{"id":"https://openalex.org/W2774485847","doi":"https://doi.org/10.1161/jaha.117.007622","title":"Sodium Channel Remodeling in Subcellular Microdomains of Murine Failing Cardiomyocytes","display_name":"Sodium Channel Remodeling in Subcellular Microdomains of Murine Failing Cardiomyocytes","publication_year":2017,"publication_date":"2017-12-02","ids":{"openalex":"https://openalex.org/W2774485847","doi":"https://doi.org/10.1161/jaha.117.007622","mag":"2774485847","pmid":"https://pubmed.ncbi.nlm.nih.gov/29222390","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5779058"},"language":"en","primary_location":{"id":"doi:10.1161/jaha.117.007622","doi":"https://doi.org/10.1161/jaha.117.007622","is_oa":true,"landing_page_url":"https://doi.org/10.1161/jaha.117.007622","pdf_url":null,"source":{"id":"https://openalex.org/S2489920150","display_name":"Journal of the American Heart Association","issn_l":"2047-9980","issn":["2047-9980"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Heart Association","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1161/jaha.117.007622","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037475012","display_name":"Mathilde R. Rivaud","orcid":"https://orcid.org/0000-0002-0680-3483","observed_orcids":["https://orcid.org/0000-0002-0680-3483"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Mathilde R. Rivaud","raw_affiliation_strings":["Department of Medical Physiology, University Medical Center Utrecht, Utrecht, the Netherlands","Division of Cardiology, New York University Medical Center, New York, NY","Heart Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, the Netherlands","Mathilde R. Rivaud Heart Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, the Netherlands Division of Cardiology, New York University Medical Center, New York, NY Department of Medical Physiology, University Medical Center Utrecht, Utrecht, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physiology, University Medical Center Utrecht, Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Division of Cardiology, New York University Medical Center, New York, NY","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]},{"raw_affiliation_string":"Heart Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]},{"raw_affiliation_string":"Mathilde R. Rivaud Heart Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, the Netherlands Division of Cardiology, New York University Medical Center, New York, NY Department of Medical Physiology, University Medical Center Utrecht, Utrecht, the Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I3018483916","https://openalex.org/I4210086933","https://openalex.org/I57206974","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054022818","display_name":"Esperanza Agull\u00f3-Pascual","orcid":"https://orcid.org/0000-0003-1033-7830","observed_orcids":["https://orcid.org/0000-0003-1033-7830"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Esperanza Agullo\u2010Pascual","raw_affiliation_strings":["Division of Cardiology, New York University Medical Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, New York University Medical Center, New York, NY","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066635265","display_name":"Xianming Lin","orcid":"https://orcid.org/0000-0002-3638-8137","observed_orcids":["https://orcid.org/0000-0002-3638-8137"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xianming Lin","raw_affiliation_strings":["Division of Cardiology, New York University Medical Center, New York, NY","Xianming Lin Division of Cardiology, New York University Medical Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, New York University Medical Center, New York, NY","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]},{"raw_affiliation_string":"Xianming Lin Division of Cardiology, New York University Medical Center, New York, NY","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008486598","display_name":"Alejandra Leo\u2010Mac\u00edas","orcid":"https://orcid.org/0000-0002-7579-9764","observed_orcids":["https://orcid.org/0000-0002-7579-9764"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alejandra Leo\u2010Macias","raw_affiliation_strings":["Division of Cardiology, New York University Medical Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, New York University Medical Center, New York, NY","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100349281","display_name":"Mingliang Zhang","orcid":"https://orcid.org/0000-0003-2285-3592","observed_orcids":["https://orcid.org/0000-0003-2285-3592","https://orcid.org/0000-0001-8610-9055","https://orcid.org/0009-0007-7600-3821"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mingliang Zhang","raw_affiliation_strings":["Division of Cardiology, New York University Medical Center, New York, NY","Mingliang Zhang Division of