{"id":"https://openalex.org/W2775769578","doi":"https://doi.org/10.1096/fj.201700998rr","title":"IGFBP7 regulates the osteogenic differentiation of bone marrow\u2010derived mesenchymal stem cells via Wnt/\u03b2\u2010catenin signaling pathway","display_name":"IGFBP7 regulates the osteogenic differentiation of bone marrow\u2010derived mesenchymal stem cells via Wnt/\u03b2\u2010catenin signaling pathway","publication_year":2017,"publication_date":"2017-12-14","ids":{"openalex":"https://openalex.org/W2775769578","doi":"https://doi.org/10.1096/fj.201700998rr","mag":"2775769578","pmid":"https://pubmed.ncbi.nlm.nih.gov/29242275"},"language":"en","primary_location":{"id":"doi:10.1096/fj.201700998rr","doi":"https://doi.org/10.1096/fj.201700998rr","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.201700998rr","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100441686","display_name":"Wei Zhang","orcid":"https://orcid.org/0000-0002-6885-5166","observed_orcids":["https://orcid.org/0000-0002-6885-5166"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["Department of Orthopedics Zhejiang University Hangzhou China","Research Institute of Orthopaedics Zhejiang University Hangzhou China","Department of Orthopedics, Zhejiang University, Hangzhou, China","Research Institute of Orthopaedics, Zhejiang University, Hangzhou, China","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics Zhejiang University Hangzhou China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Research Institute of Orthopaedics Zhejiang University Hangzhou China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Orthopedics, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Research Institute of Orthopaedics, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003565023","display_name":"Erman Chen","orcid":"https://orcid.org/0000-0002-0328-4016","observed_orcids":["https://orcid.org/0000-0002-0328-4016"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Erman Chen","raw_affiliation_strings":["Department of Orthopedics Zhejiang University Hangzhou China","Research Institute of Orthopaedics Zhejiang University Hangzhou China","Department of Orthopedics, Zhejiang University, Hangzhou, China","Research Institute of Orthopaedics, Zhejiang University, Hangzhou, China","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics Zhejiang University Hangzhou China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Research Institute of Orthopaedics Zhejiang University Hangzhou China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Orthopedics, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Research Institute of Orthopaedics, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100387246","display_name":"Mo Chen","orcid":"https://orcid.org/0000-0002-1822-2731","observed_orcids":["https://orcid.org/0000-0002-1822-2731","https://orcid.org/0009-0003-9777-3439"]},"institutions":[{"id":"https://openalex.org/I4210139110","display_name":"Hangzhou Hospital of Traditional Chinese Medicine","ror":"https://ror.org/03a8g0p38","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139110"]},{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mo Chen","raw_affiliation_strings":["Department of Nephrology Hangzhou Hospital of Traditional Chinese Medicine Hangzhou China","Department of Rheumatology Second Affiliated Hospital, School of Medicine, and Zhejiang University Hangzhou China","Department of Nephrology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, China","Department of Rheumatology, Second Affiliated Hospital, School of Medicine, and Zhejiang University, Hangzhou, China","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology Hangzhou Hospital of Traditional Chinese Medicine Hangzhou China","institution_ids":["https://openalex.org/I4210139110"]},{"raw_affiliation_string":"Department of Rheumatology Second Affiliated Hospital, School of Medicine, and Zhejiang University Hangzhou China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Nephrology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I4210139110"]},{"raw_affiliation_string":"Department of Rheumatology, Second Affiliated Hospital, School of Medicine, and Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012762146","display_name":"Chenyi Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenyi Ye","raw_affiliation_strings":["Department of Orthopedics Zhejiang University Hangzhou China","Research Institute of Orthopaedics Zhejiang University Hangzhou China","Department of Orthopedics, Zhejiang University, Hangzhou, China","Research Institute of Orthopaedics, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics Zhejiang University Hangzhou China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Research Institute of Orthopaedics Zhejiang University Hangzhou