{"id":"https://openalex.org/W27742916","doi":null,"title":"Liver function under interferon/ribavirin therapy of chronic hepatitis C.","display_name":"Liver function under interferon/ribavirin therapy of chronic hepatitis C.","publication_year":2009,"publication_date":"2009-03-01","ids":{"openalex":"https://openalex.org/W27742916","mag":"27742916","pmid":"https://pubmed.ncbi.nlm.nih.gov/19579621"},"language":"en","primary_location":{"id":"pmid:19579621","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19579621","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepato-gastroenterology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028841026","display_name":"Sebastian Stintzing","orcid":"https://orcid.org/0000-0002-3297-5801","observed_orcids":["https://orcid.org/0000-0002-3297-5801"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S Stintzing","raw_affiliation_strings":["Department of Medicine 1, University of Erlangen-Nuremberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine 1, University of Erlangen-Nuremberg, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C Schmitt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Schmitt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041718629","display_name":"Matthias Ocker","orcid":"https://orcid.org/0000-0001-8263-6288","observed_orcids":["https://orcid.org/0000-0001-8263-6288"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Ocker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037850791","display_name":"Marion Ganslmayer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Ganslmayer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109401583","display_name":"Steffen Zopf","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Zopf","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027318510","display_name":"Susanne Gahr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Gahr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113661192","display_name":"E.G. Hahn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E G Hahn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108622273","display_name":"C. J. Herold","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Herold","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3883,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.68237063,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"56","issue":"90","first_page":"462","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.9980000257492065},{"id":"https://openalex.org/keywords/peginterferon-alfa-2a","display_name":"peginterferon alfa-2a","score":0.8500000238418579},{"id":"https://openalex.org/keywords/ribavirin","display_name":"ribavirin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.8899999856948853},{"id":"https://openalex.org/keywords/liver-function-tests","display_name":"liver function tests","score":0.7440000176429749},{"id":"https://openalex.org/keywords/aminopyrine-breath-test","display_name":"aminopyrine breath test","score":0.9150000214576721},{"id":"https://openalex.org/keywords/galactose-elimination-capacity","display_name":"galactose elimination capacity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/indocyanine-green-clearance","display_name":"indocyanine green clearance","score":0.996999979019165},{"id":"https://openalex.org/keywords/liver-perfusion","display_name":"liver perfusion","score":0.675000011920929},{"id":"https://openalex.org/keywords/hcv-rna-clearance","display_name":"HCV RNA clearance","score":0.6000000238418579},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.7139999866485596},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2780040827","wikidata":"https://www.wikidata.org/wiki/Q421862","display_name":"Ribavirin","level":4,"score":0.8824933171272278},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7674376964569092},{"id":"https://openalex.org/C2992208098","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function","level":2,"score":0.6637861728668213},{"id":"https://openalex.org/C512861765","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function tests","level":2,"score":0.5999398231506348},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5981645584106445},{"id":"https://openalex.org/C2781065829","wikidata":"https://www.wikidata.org/wiki/Q905662","display_name":"Indocyanine green","level":2,"score":0.5825772881507874},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.571134626865387},{"id":"https://openalex.org/C2776461080","wikidata":"https://www.wikidata.org/wiki/Q7160835","display_name":"Pegylated