Cardiology, New York University Medical Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, New York University Medical Center, New York, NY","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]},{"raw_affiliation_string":"Mingliang Zhang Division of Cardiology, New York University Medical Center, New York, NY","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081602466","display_name":"Eli Rothenberg","orcid":"https://orcid.org/0000-0002-1382-1380","observed_orcids":["https://orcid.org/0000-0002-1382-1380"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eli Rothenberg","raw_affiliation_strings":["Department of Biochemistry and Molecular Pharmacology, NYU\u2010School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Pharmacology, NYU\u2010School of Medicine, New York, NY","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016023161","display_name":"Connie R. Bezzina","orcid":"https://orcid.org/0000-0002-0633-3514","observed_orcids":["https://orcid.org/0000-0002-0633-3514"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Connie R. Bezzina","raw_affiliation_strings":["Heart Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, the Netherlands","Connie R. Bezzina Heart Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]},{"raw_affiliation_string":"Connie R. Bezzina Heart Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051953374","display_name":"Mario Delmar","orcid":"https://orcid.org/0000-0002-2085-5589","observed_orcids":["https://orcid.org/0000-0002-2085-5589"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mario Delmar","raw_affiliation_strings":["Division of Cardiology, New York University Medical Center, New York, NY","Mario Delmar Division of Cardiology, New York University Medical Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, New York University Medical Center, New York, NY","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]},{"raw_affiliation_string":"Mario Delmar Division of Cardiology, New York University Medical Center, New York, NY","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033167666","display_name":"Carol Ann Remme","orcid":"https://orcid.org/0000-0003-0095-0084","observed_orcids":["https://orcid.org/0000-0003-0095-0084"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Carol Ann Remme","raw_affiliation_strings":["Heart Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, the Netherlands","Carol Ann Remme Heart Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]},{"raw_affiliation_string":"Carol Ann Remme Heart Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5033167666","https://openalex.org/A5051953374"],"corresponding_institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I4210086933","https://openalex.org/I57206974","https://openalex.org/I887064364"],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":{"value":3810,"currency":"USD","value_usd":3810},"fwci":2.8465,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.92097146,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"6","issue":"12","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nav1-5","display_name":"cardiac sodium channel","score":0.9879999756813049},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9160000085830688},{"id":"https://openalex.org/keywords/intercalated-discs","display_name":"intercalated discs","score":0.8140000104904175},{"id":"https://openalex.org/keywords/lateral-membrane","display_name":"lateral membrane","score":0.9300000071525574},{"id":"https://openalex.org/keywords/t-tubules","display_name":"T-tubules","score":0.8429999947547913},{"id":"https://openalex.org/keywords/microtubule-cytoskeleton","display_name":"microtubule cytoskeleton","score":0.9210000038146973},{"id":"https://openalex.org/keywords/sodium-current","display_name":"sodium current","score":0.5989999771118164},{"id":"https://openalex.org/keywords/ion-channel-clustering","display_name":"ion channel clustering","score":0.6389999985694885},{"id":"https://openalex.org/keywords/transverse-aortic-constriction","display_name":"transverse aortic constriction","score":0.9160000085830688},{"id":"https://openalex.org/keywords/arrhythmogenesis","display_name":"arrhythmogenesis","score":0.8889999985694885}],"concepts":[{"id":"https://openalex.org/C50952357","wikidata":"https://www.wikidata.org/wiki/Q424960","display_name":"Sodium channel","level":3,"score":0.5789878368377686},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.5347124338150024},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5044749975204468},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.48399806022644043},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46691134572029114},{"id":"https://openalex.org/C2781175142","wikidata":"https://www.wikidata.org/wiki/Q6045608","display_name":"Intercalated