{"id":"https://openalex.org/W2774876944","doi":"https://doi.org/10.1016/j.jconrel.2017.12.005","title":"Application of 3D cultured multicellular spheroid tumor models in tumor-targeted drug delivery system research","display_name":"Application of 3D cultured multicellular spheroid tumor models in tumor-targeted drug delivery system research","publication_year":2017,"publication_date":"2017-12-09","ids":{"openalex":"https://openalex.org/W2774876944","doi":"https://doi.org/10.1016/j.jconrel.2017.12.005","mag":"2774876944","pmid":"https://pubmed.ncbi.nlm.nih.gov/29233763"},"language":"en","primary_location":{"id":"doi:10.1016/j.jconrel.2017.12.005","doi":"https://doi.org/10.1016/j.jconrel.2017.12.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jconrel.2017.12.005","pdf_url":null,"source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023289922","display_name":"Buwei Huang","orcid":"https://orcid.org/0000-0002-0762-7178","observed_orcids":["https://orcid.org/0000-0002-0762-7178"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Bu-Wei Huang","raw_affiliation_strings":["Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China; Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, MD 21231, USA; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, MD 21205, USA","Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, MD 21231, USA","Department of Biomedical Engineering, Johns Hopkins University School of Medicine, MD 21205, USA","Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China; Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, MD 21231, USA; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, MD 21205, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, MD 21231, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University School of Medicine, MD 21205, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100730084","display_name":"Jianqing Gao","orcid":"https://orcid.org/0000-0003-1052-7060","observed_orcids":["https://orcid.org/0000-0003-1052-7060","https://orcid.org/0000-0002-6773-3546"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian-Qing Gao","raw_affiliation_strings":["Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China. Electronic address: gaojianqing@zju.edu.cn","Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China"],"raw_orcid":"https://orcid.org/0000-0003-1052-7060","affiliations":[{"raw_affiliation_string":"Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China. Electronic address: gaojianqing@zju.edu.cn","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China","institution_ids":["https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100730084"],"corresponding_institution_ids":["https://openalex.org/I76130692"],"apc_list":{"value":4440,"currency":"USD","value_usd":4440},"apc_paid":null,"fwci":1.1391,"has_fulltext":false,"cited_by_count":180,"citation_normalized_percentile":{"value":0.75183374,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"270","issue":null,"first_page":"246","last_page":"259"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-spheroids","display_name":"tumor spheroids","score":0.9980000257492065},{"id":"https://openalex.org/keywords/three-dimensional-tumor-models","display_name":"3D tumor models","score":0.7900000214576721},{"id":"https://openalex.org/keywords/anticancer-drug-delivery","display_name":"anticancer drug delivery","score":0.9959999918937683},{"id":"https://openalex.org/keywords/nanomedicine","display_name":"nanomedicine","score":0.9179999828338623},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9110000133514404},{"id":"https://openalex.org/keywords/drug-delivery-barriers","display_name":"drug delivery barriers","score":0.6439999938011169},{"id":"https://openalex.org/keywords/nanocarriers","display_name":"nanocarriers","score":0.7649999856948853},{"id":"https://openalex.org/keywords/drug-penetration","display_name":"drug penetration","score":0.5989999771118164},{"id":"https://openalex.org/keywords/receptor-targeting","display_name":"receptor targeting","score":0.7799999713897705},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.7609999775886536},{"id":"https://openalex.org/keywords/preclinical-models","display_name":"preclinical models","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C175369904","wikidata":"https://www.wikidata.org/wiki/Q208395","display_name":"Spheroid","level":3,"score":0.6981861591339111},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6802232265472412},{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.6701794266700745},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.60566645860672},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5875872373580933},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.504970133304596},{"id":"https://openalex.org/C163688615","wikidata":"https://www.wikidata.org/wiki/Q15883629","display_name":"3D cell culture","level":3,"score":0.47920307517051697},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.47469562292099},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4440980851650238},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4439111649990082},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.42553412914276123},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.39241164922714233},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3779946267604828},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34750598669052124},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.2938653826713562},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.263286292552948},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2124449610710144},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19575169682502747},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.13458049297332764},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.12438696622848511},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018874","descriptor_name":"Spheroids, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jconrel.2017.12.005","doi":"https://doi.org/10.1016/j.jconrel.2017.12.