{"id":"https://openalex.org/W2775999923","doi":"https://doi.org/10.1152/ajplung.1991.261.2.l118","title":"Lung surfactant protein SP-C from human, bovine, and canine sources contains palmityl cysteine thioester linkages","display_name":"Lung surfactant protein SP-C from human, bovine, and canine sources contains palmityl cysteine thioester linkages","publication_year":1991,"publication_date":"1991-08-01","ids":{"openalex":"https://openalex.org/W2775999923","doi":"https://doi.org/10.1152/ajplung.1991.261.2.l118","mag":"2775999923","pmid":"https://pubmed.ncbi.nlm.nih.gov/1872406"},"language":"en","primary_location":{"id":"doi:10.1152/ajplung.1991.261.2.l118","doi":"https://doi.org/10.1152/ajplung.1991.261.2.l118","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.1991.261.2.l118","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056870233","display_name":"John T. Stults","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. T. Stults","raw_affiliation_strings":["Department of Protein Chemistry, Genentech, South San Francisco94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Protein Chemistry, Genentech, South San Francisco94080","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000139914","display_name":"Patrick R. Griffin","orcid":"https://orcid.org/0000-0002-3404-690X","observed_orcids":["https://orcid.org/0000-0002-3404-690X"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. R. Griffin","raw_affiliation_strings":["Department of Protein Chemistry, Genentech, South San Francisco94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Protein Chemistry, Genentech, South San Francisco94080","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007726016","display_name":"David D. Lesikar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. D. Lesikar","raw_affiliation_strings":["Department of Protein Chemistry, Genentech, South San Francisco94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Protein Chemistry, Genentech, South San Francisco94080","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110691235","display_name":"Aniketh Naidu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Naidu","raw_affiliation_strings":["Department of Protein Chemistry, Genentech, South San Francisco94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Protein Chemistry, Genentech, South San Francisco94080","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108188496","display_name":"B Moffat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Moffat","raw_affiliation_strings":["Department of Protein Chemistry, Genentech, South San Francisco94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Protein Chemistry, Genentech, South San Francisco94080","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037702686","display_name":"Bradley J. Benson","orcid":"https://orcid.org/0000-0002-6923-6869","observed_orcids":["https://orcid.org/0000-0002-6923-6869"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. J. Benson","raw_affiliation_strings":["Department of Protein Chemistry, Genentech, South San Francisco94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Protein Chemistry, Genentech, South San Francisco94080","institution_ids":["https://openalex.org/I183934855"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I183934855"],"apc_list":null,"apc_paid":null,"fwci":1.7482,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.87235469,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"261","issue":"2","first_page":"L118","last_page":"L125"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.02800000086426735,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/surfactant-protein-c","display_name":"surfactant protein C","score":0.9750000238418579},{"id":"https://openalex.org/keywords/pulmonary-surfactant","display_name":"pulmonary surfactant","score":0.953000009059906},{"id":"https://openalex.org/keywords/cysteine-modification","display_name":"cysteine modification","score":0.6389999985694885},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.43700000643730164},{"id":"https://openalex.org/keywords/species-comparison","display_name":"species comparison","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.7664895057678223},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.6717633605003357},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6673846244812012},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5829976797103882},{"id":"https://openalex.org/C2778834346","wikidata":"https://www.wikidata.org/wiki/Q422794","display_name":"Thioester","level":3,"score":0.5680014491081238},{"id":"https://openalex.org/C2777824588","wikidata":"https://www.wikidata.org/wiki/Q414783","display_name":"Dithiothreitol","level":3,"score":0.513892650604248},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5057516098022461},{"id":"https://openalex.org/C193557335","wikidata":"https://www.wikidata.org/wiki/Q61424","display_name":"Acylation","level":3,"score":0.4549334943294525},{"id":"https://openalex.org/C2779936771","wikidata":"https://www.wikidata.org/wiki/Q209727","display_name":"Palmitic acid","level":3,"score":0.4301317036151886},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3337252140045166},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19663438200950623},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.0993206799030304},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000215","descriptor_name":"Acylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002849","descriptor_name":"Chromatography, Gas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004229","descriptor_name":"Dithiothreitol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010169","descriptor_name":"Palmitic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011510","descriptor_name":"Proteolipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011663","descriptor_name":"Pulmonary Surfactants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013057","descriptor_name":"Spectrum Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019308","descriptor_name":"Palmitic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajplung.1991.261.2.l118","doi":"https://doi.org/10.1152/ajplung.1991.261.2.l118","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.1991.261.2.l118","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},{"id":"pmid:1872406","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1872406","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2481516375","https://openalex.org/W2011225090","https://openalex.org/W2074190785","https://openalex.org/W1980565826","https://openalex.org/W2069532558","https://openalex.org/W1994112963","https://openalex.org/W2072647063","https://openalex.org/W2013804424","https://openalex.org/W4390813911","https://openalex.org/W778809292"],"abstract_inverted_index":{"Lung":[0],"surfactant":[1,28],"is":[2,50,66],"a":[3],"complex":[4],"mixture":[5],"of":[6,23,52,87,91,105],"lipids":[7],"and":[8,18,40,102],"proteins":[9],"that":[10],"coats":[11],"the":[12,24,56,106,115],"alveoli":[13],"to":[14,60,82],"reduce":[15],"surface":[16],"tension":[17],"prevent":[19],"airspace":[20],"collapse.":[21],"One":[22],"principal":[25],"protein":[26,29,49],"constituents,":[27],"C":[30],"(SP-C),":[31],"has":[32],"been":[33],"characterized":[34],"following":[35],"isolation":[36],"from":[37],"human,":[38],"canine,":[39],"bovine":[41],"sources.":[42],"In":[43],"each":[44,72],"species,":[45],"this":[46],"highly":[47],"hydrophobic":[48],"composed":[51],"33-35":[53],"amino":[54],"acids,":[55],"differences":[57],"being":[58],"due":[59],"NH2-terminal":[61],"heterogeneity.":[62],"A":[63],"COOH-terminal":[64],"leucine":[65],"conserved":[67],"throughout.":[68],"The":[69],"cysteines":[70],"in":[71],"species":[73],"were":[74],"found":[75],"by":[76,99],"fast":[77],"atom":[78],"bombardment":[79],"mass":[80],"spectrometry":[81],"be":[83],"present":[84],"as":[85],"thioesters":[86],"palmitic":[88],"acid.":[89],"Acylation":[90],"recombinant":[92],"SP-C":[93],"with":[94,109],"palmityl":[95],"coenzyme":[96],"A,":[97],"followed":[98],"characterization":[100],"before":[101],"after":[103],"release":[104],"acyl":[107],"group":[108],"1,4-dithiothreitol,":[110],"provided":[111],"corroborating":[112],"evidence":[113],"for":[114],"native":[116],"structure.":[117]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-01-05T00:00:00"}