disc","level":4,"score":0.45780205726623535},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43288755416870117},{"id":"https://openalex.org/C2776250582","wikidata":"https://www.wikidata.org/wiki/Q14905729","display_name":"Nav1.5","level":4,"score":0.416882187128067},{"id":"https://openalex.org/C158157758","wikidata":"https://www.wikidata.org/wiki/Q232438","display_name":"Gap junction","level":3,"score":0.354217529296875},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.30766284465789795},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.22963321208953857},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19141104817390442},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.17598861455917358},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062554","descriptor_name":"NAV1.5 Voltage-Gated Sodium Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1161/jaha.117.007622","doi":"https://doi.org/10.1161/jaha.117.007622","is_oa":true,"landing_page_url":"https://doi.org/10.1161/jaha.117.007622","pdf_url":null,"source":{"id":"https://openalex.org/S2489920150","display_name":"Journal of the American Heart Association","issn_l":"2047-9980","issn":["2047-9980"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Heart Association","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5779058","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5779058","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Am Heart Assoc","raw_type":"Text"},{"id":"pmid:29222390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29222390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Heart Association","raw_type":"Journal Article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/ad54ff9d-8e60-4606-a012-b10f140912aa","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/ad54ff9d-8e60-4606-a012-b10f140912aa","pdf_url":"https://pure.amsterdamumc.nl/ws/files/159153512/Sodium-channel-remodeling-in-subcellular-microdomains-of-murine-failing-cardiomyocytes.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Rivaud, M R, Agullo-Pascual, E, Lin, X, Leo-Macias, A, Zhang, M, Rothenberg, E, Bezzina, C R, Delmar, M & Remme, C A 2017, 'Sodium Channel Remodeling in Subcellular Microdomains of Murine Failing Cardiomyocytes', Journal of the American Heart Association, vol. 6, no. 12, pp. e007622. https://doi.org/10.1161/JAHA.117.007622","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/1587ace9-e441-4837-86e2-a6a6c2652a51","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/sodium-channel-remodeling-in-subcellular-microdomains-of-murine-failing-cardiomyocytes(1587ace9-e441-4837-86e2-a6a6c2652a51).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of the American Heart Association, 6(12). Wiley-Blackwell","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:070210c834d243c486f39f8d237ac11c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/070210c834d243c486f39f8d237ac11c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 12 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1161/jaha.117.007622","doi":"https://doi.org/10.1161/jaha.117.007622","is_oa":true,"landing_page_url":"https://doi.org/10.1161/jaha.117.007622","pdf_url":null,"source":{"id":"https://openalex.org/S2489920150","display_name":"Journal of the American Heart Association","issn_l":"2047-9980","issn":["2047-9980"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Heart Association","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1495734770","display_name":"A gap junction-independent role for Connexin43 in cardiac electrophysiology","funder_award_id":"R01GM057691","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1515809401","display_name":"Role of PKP2 in epicardial structure and function","funder_award_id":"R01HL136179","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2938772455","display_name":null,"funder_award_id":"91714371","funder_id":"https://openalex.org/F4320321007","funder_display_name":"ZonMw"},{"id":"https://openalex.org/G5436553681","display_name":"Role of desmosomes in cardiac electrical function","funder_award_id":"R01HL134328","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320321007","display_name":"ZonMw","ror":"https://ror.org/01yaj9a77"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2774485847.pdf","grobid_xml":"https://content.openalex.org/works/W2774485847.