{"id":"https://openalex.org/W2776265387","doi":null,"title":"The Role of Acetylcholine Nicotinic Receptors, Protein Kinase B and Protein Kinase M on the Protective Effect of Rosmarinic Acid in Beta Amyloid (25-35) Induced Rat Model of Alzheimer\u2019s Disease","display_name":"The Role of Acetylcholine Nicotinic Receptors, Protein Kinase B and Protein Kinase M on the Protective Effect of Rosmarinic Acid in Beta Amyloid (25-35) Induced Rat Model of Alzheimer\u2019s Disease","publication_year":2017,"publication_date":"2017-08-10","ids":{"openalex":"https://openalex.org/W2776265387","mag":"2776265387"},"language":"en","primary_location":{"id":"mag:2776265387","doi":null,"is_oa":false,"landing_page_url":"http://zums.ac.ir/journal/article-1-4792-en.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306515292","display_name":"Journal of Advances in Medical and Biomedical Research","issn_l":"1606-9366","issn":["1606-9366","2322-4231","2676-6264"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Advances in Medical and Biomedical Research","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073707783","display_name":"Tourandokht Baluchnejadmojarad","orcid":"https://orcid.org/0000-0002-2703-728X","observed_orcids":["https://orcid.org/0000-0002-2703-728X"]},"institutions":[{"id":"https://openalex.org/I161106909","display_name":"Iran University of Medical Sciences","ror":"https://ror.org/03w04rv71","country_code":"IR","type":"education","lineage":["https://openalex.org/I161106909"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Tourandokht Baluchnejadmojarad","raw_affiliation_strings":["Department of Physiology, School of Medicine, Iran University of Medical sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Iran University of Medical sciences, Tehran, Iran","institution_ids":["https://openalex.org/I161106909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070346344","display_name":"Mehrdad Roghani","orcid":"https://orcid.org/0000-0002-9209-8484","observed_orcids":["https://orcid.org/0000-0002-9209-8484"]},"institutions":[{"id":"https://openalex.org/I119025939","display_name":"Shahed University","ror":"https://ror.org/01e8ff003","country_code":"IR","type":"education","lineage":["https://openalex.org/I119025939"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mehrdad Roghani","raw_affiliation_strings":["Dept of Physiology, School of Medicine, Neurophysiology Research Center, Shahed University, Tehran, Iran"],"raw_orcid":"https://orcid.org/0000-0002-9209-8484","affiliations":[{"raw_affiliation_string":"Dept of Physiology, School of Medicine, Neurophysiology Research Center, Shahed University, Tehran, Iran","institution_ids":["https://openalex.org/I119025939"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033358864","display_name":"Parastoo Kazemloo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161106909","display_name":"Iran University of Medical Sciences","ror":"https://ror.org/03w04rv71","country_code":"IR","type":"education","lineage":["https://openalex.org/I161106909"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Parastoo Kazemloo","raw_affiliation_strings":["Department of Physiology, School of Medicine, Iran University of Medical sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Iran University of Medical sciences, Tehran, Iran","institution_ids":["https://openalex.org/I161106909"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"113","first_page":"43","last_page":"57"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rosmarinic-acid","display_name":"rosmarinic acid","score":0.906000018119812},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9890000224113464},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7179999947547913},{"id":"https://openalex.org/keywords/nicotinic-acetylcholine-receptors","display_name":"nicotinic acetylcholine receptors","score":0.9860000014305115},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.996999979019165},{"id":"https://openalex.org/keywords/protein-kinase-m","display_name":"protein kinase M","score":0.9800000190734863},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7229999899864197},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8349999785423279},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.578000009059906},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7900000214576721},{"id":"https://openalex.org/keywords/memory-impairment","display_name":"memory impairment","score":0.574999988079071},{"id":"https://openalex.org/keywords/neuronal-density","display_name":"neuronal density","score":0.5630000233650208},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C2778771215","wikidata":"https://www.wikidata.org/wiki/Q50380051","display_name":"Rosmarinic acid","level":3,"score":0.8657056093215942},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5559979677200317},{"id":"https://openalex.org/C2776156579","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid beta","level":3,"score":0.5072205066680908},{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.4989314079284668},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.4975276291370392},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.47379323840141296},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46418043971061707},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4071057438850403},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3631681501865387},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3223370313644409},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29570579528808594},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1931457221508026},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.13848727941513062},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.04770183563232422},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2776265387","doi":null,"is_oa":false,"landing_page_url":"http://zums.ac.ir/journal/article-1-4792-en.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306515292","display_name":"Journal of Advances in Medical and Biomedical Research","issn_l":"1606-9366","issn":["1606-9366","2322-4231","2676-6264"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Advances in Medical and Biomedical Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1974491267","https://openalex.org/W1998553787","https://openalex.org/W2009021591","https://openalex.org/W2010022125","https://openalex.org/W2018317802","https://openalex.org/W2022682759","https://openalex.org/W2038471912","https://openalex.org/W2046324408","https://openalex.org/W2048167422","https://openalex.org/W2066358338","https://openalex.org/W2070732456","https://openalex.org/W2072699152","https://openalex.org/W2092112738","https://openalex.org/W2097335530","https://openalex.org/W2114842668","https://openalex.org/W2129537013","https://openalex.org/W2133758473","https://openalex.org/W2144382886","https://openalex.org/W2154608911"],"related_works":["https://openalex.org/W2503634245","https://openalex.org/W2797459878","https://openalex.org/W2044855856","https://openalex.org/W4312187540","https://openalex.org/W3126461780","https://openalex.org/W2980374624","https://openalex.org/W2791049255","https://openalex.org/W2949773701","https://openalex.org/W7204913096","https://openalex.org/W3021751853"],"abstract_inverted_index":{"Background":[0],"and":[1,14,23,41,69,96,101,117,125,129,149,162,172,228,235],"Objective:":[2],"Alzheimers":[3,66,214],"disease":[4,215],"(AD)":[5],"is":[6],"one":[7],"of":[8,20,33,54,58,65,79,138,203,213,219],"the":[9,17,24,31,52,55,147,154,201,216],"most":[10],"common":[11],"neurodegenerative":[12],"diseases":[13],"results":[15],"from":[16,224],"extracellular":[18],"accumulation":[19],"b-amyloid":[21],"peptides":[22],"resulting":[25],"neuronal":[26,130,186],"dysfunction.":[27],"In":[28,156,180],"this":[29,157,204,210],"study,":[30,205],"role":[32],"nicotinic":[34,159,231],"acetylcholine":[35,102,160,232],"receptors,":[36,233],"protein":[37,42],"kinase":[38,43],"B":[39],"(PKB)":[40],"M":[44],"(PKM)":[45],"were":[46,73,134,222],"evaluated":[47],"in":[48,61,114,121,188,209],"order":[49],"to":[50,153],"examine":[51],"mechanism":[53],"protective":[56,217],"effects":[57,218],"rosmarinic":[59,143,189,220],"acid":[60,87,95,144,190,221],"a":[62],"rat":[63],"model":[64,212],"disease.":[67],"Materials":[68],"Methods:":[70],"Animals[vog1]":[71],"divided":[74],"into":[75],"6":[76],"groups":[77],"consisting":[78],"1)":[80],"Sham,":[81],"2)":[82],"Beta":[83],"amyloid,":[84],"3)":[85],"Rosmarinic":[86,94],"pretreated":[88,105,191],"beta":[89,106,139,192],"amyloid":[90,140,193],"(25":[91],"mg/kg),":[92],"4-6)":[93],"PKM":[97],"inhibitor,":[98],"PKB":[99,163,182,234],"inhibitor":[100,104],"receptor":[103],"amyloid.":[107],"Two":[108],"weeks":[109],"post-surgery,":[110],"behavioral":[111,148],"(alternation":[112],"percent":[113],"Y":[115],"maze":[116],"step":[118,166],"through":[119,167],"latency":[120,168],"passive":[122],"avoidance":[123],"task)":[124],"histochemical":[126,150],"(hippocampal":[127],"malondialdehyde":[128,175],"density":[131,187],"measurement)":[132],"studies":[133],"performed.":[135],"Results:":[136],"Pretreatment":[137],"animals":[141],"with":[142],"considerably":[145],"alleviated":[146],"disturbances":[151],"related":[152],"hippocampus.":[155],"group,":[158],"receptors":[161],"inhibitors":[164,183],"decreased":[165,184],"(p":[169,177,195],"less-than":[170,178,196],"0.001)":[171],"increased":[173],"hippocampal":[174,185],"levels":[176],"0.001).":[179],"addition,":[181],"rats":[194],"0.05).":[197],"Conclusion:":[198],"Based":[199],"on":[200],"findings":[202],"it":[206],"seems":[207],"that":[208],"experimental":[211],"derived":[223],"its":[225],"antioxidant":[226],"properties":[227],"partially":[229],"via":[230],"PKM.":[236],"[vog1]Which":[238],"animals??":[239],"How":[240],"many???":[241]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-01-05T00:00:00"}
