{"id":"https://openalex.org/W2775765482","doi":"https://doi.org/10.1523/jneurosci.2864-16.2017","title":"The Protein Tyrosine Phosphatase Shp2 Regulates Oligodendrocyte Differentiation and Early Myelination and Contributes to Timely Remyelination","display_name":"The Protein Tyrosine Phosphatase Shp2 Regulates Oligodendrocyte Differentiation and Early Myelination and Contributes to Timely Remyelination","publication_year":2017,"publication_date":"2017-12-07","ids":{"openalex":"https://openalex.org/W2775765482","doi":"https://doi.org/10.1523/jneurosci.2864-16.2017","mag":"2775765482","pmid":"https://pubmed.ncbi.nlm.nih.gov/29217681","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5783963"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.2864-16.2017","doi":"https://doi.org/10.1523/jneurosci.2864-16.2017","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.2864-16.2017","pdf_url":"https://www.jneurosci.org/content/jneuro/38/4/787.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/38/4/787.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086124836","display_name":"Jared T. Ahrendsen","orcid":"https://orcid.org/0000-0002-9309-6544","observed_orcids":["https://orcid.org/0000-0002-9309-6544"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jared T. Ahrendsen","raw_affiliation_strings":["Department of Cell and Developmental Biology, and","Neuroscience Graduate Program and Medical Scientist Training Program, University of Colorado School of Medicine, Aurora, Colorado 80045","1Department of Cell and Developmental Biology, and","2Neuroscience Graduate Program and Medical Scientist Training Program, University of Colorado School of Medicine, Aurora, Colorado 80045"],"raw_orcid":"https://orcid.org/0000-0002-9309-6544","affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, and","institution_ids":[]},{"raw_affiliation_string":"Neuroscience Graduate Program and Medical Scientist Training Program, University of Colorado School of Medicine, Aurora, Colorado 80045","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]},{"raw_affiliation_string":"1Department of Cell and Developmental Biology, and","institution_ids":[]},{"raw_affiliation_string":"2Neuroscience Graduate Program and Medical Scientist Training Program, University of Colorado School of Medicine, Aurora, Colorado 80045","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067939757","display_name":"Danielle E. Harlow","orcid":"https://orcid.org/0000-0003-1273-4768","observed_orcids":["https://orcid.org/0000-0003-1273-4768"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Danielle E. Harlow","raw_affiliation_strings":["Department of Cell and Developmental Biology, and","1Department of Cell and Developmental Biology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, and","institution_ids":[]},{"raw_affiliation_string":"1Department of Cell and Developmental Biology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022850033","display_name":"Lisbet T. Finseth","orcid":"https://orcid.org/0000-0001-6128-1828","observed_orcids":["https://orcid.org/0000-0001-6128-1828"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisbet T. Finseth","raw_affiliation_strings":["Department of Cell and Developmental Biology, and","1Department of Cell and Developmental Biology, and"],"raw_orcid":"https://orcid.org/0000-0001-6128-1828","affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, and","institution_ids":[]},{"raw_affiliation_string":"1Department of Cell and Developmental Biology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079103954","display_name":"Jennifer N. Bourne","orcid":"https://orcid.org/0000-0001-5501-0351","observed_orcids":["https://orcid.org/0000-0001-5501-0351"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer N. Bourne","raw_affiliation_strings":["Department of Cell and Developmental Biology, and","1Department of Cell and Developmental Biology, and"],"raw_orcid":"https://orcid.org/0000-0001-5501-0351","affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, and","institution_ids":[]},{"raw_affiliation_string":"1Department of Cell and Developmental Biology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018359655","display_name":"Sean P. Hickey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sean P. Hickey","raw_affiliation_strings":["Department of Cell and Developmental Biology, and","1Department of Cell and Developmental Biology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, and","institution_ids":[]},{"raw_affiliation_string":"1Department of Cell and Developmental Biology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Elizabeth A. Gould","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth A. Gould","raw_affiliation_strings":["Department of Cell and Developmental Biology, and","1Department of Cell and Developmental Biology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, and","institution_ids":[]},{"raw_affiliation_string":"1Department of Cell and Developmental Biology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047404662","display_name":"Cecilia M. Culp","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cecilia M. Culp","raw_affiliation_strings":["Department of Cell and Developmental Biology, and","1Department of