China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Orthopedics, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Research Institute of Orthopaedics, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103122979","display_name":"Yiying Qi","orcid":"https://orcid.org/0000-0003-1535-279X","observed_orcids":["https://orcid.org/0000-0003-1535-279X"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiying Qi","raw_affiliation_strings":["Department of Orthopedics Zhejiang University Hangzhou China","Research Institute of Orthopaedics Zhejiang University Hangzhou China","Department of Orthopedics, Zhejiang University, Hangzhou, China","Research Institute of Orthopaedics, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics Zhejiang University Hangzhou China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Research Institute of Orthopaedics Zhejiang University Hangzhou China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Orthopedics, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Research Institute of Orthopaedics, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020474422","display_name":"Qianhai Ding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qianhai Ding","raw_affiliation_strings":["Department of Orthopedics Zhejiang University Hangzhou China","Research Institute of Orthopaedics Zhejiang University Hangzhou China","Department of Orthopedics, Zhejiang University, Hangzhou, China","Research Institute of Orthopaedics, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics Zhejiang University Hangzhou China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Research Institute of Orthopaedics Zhejiang University Hangzhou China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Orthopedics, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Research Institute of Orthopaedics, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100455156","display_name":"Hang Li","orcid":"https://orcid.org/0000-0003-2600-0298","observed_orcids":["https://orcid.org/0000-0003-2600-0298"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hang Li","raw_affiliation_strings":["Department of Orthopedics Zhejiang University Hangzhou China","Research Institute of Orthopaedics Zhejiang University Hangzhou China","Department of Orthopedics, Zhejiang University, Hangzhou, China","Research Institute of Orthopaedics, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics Zhejiang University Hangzhou China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Research Institute of Orthopaedics Zhejiang University Hangzhou China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Orthopedics, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Research Institute of Orthopaedics, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007564415","display_name":"Deting Xue","orcid":"https://orcid.org/0000-0001-6388-2862","observed_orcids":["https://orcid.org/0000-0001-6388-2862"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Deting Xue","raw_affiliation_strings":["Department of Orthopedics Zhejiang University Hangzhou China","Research Institute of Orthopaedics Zhejiang University Hangzhou China","Department of Orthopedics, Zhejiang University, Hangzhou, China","Research Institute of Orthopaedics, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics Zhejiang University Hangzhou China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Research Institute of Orthopaedics Zhejiang University Hangzhou China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Orthopedics, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Research Institute of Orthopaedics, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiang Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiang Gao","raw_affiliation_strings":["Department of Orthopedics Zhejiang University Hangzhou China","Research Institute of Orthopaedics Zhejiang University Hangzhou China","Department of Orthopedics, Zhejiang University, Hangzhou, China","Research Institute of Orthopaedics, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics Zhejiang University Hangzhou China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Research Institute of Orthopaedics Zhejiang University Hangzhou China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Orthopedics, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Research Institute of Orthopaedics, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068856668","display_name":"Zhijun Pan","orcid":"https://orcid.org/0000-0002-4618-5990","observed_orcids":["https://orcid.org/0000-0002-4618-5990"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhijun Pan","raw_affiliation_strings":["Department of Orthopedics Zhejiang University Hangzhou China","Research Institute of Orthopaedics Zhejiang University Hangzhou China","Department of Orthopedics, Zhejiang