{"id":"https://openalex.org/W2774889065","doi":"https://doi.org/10.1183/1393003.congress-2017.oa1758","title":"Autoantibody against NBL1 in obstructive sleep apnea patients with cardiovascular disease","display_name":"Autoantibody against NBL1 in obstructive sleep apnea patients with cardiovascular disease","publication_year":2017,"publication_date":"2017-09-01","ids":{"openalex":"https://openalex.org/W2774889065","doi":"https://doi.org/10.1183/1393003.congress-2017.oa1758","mag":"2774889065"},"language":"en","primary_location":{"id":"doi:10.1183/1393003.congress-2017.oa1758","doi":"https://doi.org/10.1183/1393003.congress-2017.oa1758","is_oa":false,"landing_page_url":"https://doi.org/10.1183/1393003.congress-2017.oa1758","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep and Control of Breathing","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063904041","display_name":"Takuma Matsumura","orcid":"https://orcid.org/0000-0003-2972-9455","observed_orcids":["https://orcid.org/0000-0003-2972-9455"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuma Matsumura","raw_affiliation_strings":["Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022345052","display_name":"Jiro Terada","orcid":"https://orcid.org/0000-0001-9019-4053","observed_orcids":["https://orcid.org/0000-0001-9019-4053"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jiro Terada","raw_affiliation_strings":["Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005298497","display_name":"Taku Kinoshita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taku Kinoshita","raw_affiliation_strings":["Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100910488","display_name":"Yoriko Sakurai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoriko Sakurai","raw_affiliation_strings":["Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020235616","display_name":"Misuzu Yahaba","orcid":"https://orcid.org/0000-0003-2004-6930","observed_orcids":["https://orcid.org/0000-0003-2004-6930"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Misuzu Yahaba","raw_affiliation_strings":["Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026303520","display_name":"Kenji Tsushima","orcid":"https://orcid.org/0000-0002-4766-8089","observed_orcids":["https://orcid.org/0000-0002-4766-8089"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Tsushima","raw_affiliation_strings":["Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001206807","display_name":"Seiichiro Sakao","orcid":"https://orcid.org/0000-0001-6719-1022","observed_orcids":["https://orcid.org/0000-0001-6719-1022"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seiichiro Sakao","raw_affiliation_strings":["Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005005279","display_name":"Koichiro Tatsumi","orcid":"https://orcid.org/0000-0001-9484-7912","observed_orcids":["https://orcid.org/0000-0001-9484-7912"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichiro Tatsumi","raw_affiliation_strings":["Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068381565","display_name":"Reiko Kunii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Reiko Kunii","raw_affiliation_strings":["Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I159385669"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"OA1758","last_page":"OA1758"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13505","display_name":"Apelin-related biomedical research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obstructive-sleep-apnea","display_name":"obstructive sleep apnea","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.7570000290870667},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.9300000071525574},{"id":"https://openalex.org/keywords/nbl1","display_name":"NBL1","score":0.9539999961853027},{"id":"https://openalex.org/keywords/acute-coronary-syndrome","display_name":"acute coronary syndrome","score":0.9890000224113464},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cardiovascular-risk-prediction","display_name":"cardiovascular risk prediction","score":0.777999997138977},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9629909992218018},{"id":"https://openalex.org/C2776006263","wikidata":"https://www.wikidata.org/wiki/Q16606552","display_name":"Obstructive sleep apnea","level":2,"score":0.789736270904541},{"id":"https://openalex.org/C2778205975","wikidata":"https://www.wikidata.org/wiki/Q1754874","display_name":"Polysomnography","level":3,"score":0.7761634588241577},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7570054531097412},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5472594499588013},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4865554869174957},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.4834612309932709},{"id":"https://openalex.org/C2777935920","wikidata":"https://www.wikidata.org/wiki/Q213600","display_name":"Sleep apnea","level":2,"score":0.4658642113208771},{"id":"https://openalex.org/C2777698277","wikidata":"https://www.wikidata.org/wiki/Q266018","display_name":"Acute coronary syndrome","level":3,"score":0.46438512206077576},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.34796175360679626},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3280579447746277},{"id":"https://openalex.org/C2781326671","wikidata":"https://www.wikidata.org/wiki/Q754424","display_name":"Apnea","level":2,"score":0.3114456534385681},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17800253629684448},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.06975939869880676},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/1393003.congress-2017.oa1758","doi":"https://doi.org/10.1183/1393003.congress-2017.oa1758","is_oa":false,"landing_page_url":"https://doi.org/10.1183/1393003.congress-2017.oa1758","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep and Control of Breathing","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2794595652","https://openalex.org/W2126775711","https://openalex.org/W2980701125","https://openalex.org/W2405340466","https://openalex.org/W7143901418","https://openalex.org/W1870305703","https://openalex.org/W3002453616","https://openalex.org/W1892680935","https://openalex.org/W2410270383","https://openalex.org/W4377195278"],"abstract_inverted_index":{"Moderate-to-severe":[0],"obstructive":[1],"sleep":[2],"apnea":[3],"(OSA)":[4],"is":[5,17],"known":[6],"to":[7,110],"increase":[8],"the":[9,22,31,85],"risk":[10,170],"of":[11,21,24,33,38,44,62,87,160,171],"cardiovascular":[12,45,172],"disease":[13],"(CVD),":[14],"but":[15],"there":[16],"no":[18],"accepted":[19],"marker":[20],"development":[23],"CVD":[25,161],"in":[26,47,116,121,137,162,174],"OSA":[27,48,54,80,124,138,143,163],"patients.":[28,49,91,164],"We":[29],"evaluated":[30],"association":[32,105],"autoantibodies":[34],"against":[35],"neuroblastoma":[36],"suppressor":[37],"tumorigenicity":[39],"1":[40],"(NBL1-Abs)":[41],"and":[42,67,103,125,131,144,147,187],"occurrence":[43],"events":[46,173],"Eighty-two":[50],"adults":[51],"diagnosed":[52],"with":[53,59,106,123,128,141,176,179],"by":[55,97],"polysomnography,":[56],"96":[57],"patients":[58,122,139,175],"a":[60,157],"diagnosis":[61],"acute":[63],"coronary":[64],"syndrome":[65],"(ACS)":[66],"64":[68],"healthy":[69,129],"volunteers":[70],"were":[71,74,119,134],"evaluated.":[72,113],"Serum":[73,92],"collected":[75,83],"on":[76],"polysomnography":[77],"evaluation":[78],"from":[79,89],"patients,":[81],"while":[82],"at":[84],"onset":[86],"ACS":[88,90,126],"NBL1-Ab":[93,117,132,154,181],"level":[94,118,155],"was":[95,112],"measured":[96],"amplified":[98],"luminescence":[99],"proximity":[100],"homogeneous":[101],"assay":[102],"its":[104],"clinical":[107],"variables":[108],"related":[109],"atherosclerosis":[111],"Significant":[114],"differences":[115],"observed":[120],"compared":[127],"volunteers,":[130],"levels":[133,182],"significantly":[135],"increased":[136,169],"especially":[140],"severe":[142],"CVD.":[145],"Univariate":[146],"multivariate":[148],"logistic":[149],"regression":[150],"analyses":[151],"identified":[152],"elevated":[153],"as":[156],"significant":[158],"predictor":[159],"Elevated":[165],"NBL1-Abs":[166],"may":[167,183],"predict":[168],"OSA.":[177],"Patients":[178],"higher":[180],"require":[184],"more":[185],"careful":[186],"intensive":[188],"treatment.":[189]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-12-22T00:00:00"}