{"id":"https://openalex.org/W27752073","doi":"https://doi.org/10.1161/circ.120.suppl_18.s1146-d","title":"Abstract 5778: Protein Phosphatase 1 Signalling Pathway is Involved in the Control of Vascular Smooth Muscle Cells Proliferation","display_name":"Abstract 5778: Protein Phosphatase 1 Signalling Pathway is Involved in the Control of Vascular Smooth Muscle Cells Proliferation","publication_year":2009,"publication_date":"2009-11-03","ids":{"openalex":"https://openalex.org/W27752073","doi":"https://doi.org/10.1161/circ.120.suppl_18.s1146-d","mag":"27752073"},"language":"en","primary_location":{"id":"doi:10.1161/circ.120.suppl_18.s1146-d","doi":"https://doi.org/10.1161/circ.120.suppl_18.s1146-d","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.120.suppl_18.s1146-d","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Lahouraria Hadri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lahouraria Hadri","raw_affiliation_strings":["Mount Sinai Sch of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Sinai Sch of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075839695","display_name":"Ioannis Karakikes","orcid":"https://orcid.org/0000-0002-4348-600X","observed_orcids":["https://orcid.org/0000-0002-4348-600X"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ioannis Karakikes","raw_affiliation_strings":["Mount Sinai Sch of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Sinai Sch of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016611955","display_name":"Elise Merlet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]},{"id":"https://openalex.org/I4405278206","display_name":"G\u00e9n\u00e9tique, pharmacologie et physiopathologie des maladies cardiovasculaires","ror":"https://ror.org/05aey2r42","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210154657","https://openalex.org/I4405264447","https://openalex.org/I4405278206"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elise Merlet","raw_affiliation_strings":["UPMC-Paris 6, INSERM UMR S 956., Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UPMC-Paris 6, INSERM UMR S 956., Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4405264447","https://openalex.org/I4405278206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031426939","display_name":"Anne\u2010Marie Lompr\u00e9","orcid":"https://orcid.org/0000-0002-0004-7197","observed_orcids":["https://orcid.org/0000-0002-0004-7197"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]},{"id":"https://openalex.org/I4405278206","display_name":"G\u00e9n\u00e9tique, pharmacologie et physiopathologie des maladies cardiovasculaires","ror":"https://ror.org/05aey2r42","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210154657","https://openalex.org/I4405264447","https://openalex.org/I4405278206"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anne-Marie Lompre\u0301","raw_affiliation_strings":["UPMC-Paris 6, INSERM UMR S 956, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UPMC-Paris 6, INSERM UMR S 956, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4405264447","https://openalex.org/I4405278206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080329479","display_name":"Evangelia Galani Kranias","orcid":"https://orcid.org/0000-0002-4621-6179","observed_orcids":["https://orcid.org/0000-0002-4621-6179"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evangelia Kranias","raw_affiliation_strings":["Pharmacology &amp; Cell Biophysics, university of Cincinnati College of Medicine, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology &amp; Cell Biophysics, university of Cincinnati College of Medicine, OH","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032209826","display_name":"Roger J. Hajjar","orcid":"https://orcid.org/0000-0003-2522-1507","observed_orcids":["https://orcid.org/0000-0003-2522-1507"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger J Hajjar","raw_affiliation_strings":["Mount Sinai Sch of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Sinai Sch of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080344499","display_name":"Larissa Lipskaia","orcid":"https://orcid.org/0000-0002-7998-8378","observed_orcids":["https://orcid.org/0000-0002-7998-8378"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larissa Lipskaia","raw_affiliation_strings":["Mount Sinai Sch of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Sinai Sch of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"120","issue":"suppl_18","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.40549999475479126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.40549999475479126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.39890000224113464,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.17810000479221344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-phosphatase-1","display_name":"protein phosphatase 1","score":0.996999979019165},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cell-proliferation","display_name":"vascular smooth muscle cell