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1449298895","https://openalex.org/W1573751470","https://openalex.org/W1785817244","https://openalex.org/W1864296857","https://openalex.org/W1978151809","https://openalex.org/W1983328246","https://openalex.org/W1986179165","https://openalex.org/W1987902012","https://openalex.org/W1989950796","https://openalex.org/W1991798507","https://openalex.org/W1996344039","https://openalex.org/W2001892782","https://openalex.org/W2003398434","https://openalex.org/W2003964447","https://openalex.org/W2005238372","https://openalex.org/W2006700820","https://openalex.org/W2011549186","https://openalex.org/W2019057727","https://openalex.org/W2021981998","https://openalex.org/W2031699506","https://openalex.org/W2033813555","https://openalex.org/W2041421272","https://openalex.org/W2042358404","https://openalex.org/W2048996984","https://openalex.org/W2052783271","https://openalex.org/W2054336104","https://openalex.org/W2056550364","https://openalex.org/W2066313519","https://openalex.org/W2068995617","https://openalex.org/W2076792105","https://openalex.org/W2084127838","https://openalex.org/W2087302417","https://openalex.org/W2098534133","https://openalex.org/W2104431345","https://openalex.org/W2109422517","https://openalex.org/W2118896450","https://openalex.org/W2119201749","https://openalex.org/W2126318057","https://openalex.org/W2134740652","https://openalex.org/W2135662719","https://openalex.org/W2142349419","https://openalex.org/W2143676329","https://openalex.org/W2149548143","https://openalex.org/W2151903951","https://openalex.org/W2158152768","https://openalex.org/W2163815754","https://openalex.org/W2170853736","https://openalex.org/W2301058553","https://openalex.org/W2316247824","https://openalex.org/W2510800797"],"related_works":["https://openalex.org/W2617936538","https://openalex.org/W2763134073","https://openalex.org/W2157876111","https://openalex.org/W1996109634","https://openalex.org/W2789994618","https://openalex.org/W6980495527","https://openalex.org/W3034808133","https://openalex.org/W4310701755","https://openalex.org/W1864296857","https://openalex.org/W2036995732"],"abstract_inverted_index":{"Background":[0],"Cardiac":[1],"sodium":[2,37,93],"channel":[3,38],"(NaV1.5)":[4],"dysfunction":[5],"contributes":[6],"to":[7,14,53,62,76],"arrhythmogenesis":[8],"during":[9,44],"pathophysiological":[10],"conditions.":[11],"Nav1.5":[12],"localizes":[13],"distinct":[15,41,264],"subcellular":[16,265],"microdomains":[17,43,266],"within":[18,40,263],"the":[19,122,130,143,183,221,240],"cardiomyocyte,":[20],"where":[21],"it":[22],"associates":[23],"with":[24,228],"region\u2010specific":[25],"proteins,":[26],"yielding":[27],"complexes":[28],"whose":[29],"function":[30],"is":[31],"location":[32],"specific.":[33],"We":[34],"herein":[35],"investigated":[36],"remodeling":[39,141,238],"cardiomyocyte":[42],"heart":[45,64,85],"failure.":[46,65],"Methods":[47],"and":[48,87,126,135,153,159,177,207,244,260],"Results":[49],"Mice":[50],"were":[51,69],"subjected":[52],"6":[54],"weeks":[55],"of":[56,89,142,147,185,223,239,267],"transverse":[57],"aortic":[58],"constriction":[59],"(TAC;":[60],"n=32)":[61],"induce":[63],"Sham\u2013operated":[66],"on":[67,107],"mice":[68],"used":[70],"as":[71],"controls":[72],"(n=20).":[73],"TAC":[74,104,115,186,224],"led":[75],"reduced":[77,118,160,213,229],"left":[78],"ventricular":[79],"ejection":[80],"fraction,":[81],"QRS":[82],"prolongation,":[83],"increased":[84,178,205],"mass,":[86],"upregulation":[88],"prohypertrophic":[90],"genes.":[91],"Whole\u2010cell":[92],"current":[94],"(I":[95],"Na":[96,113,176,215,231,256,262],")":[97],"density":[98],"was":[99,117],"decreased":[100,174],"by":[101,119,127,150,204,253],"30%":[102],"in":[103,114,170,190,226,247,255],"versus":[105],"sham\u2013operated":[106],"cardiomyocytes.":[108,248,269],"On":[109],"macropatch":[110],"analysis,":[111],"I":[112,175,230,261],"cardiomyocytes":[116,194],"50%":[120],"at":[121,129,182,220],"lateral":[123],"membrane":[124],"(LM)":[125],"40%":[128],"intercalated":[131,144,241],"disc.":[132],"Electron":[133],"microscopy":[134,139,211],"scanning":[136,164],"ion":[137,165],"conductance":[138,166],"revealed":[140,173],"disc":[145],"(replacement":[146],"[inter\u2010]plicate":[148],"regions":[149],"large":[151],"foldings)":[152],"LM":[154,171,222],"(less":[155],"identifiable":[156],"T":[157],"tubules":[158],"Z\u2010groove":[161],"ratios).":[162],"Using":[163],"microscopy,":[167],"cell\u2010attached":[168],"recordings":[169],"subdomains":[172],"late":[179],"openings":[180],"specifically":[181],"crest":[184],"cardiomyocytes,":[187],"but":[188,198],"not":[189],"groove/T":[191],"tubules.":[192],"Failing":[193],"displayed":[195],"a":[196],"denser,":[197],"more":[199],"stable,":[200],"microtubule":[201,245],"network":[202,246],"(demonstrated":[203],"\u03b1\u2010tubulin":[206],"Glu\u2010tubulin":[208],"expression).":[209],"Superresolution":[210],"showed":[212],"average":[214],"V":[216,257],"1.5":[217,258],"cluster":[218],"size":[219],"cells,":[225],"line":[227],".":[232],"Conclusions":[233],"Heart":[234],"failure":[235],"induces":[236],"structural":[237],"disc,":[242],"LM,":[243],"These":[249],"adaptations":[250],"are":[251],"accompanied":[252],"alterations":[254],"clustering":[259],"failing":[268]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-12-22T00:00:00"}