Cell and Developmental Biology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, and","institution_ids":[]},{"raw_affiliation_string":"1Department of Cell and Developmental Biology, and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062518246","display_name":"Wendy B. Macklin","orcid":"https://orcid.org/0000-0002-1252-0607","observed_orcids":["https://orcid.org/0000-0002-1252-0607"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendy B. Macklin","raw_affiliation_strings":["Department of Cell and Developmental Biology, and Wendy.Macklin@ucdenver.edu","Neuroscience Graduate Program and Medical Scientist Training Program, University of Colorado School of Medicine, Aurora, Colorado 80045","1Department of Cell and Developmental Biology, and","2Neuroscience Graduate Program and Medical Scientist Training Program, University of Colorado School of Medicine, Aurora, Colorado 80045"],"raw_orcid":"https://orcid.org/0000-0002-1252-0607","affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, and Wendy.Macklin@ucdenver.edu","institution_ids":[]},{"raw_affiliation_string":"Neuroscience Graduate Program and Medical Scientist Training Program, University of Colorado School of Medicine, Aurora, Colorado 80045","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]},{"raw_affiliation_string":"1Department of Cell and Developmental Biology, and","institution_ids":[]},{"raw_affiliation_string":"2Neuroscience Graduate Program and Medical Scientist Training Program, University of Colorado School of Medicine, Aurora, Colorado 80045","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4467,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.52309666,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"38","issue":"4","first_page":"787","last_page":"802"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.015599999576807022,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/shp2","display_name":"SHP2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/protein-tyrosine-phosphatase","display_name":"protein tyrosine phosphatase","score":0.9860000014305115},{"id":"https://openalex.org/keywords/oligodendrocyte-differentiation","display_name":"oligodendrocyte differentiation","score":1.0},{"id":"https://openalex.org/keywords/myelination","display_name":"myelination","score":0.9279999732971191},{"id":"https://openalex.org/keywords/remyelination","display_name":"remyelination","score":0.9580000042915344},{"id":"https://openalex.org/keywords/demyelination","display_name":"demyelination","score":0.9819999933242798},{"id":"https://openalex.org/keywords/lysolecithin-induced-demyelination","display_name":"lysolecithin-induced demyelination","score":0.9549999833106995},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.7590000033378601},{"id":"https://openalex.org/keywords/akt-mtor-signaling-pathway","display_name":"Akt/mTOR signaling","score":0.8519999980926514},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.9950000047683716},{"id":"https://openalex.org/keywords/myelin-maintenance","display_name":"myelin maintenance","score":0.6869999766349792},{"id":"https://openalex.org/keywords/central-nervous-system-development","display_name":"central nervous system development","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C2777619251","wikidata":"https://www.wikidata.org/wiki/Q7312279","display_name":"Remyelination","level":4,"score":0.9245859384536743},{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.8649994134902954},{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.7343067526817322},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6534532904624939},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.6481902003288269},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6175867319107056},{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.5323439240455627},{"id":"https://openalex.org/C2780876595","wikidata":"https://www.wikidata.org/wiki/Q410974","display_name":"Myelin basic protein","level":4,"score":0.5297495126724243},{"id":"https://openalex.org/C2779055221","wikidata":"https://www.wikidata.org/wiki/Q18035130","display_name":"OLIG2","level":5,"score":0.4850549101829529},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.44018983840942383},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.4155963361263275},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4019566774368286},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3588413596153259},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2011263370513916},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.15851545333862305},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1150931715965271},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009186","descriptor_name":"Myelin Sheath","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054592","descriptor_name":"Protein Tyrosine Phosphatase, Non-Receptor Type 11","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1523/jneurosci.2864-16.2017","doi":"https://doi.org/10.1523/jneurosci.2864-16.2017","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.2864-16.2017","pdf_url":"https://www.jneurosci.org/content/jneuro/38/4/787.