proliferation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":0.6169999837875366},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.6769999861717224},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.7829999923706055},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.7590000033378601},{"id":"https://openalex.org/keywords/retinoblastoma-protein","display_name":"retinoblastoma protein","score":0.675000011920929},{"id":"https://openalex.org/keywords/restenosis","display_name":"restenosis","score":0.7179999947547913},{"id":"https://openalex.org/keywords/neointimal-proliferation","display_name":"neointimal proliferation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/carotid-artery-injury","display_name":"carotid artery injury","score":0.8130000233650208},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/adenoviral-gene-transfer","display_name":"adenoviral gene transfer","score":0.9110000133514404},{"id":"https://openalex.org/keywords/vascular-remodeling","display_name":"vascular remodeling","score":0.7889999747276306}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.803749680519104},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.648677408695221},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5408466458320618},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.4728439450263977},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.47100913524627686},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.4663580656051636},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.45349985361099243},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28243404626846313},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.21401095390319824},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09756532311439514}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.120.suppl_18.s1146-d","doi":"https://doi.org/10.1161/circ.120.suppl_18.s1146-d","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.120.suppl_18.s1146-d","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3175034853","https://openalex.org/W2095395921","https://openalex.org/W2603379001","https://openalex.org/W2155058150","https://openalex.org/W2971685193","https://openalex.org/W2977950458","https://openalex.org/W1995928382","https://openalex.org/W2138792619","https://openalex.org/W2372562064","https://openalex.org/W4402053229"],"abstract_inverted_index":{"Protein":[0],"phosphatase":[1,29,42],"1":[2],"(PP1),":[3],"the":[4,8,16,73,79,100,206,214,258,264,271,279],"main":[5],"regulator":[6],"of":[7,18,81,103,123,136,147,171,184,187,195,209,216,252,273],"transcription":[9,280],"factor":[10,281],"CREB,":[11,185],"is":[12,26,33,48,76,268],"strongly":[13],"involved":[14,77,269],"in":[15,50,65,78,99,113,131,158,164,213,229,257,270],"control":[17,80,272],"cell":[19,196],"proliferation":[20,83,155,256,275],"via":[21,278],"p53":[22,189],"and":[23,38,44,89,107,110,116,156,179,190,202,276],"p21.":[24],"PP1":[25,127,141,181],"regulated":[27,112],"by":[28,35,40,139,143],"inhibitor-1":[30],"(I-1),":[31],"which":[32,241],"activated":[34],"PKA":[36],"phosphorylation":[37,183],"inhibited":[39,153],"protein":[41,96],"PP2A":[43],"PP2B":[45],"(calcineurin).":[46],"I-1":[47,95,151,226],"expressed":[49,98,228],"vascular":[51,244],"smooth":[52],"muscle":[53],"cells":[54],"(VSMC),":[55],"but":[56,233],"does":[57],"not":[58],"appear":[59],"to":[60,192],"play":[61],"a":[62,148,220],"significant":[63],"role":[64],"contractile":[66],"or":[67,142],"relaxant":[68],"response":[69],"We":[70],"tested":[71],"whether":[72],"I-1/PP1":[74,137,265],"pathway":[75,267],"VSMC":[82,119,154,274],"Confocal":[84],"immunofluorescence,":[85],"Western":[86,173],"blot":[87,174],"analysis":[88,175],"real":[90],"time":[91],"PCR":[92],"demonstrated":[93,176],"that":[94,163,177],"was":[97,129,227,235],"media":[101],"layer":[102],"healthy":[104],"human":[105,118,133],"coronary":[106],"mammary":[108],"arteries":[109],"down":[111,193],"atherosclerotic":[114],"vessels":[115],"proliferating":[117,132],"(1000":[120],"fold":[121],"lower":[122],"mRNA).":[124],"By":[125],"contrast,":[126],"expression":[128,186],"increased":[130,169,182],"VSMC.":[134],"Inhibition":[135],"signalling":[138,266],"siRNA":[140,180],"adenoviral":[144],"gene":[145,167,211,250],"transfer":[146,168,212,251],"constitutively":[149],"active":[150],"(I-1c)":[152],"migration":[157,277],"vitro.":[159],"Promoter-reporter":[160],"assay":[161],"showed":[162],"vitro":[165],"I-1c":[166,178,210,253],"activity":[170],"CREB.":[172,282],"p21,":[188],"led":[191],"regulation":[194],"cycle":[197],"controlling":[198],"proteins":[199],"cyclin":[200],"D1":[201],"pRB.":[203],"To":[204],"assess":[205],"potential":[207],"effect":[208],"treatment":[215],"restenosis,":[217],"we":[218],"used":[219],"rat":[221],"carotid":[222,231,259],"artery":[223,232],"injury":[224,260],"model.":[225,261],"normal":[230],"it":[234],"non-detectable":[236],"two":[237],"weeks":[238],"after":[239],"injury,":[240],"correlated":[242],"with":[243],"remodelling":[245],"during":[246],"neointimal":[247,255],"proliferation.":[248],"Adenoviral":[249],"prevented":[254],"In":[262],"conclusion,":[263]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}
