085435652","https://openalex.org/W4302331871"],"abstract_inverted_index":{"Platelet":[0],"recruitment":[1],"to":[2,54,79,202],"sites":[3,258],"of":[4,17,24,65,116,118,160,169,173,177,200,213,259],"vascular":[5],"injury":[6],"is":[7,60,68],"mediated":[8],"by":[9,51,179,191,250],"von":[10],"Willebrand":[11],"factor":[12,91],"(VWF).":[13],"The":[14,70],"shear-induced":[15],"unraveling":[16],"ultra-large":[18],"VWF":[19,53,204,214],"multimers":[20],"causes":[21],"the":[22,33,63,106,119,124,132,140,145,158,161,167,174,198,206],"formation":[23],"a":[25,40,110,114,149,192,229],"\"stringlike\"":[26],"conformation,":[27],"which":[28,251],"rapidly":[29],"recruits":[30],"platelets":[31],"from":[32,164],"bloodstream.":[34],"A":[35],"disintegrin":[36],"and":[37,74,123,135,143,196,216,241],"metalloproteinase":[38],"with":[39,113],"thrombospondin":[41,120],"type":[42],"1":[43],"motif,":[44],"member":[45],"13":[46],"(ADAMTS13)":[47],"regulates":[48],"this":[49],"process":[50],"cleaving":[52],"prevent":[55],"aberrant":[56],"platelet":[57,221,255],"adhesion;":[58],"it":[59],"unclear":[61],"whether":[62],"activity":[64,188,240],"ADAMTS13":[66,104,112,130,138,165,178,187,201,239],"itself":[67],"regulated.":[69],"serine":[71],"proteases":[72],"\u03b1-thrombin":[73,128,182],"plasmin":[75,136],"have":[76,227],"been":[77],"shown":[78],"cleave":[80,96,203],"ADAMTS13.":[81,97],"Based":[82],"on":[83,166,205],"sequence":[84],"homology,":[85],"we":[86,153],"hypothesized":[87],"that":[88,101,155],"activated":[89],"coagulation":[90,233],"XI":[92],"(FXIa)":[93],"would":[94],"likewise":[95],"Our":[98],"results":[99],"show":[100],"FXIa":[102,156,180,236,252],"cleaves":[103,129,137],"at":[105,139,144,257],"C-terminal":[107,146,175],"domains,":[108,126],"generating":[109],"truncated":[111],"deletion":[115,159],"part":[117],"type-1":[121],"domain":[122,142,176],"CUB1-2":[125,133,162],"while":[127],"near":[131],"domains":[134,163],"metalloprotease":[141],"domain.":[147],"Using":[148],"cell":[150,208],"surface":[151,168],"immunoassay,":[152],"observed":[154],"induced":[157],"endothelial":[170,207],"cells.":[171],"Removal":[172],"or":[181],"caused":[183],"an":[184,218,246],"increase":[185,219],"in":[186,211,220,237],"as":[189],"measured":[190],"fluorogenic":[193],"substrate":[194],"(FRETS)":[195],"blocked":[197],"ability":[199],"surface,":[209],"resulting":[210],"persistence":[212],"strands":[215],"causing":[217],"adhesion":[222],"under":[223],"flow":[224],"conditions.":[225],"We":[226],"demonstrated":[228],"novel":[230],"mechanism":[231],"for":[232],"proteinases":[234],"including":[235],"regulating":[238],"function.":[242],"This":[243],"may":[244],"represent":[245],"additional":[247],"hemostatic":[248],"function":[249],"promotes":[253],"local":[254],"deposition":[256],"vessel":[260],"injury.":[261]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2018-01-05T00:00:00"}