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5008551","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5783963","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:29217681","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29217681","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5783963","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5783963/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.2864-16.2017","doi":"https://doi.org/10.1523/jneurosci.2864-16.2017","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.2864-16.2017","pdf_url":"https://www.jneurosci.org/content/jneuro/38/4/787.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1378513820","display_name":"Institutional Training in Otolaryngology Research","funder_award_id":"T32DC012280","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G437495844","display_name":"Signaling pathways regulating myelination in the CNS","funder_award_id":"F31NS081834","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2775765482.pdf","grobid_xml":"https://content.openalex.org/works/W2775765482.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1493843813","https://openalex.org/W1522048223","https://openalex.org/W1580040847","https://openalex.org/W1901712533","https://openalex.org/W1963559255","https://openalex.org/W1965480344","https://openalex.org/W1981260256","https://openalex.org/W1989963039","https://openalex.org/W2000485285","https://openalex.org/W2022084199","https://openalex.org/W2029435715","https://openalex.org/W2030860399","https://openalex.org/W2031052253","https://openalex.org/W2033504830","https://openalex.org/W2035643452","https://openalex.org/W2037367250","https://openalex.org/W2044269722","https://openalex.org/W2048082433","https://openalex.org/W2048788946","https://openalex.org/W2049767583","https://openalex.org/W2050624235","https://openalex.org/W2054245229","https://openalex.org/W2058358434","https://openalex.org/W2062527576","https://openalex.org/W2063851696","https://openalex.org/W2078748602","https://openalex.org/W2092564339","https://openalex.org/W2094284349","https://openalex.org/W2097849969","https://openalex.org/W2108059843","https://openalex.org/W2108846064","https://openalex.org/W2112064552","https://openalex.org/W2118719488","https://openalex.org/W2121879561","https://openalex.org/W2125349610","https://openalex.org/W2132670847","https://openalex.org/W2136382082","https://openalex.org/W2137016822","https://openalex.org/W2140884992","https://openalex.org/W2146882075","https://openalex.org/W2148006813","https://openalex.org/W2167279371"],"related_works":["https://openalex.org/W2029435715","https://openalex.org/W2277731513","https://openalex.org/W2049767583","https://openalex.org/W2078748602","https://openalex.org/W7098855591","https://openalex.org/W2108846064","https://openalex.org/W1968507777","https://openalex.org/W2067701545","https://openalex.org/W2015561849","https://openalex.org/W3133386332"],"abstract_inverted_index":{"Shp2":[0,19,65,80,100,124,148,181,196],"is":[1,20,66,81,90,125,149],"a":[2,21,67,116,126,184],"nonreceptor":[3],"protein":[4,146],"tyrosine":[5],"phosphatase":[6,147],"that":[7,64,79,99,123,144,180,195],"has":[8,53,204],"been":[9,55],"shown":[10],"to":[11,50,187],"influence":[12],"neurogenesis,":[13],"oligodendrogenesis,":[14],"and":[15,30,86,156,178,202],"oligodendrocyte":[16,84,154,198],"differentiation.":[17],"Furthermore,":[18,192],"known":[22],"regulator":[23,69],"of":[24,28,70,105,153],"the":[25,59,102,139,145,173,188],"Akt/mammalian":[26],"target":[27,129],"rapamycin":[29],"ERK":[31],"signaling":[32,174],"pathways":[33],"in":[34,48,83,130,208],"multiple":[35,135,212],"cellular":[36],"contexts,":[37],"including":[38],"oligodendrocytes.":[39],"Its":[40],"role":[41],"during":[42,159,165],"later":[43],"postnatal":[44],"CNS":[45,71],"development":[46],"or":[47],"response":[49],"demyelination":[51,201],"injury":[52],"not":[54,91],"examined.":[56],"Based":[57],"on":[58],"current":[60],"studies,":[61],"we":[62,77,142,193],"hypothesize":[63],"negative":[68],"myelination.":[72],"Using":[73],"transgenic":[74],"mouse":[75],"technology,":[76],"show":[78,98,143,194],"involved":[82],"differentiation":[85,104,155,199],"early":[87],"myelination,":[88,157],"but":[89],"necessary":[92],"for":[93],"myelin":[94,166],"maintenance.":[95],"We":[96,168],"also":[97],"regulates":[101,197],"timely":[103],"oligodendrocytes":[106],"following":[107,200],"lysolecithin-induced":[108],"demyelination,":[109],"although":[110],"apparently":[111],"normal":[112],"remyelination":[113],"occurs":[114],"at":[115],"delayed":[117],"time":[118],"point.":[119],"These":[120],"data":[121],"suggest":[122],"relevant":[127],"therapeutic":[128,206],"demyelinating":[131],"diseases":[132,209],"such":[133,210],"as":[134,162,164,183,211],"sclerosis.":[136,213],"SIGNIFICANCE":[137],"STATEMENTIn":[138],"present":[140],"study,":[141],"an":[150],"important":[151,170,205],"mediator":[152],"both":[158],"developmental":[160,189],"myelination":[161,177,190],"well":[163],"regeneration.":[167],"provide":[169],"insight":[171],"into":[172],"mechanisms":[175],"regulating":[176],"propose":[179],"acts":[182],"transient":[185],"brake":[186],"process.":[191],"therefore":[203],"implications":[207]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-12-22T00:00:00"}