University, Hangzhou, China","Research Institute of Orthopaedics, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics Zhejiang University Hangzhou China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Research Institute of Orthopaedics Zhejiang University Hangzhou China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Orthopedics, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Research Institute of Orthopaedics, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5007564415"],"corresponding_institution_ids":["https://openalex.org/I76130692"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":3.2118,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.92859319,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"32","issue":"4","first_page":"2280","last_page":"2291"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.5023999810218811,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.5023999810218811,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.2506999969482422,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.08229999989271164,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igfbp7","display_name":"IGFBP7","score":0.9990000128746033},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9589999914169312},{"id":"https://openalex.org/keywords/bone-marrow-derived-mesenchymal-stem-cells","display_name":"bone marrow-derived mesenchymal stem cells","score":0.9800000190734863},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9480000138282776},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.7559999823570251},{"id":"https://openalex.org/keywords/osteotomy","display_name":"osteotomy","score":0.5419999957084656},{"id":"https://openalex.org/keywords/bone-metabolism","display_name":"bone metabolism","score":0.5370000004768372},{"id":"https://openalex.org/keywords/alkaline-phosphatase-activity","display_name":"alkaline phosphatase activity","score":0.8019999861717224},{"id":"https://openalex.org/keywords/mineral-deposition","display_name":"mineral deposition","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.7817404270172119},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.6346357464790344},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6090662479400635},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5547253489494324},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4967956840991974},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.4448601007461548},{"id":"https://openalex.org/C2776363554","wikidata":"https://www.wikidata.org/wiki/Q14907085","display_name":"RUNX2","level":4,"score":0.41733455657958984},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4163423776626587},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.411424458026886},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4108952581882477},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24168407917022705},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1298123598098755},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05845490097999573},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001861","descriptor_name":"Bone Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001861","descriptor_name":"Bone Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001861","descriptor_name":"Bone Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018969","descriptor_name":"Insulin-Like Growth Factor Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018969","descriptor_name":"Insulin-Like Growth Factor Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018969","descriptor_name":"Insulin-Like Growth Factor Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018969","descriptor_name":"Insulin-Like Growth Factor Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018969","descriptor_name":"Insulin-Like Growth Factor Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018969","descriptor_name":"Insulin-Like Growth Factor Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1096/fj.201700998rr","doi":"https://doi.org/10.1096/fj.201700998rr","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.201700998rr","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmid:29242275","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29242275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3121151269","display_name":null,"funder_award_id":"81572124","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8122160266","display_name":null,"funder_award_id":"81501906","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8229045893","display_name":null,"funder_award_id":"81672147","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W1486387963","https://openalex.org/W1767511027","https://openalex.org/W1815588165","https://openalex.org/W1851902100","https://openalex.org/W1895949831","