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jconrel.2017.12.005","pdf_url":null,"source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},{"id":"pmid:29233763","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29233763","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of controlled release : official journal of the Controlled Release Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3875012174","display_name":null,"funder_award_id":"81620108028","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":157,"referenced_works":["https://openalex.org/W111438725","https://openalex.org/W218869826","https://openalex.org/W339936374","https://openalex.org/W598202522","https://openalex.org/W943412137","https://openalex.org/W1493975488","https://openalex.org/W1578597258","https://openalex.org/W1678674047","https://openalex.org/W1773149959","https://openalex.org/W1842468602","https://openalex.org/W1900663376","https://openalex.org/W1964014096","https://openalex.org/W1965426853","https://openalex.org/W1965568849","https://openalex.org/W1966961208","https://openalex.org/W1967217835","https://openalex.org/W1968695777","https://openalex.org/W1968754817","https://openalex.org/W1969388062","https://openalex.org/W1970590657","https://openalex.org/W1971914762","https://openalex.org/W1975088956","https://openalex.org/W1975429911","https://openalex.org/W1979524509","https://openalex.org/W1979700784","https://openalex.org/W1979721854","https://openalex.org/W1981059065","https://openalex.org/W1983519686","https://openalex.org/W1986232860","https://openalex.org/W1986299453","https://openalex.org/W1991517939","https://openalex.org/W1996560526","https://openalex.org/W1997203755","https://openalex.org/W2000000541","https://openalex.org/W2000744297","https://openalex.org/W2004049846","https://openalex.org/W2004096983","https://openalex.org/W2004554066","https://openalex.org/W2005451446","https://openalex.org/W2005840555","https://openalex.org/W2010069724","https://openalex.org/W2010509371","https://openalex.org/W2014630203","https://openalex.org/W2015139117","https://openalex.org/W2015963176","https://openalex.org/W2017525816","https://openalex.org/W2019246838","https://openalex.org/W2021836199","https://openalex.org/W2023515883","https://openalex.org/W2024002740","https://openalex.org/W2024050967","https://openalex.org/W2028156849","https://openalex.org/W2035342960","https://openalex.org/W2035573463","https://openalex.org/W2036200411","https://openalex.org/W2036305948","https://openalex.org/W2041585886","https://openalex.org/W2042201808","https://openalex.org/W2044191242","https://openalex.org/W2044332216","https://openalex.org/W2044350044","https://openalex.org/W2044966365","https://openalex.org/W2045387133","https://openalex.org/W2049772098","https://openalex.org/W2050165619","https://openalex.org/W2050910055","https://openalex.org/W2052795767","https://openalex.org/W2053781426","https://openalex.org/W2055558856","https://openalex.org/W2057771278","https://openalex.org/W2057853951","https://openalex.org/W2061896947","https://openalex.org/W2062333622","https://openalex.org/W2063396729","https://openalex.org/W2064212361","https://openalex.org/W2067913320","https://openalex.org/W2070518196","https://openalex.org/W2076214664","https://openalex.org/W2079142824","https://openalex.org/W2082289995","https://openalex.org/W2088594432","https://openalex.org/W2094082198","https://openalex.org/W2094854635","https://openalex.org/W2095412415","https://openalex.org/W2095533624","https://openalex.org/W2096391616","https://openalex.org/W2098301610","https://openalex.org/W2099638616","https://openalex.org/W2101022542","https://openalex.org/W2105017561","https://openalex.org/W2110419119","https://openalex.org/W2113939544","https://openalex.org/W2114229735","https://openalex.org/W2117522754","https://openalex.org/W2119698183","https://openalex.org/W2121982033","https://openalex.org/W2122751535","https://openalex.org/W2124935569","https://openalex.org/W2126036312","https://openalex.org/W2131430454","https://openalex.org/W2131464730","https://openalex.org/W2133379217","https://openalex.org/W2133440826","https://openalex.org/W2134257943","https://openalex.org/W2136445803","https://openalex.org/W2138151577","https://openalex.org/W2142454469","https://openalex.org/W2145181376","https://openalex.org/W2146989732","https://openalex.org/W2147813074","https://openalex.org/W2148512402","https://openalex.org/W2152205322","https://openalex.org/W2157355425","https://openalex.org/W2159058529","https://openalex.org/W2165200432","https://openalex.org/W2166672922","https://openalex.org/W2221584143","https://openalex.org/W2233779473","https://openalex.org/W2236643502","https://openalex.org/W2236945153","https://openalex.org/W2238565156","https://openalex.org/W2238958727","https://openalex.org/W2254867710","https://openalex.org/W2261438566","https://openalex.org/W2266212415","https://openalex.org/W2275816640","https://openalex.org/W2291307592","https://openalex.org/W2312309812","https://openalex.org/W2313811022","https://openalex.org/W2320748066","https://openalex.org/W2405899780","https://openalex.org/W2409627395","https://openalex.org/W2415847618","https://openalex.org/W2461461899","https://openalex.org/W2464138887","https://openalex.org/W2471940455","https://openalex.org/W2504790555","https://openalex.org/W2509934805","https://openalex.org/W2514762476","https://openalex.org/W2515795587","https://openalex.org/W2516298989","https://openalex.org/W2519985055","https://openalex.org/W2530193963","https://openalex.org/W2543955367","https://openalex.org/W2549628327","https://openalex.org/W2565213069","https://openalex.org/W2580794097","https://openalex.org/W2588307382","https://openalex.org/W2594465601","https://openalex.org/W2601774725","https://openalex.org/W2604906306","https://openalex.org/W2747317315","https://openalex.org/W2752291796","https://openalex.org/W2753794398","https://openalex.org/W2766735449","https://openalex.org/W6651346370","https://openalex.org/W6714470134"],"related_works":["https://openalex.org/W2765291098","https://openalex.org/W2341087208","https://openalex.org/W7167698038","https://openalex.org/W4406725261","https://openalex.org/W2043739827","https://openalex.org/W3134164720","https://openalex.org/W4410519085","https://openalex.org/W2133440826","https://openalex.org/W4403828765","https://openalex.org/W1992509947"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":26},{"year":2023,"cited_by_count":22},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":27},{"year":2020,"cited_by_count":37},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":12}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-12-22T00:00:00"}