interferon","level":5,"score":0.5003643035888672},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.4698666036128998},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.4457566738128662},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.4082428812980652},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31957268714904785},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24945777654647827},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.18020087480545044}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008111","descriptor_name":"Liver Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012254","descriptor_name":"Ribavirin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:19579621","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19579621","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepato-gastroenterology","raw_type":"Journal Article"},{"id":"mag:27742916","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19579621","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W988698809","https://openalex.org/W1972013249","https://openalex.org/W1972841716","https://openalex.org/W1976323490","https://openalex.org/W1994216586","https://openalex.org/W1996522640","https://openalex.org/W2000914459","https://openalex.org/W2007921736","https://openalex.org/W2010363289","https://openalex.org/W2017505626","https://openalex.org/W2024831487","https://openalex.org/W2025070618","https://openalex.org/W2038691033","https://openalex.org/W2040467914","https://openalex.org/W2050444947","https://openalex.org/W2052767160","https://openalex.org/W2057799498","https://openalex.org/W2080588816","https://openalex.org/W2082298277","https://openalex.org/W2089548046","https://openalex.org/W2099625896","https://openalex.org/W2100784772","https://openalex.org/W2109047336","https://openalex.org/W2112165124","https://openalex.org/W2129008216","https://openalex.org/W2129415564","https://openalex.org/W2138526108","https://openalex.org/W2141281277","https://openalex.org/W2335723263","https://openalex.org/W2916040650","https://openalex.org/W4232665790","https://openalex.org/W4247665917"],"related_works":["https://openalex.org/W3145456368","https://openalex.org/W7096948298","https://openalex.org/W1986285172","https://openalex.org/W2361058097","https://openalex.org/W2101774228","https://openalex.org/W2069235364","https://openalex.org/W2029068123","https://openalex.org/W1922890115","https://openalex.org/W6960214320","https://openalex.org/W245952103"],"abstract_inverted_index":{"BACKGROUND:":[0],"Quantitative":[1,71],"testing":[2,47,72],"of":[3,14,17,48,73,101,110,124,141,168,177,213],"liver":[4,22,49,74,145,169,203,221],"function":[5,23,50,146],"(QTLF)":[6],"is":[7],"one":[8,175,209],"way":[9],"to":[10,40,157,181,206,230,236],"show":[11],"the":[12,108,111,161,199,214,220],"efficacy":[13],"antiviral":[15,31,43,102],"treatment":[16,178],"Hepatitis":[18,28,59,215],"C.":[19],"Data":[20],"on":[21],"in":[24,149,160,192],"patients":[25,56,127,151],"with":[26,57,65],"chronic":[27,58],"C":[29,60,216],"during":[30,190],"therapy":[32,44,112,153,162],"are":[33],"lacking.":[34],"We":[35],"therefore":[36],"investigated":[37],"if":[38],"and":[39,88,96,115,131,137,143,155,172,225],"what":[41],"extent":[42],"influenced":[45],"quantitative":[46],"(QTLF).":[51],"METHODOLOGY:":[52],"One":[53],"hundrend":[54],"seven":[55],"(genotype":[61],"1)":[62],"were":[63,132,147],"treated":[64],"pegylated-interferon":[66],"2alpha/ribavirin":[67],"for":[68,134],"48":[69],"weeks.":[70],"function,":[75],"including":[76],"aminopyrine":[77],"breath":[78],"test":[79],"(ABT),":[80],"galactose":[81],"elimination":[82],"capacity":[83],"(GEC),":[84],"sorbitol":[85],"clearance":[86,91],"(SCl)":[87],"indocyanine":[89],"green":[90],"(ICG)":[92],"was":[93,105],"performed":[94],"before":[95,152,179],"12":[97],"weeks":[98],"after":[99,118,164,197,211],"initiation":[100,154],"therapy.":[103,119,200],"QTLF":[104,186,194],"repeated":[106],"at":[107],"end":[109],"(week":[113],"48)":[114],"6":[116],"months":[117,123],"RESULTS:":[120],"After":[121],"3":[122,165],"treatment,":[125],"97":[126],"showed":[128],"normal":[129,158,182,207],"transaminases":[130],"negative":[133],"HCV-RNA.":[135],"ABT":[136],"GEC":[138],"as":[139],"parameters":[140],"microsomal":[142],"cytosolic":[144],"reduced":[148],"all":[150],"returned":[156],"values":[159],"responders":[163],"months.":[166],"Parameters":[167,218],"perfusion":[170],"(SCl":[171],"ICG)":[173,226],"require":[174,227],"year":[176,210],"returning":[180],"levels.":[183],"In":[184],"non-responders,":[185],"did":[187],"not":[188],"change":[189],"therapy,":[191],"relapsers,":[193],"results":[195],"deteriorated":[196],"ending":[198],"CONCLUSION:":[201],"All":[202],"tests":[204],"return":[205],"within":[208],"eradication":[212],"virus.":[217],"measuring":[219],"plasma":[222],"flow":[223],"(SCI":[224],"more":[228],"time":[229],"become":[231],"normal,":[232],"most":[233],"likely":[234],"due":[235],"tissue":[237],"remodelling":[238],"processes.":[239]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