https://openalex.org/W1964429509","https://openalex.org/W1964646604","https://openalex.org/W1965174761","https://openalex.org/W1971879396","https://openalex.org/W1974292102","https://openalex.org/W1977955230","https://openalex.org/W1979737063","https://openalex.org/W1984198063","https://openalex.org/W1987174866","https://openalex.org/W1991222088","https://openalex.org/W1998511060","https://openalex.org/W2012982001","https://openalex.org/W2024511149","https://openalex.org/W2036557984","https://openalex.org/W2036928635","https://openalex.org/W2044640123","https://openalex.org/W2045450434","https://openalex.org/W2050678422","https://openalex.org/W2053074008","https://openalex.org/W2057378819","https://openalex.org/W2058183752","https://openalex.org/W2062465228","https://openalex.org/W2064957234","https://openalex.org/W2066749771","https://openalex.org/W2075472427","https://openalex.org/W2077248954","https://openalex.org/W2096434919","https://openalex.org/W2101171643","https://openalex.org/W2104774845","https://openalex.org/W2122954559","https://openalex.org/W2129828616","https://openalex.org/W2133473323","https://openalex.org/W2139145539","https://openalex.org/W2139753760","https://openalex.org/W2141370047","https://openalex.org/W2142728379","https://openalex.org/W2144268541","https://openalex.org/W2145853734","https://openalex.org/W2147689449","https://openalex.org/W2150957189","https://openalex.org/W2159999899","https://openalex.org/W2161080185","https://openalex.org/W2169636321","https://openalex.org/W2169726287","https://openalex.org/W2179715594","https://openalex.org/W2185754772","https://openalex.org/W2198125811","https://openalex.org/W2203876861","https://openalex.org/W2268730974","https://openalex.org/W2279649931","https://openalex.org/W2291314161","https://openalex.org/W2315361770","https://openalex.org/W2330308886","https://openalex.org/W2346119783","https://openalex.org/W2467803204","https://openalex.org/W2604655234","https://openalex.org/W4239989429","https://openalex.org/W4243294582","https://openalex.org/W7075685070"],"related_works":["https://openalex.org/W3103789129","https://openalex.org/W4213065871","https://openalex.org/W4386799875","https://openalex.org/W4361818220","https://openalex.org/W4361818978","https://openalex.org/W2775056685","https://openalex.org/W2901082211","https://openalex.org/W2237818184","https://openalex.org/W1482045571","https://openalex.org/W2438447375"],"abstract_inverted_index":{"Insulin-like":[0],"growth":[1],"factor-binding":[2],"protein":[3,90],"7":[4],"(IGFBP7),":[5],"a":[6,119,124],"low-affinity":[7],"IGF":[8],"binder,":[9],"may":[10],"play":[11],"an":[12],"important":[13],"role":[14],"in":[15,21,101],"bone":[16,26,130,184],"metabolism.":[17],"However,":[18],"its":[19,37],"function":[20],"osteogenic":[22,40,102,149,181],"differentiation":[23,103,150,182],"of":[24,43,48,72,82,87,97,108,126,151,183],"human":[25],"marrow-derived":[27,185],"mesenchymal":[28,186],"stem":[29,187],"cells":[30,188],"(BMSCs)":[31],"remains":[32],"unclear.":[33],"Therefore,":[34],"we":[35],"investigated":[36],"effects":[38],"on":[39],"differentiation.":[41],"Overexpression":[42],"IGFBP7":[44,54,83,89,109,146,178],"enhanced":[45],"the":[46,70,80,85,95,106,148,155,180],"expression":[47],"osteo-specific":[49],"genes":[50],"and":[51,53,62,91,137],"proteins,":[52],"knockdown":[55],"decreased":[56,112],"osteogenesis-specific":[57],"markers.":[58],"More":[59],"mineral":[60],"deposits":[61],"higher":[63],"alkaline":[64],"phosphatase":[65],"activity":[66],"were":[67,77,92],"observed":[68],"after":[69],"up-regulation":[71],"IGFBP7.":[73,98],"Moreover,":[74],"\u03b2-catenin":[75],"levels":[76],"up-regulated":[78],"by":[79,94,113,134],"overexpression":[81,107],"or":[84],"addition":[86],"extracellular":[88],"reduced":[93],"depletion":[96],"The":[99],"increase":[100],"due":[104],"to":[105],"was":[110],"partially":[111],"specific":[114],"Wnt/\u03b2-catenin":[115,156,190],"signaling":[116,157,191],"inhibitors.":[117],"Using":[118],"rat":[120],"tibial":[121],"osteotomy":[122],"model,":[123],"sheet":[125],"IGFBP7-overexpressing":[127],"BMSCs":[128,152],"improved":[129],"healing,":[131],"as":[132],"demonstrated":[133],"imaging,":[135],"biomechanical,":[136],"histologic":[138],"analyses.":[139],"Taken":[140],"together,":[141],"these":[142],"findings":[143],"indicate":[144],"that":[145],"regulates":[147,179],"partly":[153],"via":[154,189],"pathway.-Zhang,":[158],"W.,":[159],"Chen,":[160,162],"E.,":[161],"M.,":[163],"Ye,":[164],"C.,":[165],"Qi,":[166],"Y.,":[167],"Ding,":[168],"Q.,":[169],"Li,":[170],"H.,":[171],"Xue,":[172],"D.,":[173],"Gao,":[174],"X.,":[175],"Pan,":[176],"Z.":[177],"pathway.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":4}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2017-12-22T00:00:00"}